Pyrazinamide hmoov

Dab tsi yog Pyrazinamide Hauv Kev Kho Mob Tb

Pyrazinamide hmoovyog ib yam tshuaj uas siv los kho tuberculosis (TB). Nws yog cov hmoov crystalline uas yog xim dawb lossis dawb dawb, me ntsis soluble hauv dej, thiab tsuas yog soluble hauv ethanol lossis methanol. Cov khoom no tsuas yog tua cov kab mob Mycobacterium tuberculosis thiab tsis muaj cov tshuaj tua kab mob tiv thaiv lwm cov kab mob. Lub zog ntawm nws cov nyhuv tiv thaiv kab mob yog ze rau PH ntawm ib puag ncig. Thaum PH=5~5.5, cov tshuaj tua kab mob muaj zog tshaj plaws; thaum PH=7, cov nyhuv antibacterial yog qhov tsis muaj zog; Cov kev sim tsiaj tau lees paub tias cov khoom no tuaj yeem nkag mus rau cov hlwb thiab muaj cov txiaj ntsig tseem ceeb thaum ua ke nrog isoniazid. Nws kuj tseem muaj txiaj ntsig zoo tiv thaiv kab mob kab mob extracellular tuberculosis hauv thaj chaw acidic. Tsis muaj qhov sib txawv ntawm cov khoom no thiab lwm yam tshuaj tiv thaiv kab mob, thiab nws yooj yim los tsim cov tshuaj tiv thaiv thaum siv ib leeg. Cov txheej txheem ntawm kev txiav txim yuav yog tias PZA nkag mus rau cov macrophages uas muaj Mycobacterium tuberculosis thiab hloov mus rau hauv pyrazinoic acid kom nws cov tshuaj tua kab mob. Nyob ntawm cov tshuaj concentration thiab cov kab mob rhiab heev, cov khoom no yog nicotinamide derivative nrog bacteriostatic lossis bactericidal teebmeem. Cov khoom no tsuas muaj cov kab mob tua kab mob thaum PH yog acidic.

Cov qauv ntawm cov khoom no zoo ib yam li nicotinamide, thiab nws tuaj yeem muaj cov kab mob bactericidal thaum nws nkag mus rau hauv hlwb. Nyob rau hauv cov xwm txheej PH tsawg, cov tshuaj tua kab mob yog khaus. Cov khoom no yog thawj kab tshuaj tiv thaiv tuberculosis yam tsis muaj kev sib tw nrog lwm cov tshuaj tiv thaiv kab mob. Nws yog tsuas yog siv rau cov xwm txheej uas thawj kab kev kho mob tsis zoo. Cov khoom no tuaj yeem txhim kho cov tshuaj tiv thaiv sai sai thaum siv ib leeg thiab yuav tsum tau siv ua ke nrog lwm cov tshuaj tiv thaiv kab mob.

Lawv tau ua ke nrog lwm cov tshuaj tiv thaiv kab mob rau tuberculosis uas tsis tuaj yeem teb rau thawj kab tshuaj tiv thaiv kab mob (xws li streptomycin, isoniazid, rifampicin, thiab ethambutol). Cov khoom no tsuas yog siv tau los tiv thaiv mycobacteria. Yav dhau los, cov khoom no tau siv los ua cov tshuaj thib ob thiab feem ntau siv rau kev thim rov qab ntawm cov neeg mob uas ua tsis tau lwm yam tshuaj tiv thaiv kab mob. Ntau qhov kev tshawb fawb soj ntsuam tau pom tias cov phiaj xwm kev kho mob luv luv uas muaj cov khoom no yog tsim rau kev kho thawj zaug ntawm cov kab mob phlegm-zoo thiab feem ntau yog siv rau 2 mus rau 3 lub hlis. Txoj kev npaj no tuaj yeem txo qhov rov zoo ntawm cov kab mob phlegm tom qab kho. Cov khoom no tau raug lees paub tias yog ib qho ntawm cov khoom ntawm triple lossis quadruple regimens nyob rau hauv cov chav kawm luv luv chemotherapy.

Yog tias koj xav tau PZA hmoov, Xi'an Sonwu tuaj yeem muab cov pyrazinamide. tos ntsoov hnov ​​los ntawm koj.

Certificate Of Analysis

Qhov Yuav Yuav Pyrazinamide

Xi'an Sonwu Biotech Co. Ltd. muaj kev paub dhau los hauv kev lag luam thoob ntiaj teb thiab kev lag luam kev noj qab haus huv. Insisting rau txoj kev ntseeg raws li kev ntseeg thiab zoo ua ntej yog peb lub tuam txhab txoj cai. Peb nruj me ntsis tswj cov khoom zoo, uas txhais tau tias kev xaiv pib los ntawm raw khoom. Tsis tas li ntawd, peb tswj txhua qhov kev nthuav dav thiab txo cov nqi kom siab tshaj plaws kom peb cov neeg siv khoom tuaj yeem tau txais cov khoom lag luam zoo. Raws li cov no, cov neeg siv khoom tau muab cov lus pom zoo rau peb cov khoom. Yog li nrhiav Xi'an Sonwu Biotech Co. Ltd. thaum yuav PZA Hmoov.

Xi'an Sonwu ua kom cov khoom zoo yog li cov qauv tuaj yeem muab tau. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'Cov lus pom zoo

Dab tsi yog Pyrazinamide siv rau

Nws yog feem ntau siv rau kev kho mob tuberculosis (TB). Nws yog ib qho tseem ceeb ntawm cov txheej txheem tswj hwm lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv (WHO) pom zoo rau cov tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob.

Thaum ua ke nrog lwm cov tshuaj tiv thaiv kab mob, xws li isoniazid, rifampicin, thiab ethambutol, nws pab kho cov kab mob TB zoo. Nws muaj txiaj ntsig tshwj xeeb hauv kev tua cov kab mob dormant lossis qeeb qeeb uas feem ntau tshwm sim hauv cov kab mob TB.

Nws kuj yog qee zaum siv los ua kev tiv thaiv kev kho mob rau cov tib neeg uas nyuam qhuav kis tus kab mob TB los yog cov uas muaj tus kab mob TB latent tab sis tseem tsis tau tsim muaj tus kab mob nquag. Qhov kev tiv thaiv kev kho mob no tuaj yeem pab txo qis kev pheej hmoo ntawm latent TB mus rau active TB.

Dab tsi ntawm cov tshuaj tua kab mob yog Pyrazinamide

Nws tsis raug cais raws li tshuaj tua kab mob. Nws raug cais raws li tus neeg sawv cev antimycobacterial siv tshwj xeeb rau kev kho tuberculosis (TB). Txawm hais tias muaj ntau yam tshuaj tua kab mob tuaj yeem kho cov kab mob zoo, PZA feem ntau yog siv los tiv thaiv Mycobacterium tuberculosis, cov kab mob ua rau TB. Nws cuam tshuam nrog cov kab mob no txoj kev loj hlob thiab cov metabolism, pab tshem tawm cov kab mob.

Pyrazinamide Mechanism Ntawm Kev Ua

Pyrazinamide hmoovqhov tseeb mechanism ntawm kev txiav txim yog tsis to taub tag nrho, tab sis ob peb txoj kev xav tau raug npaj. Nov yog ob peb txoj hauv kev uas PZA tuaj yeem siv nws cov teebmeem:

1. Kev hloov pauv mus rau pyrazinoic acid (POA): Nws hloov mus rau nws daim ntawv nquag, pyrazinoic acid, los ntawm enzyme pyrazinamidase. Qhov kev hloov pauv no tshwm sim intracellularly hauv Mycobacterium tuberculosis. POA xav tias yuav cuam tshuam cov kab mob ntawm daim nyias nyias thiab cov txheej txheem acidification, inhibiting nws txoj kev loj hlob thiab ciaj sia.

2. Kev cuam tshuam ntawm fatty acid metabolism: Nws tuaj yeem cuam tshuam nrog fatty acid synthesis thiab siv nyob rau hauv cov kab mob ntawm tes. Qhov kev cuam tshuam yuav ua rau lub zog ntawm lub zog reserves, impeding tus kab mob lub peev xwm mus nce thiab nyiaj txiag.

3. PH-dependent action: Nws ua qhov nyiam nyob rau hauv ib puag ncig acidic, xws li pom nyob rau hauv phagolysosome ntawm macrophages qhov twg M. tuberculosis nyob. Nws ntseeg tau tias PZA yog qhov zoo tshaj plaws nyob rau hauv qhov chaw acidic no, tejzaum nws los ntawm protonation ntawm nws daim ntawv nquag, POA.

4. Synergistic effect: Pyrazinam de tau ua ke nrog cov tshuaj tiv thaiv kab mob TB xws li rifampicin thiab isoniazid. Kev sib xyaw ntawm cov tshuaj no txhim kho lawv cov txiaj ntsig tag nrho tiv thaiv M. tuberculosis.

Nws yog ib qho tseem ceeb kom nco ntsoov tias cov txheej txheem meej los ntawm kev ua haujlwm yuav ua rau muaj kev sib xyaw ntawm cov ntsiab lus no thiab yuav txawv raws li qhov tshwj xeeb thiab teeb tsa ntawm tus mob. Kev tshawb fawb ntxiv tseem xav tau los piav qhia txog kev ua tiav ntawm PZA tag nrho.

Dab tsi yog Cov Teeb Meem Ntawm Pyrazinamide

PZA, zoo li txhua yam tshuaj, tuaj yeem ua rau muaj kev phiv. Cov kev mob tshwm sim feem ntau muaj xws li:

1. Mob plab hnyuv: xeev siab, ntuav, thiab tsis qab los noj mov feem ntau qhia txog kev phiv. Noj nrog zaub mov tuaj yeem pab txo cov tsos mob no.

2. Hyperuricemia: Nws tuaj yeem nce qib uric acid hauv cov ntshav, uas tuaj yeem ua rau mob gout lossis ua rau cov tsos mob ntawm gout ua ntej. Cov neeg uas muaj keeb kwm ntawm gout yuav tsum tau saib xyuas zoo thaum kho.

3. Mob pob qij txha: Qee tus neeg yuav muaj mob pob qij txha lossis mob caj dab zoo li cov tsos mob thaum kho. Qhov kev mob tshwm sim no feem ntau yog rov qab los thaum tsis siv tshuaj.

4. Kev tshwm sim ntawm daim tawv nqaij: daim tawv nqaij ua pob khaus thiab khaus khaus tau raug tshaj tawm nyob rau qee kis. Yog tias muaj pob liab liab lossis lwm yam qhia txog kev ua xua tshwm sim, xws li khaus khaus lossis ua pa nyuaj, nrhiav kev kho mob tam sim ntawd.

5. Hepatotoxicity: Nws muaj peev xwm ua rau lub siab puas tsuaj. Cov tsos mob ntawm daim siab toxicity yuav muaj xws li yellowing ntawm daim tawv nqaij los yog ob lub qhov muag (jaundice), zis tsaus nti, mob plab, los yog unexplained qaug zog. Kev saib xyuas lub siab ua haujlwm tsis tu ncua yog qhov tseem ceeb thaum kho.

6. Cov teebmeem hauv nruab nrab ntawm lub paj hlwb: Tsis tshua muaj, nws tuaj yeem ua rau cov kev mob tshwm sim hauv paj hlwb, nrog rau kev tsis meej pem, kiv taub hau, lossis hnov ​​​​lus. Yog tias koj muaj cov tsos mob tsis zoo hauv lub paj hlwb, nrog koj tus kws kho mob tham.

Kuv yuav tsum noj pes tsawg Mg ntawm Pyrazinamide

Cov koob tshuaj ib txwm muaj rau cov neeg laus, suav nrog lwm cov tshuaj tiv thaiv kab mob, yog 5 txog 8.75 mg / kg ntawm lub cev hnyav txhua 6 teev, lossis 6.7 txog 11.7 mg / kg txhua 8 teev, txog 3g ib hnub. Thaum kho cov kab mob isoniazid-resistant, nws tuaj yeem nce mus rau 60 mg / kg ib hnub. Cov menyuam yaus yuav tsum tsis txhob siv kuv tshwj tsis yog tias tsim nyog. Thaum siv lawv, ib tug yuav tsum ua tib zoo xav txog cov txiaj ntsig thiab qhov tsis zoo.

① Nws kuj tseem tuaj yeem ua haujlwm tsis tu ncua, 50 mg / kg ob zaug hauv ib lub lis piam. ② Thaum nws siv ib leeg los kho tuberculosis, cov kab mob tuaj yeem tsim cov tshuaj tiv thaiv, yog li nws feem ntau siv ua ke nrog lwm cov tshuaj tiv thaiv kab mob. Kev kho mob yuav kav ntev li 1-2 xyoo, txawm tias ob peb xyoos, lossis tsis tas li. ③ Nws feem ntau tsis haum rau cov neeg mob uas lub siab tsis ua haujlwm tshwj tsis yog tias tsim nyog. Cov neeg uas muaj lub raum tsis ua haujlwm tsis tas yuav txo cov koob tshuaj thaum siv nws. Cov neeg laus noj 30 mus rau 35 mg kg hauv ib pluas noj ib hnub. Rau cov neeg uas hnyav dua 50 kg, 1.5 g ib hnub twg; rau cov neeg uas hnyav tshaj 50 kg, 2 g ib hnub twg; Rau cov neeg uas hnyav tshaj 75 kg, 2.5 g ib hnub twg. Rau cov menyuam yaus, 20-25 mg/kg ib hnub twg.

Tsuas yog kho koj cov koob tshuaj tom qab nrog koj tus kws kho mob tham.

Hoobkas

1. Xi'an Sonwu muaj lub Hoobkas nrog cov khoom lag luam txaus. Tsis tas li ntawd, Xi'an Sonwu muaj chav ua haujlwm huv thiab huv si nrog cov cuab yeej siv siab heev. Raws li lub tuam txhab kev coj noj coj ua, cov kws tshawb fawb txuas ntxiv tsim cov khoom tshiab kom tau raws li cov neeg siv khoom xav tau.

2. Xi'an Sonwu tau tshaj t sting cov cuab yeej thiab cov neeg ua haujlwm kuaj cov kws tshaj lij, txhua yam qhia tau tias Xi'an Sonwu lub hom phiaj muab cov ntaub ntawv raug thiab ua tau zoo thiab kev pabcuam zoo.

Daim ntawv pov thawj

Ntim

Logistics Hloov tshiab

Ntxiv nrog rau kev lees paub cov khoom zoo, lwm qhov tseem ceeb tshaj plaws yog cov neeg tau txais cov khoom lag luam zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ

1. Yuav nug li cas?

Peb tuaj yeem hu xovtooj, email, lossis social media.

2. Koj tuaj yeem lav qhov khoom zoo li cas?

Txhua pawg yuav tsum tau kuaj thiab tuaj yeem muab COA rau cov neeg siv khoom. Tsis tas li ntawd, tag nrho cov khoom dhau qhov kev xeem: HPLC, UV, GC, TLC, thiab lwm yam. Peb koom tes nrog cov neeg thib peb, zoo li SGS.

3. Koj ntim thiab khaws NMN li cas?

Pob: Siv cov thawv ntim khoom ntim thiab ntim cov ntawv ntim khoom ntim, lossis ntim cov khoom raws li cov neeg siv khoom xav tau.

Cia: Rau lub sijhawm luv luv, koj tuaj yeem khaws cia rau hauv qhov chaw qhuav thiab txias thiab ua kom tsis txhob tshav ntuj. Rau lub sijhawm ntev, thov khaws cia hauv qab 15 degree hauv qab xoom.

Cia: Cia nws qhuav thiab txias, thiab tsis txhob muaj lub teeb thiab kub.

Yog tias koj xav paub cov pyrazinamide ntshiab, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email, thiab tom qab ntawd koj tau txais cov khoom zoopyrazinamide hmoov.

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