3,3′-Diindolylmethane

DIM Ntxiv
3,3′-Diindolylmethaneyog ib qho tseem ceeb hauv chav kawm ntawm indole alkaloids, thiab nws cov qauv dav dav nyob rau hauv cov khoom ntuj, cov khoom siv, thiab cov tshuaj hluavtaws molecules. Diindolylmethane derivatives feem ntau yog siv rau hauv cov tshuaj, tshuaj ua liaj ua teb, thiab cov ntaub ntawv thiab feem ntau yog synthesized los ntawm cov tshuaj tiv thaiv ntawm indole nrog aldehydes, ketones, cawv, ethers, thiab amines. DIM yog tsim los ntawm condensing ob indole 3-carbinol molecules, thiab nws yog lub ntsiab ntawm ntau yam condensation khoom ntawm indole 3-carbinol. DIM yog polycyclic aromatic hydrocarbon compound uas tuaj yeem tshem tawm cov dawb radicals, quench singlet oxygen, thiab muaj zog antioxidant. Cov kev tshawb fawb tau pom tias indole 3-carbinol thiab DIM tuaj yeem siv los ua cov tshuaj tua kab mob hauv ntau yam kab mob los tiv thaiv, inhibit thiab thim rov qab cov txheej txheem ntawm cov kab mob tseem ceeb.
Kev siv cov tshuaj no hauv kev ua lag luam yog ntau thiab ntau dua. Yog tias koj txaus siab rau DIM ntshiab, thov hu rau Xi'an Sonwu.

Certificate Of Analysis

Qhov twg yuav DIM
Xi'an Sonwu Biotech Co., Ltd. yog ib tug distributor nrog ntau tshaj kaum xyoo ntawm kev paub. Xi'an Sonwu yeej ib txwm hais kom zoo ua ntej. Pab txhua tus neeg siv khoom zoo thiab txaus siab yog Xi'an Sonwu txoj kev nrhiav. Xi'an Sonwu tseem tswj hwm txhua kauj ruam, los ntawm kev xaiv thiab tshawb nrhiav. Raws li qhov no, cov neeg siv khoom tau muab cov lus pom zoo ntawm cov khoom thiab kev pabcuam. Yog li yog tias koj xav tau DIM hmoov lossis tshuaj ntsiav, thov hu rau Xi'an Sonwu.
Xi'an Sonwu thaum kawg ua kom cov khoom zoo thiab tseem muaj cov qauv. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'Cov lus pom zoo

Kev Pabcuam OEM
Xi'an Sonwu tuaj yeem muab cov hmoov nyoos thiab tseem DIM capsules.
Yog li cov neeg siv khoom tuaj yeem kho cov tshuaj ntsiav thiab cov khoom hauv qab no.
1. Customized capsules shells (loj, xim, khoom)
2. Customized fwj (loj, xim, khoom, style)
3. Customized ntim (nqus foil ntim, thawv, nruas)
4. Customized daim ntawv lo (xim zaj duab xis, matte zaj duab xis, daim npog qhov muag)

Dab tsi Yog Diindolylmethane (DIM) Ua Rau Lub Cev

1. cuam tshuam cov metabolic ua kom cov hlwb tsis zoo
DIM tuaj yeem hloov cov txheej txheem metabolic ntawm cov hlwb tsis zoo los ntawm kev tswj cov enzymes ntsig txog cov metabolism hauv cov hlwb tsis zoo, suav nrog theem I enzymes CYP1 thiab CYP2B tsev neeg thiab theem II enzymes, kom ua tiav cov kev cai ntawm glutathione sulfur transferase. Kev tswj hwm plaub lub lis piam rau nas tuaj yeem cuam tshuam qhov tsim ntawm mammary sarcoma tshwm sim los ntawm 7, 12-dimethylbenz pallium thiab plawv sinus sarcoma tshwm sim los ntawm benzopyrene. Tsis tas li ntawd, DIM tuaj yeem cuam tshuam cov metabolism ntawm aflatoxins kho los ntawm lawv los ntawm inhibiting tib neeg CYP1A1 thiab CYP1A2.

2. Kev cuam tshuam rau kev puas hlwb kev loj hlob thiab lub voj voog ntawm tes
Estrogen receptor-zoo mis lub mis tsis zoo hlwb MCF7 thiab lub mis tsis zoo MDA-MB-231 yog cov kab sawv cev ntawm lub mis loj heev. DIM tau pom tias muaj feem cuam tshuam rau ob kab ntawm lub mis tsis zoo nyob rau hauv thaj tsam ntawm 0-100 μmol / L. Inhibition ntawm proliferation, thiab qhov no inhibition ntawm proliferation, muaj feem xyuam rau cell voj voog ntes nyob rau hauv lub G theem thiab nce qhia ntawm p21. Tsis tas li ntawd, hauv ob kab ntawm tes no, DIM tuaj yeem cuam tshuam qhov kev qhia ntawm cyclin E2, Survivin, thiab Bcl-2, txhim kho qhov kev nthuav qhia ntawm p27 thiab p57, thiab ua rau lub voj voog ntawm tes thiab apoptosis.
Ib txoj kev tshawb fawb tsis ntev los no ntawm cov kab mob prostate tau pom tias DIM tuaj yeem cuam tshuam qhov kev loj hlob ntawm G1 mus rau theem S los ntawm kev tswj hwm p27 thiab txo qis- tswj kev qhia ntawm androgen receptor. Lwm txoj kev tshawb nrhiav pom tias txawm nyob hauv androgen-dependent LNCaP lossis androgen receptor-negative DU145 prostate disease, DIM tuaj yeem ntes G1 theem thiab cuam tshuam qhov kev qhia ntawm cdk2 thiab cdk4, nrog rau kev tswj hwm ntawm p27 qhia. Cov txiaj ntsig no qhia tias DIM tuaj yeem muaj qhov cuam tshuam loj rau cov kab mob prostate thiab tsis cuam tshuam los ntawm androgens. Lwm txoj kev tshawb fawb pom tias 1: 1 kev sib xyaw ntawm DIM thiab isothiocyanate tuaj yeem ua rau ntau lub voj voog ntawm tes raug ntes nyob rau theem G2 / M.

3. Ua kom rhiab heev ntawm sarcoma hlwb rau cov tshuaj chemotherapy

3,3′-Diindolylmethanetuaj yeem ua rau apoptosis ntawm squamous hlwb, cov kua tsib duct epithelium, txoj hnyuv, ncauj tsev menyuam, thiab lwm yam sarcoma hlwb. Txoj kev tshawb nrhiav pom tias cov nyhuv inhibitory ntawm DIM ntawm lub ncauj tsev menyuam SiHa hlwb yog nyob ntawm lub sijhawm. Tsis tas li ntawd, cov kev tshawb fawb tau pom tias nws tuaj yeem ua rau muaj kev cuam tshuam ntawm kev siv tshuaj tua kab mob ntawm sarcoma cell apoptosis thiab rhiab heev ntawm sarcoma rau cov tshuaj no. Tus apoptosis tus nqi tau nce ntxiv, uas tuaj yeem ua tiav los ntawm kev tswj hwm Bcl-xL, XIAP, cIAP, thiab Surivin.
DIM kuj tseem txhim kho cov nyhuv apoptosis-inducing ntawm EGFR inhibitor erlotinib. Hauv cov qog prostate txaus ntshai, kev siv 0.5 mg / L ntawm daunorubicin ua ke nrog 60 μmol / L ntawm DIM nce qhov kev loj hlob inhibition tus nqi ntawm cov tshuaj ua ke ntawm cov cell tsis zoo los ntawm 27.8 feem pua ​​​​rau 69.9 feem pua ​​​​, tus nqi ntawm induced apoptosis tau nce los ntawm 3.2 feem pua ​​​​rau 47.0 feem pua, sib npaug rau cov nyhuv ntawm 10 npaug ntawm koob tshuaj (5 mg / L) ntawm IDA, qhia tias DIM tuaj yeem txhim kho kev loj hlob inhibitory nyhuv ntawm IDA ntawm PC{{ 14}}M hlwb. Nws cov txheej txheem muaj feem xyuam rau apoptosis ntsig txog cov nyhuv induction.

4. Inhibition ntawm phem cell angiogenesis

DIM muaj cov nyhuv inhibitory ntawm sarcoma angiogenesis, thiab tsib μmol / L DIM tuaj yeem cuam tshuam kev loj hlob, kev ntxeem tau, kev tsiv teb tsaws, thiab angiogenesis ntawm HUVECs. Tus qauv hauv vivo pom tias nws tuaj yeem cuam tshuam kev loj hlob ntawm tib neeg lub caj pas mammary cell MCF-7 tsis muaj cell-bearing liab qab nas thiab qhia cov nyhuv ntawm anti-sarcoma angiogenesis.

5. Qhov cuam tshuam rau ntawm tes teeb liab transduction txoj kev

Cov teebmeem ntawm NFrB

Tom qab DIM ua rau cov kab mob ntawm lub mis, MCF-7 cov hlwb rau 24 teev ua rau muaj kev cuam tshuam DNA-binding kev ua haujlwm ntawm NF-kB thiab muaj peev xwm hloov pauv ntawm p65. Tsis tas li ntawd, ntau cov kev tshawb fawb tau pom tias DIM-induced apoptosis tuaj yeem ua tiav los ntawm kev tswj hwm ntawm txoj kev NF-kB. Hauv kev tshawb fawb ntawm cov kab mob ntawm lub mis, DIM muaj kev sib koom ua ke ntawm kev cuam tshuam ntawm NF-kB tshwm sim los ntawm cov tshuaj tua kab mob docetaxel, qhia tias qhov no kuj yog ib qho tseem ceeb rau DIM los txhim kho cov chemosensitivity ntawm docetaxel. Hauv cov kab mob prostate, DIM tuaj yeem txo qis-tswj cov kev qhia ntawm nws lub hom phiaj cov noob xws li VEGF, IL-8, uPA, thiab MMP-9 los ntawm inhibiting DNA binding kev ua ntawm NF-kB thiab tom qab ntawd cuam tshuam rau angiogenesis, migration, thiab metastasis ntawm cov hlwb puas.

Qhov cuam tshuam rau Survivin
Survivin, ib qho classic inhibitor ntawm caspase-9, yog ib qho ntawm cov molecules tseem ceeb tswj apoptosis. Survivin muaj feem xyuam rau ntau txoj kev taw qhia, cuam tshuam cov hlwb tsis zoo 'kev loj hlob thiab lub voj voog ntawm tes. Survivin tau dhau los ua lub hom phiaj tseem ceeb rau kev tiv thaiv thiab kho cov hlwb tsis zoo. DIM tuaj yeem txo cov kev qhia ntawm Survivin hauv cov kab mob hauv lub mis MDA-MB-231, thiab cuam tshuam Survivin qhia nrog si-RNA tuaj yeem txhim kho qhov apoptosis thiab kev loj hlob inhibition ntawm cov kab mob hauv lub mis uas raug ntxias los ntawm DIM. Thaum Survivin yog overexpressed, DIM Apoptosis thiab kev loj hlob inhibition raug thaiv.

Cov teebmeem ntawm uPA thiab nws cov receptors
uPA yog ib qho tseem ceeb ntawm cov tswv cuab protein ntawm urokinase plasminogen ua kom lub cev. Cov kev tshawb fawb tam sim no tau pom tias uPA muaj feem cuam tshuam nrog kev txhim kho thiab metastasis ntawm ntau yam kab mob. Nyob rau hauv tus txheej txheem ntawm DIM-induced apoptosis ntawm prostate kab mob cell PC3, nrog rau cov down-regulation ntawm uPA qhia, lub cell proliferation thiab metastasis kev ua si yuav txo tau ntxiv tom qab siv tshwj xeeb si-RNA los cuam tshuam nrog uPA, qhia tias uPA koom nrog. cov kev cai ntawm cov nyhuv ntawm DIM rau cov kab mob prostate. Tsis tas li ntawd, hauv qhov tshwm sim ntawm DIM ntawm cov kab mob hauv lub mis MDA-MB-231 thiab MCF-7, uPA tau koom nrog hauv txoj cai.

Hoobkas
1. Xi'an Sonwu muaj cov chaw tsim khoom, tsim khoom, thiab chaw cia khoom nrog cov khoom muag txaus. Xi'an Sonwu muaj lub chaw tsim khoom kom zoo thiab huv si. Ntawm Xi'an Sonwu, cov kws tshawb fawb tuaj yeem txhim kho cov khoom lag luam zoo.
2. Xi'an Sonwu muaj cov neeg ua haujlwm nruj heev los ntawm kev tsim khoom thiab kev sim rau kev muag khoom. Txhawm rau kom ntseeg tau tias txhua yam khoom thauj khoom, muab cov ntaub ntawv tsis sib haum xeeb thiab kev pab cuam tom qab muag.

Daim ntawv pov thawj

Ntim

Logistics

Xi'an Sonwu, dhau li kev lees paub cov khoom zoo, lwm yam yog los pab cov neeg siv khoom tuaj yeem tau txais cov khoom zoo. Yog li, Xi'an Sonwu tuaj yeem muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ
Lub hom phiaj tseem ceeb ntawm DIM yog kom sib npaug ntawm cov tshuaj estrogen. Nyob ntawm cov koob tshuaj siv, nws tuaj yeem cuam tshuam rau qib estrogen hauv lub cev. DIM tseem tiv thaiv testosterone los ntawm kev tsim cov tshuaj estrogen los ntawm aromatase inhibitor. DIM ntau dhau muaj qhov cuam tshuam rau qhov sib txawv, ua rau cov tshuaj estrogen. Nws kuj tuaj yeem cuam tshuam rau cov metabolism hauv cov tshuaj estrogen, ua rau nws tsis zoo.
Yog tias koj xav paub DIM cov chaw tsim khoom, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email ces koj tau txais high-zoo3,3′-Diindolylmethane.
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