Tianeptine Ethyl Ester

TEE yog dab tsi?

Tianeptine ethyl ester, lub npe tshuaj yog 7-[(3-chloro-6, 11-dihydro-6-methyl-5, 5-dioxidodibenzo[c ,f][1,2] thiazepin-11-yl)amino] heptanoic acid ethyl ester sulfate, tseem hu ua tianeptine-001, los yog tianeptine EP impurity B, thiab feem ntau abbreviated li TEE, yog ib tug derivative ntawm tianeptine tshuaj. Tianeptine yog ib qho tshuaj siv feem ntau hauv kev kho mob ntawm kev nyuaj siab loj. Raws li txoj cai, nws raug cais raws li tricyclic antidepressant (TCA). Raws li kev sim tshuaj ntawm tianeptine, nws pom zoo tias nws tsuas yog siv tau zoo li lwm yam, ntau cov tshuaj tiv thaiv kev ntxhov siab xws li fluoxetine (ie, SSRI) thiab amitriptyline (ie, TCA). Txawm li cas los xij, tianeptine zoo li muaj qhov tshwm sim tsawg dua thiab muaj teeb meem ntau dua li cov tshuaj tiv thaiv kev ntxhov siab. Vim nws cov txiaj ntsig zoo, TEE tau yeej qhov chaw ua tshuaj tiv thaiv kev nyuaj siab hauv khw. Raws li cov chaw tsim khoom ntawm TEE, Xi'an Sonwu tuaj yeem muab TEE hmoov zoo nrog tus nqi sib tw. Yog tias koj txaus siab rau nws, thov hu rau Xi'an Sonwu.

Specification

TEE siv rau dab tsi?

Tianeptine ethyl esteryog cais raws li cov tshuaj tiv thaiv kev nyuaj siab, raws li kev kho mob rau cov neeg uas raug kev nyuaj siab. Kev nyuaj siab yog ib yam kab mob uas tshwm sim ntau tshaj plaws nyob rau hauv lub neej niaj hnub no, thiab nws cov tsos mob tseem ceeb yog kev xav tsis zoo, kev xav qeeb, kev ua haujlwm tsis zoo, kev xav tsis zoo, thiab cov tsos mob somatic. Nws cuam tshuam rau tib neeg lub siab lub ntsws puas siab ntsws, thiab yog li muaj kev cuam tshuam loj heev rau tib neeg lub neej. Yog li ntawd, nyob rau hauv xyoo tas los no, ntau thiab ntau tus neeg tau pib xav txog kev mob hlwb thiab kev nyuaj siab. Yog li ntawd, ntau yam tshuaj rau kev nyuaj siab tau tshwm sim hauv khw.

Muaj ntau yam uas cuam tshuam rau kev nyuaj siab, feem ntau yog cov hauv qab no.

1. Dopamine

Dopamine yog ib tug precursor rau norepinephrine, ib tug tseem ceeb neurotransmitter nyob rau hauv lub hypothalamus thiab pituitary caj pas, thiab cov concentration ntawm dopamine nyob rau hauv lub hauv paus paj hlwb yog cuam tshuam los ntawm kev puas siab puas ntsws yam.

2. Serotonin (Serum)

Cov khoom xyaw tseem ceeb yog 5-hydroxytryptamine (5-HT), uas yog cov khoom sib xyaw uas cov paj hlwb siv los xa cov ntaub ntawv rau ib leeg.

3. Norepinephrine (NA)

Nws tsis yog tsuas yog neurotransmitter, uas yog synthesized thiab secreted los ntawm sympathetic postganglionic neurons thiab adrenergic paj endings nyob rau hauv lub hlwb, thiab yog lub ntsiab transmitter tso tawm tom kawg; Nws kuj yog ib qho tshuaj hormones, uas yog synthesized thiab secreted los ntawm adrenal medulla, tab sis cov ntsiab lus kuj tsawg.

TEE Puas cuam tshuam rau lub hlwb?

Lub hauv paus tseem ceeb ntawm kev kho cov tshuaj tiv thaiv kev ntxhov siab yog: cov neeg mob kev nyuaj siab feem ntau qhia tau hais tias qhov concentration ntawm serotonin thiab norepinephrine (hormone uas tuaj yeem tswj tau lub siab xav, hu ua kev zoo siab hormone) hauv lub hlwb ib puag ncig tsawg dhau, ua rau nws muaj txiaj ntsig zoo. kev puas tsuaj loj heev.

Thaum peb ua haujlwm, neurons (uas yog, paj hlwb) xa cov ntaub ntawv rau ib leeg. Cov tshuaj hormones yog cov khoom uas tau tso tawm thaum cov neurons xa cov ntaub ntawv mus rau ib leeg kom qhib cov neuron tom ntej. Neuron A tso tawm ntau cov tshuaj hormones, neuron B tshem tawm cov tshuaj hormones ntau, thiab thaum kawg ua tiav cov ntaub ntawv xa mus. Yuav muaj qee qhov concentration ntawm cov tshuaj hormones nyob rau hauv peb lub hlwb ib puag ncig, thiab ntawm lawv, txoj cai concentration ntawm kev zoo siab hormone yuav ua rau peb zoo siab. Thiab thaum muaj kev tso tawm, muaj kev noj. Nyob rau hauv ib txwm muaj xwm txheej, lub hlwb tswj cov concentration ntawm cov tshuaj hormones dawb nyob rau hauv lub hlwb ib puag ncig los ntawm nws tus kheej txoj kev, cia qee cov tshuaj hormones ploj lawm. Hauv thawj kis, lub hlwb tso tawm cov tshuaj hu ua monoamine oxidase, uas khi rau ntau yam tshuaj hormones thiab inactivates lawv. Hauv qhov thib ob, cov tshuaj hormone-tso tawm neuron A, reabsorbs (lossis uptakes) cov tshuaj hormones dawb.

Txawm li cas los xij, qhov kev nyuaj siab hauv kev nyuaj siab yuav ua rau muaj kev zoo siab hormone hauv lub hlwb ib puag ncig, cuam tshuam nrog nws cov txheej txheem hloov pauv, thiab txo tus neeg lub siab ntawm kev zoo siab, uas yog, qhov tseem ceeb ntawm qhov tseem ceeb yog cuam tshuam. Yog li ntawd, lub hauv paus ntsiab lus ntawm kev kho mob antidepressant yog los cuam tshuam lub ntuj ploj mus ntawm cov tshuaj hormones zoo siab thiab ua kom nws cov concentration hauv lub hlwb.

Muaj ob lub ntsiab ntawm kev ua ntawm cov tshuaj tiv thaiv kev ntxhov siab.

Thawj yog inhibition ntawm cov txheej txheem reabsorption, uas txhais tau hais tias thaiv cov reabsorption ntawm cov tshuaj hormones txaus siab (5-HT thiab NA), tso cai rau lawv nyob rau hauv lub synaptic cleft ntev dua thiab ntau dua. Qhov no ua rau muaj qhov tshwm sim ntawm ob qho ntawm feem ntau siv tshuaj tiv thaiv kev nyuaj siab, SSRIs (xaiv serotonin reuptake inhibitors) thiab SNRIs (serotonin thiab norepinephrine reuptake inhibitors), uas tsis yog tsuas yog siv tau los tiv thaiv kev nyuaj siab, Nws kuj tseem siv tau rau lwm yam kev puas siab puas ntsws uas feem ntau nrog. Kev nyuaj siab, nrog rau TCAs (heterocyclic antidepressants) suav nrog tricyclic thiab tetracyclic antidepressants. Lawv ib zaug yog qhov tseem ceeb ntawm kev kho mob rau kev nyuaj siab.

Qhov thib ob yog los txo qhov kev puas tsuaj ntawm cov tshuaj hormones txaus siab (5-HT thiab NA). Los ntawm inhibiting zus tau tej cov monoamine oxidase uas noj cov tshuaj hormones zoo siab, lub hom phiaj ntawm kev ua kom cov concentration ntawm cov tshuaj hormones zoo siab nyob rau hauv lub hlwb ib puag ncig yog tiav. Ib chav kawm ntawm cov tshuaj tiv thaiv kev ntxhov siab muab los ntawm nws yog MAOIs (monoamine oxidase inhibitors), uas zoo heev tab sis tsis tshua siv los ua cov tshuaj xaiv, feem ntau yog thaum lwm cov tshuaj tiv thaiv kev ntxhov siab tsis ua tiav.

Thaum tianeptine raug cais raws li tricyclic antidepressant (TCA), nws cov tshuaj pharmacological txawv ntawm cov tshuaj tiv thaiv kev nyuaj siab. Qhov no feem ntau yog vim qhov tseeb tias nws tsis xav ua tam sim ntawd los ntawm kev tswj hwm ntawm monoaminergic neurotransmitters (xws li serotonin, dopamine, lossis noradrenaline.) Tiam sis, nws yog theorized ua raws li glutamate thiab glutamatergic mechanisms, ua rau lub hlwb hloov. yooj yim rau kev ntxhov siab thiab kev nyuaj siab.

Tianeptine tau tawm tsam qhov kev xav ntawm monoaminergic ntawm kev nyuaj siab, nrog rau cov kev txhawb nqa dav dav monoaminergic mechanisms uas tau piav qhia txog qhov kev txiav txim ntawm cov tshuaj tiv thaiv kev ntxhov siab feem ntau tau piav qhia. Tshwj xeeb, cov tshuaj no yog xav kom pheej hloov glutamate receptor bursting ntawm hippocampal CA3 commissural koom haum synapse. Kev tshawb fawb tam sim no qhia tias tianeptine tsim nws cov tshuaj tiv thaiv kev ntxhov siab los ntawm kev hloov kho ntawm glutamate receptor kev ua (piv txwv li, AMPA receptors thiab NMDA receptors) thiab cuam tshuam rau kev tso tawm ntawm lub hlwb-derived neurotrophic factor (BDNF), uas cuam tshuam rau neural plasticity. Cov kev tshawb fawb tsis ntev los no los ntawm kev txhawb nqa lub luag haujlwm ntawm tianeptine hauv kev hloov pauv ntawm glutaminergic kev ua haujlwm hauv amygdala, thaj tsam ntawm lub hlwb cuam tshuam nrog kev nco. Qhov no ua rau nws dhau los ua qhov kev xaiv zoo dua rau cov neeg muaj kev nyuaj siab.

Vim Li Cas Xaiv Peb

1. Xi'an Sonwu tau koom nrog ntshuam-export rau ntau tshaj 10 xyoo nrog kev nplua nuj nyob rau hauv txoj kev loj hlob, kev tshawb fawb thiab zus tau tej cov API, cog extract, khoom noj khoom haus additives, thiab lwm yam raw cov khoom xyaw ntawm cov khoom kho mob;

2. Xi'an Sonwu muaj cov kws tshaj lij nrog kev faib ua haujlwm kom meej;

3. Cov khoom raug kuaj los ntawm peb tog;

4. Qauv muaj;

5. Kev pabcuam OEM tau txais kev txhawb nqa;

Yog tias koj xav yuav tianeptine ethyl ester, txais tos hu rau Xi'an Sonwu.

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