Pazopanib Hydrochloride

Pazopanib Votient

Pazopanib hydrochloridetseem hu ua votient HCl; pazopanib HCl; CS -462; ArMala; GW-786034B; GW786034 HCl; Unii -33Y9anm545. Nws yog qhov ncauj angiogenesis inhibitor tsom VEGFR thiab PDGFR. Pazopanib yog ib qho multikinase inhibitor active tiv thaiv vascular endothelial kev loj hlob yam receptors 1, -2, thiab -3. Kev kho Pazopanib feem ntau cuam tshuam nrog kev nce siab hauv cov ntshav transaminases thaum kho. Nws tau raug cuam tshuam nrog tsawg tab sis qee zaus mob hnyav thiab tuag taus ntawm kev kho mob pom tseeb mob siab.

Txoj kev hauv qab no ua kom cov pazopanib feem ntau muaj nyob rau ntawm kev ua lag luam:

Cov teebmeem ntawm 3-methyl-6-nitroimidazole ntawm trimethyl oxide fluoroborate, trimethyl orthoformate/boron trifluoride etherate thiab dimethylsulfate/sulfuric acid alkylating agent Methylation muab 2,3-dimethylimidazole analogs. Tom qab ntawd 2, 3-dimethyl-6-nitroimidazole txo qis hauv stannous chloride thiab hydrochloric acid kom tau txais aminoindazole derivatives, thiab qhov nruab nrab no yog concentrated nyob rau hauv qhov kev txiav txim ntawm 2, 4-dichloropyrimidine kom tau pyrimidine aminoindazole azole . Tom qab ntawd tus kws txiav txim plaub yog methylated nyob rau hauv kev siv zog ntawm methyl iodide thiab cesium carbonate kom tau txais fluoropyrimidine aminoindazole, thiab qhov nruab nrab no tau rov ua dua nrog 5-amino-2-methylbenzenesulfonamide kom txais cov khoom kawg pazopanib HCL.

Xi'an Sonwu nrhiav txoj hauv kev nyab xeeb thiab siv tau zoo dua los ua kom cov pazopanib HCL ntshiab. Yog tias txaus siab rau cov khoom no, koj tuaj yeem tiv tauj Xi'an Sonwu ncaj qha.

Certificate Of Analysis

Qhov twg Yuav Pazopanib

Xi'an Sonwu Biotech Co., Ltd. muaj kev paub nplua nuj nyob hauv kev lag luam thoob ntiaj teb thiab kev lag luam kho mob. Xi'an Sonwu nruj me ntsis tswj cov xim, duab, tsw, thiab lwm yam kom ntseeg tau tias cov khoom zoo. Xi'an Sonwu siv zog ua txoj haujlwm zoo hauv txhua qhov txuas ntau lawm, uas txhais tau hais tias txhua kauj ruam, los ntawm kev xaiv cov khoom siv raw mus rau qhov kev nthuav qhia zaum kawg ntawm cov khoom, yog tswj nruj heev. Xi'an Sonwu nrhiav kev pab txhua tus neeg siv khoom zoo thiab ua tau raws li qhov xav tau ntawm txhua tus neeg siv khoom. Raws li qhov no, cov neeg siv khoom tau muab cov lus pom zoo ntawm cov khoom thiab cov kev pabcuam. Yog li yog tias koj xav tau pazopanib, seb nws yog pazopanib HCL lossis pazopanib puag, thov nrhiav Xi'an Sonwu Biotech Co., Ltd.

Xi'an Sonwu thaum kawg ua rau qee yam khoom zoo thiab muab cov qauv. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'Cov lus pom zoo

Pazopanib Target yog dab tsi

1. Inhibition ntawm vascularization

Cov kev sim tsiaj tau pom tias noj Votient HCl ob zaug hauv ib hnub ntawm 100mg / kg / hnub los kho cov nas rau tsib hnub tuaj yeem cuam tshuam cov qib vascularization hauv cov nas. Koj yuav kuaj pom cov kev ua haujlwm antiangiogenic hauv cov nas muaj kabmob HT29, A375P, thiab HN5 malignant hlwb tom qab kev kho mob peb lub lis piam. HN5 thiab HT29 xenografts teb zoo dua ntawm txhua koob dua li A375P qauv. Tus qauv A375P muaj keeb kwm ua tau zoo dua rau VEGFR-2 inhibitors. Tsis muaj cov tshuaj tiv thaiv kab mob tau pom zoo nrog pazopanib qis dua kaum μM los ntawm antiangiogenic tawm tsam HT29, HN5, thiab A375P loj hlob hauv cov tshuaj yeeb dej caw. Tsis muaj kev cuam tshuam loj rau nas lub cev qhov hnyav tau pom, thiab cov tsiaj muaj kev noj qab haus huv thiab muaj zog thoob plaws hauv txoj kev tshawb no.

2. Ib qho biocompatible multi-target tyrosine kinase receptor inhibitor

ATP-zoo li ib feem ntawm Votient HCl qauv tuaj yeem tsim cov ntawv cog lus hydrogen nrog tyrosine kinase receptors thiab sib tw nrog ATP los khi rau intracellular tyrosine kinase receptors, inhibiting ATP-induced activation. Pazopanib tuaj yeem txwv tsis pub VEGFR-1/-2/-3, PDGFR- / , M-CSF receptor/FMS, thiab CSFR/c-kit. Inhibition ntawm cov hom phiaj no tsis tshua muaj peev xwm tsim cov tshuaj tiv thaiv vim tias cov noob ntawm vascular endothelial hlwb kuj ruaj khov. Qhov thib ob, cov hom phiaj no yog lub hom phiaj tseem ceeb ntawm kev loj hlob sai ntawm cov kab mob vascular endothelial, thiab cov hlab ntsha ntawm cov hlab ntsha tsis yooj yim puas.

Pazopanib Side Effects

Qhov pom zoo noj ntawm Votient HCL yog 200 mg thiab 400 mg. Tsis txhob siv cytochrome P450 3A4 enzyme inhibitors thiab ketoconazole, ritonavir, thiab rifampin cov khoom ib txhij thaum noj cov tshuaj no ntawm Votient HCL. Feem ntau cov kev mob tshwm sim thaum noj Votient HCL yog qhov ncauj qhov ntswg, mob hniav, raws plab, xeev siab, ntuav, tsis qab los noj mov, thiab lwm yam. Lwm yam kev tsis zoo ntawm kev noj pazopanib HCL muaj xws li raws plab, ntshav siab, plaub hau hloov, xim hloov, tsis qab los noj mov. , ntuav, qaug zog, qaug zog, mob plab, thiab mob taub hau. Hauv cov xwm txheej hnyav, nws tuaj yeem ua rau muaj teeb meem loj hauv lub siab, lub plawv dhia tsis xwm yeem, hypothyroidism, proteinuria, thiab lwm yam. Cov khoom no muaj kev phom sij rau tus menyuam hauv plab, thiab cov tshuaj no yog contraindicated thaum cev xeeb tub.

Kev daws:

1. hnoos: Koj tuaj yeem nqa Xiuzheng hom honeysuckle granules ntawm qhov ncauj thiab Yangyin Qingfei.

2. Ua npaws: Npaj cov tshuaj tiv thaiv kab mob, thiab nws yog qhov zoo tshaj rau kev kuaj ntshav kom paub tseeb tias qhov kub taub hau yog tshwm sim los ntawm kev mob los yog cov kab mob malignant. Siv cov tshuaj tua kab mob yog tias qhov kub siab tshaj 38.5 degrees. Ibuprofen Sustained-release Capsules tuaj yeem txo hws, txo qhov kub taub hau thiab txo qhov mob.

3. Neuralgia: Koj tuaj yeem noj pregabalin ib leeg. Yog tias qhov mob tsis zoo tom qab noj cov tshuaj tua kab mob ib leeg, koj tuaj yeem ntxiv gabapentin.

4. Mob plab, kua qaub reflux, xeev siab, thiab ntuav: koj tuaj yeem noj Daxi thiab metoclopramide ua ntej xeev siab thiab ntuav.

5. Cov ntshav siab: qis siab tshaj 100 yuav ua rau muaj kev puas tsuaj loj rau cov hlab plawv thiab paj hlwb. Cov tshuaj dipine antihypertensive yuav cuam tshuam qhov concentration ntawm cov tshuaj tsom, thiab koj tuaj yeem noj sartan thiab puril antihypertensive tshuaj.

6. Txo cov platelet concentration: tuaj yeem ua rau mob ntshav qab zib thiab ua rau cov kab mob loj, xws li cardiopulmonary tsis ua haujlwm. Cov plasma tshiab khov los yog cryoprecipitate tuaj yeem siv tau.

Thov nyeem cov lus saum toj no kom zoo thiab tiv tauj koj tus kws kho mob yog tias tsim nyog.

Pazopanib ua haujlwm li cas

Pazopanib hydrochlorideyog ntau lub hom phiaj tyrosine kinase inhibitor uas inhibits angiogenesis thiab siv los kho RCC. Tyrosine kinase yog qhov kev loj hlob zoo tshaj plaws receptor. Feem ntau cov neeg mob RCC tau qhib los ntawm hypoxia-inducible yam cuam tshuam txog kev hloov pauv vim VHL noob hloov thiab kev loj hlob txawv txav ntawm cov ntaub so ntswg ntawm tes. Qhov no transcriptional activation overexpresses vascular endothelial kev loj hlob yam, epidermal kev loj hlob yam, platelet-derived kev loj hlob yam, transforming loj hlob yam 2, thiab activates Raf / MEK / ERK thiab PI3K / Akt los ntawm receptor tyrosine kinase autophosphorylation. Txoj kev /mTOR ua rau cov hlwb tsis tuaj yeem sib faib, proliferate thiab hloov pauv, txhawb cov hlab ntsha tshiab, thiab txhawb kev loj hlob thiab metastasis ntawm cov hlwb malignant. Pazopanib tuaj yeem xaiv inhibit VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-, PDGFR-, thiab C-2Kit, thiab tuaj yeem rhuav tshem cov teeb liab kis ntawm cov hlwb tsis zoo los ntawm thaiv cov tyrosine kinases, yog li inhibiting qog cell proliferation thiab cov hlab ntsha tshiab, kom ua tiav lub hom phiaj ntawm kev tiv thaiv malignant hlwb.

Hoobkas

1. Xi'an Sonwu Biotech Co., Ltd muaj lub Hoobkas nrog cov khoom muag txaus. Xi'an Sonwu muaj chav ua haujlwm huv thiab muaj kev tsim khoom zoo. Raws li Xi'an Sonwu, cov kws tshawb fawb lossi tsim cov khoom zoo tshaj plaws kom tau raws li cov neeg siv khoom xav tau.

2. Xi'an Sonwu Biotech Co., Ltd. muaj cov cuab yeej ntsuas qib siab thiab cov neeg ua haujlwm xeem, txhua tus qhia tias Xi'an Sonwu tau cog lus los muab cov ntaub ntawv raug thiab ua tau zoo thiab cov kev pabcuam zoo.

Daim ntawv pov thawj

Pob

Logistics

Dhau li lav cov khoom, lwm qhov tseem ceeb tshaj plaws yog cov neeg siv khoom tuaj yeem tau txais cov khoom zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ

Xi'an Sonwu yog ibpazopanib hydrochloridetus neeg muag khoom nrog ntau xyoo ntawm kev tsim khoom thiab kev muag khoom. Yog tias koj muaj lus nug txog pazopanib, thov hu rau Xi'an Sonwu.

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Cim npe nrov: pazopanib hydrochloride, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, raw, mov, kev muag khoom