Acadesine yog dab tsi?
Kev kawm, tseem hu ua 5-aminoimidazole-4-carboxamide-1- -D-ribofuranoside, AICA-riboside, thiab AICAR. Nws yog ib qho AMPK activator, feem ntau yog siv los kho cov mob qog ntshav qog ntshav qog ntshav, tab sis nws kuj tseem tuaj yeem siv rau lwm yam kab mob xws li ntshav qab zib. Nws kuj yog ib qho nucleoside analog muaj peev xwm nkag mus rau hauv lub pas dej nucleoside, nce qib adenosine thaum ATP tawg. AICAR tuaj yeem tswj cov piam thaj thiab lipid metabolism thiab inhibit zus tau tej cov pro-inflammatory cytokines thiab iNOS. Xi'an Sonwu muag AICAR hmoov tam sim no; Yog tias koj txaus siab, thov hu rau Xi'an Sonwu.
HPLC ntawm Kev Tshawb Fawb
AMPK yog dab tsi?
AMPK yog ib qho AMP-dependent protein kinase, ib qho tseem ceeb molecule nyob rau hauv regulating lom zog metabolism, thiab lub hauv paus ntawm kev tshawb fawb txog ntshav qab zib thiab lwm yam kab mob metabolic. Nws muaj nyob rau hauv ntau yam ntawm cov kab mob metabolic. Nws tuaj yeem qhib los ntawm ntau yam stimuli hauv lub cev, suav nrog kev ntxhov siab ntawm cellular, kev tawm dag zog, thiab cov tshuaj hormones, nrog rau cov tshuaj uas cuam tshuam rau cellular metabolism. Cov kev tshawb fawb txog noob caj noob ces thiab kws tshuaj tau pom tias AMPK yuav tsum muaj rau lub cev kom tswj tau cov piam thaj. Vim lub complex molecular mechanism, activating AMP los ntawm cov tshuaj molecules yog ib qho kev sib tw zoo, tab sis nws ua kom muaj peev xwm txhim kho cov metabolic imbalance los ntawm hom II mob ntshav qab zib.
AMPK ua lub luag haujlwm tseem ceeb hauv kev tswj hwm lub zog ntawm tes, txhawb nqa ATP ntau lawm thiab inhibiting ATP noj txoj hauv kev hauv ntau cov ntaub so ntswg. AMPK tshwm sim raws li heterotrimeric complex uas muaj cov catalytic alpha subunit thiab tswj beta thiab gamma subunits. Thaum khi ntawm AMP mus rau lub subunit, lub complex yog allosterically activated, ua rau nws yooj yim phosphorylated substrate ntawm threonine 172, uas yog yooj yim phosphorylated los ntawm lub loj upstream AMPK kinase LKB1 nyob rau hauv lub activation voj ntawm lub subunit. Qhov kinase no tau qhib rau hauv kev teb rau kev ntxhov siab uas depletes cellular ATP mov. Kev khi ntawm AMP mus rau gamma subunit allosterically ua kom lub complex, ua rau nws zoo nkauj substrate rau qhov tseem ceeb AMPK kinase LKB1.
AMPK yog tus thawj tswj hwm ntawm lipid metabolism thiab qabzib metabolism. AMP-dependent protein kinase yog ib qho tseem ceeb molecule hauv kev tswj cov roj ntsha zog metabolism thiab yog lub hauv paus ntawm kev tshawb fawb txog ntshav qab zib thiab lwm yam kab mob metabolic. Hauv ntau hom, AMPK tuaj yeem ua raws li qhov tseem ceeb ntawm kev tswj hwm ntawm senescence los ntawm kev cuam tshuam nrog mTOR thiab sirtuins. Raws li nws yog lub hauv paus tswj hwm ntawm lipid thiab qabzib metabolism, AMPK yog suav tias yog lub hom phiaj kho mob tseem ceeb rau kev kho mob rog, ntshav qab zib hom II, thiab mob qog noj ntshav.
Lub luag haujlwm ntawm AMPK yog dab tsi?
1. Inhibits anabolism
Thaum lub sijhawm tsis muaj zog, AMPK inhibits ntau txoj hauv kev biosynthetic. Thawj qhov kev qhia pom txoj hauv kev inhibits lipid thiab sterol synthesis, tus nqi-txo cov kauj ruam hauv cov cholesterol synthesis, los ntawm inhibiting ACC1, ACC2, thiab phosphorylated -reductase. Yog li, AMPK tuaj yeem kho cov kab mob cuam tshuam los ntawm fatty acids. AMPK rov tswj cov metabolism hauv kev hloov pauv ntawm biosynthesis. Ntxiv rau qhov no, AMPK tseem khi cov proteins los ntawm phosphorylating sterol tswj cov ntsiab lus thiab tswj cov metabolism hauv qib transcriptional.
2. Txhawb cov synthesis ntawm mitochondria
Mitochondria yog synthesized los ua kom muaj zog tso zis, ua rau ntau ATP. Kev tawm dag zog thiab cov leeg nqaij ua rau muaj kev sib txuas ntawm mitochondria thiab ua kom cov leeg muaj peev xwm oxidative. Qhov kev ua haujlwm no ua pov thawj tias kev tawm dag zog kuj yog ib qho zoo AMPK activator, thiab kev ua kom ntev ntev ntawm AMPK tuaj yeem ua kom cov synthesis ntawm mitochondria. Tsis tas li ntawd, AMPK activatorKev kawmtuaj yeem ua raws li kev tawm dag zog mimetic tus neeg sawv cev. Cov nyhuv ntawm AMPK ntawm hluavtaws mitochondria yog qhov tseem ceeb rau kev tawm dag zog thiab cov leeg mitochondria thiab muaj kev cuam tshuam rau kev kho mob hauv ntau yam kab mob.
3. Tswj autophagy
Autophagy yog cov txheej txheem uas tshwj xeeb organelle recycles cov khoom xws li cov proteins, macromolecules, organelles, thiab cov kab mob. Lub autophagosome muaj ntau ntau cov protein ntau complexes uas tswj txhua kauj ruam cov tshuaj tiv thaiv, thiab AMPK tuaj yeem tswj cov kab mob no hauv ntau txoj hauv kev.
AMPK tau pom tias tswj hwm autophagy nyob rau hauv cov poov xab thiab mammalian hlwb. Nws cov cwj pwm molecular qhia tias AMPK tswj hwm autophagy ntawm ntau theem. Ua ntej, AMPK ncaj qha phosphorylates qhov chaw plaub ntawm Thr1227 thiab Ser1345 ntawm TSC2, tus tswj hwm ntawm mTOR, thiab qhov chaw 5 ntawm Ser722 thiab Ser792 ntawm mTORC1 subunit PASTOR. Ob qho ntawm cov txheej txheem phosphorylation no tau koom nrog hauv kev txo qis mTOR kev ua haujlwm nyob rau hauv cov xwm txheej ntawm lub zog kev ntxhov siab. Raws li tau hais los saum toj no, qhov txo qis ntawm mTOR kev ua ub no tau txo qis qhov inhibitory phosphorylation ntawm ULK1 thiab activated autophagy.
4. Kev sau thiab kev cai ntawm autophagy
Ntxiv rau kev tswj hwm kev tswj hwm kev hloov pauv dav dav, AMPK ua kom muaj peev xwm ncaj qha lossis ncaj qha tswj cov noob koom nrog hauv cov metabolism, autophagy, thiab lysosomal zog. AMPK tuaj yeem ncaj qha phosphorylate FOXO tsev neeg hloov pauv hloov pauv yam tseem ceeb 20 thiab tswj autophagy-txog cov noob 198. AMPK tswj lysosome synthesis los ntawm TFEB thaum sib txawv ntawm embryonic qia hlwb rau hauv lub cev embryoid. Raws li cov xwm txheej saum toj no, thaum AMPK qhib thiab mTOR yog inhibited, TFEB dephosphorylation imports nws mus rau hauv lub nucleus, uas pib lub CLEAR gene network 200. Gene cov khoom hauv CLEAR gene network tswj kev ua haujlwm lysosome, uas autophagy xav tau.
AMPK yog suav tias yog tus tswj hwm tseem ceeb ntawm mitochondrial homeostasis, tswj txhua yam ntawm lub neej mitochondrial, los ntawm kev sib txuas thiab kev ua kom muaj zog mus rau mitophagy. Mitochondria yog qhov chaw tseem ceeb ntawm ATP tiam hauv cov hlwb, thiab AMPK, raws li qhov qis ATP sensor, tswj lub homeostasis ntawm ATP thiab tswj cov kev taw qhia qis qis kom tswj tau lub xeev mitochondrial zoo. Yog li, AMPK dhau los ua tus tiv thaiv ntawm mitochondria.
Dab tsi yog Txoj Haujlwm ntawm AICAR?
Kev kawm, raws li AMPK activator, tuaj yeem tswj cov piam thaj thiab lipid metabolism thiab inhibit zus tau tej cov proinflammatory cytokines thiab iNOS.
1. Tom qab 30-40 feeb ntawm kev siv AICAR, ZMP nyob rau hauv cais hepatocyte extracts yuav nce thiab nyob ruaj khov ntawm li plaub nmol/g. Nws ua rau AMPK ua rau hauv nas hepatocytes thiab adipocytes ntawm 15 feeb tab sis tsis cuam tshuam rau ATP, ADP, lossis AMP qib.
2. Tseem ceeb inhibited fatty acid thiab sterol synthesis nyob rau hauv nas hepatocytes.
3. Ua rau inactivation ntawm HMG-CoA reductase.
4. Induce apoptosis ntawm B-CLL hlwb.
5. Lub cell viability ntawm tus neeg mob B-CLL hlwb raug txo los ntawm 68 feem pua mus rau 26 feem pua.
6. Induction ntawm caspase activation thiab cytochrome C tso tawm ntawm mitochondria.
7. AICAR phosphorylation yog induce apoptosis.
8. txo qis B cell ua si tab sis tsis tshua muaj txiaj ntsig rau T cell kev ua.
9. Ua rau txo cov cell metabolism hauv K562, LAMA-84 thiab JURL-MK1, thiab tuaj yeem tua tau K562 hlwb thiab Ba/F3 hlwb nqa T315I-BCR-ABL mutant.
Tawm tswv yim
Logistics
Hoobkas ib puag ncig
1.Xi'an Sonwu Biotech Co., Ltd muaj nws lub Hoobkas, yog li nws muaj txaus Tshuag. Tsis tas li, Xi'an Sonwu muaj chav ua haujlwm huv thiab huv si nrog cov khoom siv siab heev. Nrog cov thawj coj ntawm Xi'an Sonwu, cov kws tshawb fawb tau tsim cov khoom tshiab los ua kom tau raws li cov neeg siv khoom xav tau.
2.Xi'an Sonwu Biotech Co., Ltd muaj cov cuab yeej xeem thiab cov kws tshaj lij, uas txhua tus qhia tias Xi'an Sonwu lub hom phiaj muab cov ntaub ntawv raug thiab ua tau zoo thiab cov kev pabcuam zoo.
Daim ntawv pov thawj
Ntim
FAQ
1. Yuav ua li cas yuav cov khoom ntawm Xi'an Sonwu?
Koj tuaj yeem tiv tauj Xi'an Sonwu ntawm email, xov tooj, thiab kev tshaj xov xwm.
2. Yuav ua li cas kom ntseeg tau cov khoom zoo ua ntej xaj?
Txhua batch ntawm cov khoom yuav tsum raug kuaj los muab cov neeg siv khoom nrog COA thiab lwm tus neeg thib peb.
3. Yuav ntim thiab khaws AICAR Powder li cas?
Ntim: export qib ntim nruas, lub tshuab nqus tsev ntim aluminium foil ntim, kuj tuaj yeem ntim raws li cov neeg siv khoom xav tau.
Cia: thov khaws cia rau hauv qhov chaw txias thiab qhuav kom tsis txhob muaj lub teeb ci thiab kub.
Yog xav yuavKev kawm, thov hu rau Xi'an Sonwu.
E-mail:sales@sonwu.com
Cim npe nrov: acadesine, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, raw, mov, kev muag khoom
