Chenodeoxycholic Acid Hmoov

Chenodeoxycholic Acid yog dab tsi?

Chenodeoxycholic acid hmoovyog ib qho dawb organic teeb meem soluble hauv ethanol thiab glacial acetic acid. Nws tuaj yeem raug luv rau CDCA. Cov hmoov no cov nyhuv tseem ceeb yog txo cov roj cholesterol hauv cov kua tsib. Thaum feem coob ntawm cov neeg mob noj CDCA thiab CDCA suav txog 70 feem pua ​​​​ntawm cov kua tsib ntsev hauv qhov iab, cov lipids rov qab mus rau lub xeev ntawm micro granules, thiab cov roj (cholesterol) tsis txaus kom cov roj cholesterol hauv cov pob zeb tau yaj thiab los. Ib koob tshuaj txhua hnub ntawm 10mg / kg txog 15mg / kg CDCA inhibits cov roj cholesterol thiab ua kom cov kua tsib tso tawm hauv cov neeg mob cholelithiasis. Raws li qhov tshwm sim, CDCA yog ib qho ntawm lub ntiaj teb cov tshuaj siv ntau tshaj plaws rau cov pob zeb. Nws kuj yog siv los ua ke ursodeoxycholic acid (UDCA) thiab lwm cov tshuaj steroidal. Raws li tus kws tsim khoom ntawm CDCA, Xi'an Sonwu tau txais kev pom zoo los ntawm cov neeg siv khoom rau nws cov khoom zoo thiab cov kev pabcuam zoo heev. Yog tias koj xav yuav, thov hu rau Xi'an Sonwu.

COA

Qhov twg yuav CDCA?

Xi'an Sonwu Biotech Co., Ltd. muaj kev nplua nuj nyob hauv kev lag luam thoob ntiaj teb thiab kev lag luam kev noj qab haus huv. Insisting rau txoj kev ntseeg raws li kev ntseeg thiab zoo ua ntej yog peb lub tuam txhab txoj cai. Peb nruj me ntsis tswj cov khoom zoo, uas txhais tau tias kev xaiv pib los ntawm raw cov ntaub ntawv. Tsis tas li ntawd, peb tuav txhua qhov kev nthuav dav thiab txo tus nqi mus rau qhov siab tshaj plaws kom peb cov neeg siv khoom tuaj yeem tau txais cov khoom lag luam zoo. Raws li cov no, cov neeg siv khoom tau muab cov lus pom zoo rau peb cov khoom. Yog li nrhiav Xi'an Sonwu Biotech Co. Ltd. thaum yuav CDCA.

Peb xyuas kom meej cov khoom zoo kom cov qauv tuaj yeem muab tau. Ntawm no yog qhov ntau.

Cov neeg siv lus pom

CDAC Ua Haujlwm Li Cas?

CDCA yog tsim los ntawm cov roj (cholesterol) hauv lub siab los ntawm ob peb kauj ruam enzymatic. Zoo li lwm yam BAs, nws tuaj yeem ua ke nrog taurine lossis glycine los ua taurodeoxycholate lossis gandeoxycholate. Conjugation ua rau qis dua pKa. Qhov no ua rau cov kua tsib kua qaub ua rau ionized nyob rau hauv lub plab ntawm lub cev pH thiab nyob twj ywm hauv GI ib puag ncig kom txog thaum lawv ncav cuag ileum rau reabsorption. Tib lub sijhawm, CDCA thiab lwm cov kua tsib acids tsim micelles uas pab txhawb kev zom zaub mov lipid. Tom qab nqus tau, lawv tau nqus los ntawm daim siab thiab rov zais dua, yog li nqa tawm enterohepatic ncig. Cov kab mob tuaj yeem metabolize CDCA uas tsis tau nqus hauv cov nyuv los tsim cov kua tsib acid thib ob, lithic acid, lossis qhov sib txawv isomer UDCA.

Kev faib tawm ntawm CDCA hauv tib neeg lub cev

Chenodeoxycholic acid hmoovyog ib qho tshuaj purified heev unbound cholic acid uas muaj cov crystalline sib txawv. Qhov nruab nrab koob tshuaj ntawm 500mg txog 750mg ntawm CDCA yog yuav luag tag nrho absorbed, txawm tias noj ntawm lub plab khoob lossis nrog zaub mov. Ib feem me me ntawm cov protein ua ke nrog ntshav plasma hauv peripheral ntshav dissociation tswj qib qis. Ib feem ntawm nws yog tawm mus rau hauv txoj hnyuv kab noj hniav los ntawm lub biliary ib ntsuj av thiab reabsorbed, tsim enterohepatic ncig. Lub siab siv nws thiab tshem tawm kom zoo. CDCA khi rau glycine lossis taurine hauv daim siab thiab tso tawm hauv cov kua tsib. Kev khi CDcas yog absorbable thiab sai sai tshem tawm los ntawm lub siab. Hom kev khi ntawm CDCA hauv plab tuaj yeem cuam tshuam rau hauv lub pas dej ua kua qaub uas tau noj tshiab. Txawm li cas los xij, cov tshuaj tsis nqus tau raug tso tawm lossis hloov mus rau UDCA hauv cov quav, tab sis feem ntau ntawm lawv tau decomposed rau hauv LCA tom qab 7 -dehydroxylation los ntawm coliform flora. Yog li ntawd, LCA yog thawj metabolite ntawm qhov ncauj CDCA.

Dab tsi yog qhov tseem ceeb ntawm Chenodeoxycholic Acid hauv kev zom zaub mov?

CDCA yog cov kua qaub uas twb muaj lawm hauv lub cev. Nws ua haujlwm los ntawm kev rhuav tshem cov roj (cholesterol) uas ua rau lub gallstones thiab inhibiting cov roj cholesterol hauv daim siab thiab nqus tau rau hauv plab, uas yuav pab txo qis kev tsim cov pob zeb.

Chenodeoxycholic Acid siv rau dab tsi?

CDCA tam sim no yog cov tshuaj tseem ceeb tshaj plaws rau kev kho mob gallstones thoob ntiaj teb thiab yog siv ntau tshaj plaws ntawm tag nrho cov tshuaj gallstone. Nyob rau tib lub sijhawm, nws kuj yog ib qho tseem ceeb raw khoom rau synthesizing UCDA thiab lwm yam steroidal compounds. Nws yog dav siv hauv kev kho mob. CDCA tuaj yeem yaj cov roj cholesterol hauv lub gallstones, uas yog qhov zoo heev hauv kev kho lub gallbladder cholesterol gallstones nrog txoj kab uas hla tsis tshaj 2cm thiab lub gallbladder ua haujlwm zoo. Tsis tas li ntawd xwb, CDCA kuj tuaj yeem kho cov pob zeb pigmentary thiab cov pob zeb sib xyaw.

1. Pob zeb pob zeb

CDCA tau siv los ua kev kho mob kom yaj cov pob zeb. Cov tshuaj kho qhov ncauj BA tau siv rau hauv cov neeg mob uas muaj cov pob zeb me me thiab cov pob zeb muaj roj cholesterol uas tsis txaus siab rau kev phais. Nyob rau hauv tib neeg, CDCA yog ib tug physiological ligand rau cov kua tsib acid sensor farnesene X receptor (FXR), thaum LCA yog ib tug muaj zog agonist rau G protein-coupled receptors. Ua ke nrog UDCA, CDCA tau siv los kho cov pob zeb hauv cov pob zeb hauv cov koob tshuaj ntawm 375 txog 750 mg / hnub nrog kev ua tiav ntawm 8 feem pua ​​​​rau 18 feem pua. Txawm li cas los xij, kev kho CDCA ntau dhau ua rau mob raws plab, mob siab rov qab ua rau lub siab tsis zoo, thiab nce qib roj cholesterol hauv cov ntshav.

2. cem quav

CDCA tau raug tshawb xyuas raws li kev kho mob rau cem quav vim nws siv ntau zaus raws plab thaum lub plab zom mov. Thiab cov txiaj ntsig kev sim tau pom tias nws tuaj yeem ua kom lub plab zom mov thiab txhim kho txoj hnyuv.

3. Cerebrotendineous xanthomatosis

Hauv xyoo 2017, CDCA tau pom zoo los kho cov neeg mob uas muaj cerebral tendinoxanthomatosis (CTX). Tus kab mob no yog ib qho tsis tshua muaj autosomal recessive disorder tshwm sim los ntawm kev hloov pauv hauv sterol 27-hydroxylase (CYP27A1) gene. Vim tias CYP27A1 xav tau rau kev ua kom cov roj cholesterol, cov neeg mob CTX muaj qhov txawv txav lipid cia, nce ntshav plasma thiab cov ntaub so ntswg ntawm cov roj cholesterol, thiab qis heev kom tsis muaj CDCA ntau lawm. Txawm li cas los xij, CDCA yog qhov muaj zog inhibitor ntawm CYP27A1. Kev pib ntxov ntawm CDCA kev kho mob nrog koob tshuaj txog 750 mg / hnub yog suav tias yog tus qauv tshuaj kho rau CTX, txo qis cov roj cholesterol hauv cov ntshav thiab txhim kho cov tsos mob ntawm lub paj hlwb.

Yuav Ua Li Cas Koj Noj Chenodeoxycholic Acid?

CDCA yog ib hom tshuaj choleretic uas siv rau hauv kev kho mob gallstones. Nws cov ntaub ntawv thawj koob tshuaj yog ntsiav tshuaj thiab tshuaj ntsiav. CDCA ntsiav tshuaj yog cov tshuaj noj thiab tsuas yog yuav tsum tau noj raws li tus kws kho mob cov lus qhia. Cov koob tshuaj tuaj yeem hloov kho kom haum raws li qhov xwm txheej. Cov koob tshuaj dav dav yog raws li lub cev hnyav, 12mg / kg txog 15mg / kg txhua hnub, muab faib ua ob zaug thaum sawv ntxov thiab yav tsaus ntuj. Cov neeg rog rog uas hnyav lub cev hnyav yuav tsum nce koob tshuaj txhua hnub los ntawm 18mg / kg txog 20mg / kg rau li 6 lub hlis txog 24 lub hlis. Hu rau koj tus kws kho mob kom paub meej txog cov koob tshuaj tshwj xeeb. Thov ua raws li koj tus kws kho mob cov lus qhia. Tsis txhob hloov cov tshuaj koj tus kheej.

Kev ceev faj rau CDCA

1. CDCA yog ib qho tshuaj rau qhov ncauj.

2. Lwm yam kev phiv ntawm CDCA muaj xws li kiv taub hau thiab xeev siab.

3. CDCA tuaj yeem cuam tshuam txoj hnyuv nqus dej, yog li nws yuav yooj yim ua rau cov tsos mob raws plab, uas feem ntau zoo tom qab ob lub lis piam.

4. Nws yuav siv sij hawm ntev, thiab feem ntau nws yuav siv sij hawm ib nrab xyoo lossis ntau tshaj ib xyoos kom muaj cov nyhuv ntawm cov pob zeb yaj.

Leej twg tsis tuaj yeem noj CDCA?

1. Cov me nyuam yuav tsum tsis txhob noj.

2. Cov neeg mob ntshav qab zib yuav tsum tsis txhob noj thiab.

3. Cov poj niam cev xeeb tub thiab cov poj niam cev xeeb tub raug txwv tsis pub noj.

4. Cov neeg mob uas muaj kab mob siab, kab mob rwj, enteritis, thiab lub raum tsis ua haujlwm tsis tuaj yeem noj tau.

Yog tias muaj kev phiv loj heev tom qab noj nws, tsis txhob noj nws raws sijhawm.

Dab tsi yog Qhov Kev Mob Phem ntawm CDCA?

1. Cov neeg mob tsawg tsawg yuav muaj qhov hloov pauv hloov pauv tau AST (SGOT) nce.

2. Qee tus neeg mob yuav khaus tawv nqaij, kiv taub hau, xeev siab thiab ntuav, thiab mob plab.

3. Cov kev mob tshwm sim feem ntau yog raws plab, feem ntau yog mob plab plab. Qhov xwm txheej no muaj feem xyuam rau qhov ntau npaum li cas thiab ploj tom qab cov tshuaj txo. Cov neeg mob feem ntau tuaj yeem zam tau yog tias cov tshuaj maj mam nce ntxiv.

Dab tsi yuav tsum tau ceeb toom thaum noj CDCA?

1. Cholestyramine, Colestipol, thiab aluminium-muaj antacids tuaj yeem ua ke nrog CDCA kom txo tau lawv qhov nqus thiab yuav tsum tsis txhob siv ua ke.

2. Cov tshuaj tiv thaiv kev yug menyuam tuaj yeem ua rau cov kua tsib saturation. Lwm yam kev tiv thaiv kev yug me nyuam yuav tsum tau ua kom deb li deb tau thaum siv cov khoom no kom tsis txhob cuam tshuam cov nyhuv curative.

Hoobkas ib puag ncig

1. Xi'an Sonwu Biotech Co., Ltd muaj nws lub Hoobkas, yog li nws muaj Tshuag txaus. Tsis tas li, Xi'an Sonwu muaj chav ua haujlwm huv thiab huv si nrog cov khoom siv siab heev. Nrog cov thawj coj ntawm Xi'an Sonwu, cov kws tshawb fawb tau tsim cov khoom tshiab los ua kom tau raws li cov neeg siv khoom xav tau.

2. Xi'an Sonwu Biotech Co., Ltd muaj cov cuab yeej ntsuas qib siab thiab cov kws tshaj lij, uas txhua tus qhia tias Xi'an Sonwu lub hom phiaj muab cov ntaub ntawv raug thiab ua tau zoo thiab kev pabcuam zoo.

Daim ntawv pov thawj

Pob

Cov Ntaub Ntawv Logistics Tseeb

Dhau li lav cov khoom zoo, lwm qhov tseem ceeb tshaj plaws yog cov neeg siv khoom tuaj yeem tau txais cov khoom zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li qhov xav tau sib txawv.

Vim li cas thiaj xaiv peb?

Kev Muag Khoom Ua Ntej:

1. OEM customization kev pab cuam

2. Txhawb nqa cov qauv kuaj.

3. Cov lus nug yuav teb rau hauv 24 teev.

4. Txhua batch ntawm cov khoom raug kuaj xyuas kom zoo.

5. Muab cov ntawv ntim khoom, daim nqi xa khoom, daim ntawv them nqi lag luam, COA, thiab lwm yam ntaub ntawv txhawb nqa.

Kev pab cuam tom qab muag:

1. Hloov cov ntaub ntawv logistics raws sijhawm.

2. Txhua yam khoom uas muaj teeb meem zoo tuaj yeem xa rov qab.

3. Koj tuaj yeem sab laj Xi'an Sonwu txhua lub sijhawm txog kev siv cov khoom.

Yog koj xav yuavchenodeoxycholic acid hmoov, koj tuaj yeem tiv tauj Xi'an Sonwu ncaj qha.

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