Baricitinib hmoov

Baricitinib yog dab tsi

Baricitinib hmoovyog ib qho inhibitor ntawm JAK kinases 1 thiab 2, thiab nws muaj lwm lub npe, Olumiant. Nws ua haujlwm los ntawm kev thaiv Janus kinase. Baricitinib kho mob rheumatoid mob caj dab los txo qhov mob pob qij txha, txhav, thiab o. Nws tuaj yeem txo cov kab mob ua haujlwm rau cov neeg mob rheumatoid mob caj dab uas tsis tau siv cov tshuaj biologic DMARDS yav dhau los.

JAK Kinases yog dab tsi

JAK kinases yog intracellular non-receptor tyrosine kinases uas kho cov cytokine signals thiab hla lawv los ntawm JAK-STAT signaling pathway. JAK kinase tsev neeg muaj plaub tug tswv cuab: JAK kinase 1 (JAK1), JAK kinase 2 (JAK2), JAK kinase 3 (JAK3), thiab tyrosine kinase 2 (TYK2). JAK1 thiab JAK2 koom nrog hauv hom II interferon signaling, thaum JAK1 thiab TYK2 koom nrog hauv hom I interferon signaling, thiab nas uas tsis qhia TYK2 muaj kev ua haujlwm tsis zoo hauv cov hlwb tua neeg. JAK kinases khi rau thaj tsam proline-nplua nuj box1/box2 ntawm txhua qhov intramolecular domain uas nyob ib sab ntawm lub cell membrane. Thaum lub cytokine receptor khi rau nws cov cytokine ligand, ob lub JAK kinases mus rau ib leeg los ntawm kev hloov pauv, tso cai rau lawv kom phosphorylate. Lub autophosphorylation ntawm JAK kinases kuj ua rau muaj kev hloov pauv, ua rau lawv muaj phosphorylate ntxiv thiab qhib cov ntsiab lus hu ua STATs rau intracellular signal transduction. Tom qab lub tshuab txais STATs tawm ntawm lub receptor thiab daim ntawv dimers, lawv raug xa mus rau lub nucleus los tswj cov kev hloov pauv ntawm cov noob tshwj xeeb.

Xi'an Sonwu yog cov chaw tsim khoom siv raw khoom uas tuaj yeem muab cov ntaub ntawv raw nrog cov haujlwm sib txawv. Rau cov khoom, peb tuaj yeem muab cov khoom siv raw hmoov thiab cov tshuaj ntsiav tshuaj rau cov khoom. Yog tias koj xav tau, thov hu rau Xi'an Sonwnu.

COA

Qhov twg yuav Baricitinib

Xi'an Sonwu Biotech Co. ltd, cov khoom tsim tau nruj me ntsis tswj hauv kev ua tau zoo thiab tau nruj me ntsis soj ntsuam los ntawm qhov pib ntawm cov khoom siv raw. Hauv cov txheej txheem tsim khoom, peb tswj txhua qhov kev nthuav dav zoo, txo cov nqi, thiab pab kom peb cov neeg siv khoom tau txais cov khoom lag luam zoo. Ntau tus neeg siv khoom tau muab cov lus pom zoo rau peb cov khoom tom qab tau txais cov khoom.

Txhawm rau kom ntseeg tau cov khoom zoo, peb tuaj yeem muab cov qauv rau kev kuaj. Ntawm no yog qhov ntau.

Cov neeg siv khoom zoo lus

Dab tsi yog Mechanism ntawm Baricitinib

Baricitinib yog ib qho kev xaiv JAK2 thiab JAK1 inhibitor nrog tsawg zog tiv thaiv JanusKinase, jak3orTYK2. Qhov kinase no thiab nws cov teeb liab sib txuas lus thiab activator ntawm transcription (JAK-STAT) yog txoj hauv kev loj hauv lub cev uas tswj qhov loj thiab lub sijhawm ntawm cytokine signaling nrog hom I thiab hom II cytokine receptors. Cov receptors no tsis muaj kev ua haujlwm ntawm cov enzymatic uas tuaj yeem kho cov teeb liab hloov pauv; Janus kinase transducers thiab activators ntawm transcription qhib STAT los ntawm phosphorylation ntawm JAK enzymes. IL-6, granulocyte-macrophage colony-stimulating factor (GM-CSF) factor, yog koom nrog hauv pathogenesis ntawm RA, suav nrog IL-6 granulocyte-macrophage colony-stimulating factor (GM-CSF) factor. Interferon signaling los ntawm JAK-STAT signaling txoj kev. Yog li ntawd, JAK1 thiab JAK2 inhibitors tuaj yeem tsom mus rau ntau yam RA-txog cytokine txoj hauv kev, yog li txo qis kev ua haujlwm thiab kev loj hlob ntawm cov kab mob inflammatory thiab lub cev tiv thaiv kab mob tseem ceeb. Baricitinib tsis cuam tshuam rau JAK3. JAK3 tuaj yeem cuam tshuam nrog kev sib koom tes-chain receptors. Cov saw cytokines muaj xws li IL-15 thiab IL-21, uas tswj cov lymphocyte activation, muaj nuj nqi, thiab kev loj hlob.

Cov teebmeem

1. Tej yam tshwm sim: xeev siab; mob khaub thuas; mob qhov ntswg, txham, mob caj pas

2. Cov kev phiv loj heev

● Ua npaws, ua daus no, hws hmo ntuj, nkees nkees

● hawb pob, ua pa nyuaj, thiab hnoos tsis tu ncua

● Ntau zaus thiab mob thaum tso zis, zis tsaus

● poob phaus

● Cov pob hauv lub cev, xws li hauv caj dab, caj dab, lossis puab tais

● Muaj hlwv lossis kab mob herpes zoster

● Mob plab, mob plab

● Tsis qab los noj mov, ntuav, mob plab, jaundice

Ua ntej siv cov tshuaj Baricitinib, qhia rau koj tus kws kho mob yog tias koj noj lwm yam tshuaj. Siv raws li cov koob tshuaj pom zoo los ntawm koj tus kws kho mob. Yog tias muaj kev phiv tshwm sim tom qab noj cov tshuaj, tsis txhob noj tshuaj thiab qhia rau koj tus kws kho mob txog qhov xwm txheej.

Yuav Tau Txais Dab Tsi Ua Ntej Noj Baricitinib

Cov tshuaj Baricitinib tuaj yeem ua rau muaj kev pheej hmoo ntawm qee yam kab mob, yog li paub koj tus kws kho mob ua ntej yog tias koj lub cev muaj cov hauv qab no:

1. Cov kab mob tiv thaiv kab mob xws li tuberculosis, herpes zoster, HIV, lossis kab mob siab

2. Kab mob raum

3. Diverticulitis, mob plab lossis plab hnyuv

4. Teeb meem plawv

5. Cov roj (cholesterol) siab

6. Cov tsos mob ntawm tus kab mob xws li kub taub hau, ua daus no, mob nqaij, hnoos, ua pa nyuaj, mob ntawm daim tawv nqaij, raws plab, los yog mob zis.

Dose yog dab tsiBaricitinib hmoov

1. Cov neeg laus uas mob rheumatoid mob caj dab noj 2 mg ib hnub ib zaug. Nws kho cov neeg mob uas muaj mob me me mus rau mob hnyav rheumatoid mob caj dab los ntawm qog necrosis factor (TNF)

2. 4 mg ib zaug ib hnub rau cov neeg laus uas muaj COVID-19

Cov menyuam yaus uas muaj COVID-19:

◆ 2 mus rau qis dua cuaj xyoos: 2 mg ib hnub ib zaug

◆ Hnub nyoog 9 ntxiv: 4 mg ib hnub ib zaug

Kev coj mus ncig: coj nws mus rau 14 hnub kom txog thaum tso tawm.

Nws kho cov neeg mob coronavirus uas xav tau cov pa oxygen ntxiv lossis extracorporeal membrane oxygenation.

Hoobkas ib puag ncig

1.Xi'an Sonwu Biotech Co., Ltd muaj nws lub Hoobkas, yog li nws muaj txaus Tshuag. Tsis tas li, Xi'an Sonwu muaj chav ua haujlwm huv thiab huv si nrog cov khoom siv siab heev. Nrog cov thawj coj ntawm Xi'an Sonwu, cov kws tshawb fawb tau tsim cov khoom tshiab los ua kom tau raws li cov neeg siv khoom xav tau.

2.Xi'an Sonwu Biotech Co., Ltd muaj cov cuab yeej xeem thiab cov kws tshaj lij, uas txhua tus qhia tias Xi'an Sonwu lub hom phiaj muab cov ntaub ntawv raug thiab ua tau zoo thiab cov kev pabcuam zoo.

Daim ntawv pov thawj

Ntim

Tsis ntev los no Logistics

Tsuas yog lav cov khoom lag luam, lwm qhov tseem ceeb tshaj plaws yog cov neeg siv khoom tuaj yeem tau txais cov khoom zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li qhov xav tau sib txawv.

FAQ

1. Yuav ua li cas yuav cov khoom ntawm Xi'an Sonwu?

Koj tuaj yeem tiv tauj Xi'an Sonwu ntawm email, xov tooj, thiab kev tshaj xov xwm.

2.Yuav ua li cas kom ntseeg tau cov khoom zoo ua ntej xaj?

Txhua batch ntawm cov khoom yuav tsum raug kuaj los muab cov neeg siv khoom nrog COA thiab lwm tus neeg thib peb.

3. Yuav ntim thiab khaws cia li casBaricitinib hmoov?

Ntim: export qib ntim nruas, lub tshuab nqus tsev ntim aluminium foil ntim, kuj tuaj yeem ntim raws li cov neeg siv khoom xav tau.

Cia: thov khaws cia rau hauv qhov chaw txias thiab qhuav kom tsis txhob muaj lub teeb ci thiab kub.

Yog tias koj xav yuav Baricitinib, thov hu rau Xi'an Sonwu.

E-mail:sales@sonwu.com

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