Mifepristone hmoov

Mifepristone yog dab tsi
Mifepristone hmoov, lub npe tshuaj western, belongs rau qeb ntawm cov tshuaj tiv thaiv thaum ntxov cev xeeb tub. Nws tuaj yeem siv rau lub neej kev sib deev yam tsis muaj kev tiv thaiv kab mob lossis kev tiv thaiv tsis ua haujlwm tom qab siv cov tshuaj tiv thaiv kab mob. Feem ntau, peb pom RU38486, Lunarette, lossis RU486 kuj yog mifepristone. Nws tau ua ke nrog cov tshuaj prostaglandin txhawm rau txiav cev xeeb tub hauv 49 hnub ntawm kev tsim. Nws yog siv los tiv thaiv kev xeeb tub thaum ntxov, kev ua poj niam cev xeeb tub, kev ua haujlwm hauv plab hauv plab ntawm tus menyuam hauv plab tuag, thiab kev ua haujlwm hauv gynecological, xws li kev tso thiab tshem tawm cov khoom siv hauv lub cev, cov qauv endometrial, laser cais ntawm qhov txawv txav ntawm lub ncauj tsev menyuam, thiab Cervical dilation thiab curettage.
Raws li ib yam tshiab ntawm antiprogestin, mifepristone muaj antiglucocorticoid kev ua tab sis tsis muaj progestogen, estrogen, androgenic los yog antiestrogenic kev ua. Mifepristone muaj cov teebmeem ntawm kev cog qoob loo los tiv thaiv qe, inducing menstruation, thiab txhawb lub ncauj tsev menyuam ripening. Nws cov txheej txheem ntawm kev txhawb kev coj khaub ncaws thiab txwv tsis pub cev xeeb tub feem ntau yog los thaiv cov nyhuv ntawm progesterone los ntawm kev sib tw nrog cov progesterone receptor hauv endometrium. Piv nrog rau cov affinity ntawm progesterone receptor, nws yog tsib npaug zog dua li ntawm progesterone. Nyob rau hauv lub neej txhua hnub, daim ntawv thov ntawm mifepristone tau dhau los ua qhov dav, yog li muaj ntau thiab ntau tus neeg muag khoom zoo thiab tsis zoo hauv khw. Yog tias koj xav nrhiav mifepristone ntshiab, koj tuaj yeem tshawb Xi'an Sonwu.

Certificate Of Analysis

Qhov twg Yuav Mifepristone
Xi'an Sonwu Biotech Co., Ltd. muaj kev nplua nuj nyob hauv kev lag luam thoob ntiaj teb thiab kev lag luam kev noj qab haus huv. Insisting rau txoj kev ntseeg raws li kev ntseeg thiab zoo ua ntej yog peb lub tuam txhab txoj cai. Xi'an Sonwu nruj me ntsis tswj cov khoom zoo, uas txhais tau tias kev xaiv pib los ntawm raw cov ntaub ntawv. Tsis tas li ntawd, Xi'an Sonwu tuav txhua qhov kev nthuav dav thiab txo tus nqi mus rau qhov siab tshaj plaws kom cov neeg siv khoom tuaj yeem tau txais cov khoom lag luam zoo. Raws li qhov no, cov neeg siv khoom tau muab cov lus qhia zoo rau cov khoom. Yog li nrhiav Xi'an Sonwu Biotech Co. Ltd. thaum muas mifepristone.
Xi'an Sonwu tsis ua kom cov khoom zoo tab sis kuj muab cov qauv. Thov xyuas kom muaj nuj nqis.

Cov neeg siv khoom 'Cov lus pom zoo

Mifepristone Pharmacological nyhuv

1. Anti-progesterone nyhuv

(1) Kev cuam tshuam rau cov hauv paus hniav thiab corpus luteum
Kev siv mifepristone hauv kev coj khaub ncaws los yog lub sijhawm follicular lig tuaj yeem txo qhov tso tawm ntawm luteinizing hormone thiab follicle-stimulating hormone, yog li inhibiting kev loj hlob ntawm follicles, shrinking lub dominant follicles, thiab prolonging lub follicular theem, uas txhais tau hais tias anovulation tshwm sim. Yog hais tias cov tshuaj tsuas yog siv nyob rau hauv thaum ntxov follicular theem los yog ua ntej ovulation, nws yuav tsis cuam tshuam rau follicular kev loj hlob thiab ovulation. Nyob rau hauv nruab nrab-luteal theem, nws muaj peev xwm ncaj qha inhibit qhov amplitude thiab zaus ntawm LH pulses, yog li muaj cov nyhuv ntawm luteinizing. Mifepristone muaj qhov cuam tshuam ncaj qha rau kev loj hlob ntawm follicles. Hauv cov follicles thaum ntxov, nws tuaj yeem cuam tshuam kev ua haujlwm ntawm 17-hydroxylase hauv granulosa hlwb. Ntxiv rau qhov cuam tshuam tam sim ntawm nruab nrab thiab lig zes qe menyuam, nws inhibits FSH thiab LH teebmeem. Mifepristone tuaj yeem cuam tshuam kev ua haujlwm ntawm luteal theem, feem ntau nyob hauv lub luag haujlwm ntawm luteal kauj ruam nyob rau hauv nruab nrab thiab lig theem, thiab tsis muaj pronounced nyhuv rau thaum ntxov luteal theem. Cov koob tshuaj loj tuaj yeem yaj lub corpus luteum, txo qhov tso tawm ntawm cov tshuaj estrogen thiab progesterone, txo cov theem luteal, thiab ua rau kev coj khaub ncaws thaum ntxov.

(2) cuam tshuam rau endometrium
Qhov cuam tshuam ntawm endometrium yog vim nws qhov kev sib raug zoo siab nrog cov endometrial progesterone receptor, uas cuam tshuam rau kev ua haujlwm lom neeg ntawm progesterone. Mifepristone tuaj yeem antagonize lossis txawm thim rov qab cov txiaj ntsig ntawm progesterone ntawm cov ntaub so ntswg qhia hauv endometrial stromal hlwb. Nws cuam tshuam rau cov ntaub so ntswg deciduous, degeneration ntawm decidual hlwb, txo cov mitotic cov duab, theem nrab degeneration ntawm villi, tib neeg chorionic gonadotropin poob, thiab ces luteal muaj nuj nqi hypofunction, estrogen, thiab progesterone secretion poob. Yog li ntawd, cov synthesis thiab secretion ntawm endogenous prostaglandins nce nyob rau hauv decidual degeneration thiab decidual hemorrhage thiab shedding.

(3) cuam tshuam rau cov leeg nqaij ntawm lub tsev menyuam
Qhov sib npaug ntawm progesterone thiab prostaglandins tswj kev ua haujlwm ntawm lub tsev menyuam. Progesterone ua rau lub tsev menyuam nyob ntsiag to. Lub peev xwm ntawm mifepristone rau kev sib tw khi rau progesterone receptors yog peb lub sij hawm muaj zog dua li ntawm progesterone, uas cuam tshuam cov nyhuv inhibitory ntawm progesterone ntawm cov leeg hauv tsev menyuam thiab ua rau muaj kev nkag siab ntawm uterine myometrium excitation. Nyob rau hauv ib qho kev xeeb tub thaum ntxov, lub tsev me nyuam cov ntaub so ntswg collagen yog nplua nuj, thiab lub ncauj tsev menyuam raug kaw los tiv thaiv fetus. Txawm li cas los xij, nyob rau hauv qhov kev txiav txim ntawm mifepristone, progesterone receptor yog nyob, kev ua haujlwm lom neeg ntawm progesterone tsis muaj zog, thiab inhibition ntawm collagen decomposition los ntawm progesterone poob, ua rau lub zog ntawm lub ncauj tsev menyuam txo, yog li nws yog siv rau kev kho mob rho menyuam. thiab induction ntawm kev ua haujlwm.

2. Anti-glucocorticoid nyhuv

Mifepristone tsim cov teebmeem antiglucocorticoid ntawm ob koob tshuaj siab thiab qis. Qhov ntawd qhia tau hais tias mifepristone tuaj yeem cuam tshuam kev loj hlob ntawm tes thiab GRmRNA qhia tau ntxias los ntawm dexamethasone thiab nthuav tawm cov nyhuv ncaj qha lossis tsis ncaj los tiv thaiv cell proliferation. Mechanisms ntawm mifepristone's antiglucocorticoid zoo li cov teebmeem muaj xws li:
Txhim khu kev ruaj ntseg ntawm GR-heat shock protein 90 complex thiab tiv thaiv kev sib xyaw ntawm glucocorticoids thiab GR;
Receptor conformational hloov induced los ntawm GR binding tsis ua kom transcription.

(1) Kev cuam tshuam rau kev ua haujlwm ntawm hypothalamus-pituitary-adrenal axis
Mifepristone cuam tshuam rau kev ua haujlwm ntawm tib neeg hypothalamus-pituitary-adrenal axis nyob rau hauv koob tshuaj. Cov kev tshawb fawb hauv vitro tau pom tias mifepristone muaj kev sib raug zoo nrog tib neeg progesterone receptors thiab GR, yog li nws nthuav tawm ob txoj haujlwm ntawm kev tiv thaiv progesterone thiab anti-glucocorticoid. Mifepristone tuaj yeem sib tw nrog GR nkaus xwb ntawm cov koob tshuaj ntau dua. Thaum cov concentration piv ntawm serum mifepristone thiab corticosteroids ntau dua los yog sib npaug rau 10: 1, mifepristone qhia tau hais tias muaj cov nyhuv anti-glucocorticoid. Yog li ntawd, mifepristone ntawm tus txheej txheem kho cov koob tshuaj feem ntau pom muaj cov tshuaj tiv thaiv progesterone. Tsuas yog nyob rau hauv cov koob tshuaj siab xwb nws pom tias muaj kev cuam tshuam los tiv thaiv glucocorticoid, yog li nws yuav tsis ua rau muaj kev puas tsuaj rau adrenal ua haujlwm.

(2) cuam tshuam rau lub mis, pancreas, thiab endometrium
Glucocorticoids txhawb kev qhia ntawm cov noob hom phiaj, glucocorticoid-tswj kinases, nyob rau hauv ib txwm mammary epithelial hlwb thiab phem mammary hlwb thiab inhibit apoptosis induced los ntawm kev loj hlob yam tshem tawm. Cov nyhuv anti-glucocorticoid ntawm mifepristone tuaj yeem ua rau apoptosis nce 4.5 npaug. Thoob plaws hauv kev coj khaub ncaws, GR yog ib txwm qhia tau zoo heev hauv endometrial stroma, kuj tau piav qhia hauv lymphocytes thiab fibroblasts, tab sis tsis muaj nyob rau hauv lub nucleus ntawm cov qog endometrial.

Mechanism Ntawm Kev Ua Ntawm Mifepristone
Mifepristone hmoovyog ib qho progesterone receptor antagonist ntawm qib molecular, uas khi rau PR los thaiv cov teebmeem physiological ntawm progesterone. Tib neeg progesterone receptor yog tsim los ntawm 934 amino acids, thiab muaj peb thaj chaw ua haujlwm hauv molecule: pib los ntawm 567th amino acid, nws yog thaj tsam DNA khi; cheeb tsam tseem ceeb ntawm cov tshuaj hormones nyob rau thaj tsam ntau dua ntawm carboxyl kawg ntawm cov molecule; Cov cheeb tsam ua haujlwm ntsig txog tshuaj lom neeg thiab kev ua kom transcriptional. Tib neeg progesterone receptors feem ntau khi rau cov proteins ntawm 90 thiab 70 yam tsis muaj cov tshuaj hormones. Thaum progesterone nkag mus rau hauv lub cell thiab txuas mus rau lub receptor, nws yog thawj zaug hloov los ntawm lub receptor, tso tawm cua sov poob siab protein, ces dimerizes los ua ib tug dimer, thiab ces khi rau tus coj cov tshuaj hormones teb rau DNA mus qhib lub transcription activator, yog li ntawd. dhau mRNA synthesizes protein, ua hormonal teebmeem.

Mifepristone muaj affinity siab rau progesterone receptors. Thaum ob qho tib si sib xyaw ua ke, ib qho nyuaj ntawm mifepristone ntxiv rau receptor ntxiv rau cov protein ua rau kub poob. Lub complex ces nkag mus rau hauv lub nucleus, tom qab uas cov nucleoproteins thiab kub shock proteins khi. Kev sib cuam tshuam ntawm receptors, poob siab proteins, thiab nucleoproteins tau txhim kho kom lawv tsis tuaj yeem cuam tshuam nrog DNA. Mifepristone tuaj yeem ua rau hyperphosphorylation ntawm progesterone receptors, yog li kev hloov pauv noob tsis tuaj yeem ua tiav txawm tias tom qab progesterone receptors khi rau DNA. Qhov ntawd txhais tau hais tias cov tshuaj yuav inhibit qhov kev ua haujlwm ntawm corpus luteum, cuam tshuam rau kev tso tawm ntawm estrogen thiab progesterone los ntawm zes qe menyuam, thiab tiv thaiv ovulation. Tsis tas li ntawd, cov tshuaj kuj tseem tuaj yeem ua rau cov hnoos qeev hauv lub ncauj tsev menyuam nce ntxiv, yog li cov phev tsis tuaj yeem nkag mus rau hauv lub tsev menyuam thiab nkag mus rau hauv lub tsev menyuam kab noj hniav kom ua ke nrog lub qe los ua cov tshuaj tiv thaiv.

Dab tsi yog Kev Siv Mifepristone

1. Kev xeeb tub

(1) Tsis yog phais txiav ntawm cev xeeb tub thaum ntxov
Kev sib xyaw ntawm mifepristone thiab misoprostol kom tshem tawm kev xeeb tub thaum ntxov yog suav tias yog ib txoj hauv kev zoo tshaj plaws ntawm kev rho menyuam tawm uas tsis yog kev phais, uas yog tus cwj pwm los ntawm kev rho menyuam siab, muaj kev nyab xeeb, thiab qee qhov tsis zoo. Nco ntsoov tias mifepristone ntxiv rau misoprostol tau tshwm sim nyob rau hauv rooj plaub ntawm Clostridium sordellii toxic shock syndrome.

(2) Tsis yog phais phais ntawm kev xeeb tub thib ob
Mifepristone ua ke nrog misoprostol tuaj yeem siv los txiav cev xeeb tub ntawm 16 txog 24 lub lis piam, nrog cov txiaj ntsig zoo, zoo dua li cov neeg sib tw rau kev ua haujlwm induction. Nws tuaj yeem siv los ua ib txoj hauv kev niaj hnub hauv kev kho mob qib siab.

(3) Kev rho menyuam ploj
Mifepristone siv ib leeg lossis ua ke nrog prostaglandins muaj qhov siab ntawm kev rho menyuam tawm, qhov chaw mos los ntshav tsawg dua, thiab muaj kev nyab xeeb dua li qhov kev xav tsis zoo, nrog rau qhov ua tau zoo ntawm 74 feem pua ​​​​rau 93 feem pua. Nws yog ib txoj hauv kev ua tau zoo, ruaj ntseg, thiab txhim khu kev qha rau kev kho cov kev rho menyuam tawm ntawm 12 mus rau 27 lub lis piam ntawm cev xeeb tub, nrog kev ua tiav ntawm 97.5 feem pua.

(4) Induction ntawm kev yug menyuam
Mifepristone softens thiab dilates lub ncauj tsev menyuam thiab induces zog tom qab intrauterine tuag. Cov kev tshawb fawb tau pom tias cov nyhuv ntawm mifepristone ib leeg lossis ua ke nrog misoprostol yog qhov zoo dua. Txawm li cas los xij, yog tias tseem tsis tau yug los hauv 72 teev, nws yuav tsum tau hloov mus rau lwm txoj hauv kev los txhawb kev ua haujlwm.

(5) induction ntawm kev ua haujlwm
Mifepristone ua ke nrog misoprostol yog siv los txhawb kev loj hlob ntawm ncauj tsev menyuam hauv lub sijhawm cev xeeb tub. Cov nyhuv ntawm decidua thiab villi yog qhov me me, thiab nws tsis txaus los cuam tshuam rau kev noj haus ntawm cov ntshav hauv plab. Daim ntawv thov no kuj muaj kev nyab xeeb thiab txhim khu kev qha. Thiab piv nrog cov kev kho mob ntawm cov tshuaj oxytocin uas tsis tshua muaj siv yav dhau los, nws tuaj yeem ua rau cov txheej txheem ua haujlwm luv luv thiab txo qhov xwm txheej ntawm tus menyuam hauv plab thiab tus nqi ntawm neonatal asphyxia.

2. Kev tiv thaiv kab mob

(1) Kev tiv thaiv ib txwm muaj
Cov kev tshawb fawb tau pom tias mifepristone ib leeg muab kev tiv thaiv ntev ntev. Thaum koob tshuaj ntau tshaj 2mg / hnub, nws yuav inhibit ovulation.

(2) Kev tiv thaiv thaum muaj xwm ceev
Mifepristone tuaj yeem tiv thaiv kev loj hlob ntawm follicle, inhibit ovulation, induce zes qe menyuam granulosa cell apoptosis, thiab tiv thaiv embryonic kev loj hlob. Hauv 120 teev tom qab kev sib deev, noj 10mg, 25mg, 50mg, lossis 600mg ntawm mifepristone ib zaug tuaj yeem tiv thaiv kev xeeb tub.

3. Kev kho mob

Mifepristone muaj cov teebmeem ntawm kev tiv thaiv endometrial proliferation, menopause, thiab ovulation inhibition. Nws tuaj yeem kho uterine fibroids, endometriosis, dysfunctional uterine los ntshav, phem endometrial cells, tsev menyuam thiab zes qe menyuam, thiab lwm yam.

(1) Uterine fibroids
Cov kev tshawb fawb soj ntsuam tau pom tias kev kho mob leiomyoma nrog ib koob tshuaj 5-50mg / d ntawm mifepristone rau 3-6 hli tuaj yeem txo nws qhov ntim los ntawm 26 feem pua ​​-74 feem pua ​​; menopause tus nqi yog 63 feem pua ​​-100 feem pua ​​, dysmenorrhea, menstrual flow Cov tsos mob ntawm ntau yam thiab pelvic compression raug txo los yog alleviated.

(2) Endometriosis
Mifepristone muaj cov nyhuv antiproliferative ntawm endometrium, txo cov endometrial angiogenesis, ntshav ntws hauv myometrium, thinning lub endometrium, thiab atrophy ntawm cov hlab ntsha kauv. Nws yog siv los kho cov kab mob endometriosis, thiab amenorrhea tom qab noj tshuaj, txo qhov mob thiab txo qhov mob.

(3) Uterine thiab zes qe menyuam kab mob
Mifepristone (200mg / d) tej zaum yuav muaj kev cuam tshuam tshwj xeeb rau PR-zoo endometrial adenocarcinoma lossis sarcoma thiab tuaj yeem ua rau cov neeg mob nyob ruaj khov.

(4) txwv tsis pub los ntshav
Siv los txo cov ntshav tsis xwm yeem tshwm sim los ntawm kev siv tshuaj progestin nkaus xwb. Mifepristone tuaj yeem ua rau cov poj niam cev xeeb tub, thiab kev siv mifepristone tsis tu ncua tau siv los txo qis los ntshav los ntawm progestin ib leeg.

Dab tsi yog Cov Teeb Meem Ntawm Mifeprex
Cov kev mob tshwm sim feem ntau thiab hnyav ntawm mifepristone yog endometrial thickening, ua rau los ntshav loj. Ua raws li qhov chaw mos dryness, poob libido, kub flashes, mob pob qij txha, tsis tshua muaj siab puas, hypothyroidism, pob txuv, thiab hnyav nce tos. Kev siv ntev ntev ntawm mifepristone tuaj yeem ua rau ib puag ncig tsis muaj tshuaj estrogen, ua rau muaj qhov txawv txav ntawm endometrial hyperplasia. Qhov koob tshuaj loj dua, lub sijhawm ntev dua, thiab qhov ntau tshaj tawm cov hyperplasia. Nws thiaj li ua rau tshem tawm lub tsev menyuam thiab nws cov appendages, tsis sib xws rau lub hom phiaj tseem ceeb ntawm kev noj tshuaj. Tsis tas li ntawd, thaum siv mifepristone, daim siab ua haujlwm yuav tshwm sim. Thaum noj tshuaj, ALT thiab AST tshaj peb npaug ntawm tus qauv kev txwv, thiab tag nrho cov bilirubin ntau dua ob npaug ntawm qhov kev txwv sab saud. Lwm yam laj thawj tsis tuaj yeem piav qhia nws. Nws yuav tsum tau txiav txim siab kom tso tseg cov tshuaj.

Hoobkas
1. Xi'an Sonwu Biotech Co., Ltd muaj nws lub Hoobkas los tsim, tsim thiab khaws cov khoom, yog li muaj cov khoom tsim nyog. Xi'an Sonwu muaj kev txiav txim kom zoo, huv si thiab huv si ntau lawm. Nyob rau hauv Xi'an Sonwu, cov kws tshawb fawb tuaj yeem tsim cov khoom tshiab zoo.
2. Xi'an Sonwu muaj cov kev cai nruj heev ntawm kev faib cov neeg ua haujlwm los ntawm kev tsim khoom thiab kev sim rau kev muag khoom. Txhawm rau kom ntseeg tau tias txhua yam khoom raug thauj mus los, kev txhawb nqa cov ntaub ntawv nruj thiab kev pabcuam tom qab muag tau muab.

Daim ntawv pov thawj

Ntim

Logistics

Dhau li lav cov khoom, lwm qhov tseem ceeb tshaj plaws yog cov neeg siv khoom tuaj yeem tau txais cov khoom zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ
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