Temozolomide hmoov

Temozolomide Tshuaj Kho Mob
Temozolomide hmoovyog ib hom tshuaj khomob feem ntau siv rau kev kuaj mob tshiab glioblastoma multiforme. Nws tuaj yeem siv ua ke nrog kev kho hluav taws xob thiab tuaj yeem siv los ua kev kho mob ntxiv. Nws muaj cov qauv tshuaj tshiab thiab yog imidazopyridine derivative. Temozolomide tsis ncaj qha ua lub luag haujlwm. Ntawm physiological pH, nws tau hloov pauv sai sai rau hauv cov khoom siv MTIC. Nws ntseeg tau tias cytotoxicity ntawm MTIC feem ntau yog vim nws cov DNA alkylation, uas tshwm sim feem ntau ntawm O6 thiab N7 txoj haujlwm ntawm guanine. Lub luag haujlwm ntawm tus neeg sawv cev alkylating yog txhawm rau rhuav DNA cov saw hauv cov qog nqaij hlav cancer, tso cai rau cov qog nqaij hlav cancer tawg thiab tawg. Temozolomide muaj txiaj ntsig zoo rau qee qhov feem ntau glioblastomas hauv cov kev tshawb fawb yooj yim thiab kev kho mob. Nws yog tsuas yog siv rau malignant gliomas uas rov qab los tom qab kev kho mob, xws li glioblastoma multiforme lossis degenerative astrocytoma. Nws kuj yog siv los ua thawj kab tshuaj rau kev kho mob metastatic melanoma. Lub paj hlwb metastases tshwm sim los ntawm lwm yam malignancies kuj tseem siv tau.
Temozolomide yog ib qho tshiab ntawm qhov ncauj alkylating tus neeg sawv cev antineoplastic tshuaj nrog broad-spectrum los tiv thaiv cov pab pawg neeg tsis zoo, tuaj yeem dhau los ntawm cov hlab ntsha hauv hlwb, thiab muaj bioavailability ze li 100 feem pua. Nws tuaj yeem kho tau zoo uas tau kuaj pom tshiab thiab rov tshwm sim dua glioblastoma thiab anaplastic astrocytoma cell cell phem pawg, ua kom cov neeg mob muaj sia nyob ntev thiab muaj kev nyab xeeb thiab zam tau zoo. Nws yog thawj qhov ncauj tau zoo imidazopyridine antineoplastic tshuaj thiab belongs rau tiam thib ob ntawm alkylating cov neeg ua haujlwm nrog kev tiv thaiv kev ua phem ntawm tes. Yog li yog tias koj txaus siab rau cov ntshiab temozolomide, thov hu rau Xi'an 'Sonwu.

Certificate Of Analysis

Qhov Yuav Yuav Temozolomide
Xi'an Sonwu Biotech Co., Ltd. yog ib lub chaw tsim khoom thiab distributor nrog ntau tshaj kaum xyoo ntawm kev paub. Nws muaj kev koom tes dav thiab ruaj khov nrog cov teb chaws thoob ntiaj teb hauv Asmeskas, Asia, Europe, thiab Oceania. Xi'an Sonwu ib txwm hais rau cov khoom zoo ua ntej. Pab txhua tus neeg siv khoom zoo thiab txaus siab rau txhua tus neeg siv khoom yog Xi'an Sonwu txoj kev nrhiav. Tsis tas li ntawd, Xi'an Sonwu siv zog ua txhua yam kom txo tau cov nqi thiab tso cai rau cov neeg siv khoom kom tau txais cov khoom lag luam nrog cov nqi siab. Raws li cov no, cov neeg siv khoom tau muab cov lus pom zoo rau cov khoom. Yog li yog tias koj txaus siab rau temozolomide, thov hu rau Xi'an Sonwu.
Xi'an Sonwu thaum kawg ua qee yam khoom zoo thiab muab cov qauv. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'Cov lus pom zoo

Temozolomide siv rau dab tsi
1. Glial lesion cells
Glioma yog thawj lub paj hlwb sarcoma feem ntau los ntawm glial cell lesions nyob rau hauv lub hlwb thiab qaum qaum. Muaj ntau hom glial hlwb, xws li neurogenic hlwb, astrocytes, embryonic hlwb, oligodendroglial hlwb, thiab lwm yam. Tib neeg collectively hu lawv glial kab mob hlwb. Kev kho mob phais. Cov nyhuv ntawm temozolomide hauv kev kho mob rov tshwm sim glioblastoma multiforme tau raug lees paub los ntawm kev sim tshuaj kom muaj kev nyab xeeb thiab siv tau zoo.
Ib qho kev sim tshuaj ntsuam xyuas tau pom tias 225 tus neeg mob uas thawj zaug rov qab mob glioblastoma multiforme tau kho nrog temozolomide lossis procarbazine rau rau lub hlis, raws li, thiab tus nqi ciaj sia taus thiab tag nrho cov ciaj sia taus ntawm cov neeg mob hauv pawg temozolomide yog 21 feem pua ​​thiab 60 feem pua. feem pua ​​, ntau dua li 8 feem pua ​​​​thiab 44 feem pua ​​​​ntawm cov pab pawg procarbazine. Temozolomide cov neeg mob lub sijhawm nruab nrab ntawm kev muaj sia nyob tsis pub muaj sia nyob yog 2.9 thiab 7.3 lub hlis, feem ntau, siab dua li ntawm pawg procarbazine (1.9 thiab 5.8 lub hlis). Qhov kev sim no kuj tau soj ntsuam kev noj qab haus huv ntsig txog lub neej zoo hauv lub hlis thib 3 thiab 6 tom qab pib kho. Cov txiaj ntsig kuj tau lees paub tias ntau tus neeg mob hauv pawg temozolomide tau txhim kho lossis tswj lawv lub neej zoo. Yog li ntawd, temozolomide cov nyhuv curative thiab cov tshuaj tiv thaiv tsis zoo ntawm cov kab mob glioblastoma rov tshwm sim yog qhov zoo dua li tus qauv procarbazine.

2. Anaplastic astrocytic hlwb
Anaplastic astrocytic hlwb yog cov hlwb malignant uas feem ntau tshwm sim hauv lub hlwb lossis qaum qaum. Raws li kev kho mob tshwm sim, qaug dab peg feem ntau tshwm sim thawj zaug hauv cov neeg laus, thiab tom qab ntawd tuag tes tuag taw, aphasia, kev puas siab puas ntsws hloov pauv, thiab thaum kawg, nce intracranial siab tshwm sim. Kev kho mob ntawm cov kab mob malignant no yog qhov nyuaj, thiab qhov kev txiav tawm ntawm sarcoma nyob rau hauv ntau qhov chaw yuav ntxiv, tab sis nws tsis tuaj yeem rov kho dua. Txawm hais tias ntau tus neeg mob tsis zoo heev tom qab kev phais tom qab kev kho mob, qhov nruab nrab ntawm cov neeg mob feem ntau yog nyob nruab nrab ntawm 1 txog 2. 2-3 xyoo.Temozolomide hmoovtuaj yeem tawm cytotoxicity los ntawm kev kho qhov tsis sib haum xeeb ntawm methylation adducts thiab thaum kawg tuaj yeem ua tiav cov txiaj ntsig ntawm inhibiting hlwb cell lesions.
 

Temozolomide ua haujlwm li cas
DNA methylation thiab kev kho qhov tsis sib haum yog tam sim no suav tias yog lub ntsiab ntawm TMZ cytotoxicity. Nyob rau hauv physiological tej yam kev mob, TMZ tsis xav tau enzyme catalysis. Thaum cov dej molecules ua rau nws qhov zoo 4 carbon atom, nws lub nplhaib kaw qhib tam sim ntawd, tso carbon dioxide los tsim cov khoom nquag 5-(3-methyl triazine En-1-) imidazole{{4 }}amide (MTIC). MTIC hloov mus rau hauv cationic methyl diazonium ntsev, uas hloov cov methyl pawg rau DNA thiab degrades nws mus rau hauv cov khoom kawg 5-aminoimidazole-4-carboxamide-(AICA), uas yog ces tawm los ntawm ob lub raum. Cov chaw ntawm DNA methylation yog 7th nitrogen atom ntawm guanine thiab thib 3 oxygen atom ntawm adenine. Txawm hais tias methylguanine adducts ntawm 6th oxygen atom suav rau qhov tsawg tshaj plaws, lawv tau ua lub luag haujlwm tseem ceeb tshaj plaws hauv pawg tiv thaiv tsis zoo. Txawm hais tias qhov kev kho qhov tsis sib haum tuaj yeem txheeb xyuas qhov tsis sib haum xeeb hauv cov khub thaum lub sij hawm DNA replication txheej txheem, nws nrhiav tsis tau ib tug khub lub hauv paus rau lub 6th oxygen atom methylguanine, yog li muaj qhov sib txawv ntawm sub-strand DNA. Qhov sib txawv maj mam sib sau ua ke nrog kev faib cell thiab thaum kawg cuam tshuam qhov pib rov ua dua, yog li cov hlwb raug ntes nyob rau hauv G2 / M theem thiab raug apoptosis.
TMZ nkag mus rau hauv lub cev thiab nthuav dav thoob plaws hauv lub cev. Nws tuaj yeem nkag mus rau hauv cov ntshav-hlwb barrier thiab nkag mus rau hauv cov kua cerebrospinal; nws mus txog ib qho tshuaj zoo concentration nyob rau hauv lub hauv nruab nrab paj hlwb. Nws cov kua cerebrospinal/plasma tshuaj concentration piv yog ze li ntawm 30 feem pua ​​​​rau 40 feem pua. TMZ nws tus kheej tsis muaj qhov ncaj qha los tiv thaiv kab mob ntawm tes. Nyob rau hauv physiological tej yam kev mob, nws sai heev undergoes tsis-enzymatic hloov dua siab tshiab rau hauv lub active compound MTIC. MTIC yog ntxiv decomposed rau hauv 5 - Amino-imidazole-4-amide (AIC), thiab diazomethane yog ib qho active alkylating tshuaj. Nws cytotoxicity yog suav tias yog methylation ntawm DNA, uas tshwm sim ntawm guanine N7 thiab O6 txoj haujlwm. Nws ua haujlwm ntawm nucleic acid, protein, thiab peptide nucleophilic thaj tsam ntawm cov kab mob thiab ua haujlwm rau ntau theem ntawm kev faib cov pab pawg tsis zoo.

Yog Temozolomide Safe
Qhov tsis zoo tshwm sim tseem ceeb ntawm temozolomide muaj xws li xeev siab, ntuav, qaug zog, thiab cov tshuaj hematological. xeev siab, ntuav, mob taub hau, thiab qaug zog feem ntau tshwm sim. Feem ntau, NCI cov txheej txheem toxicity yog me me mus rau nruab nrab thiab nws tus kheej txwv, nrog xeev siab thiab ntuav tswj nrog cov tshuaj tiv thaiv. Txawm li cas los xij, hais txog qhov tshwm sim ntawm qhov tshwm sim tsis zoo, qhov tshwm sim ntawm cov neeg mob hnub nyoog 70 xyoo thiab tshaj saud tsis siab dua. Lwm yam kev phiv tshwm sim yog qaug zog, cem quav thiab mob taub hau, kiv taub hau, ua tsis taus pa, plaub hau poob, anemia, kub taub hau, thiab txo kev tiv thaiv. Temozolomide muaj toxicity me ntsis, tab sis nws yog feem ntau tolerated zoo.
 

Hoobkas
1. Xi'an Sonwu Biotech Co., Ltd muaj nws lub Hoobkas los tsim, tsim thiab khaws cov khoom, yog li muaj Tshuag txaus. Xi'an Sonwu muaj kev txiav txim kom zoo, huv si, thiab huv si ntau lawm. Nyob rau hauv Xi'an Sonwu, cov kws tshawb fawb tuaj yeem tsim cov khoom tshiab zoo.
2. Xi'an Sonwu Biotech Co., Ltd nruj me ntsis tswj txhua kauj ruam, xws li kev xaiv cov khoom siv, kev tsim khoom, qauv kuaj, thiab cov neeg ua haujlwm tshaj lij. Kev txhawb nqa cov ntaub ntawv nruj thiab kev pab cuam tom qab muag yog muab los xyuas kom meej tias txhua yam khoom raug thauj mus los.

Daim ntawv pov thawj

Ntim

Logistics

Dhau li lav cov khoom, lwm qhov tseem ceeb tshaj plaws yog cov neeg siv khoom tuaj yeem tau txais cov khoom zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ
1. Synchronous chemotherapy thiab radiotherapy lub sijhawm
Cov khoom no yog ib hnub koob tshuaj 75mg / m2 rau 42 hnub thaum tau txais xov tooj cua. Tom qab ntawd tau txais 6 lub voj voog ntawm kev kho adjuvant nrog cov khoom no. Cov tshuaj tuaj yeem raug ncua raws li tus neeg mob lub siab ntev, tab sis tsis tas yuav txo qhov koob tshuaj. Cov tshuaj yuav tsum tau txiav tawm thaum lub sij hawm siv tshuaj kho mob raws li cov txheej txheem hematological thiab non-hematological toxicity.
2. Adjuvant lub sijhawm kho
Rau lub voj voog ntawm kev kho mob adjuvant tau ua plaub lub lis piam tom qab cov khoom siv hluav taws xob synchronous thiab chemotherapy lub sijhawm xaus. Qhov koob tshuaj ntawm cov khoom no hauv thawj lub voj voog yog 150mg / m2 / hnub. Tom qab ntawd tso tseg cov tshuaj rau 23 hnub. Thaum pib ntawm lub voj voog 2, cov koob tshuaj tuaj yeem nce mus rau 200mg / m2 / hnub. Yog tias koj tsis ntxiv qhov ntau npaum li cas hauv Cycle 2, koj yuav tsum tsis txhob ntxiv cov nyiaj hauv lub voj voog tom ntej. Cov txheej txheem hauv qab no khaws cia ntawm 200mg / m2 txhua hnub tshwj tsis yog rau toxicity.
3. Cov neeg laus
Qhov koob tshuaj ntawm cov khoom no hauv txhua 28- hnub voj voog ntawm cov neeg mob uas tsis tau txais kev kho mob ua ntej yog 200mg / m2 ib hnub rau tsib hnub. Qhov pib koob tshuaj ntawm cov khoom no rau cov neeg mob uas tau txais kev kho mob yav dhau los yog 150mg / m2 / hnub.
Yog tias koj xav paub cov chaw tsim khoom temozolomide, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email ces koj tau txais high-zootemozolomide hmoov.
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