Ll -37 hmoov

Dab tsi yog ll -37

Ll -37 hmoovYog ib tug tib neeg antimicrobial peptide derived los ntawm tib neeg cationic antimicrobial protein 18, tseem hu ua Cathelicidin. Cov saw luv ntawm cov amino acids paub tias antimricrobial peptides yog cov khoom siv tsis tseem ceeb, muaj kev tiv thaiv kab mob, nrog rau cov kab mob, thiab fungi. Nyob rau hauv rooj plaub ntawm ll -37}}, nws yog tsim los ntawm cleaving ib feem tshwj xeeb ntawm HCAP18 protein. Nws muaj antimicrobial cov yam ntxwv, lub ntsiab lus nws tuaj yeem tua ncaj qha los yog inhibit txoj kev loj hlob ntawm microbes. Nws yog cationic peptide, lub ntsiab lus nws nqa tau tus nqi zoo, uas txhawb nws los txuas nrog thiab cuam tshuam rau qhov tsis zoo ntawm cov kab mob me me.

Nws yog tsim los ntawm ntau hom ntawm tes, suav nrog cov ntshav dawb (neurophils thiab macrophages) thiab epithelial hlwb. Nws xav tias qhov tseem ceeb hauv lub cev tiv thaiv kab mob rau cov kab mob thiab ua rau muaj kev tiv thaiv kab mob tag nrho. Txawm hais tias cov khoom siv antimicrobial, ll -37 Tau kawm rau nws lub luag haujlwm hauv qhov txhab hauv kev kho kom zoo, immunompulation, thiab tawm tsam cov txheej txheem tiv thaiv. Kev tshawb fawb yog txuas ntxiv kom nkag siab tag nrho ntawm ll {2}} 's hauv kev tsim cov tshuaj tiv thaiv kev tiv thaiv lossis kho cov mob uas cuam tshuam nrog kev kho mob thiab cov nqaij mos.

Tus qauv thiab qhov chaw
Ll -37 yog cationic (zoo them) -Yog peptide nrog 37 amino acids.
Nws yog muab tau los ntawm C-Terminal cheeb tsam ntawm tib neeg Cathelicidin (HCAP18).
Qhov tsim tawm los ntawm neutrophils, epithelial hlwb, thiab macrophages nyob rau hauv teb rau kev kis mob lossis mob.

Daim Ntawv Pov Thawj Kev Ntsuam Xyuas

Ll -37 pab ntxiv

Xi'an Songwu Biotech Co. Ltd. Tau muaj kev nplua nuj nyob hauv kev lag luam thoob ntiaj teb thiab kev noj qab haus huv. Hais txog txoj kev ntseeg thiab ua tau zoo ua ntej yog peb lub tuam txhab cov ntsiab cai. Peb tswj cov khoom lag luam nruj me ntsis, uas txhais tau tias kev xaiv pib los ntawm cov khoom siv raw. Dhau li, peb lis txhua yam thiab txo tus nqi rau qhov ntau kawg, tom qab peb cov neeg siv khoom tuaj yeem tau txais cov khoom siv nqi. Raws li cov no, cov neeg muas zaub tau muab ntau cov lus qhia zoo rau peb cov khoom. Yog li koj tuaj yeem saib rau Xi'an Soniach Co. Ltd. Thaum twg koj xav tau ll -37 pab ntxiv.

Xi'an Soniau tag ua kom paub tseeb ntawm cov khoom lag luam zoo, yog li cov qauv coj tuaj yeem muab tau. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'paub zoo

Dab tsi yog ll -37} siv rau

Nws yog peptide uas tau muab los ntawm tib neeg Cathelicidin, ib qho protein pom hauv lub cev tiv thaiv kab mob. Nws muaj antimicrobial cov yam ntxwv, lub ntsiab lus nws tuaj yeem pab tua lossis qeeb txoj kev loj hlob ntawm cov kab mob sib txawv, suav nrog cov kab mob, kab mob, thiab fungi. Nws yog ib feem ntawm lub cev tsis muaj zog ntawm lub cev, uas yog lub cev thawj kab kev tiv thaiv tiv thaiv kab mob. Kev ua antimicrobial ntawm ll -37 ua rau nws muaj txiaj ntsig zoo hauv ntau daim ntaub ntawv kho mob. Qee qhov kev siv tau suav nrog:

1. AntimicRobial defense: nws tuaj yeem tua ntau cov kab mob, cov kab mob, fungi, thiab cab los ntawm kev cuam tshuam lawv cov lauj kaub ntawm tes. Nws tau ua haujlwm tawm tsam gram-zoo (Staphylococcus aureus) thiab gram-tsis zoo (pseudomonas aeruginosa)). Dhau li, nws kuj tuaj yeem neutralize bacterial uvotoxins (LPS) kom txo qis o. Cov khoom no pab lub cev tawm tsam ntau yam ntawm pathogens, ua rau nws muaj peev xwm ua tau rau kev loj hlob tshiab cov kws tshaj lij tshiab.

2. Qhov txhab txhab zoo: Nws tau kawm rau nws lub luag haujlwm hauv kev txhawb kev kho kom zoo. Nws tuaj yeem pab cov ntaub so ntswg thiab ua kom nrawm nrawm ntawm cov txheej txheem kho kom zoo. Nws tuaj yeem txhim kho tus mob loj tuaj yeem kaw dua tshiab rau kev kaw thiab ua kom muaj mob ceev rau hauv qhov txhab, pab cov mob ntshav qab zib thiab cov tawv nqaij raug mob.

3. Los tiv thaiv kev cuam tshuam: nws kuj muaj cov khoom tiv thaiv kev tiv thaiv. Nws tuaj yeem hloov kho lub zog tiv thaiv kab xeb thiab tej zaum yuav koom tes nrog kev tswj hwm o. Nws tuaj yeem sib npaug cov pro-mob thiab anti-inflammatory cuam tshuam kom tiv thaiv kev tiv thaiv kab mob ntau dhau heev.

4. Immunomodulation: Nws tau tshawb xyuas rau nws cov kev immunomodulatory. Nws pab nrhiav kev tiv thaiv kab mob rau cov chaw ntawm kev kis mob, txhais tau tias nws tuaj yeem cuam tshuam qhov kev ua ntawm lub cev tiv thaiv kab mob. Cov cuab yeej no tuaj yeem muaj txiaj ntsig zoo hauv ntau yam kev tiv thaiv kab mob.

Kev tshawb fawb yog kev nce qib los tshawb xyuas cov peev txheej ntawmLl -37 hmoovnyob rau hauv kev kho mob sib txawv. Nws yog ib qho tseem ceeb kom nco ntsoov tias thaum LL -37 Nrhiav cov lus cog tseg hauv kev tshawb fawb, xav tau kev nyab xeeb ntxiv los tsim kev nyab xeeb thiab kev ua tau zoo rau cov ntawv thov kho mob tshwj xeeb.

Cov lus teb uas tsis muaj zog dab tsi tsis muaj kev tiv thaiv kab mob dab tsi

Ll -37}, tseem hu ua cathelicidin, modulates ob peb yam ntawm kev tiv thaiv kab xeb. Qee cov lus teb tsis muaj zog uas ll -37 tuaj yeem cuam tshuam suav nrog:

1. CyTOKine Ntau Lawm: Nws tuaj yeem hloov kho cov cytokines, uas tau piav qhia molecules uas ua rau lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob. Nws tau tshaj tawm rau ob qho tib si txhawb thiab inhibit kev tsim ntawm qee cov cytokines, nyob ntawm cov ntsiab lus tshwj xeeb thiab cov tshuaj tiv thaiv kab mob koom tes nrog.

2. Chototaxis: Nws muaj cov khoom siv tshuaj lom, lub ntsiab lus nws tuaj yeem nyiam thiab kev nrhiav kev tiv thaiv kab mob rau lub xaib ntawm kab mob lossis raug mob. Qhov kev ua yeeb yam no yuav pab kom lub cev tiv thaiv kab mob me me, xws li neurophils thiab monocytes, rau thaj chaw uas lawv muaj kev tiv thaiv thiab daws tau tus mob.

3 Nws tuaj yeem cuam tshuam kev tsiv teb tsaws thiab ua kom muaj ntau yam ntawm ntau yam kev cuam tshuam rau hauv kev kho mob raug mob, ua rau cov ntaub so ntswg thiab kev daws teeb meem.

4. Cov kev cai ntawm cov lus teb mob: Nws tuaj yeem hloov kho cov lus teb mob huam tiv thaiv kev cuam tshuam thiab ua haujlwm ntawm kev tiv thaiv kev tsim khoom ntawm cov tshuaj tivthaiv. Nws immunomodulatory cov khoom ua rau nws ib daim duab tseem ceeb tswj cov kev sib raug zoo ntawm kev txhawb nqa ntawm kev teeb tsa thiab kev ua kom zoo.

5. Antigen Kev Tshaj Tawm: nws kuj tseem yuav cuam tshuam cov antigen kev tshaj tawm, muaj kev tiv thaiv kab mob rau kev ua kom haum lwm yam kev tiv thaiv kab tiv thaiv kab mob, xws li t hlwb. Qhov no tuaj yeem cuam tshuam rau txoj cai tswj cov lus teb uas tsis muaj zog.

Cov no yog qee cov lus teb tsis muaj zog uas ll -37}} paub txog kev coj tus cwj pwm hauv kev tswj hwm lub cev muaj zog. Yog tias koj muaj cov lus nug ntxiv txog cov kev sib txawv ntawm LL {{1} ''} 'Dawb kom nug kom paub meej ntxiv.

Dab tsi yog cov tshuab ntawm kev ua ntawm ll -37

Nws yog tib neeg antimicrobial peptide, uas txhais tau tias nws muaj peev xwm tua lossis txwv txoj kev txhim kho cov kab mob, nrog rau cov kab mob, thiab fungi. Thawj lub tshuab ntawm kev ua ntawm ll -37}} koom nrog nws sib cuam tshuam nrog microbial. Ntawm no yog cov kauj ruam tseem ceeb hauv kev siv tshuab:

1. Khib rau microbial membranes: nws tau nyiam rau qhov tsis zoo them microbial vim muaj cov duab itionic, xws li Lipopolysaccharides. Cov peptide khi rau saum npoo ntawm cov kab mob me me, ua kom yooj yim nrog nws cov kev sib cuam tshuam nrog daim nyias nyias.

2. Muaj kev cuam tshuam ntawm Membrrane Kev Ntseeg: Nws tuaj yeem cuam tshuam txog kev ncaj ncees ntawm microbial membranes los ntawm kev sib sau ua hws lossis raws. Tus peptide muaj lub peev xwm rho nws tus kheej rau hauv lipid bilayer ntawm cov zaj duab xis microbial.

3. Pej xeem ntawm daim nyias nyias: Ib zaug tso, nws tuaj yeem nce kev sib npaug ntawm cov microbial membrane. Qhov no permeebilization ua rau xau ntawm cov khoom tseem ceeb, xws li ions thiab lwm yam lwg me me.

4. Kev cuam tshuam ntawm cov txheej txheem cellular: Qhov cuam tshuam ntawm Membrane Kev Ntseeg thiab Pej Xeem Cov Txheej Txheem Tseem Ceeb hauv cov txheej txheem ntawm cov microorganism, ua rau lawv tuag. Nws kuj tseem tuaj yeem muaj kev cuam tshuam ntxiv imagonodulatory, cuam tshuam rau tus tswv kev tiv thaiv kab mob.

5. Anti-inflammatory: nws tsis yog tsuas yog koom nrog hauv kev ua txhaum cai tiv thaiv antimicrobial tab sis kuj muaj cov khoom tiv thaiv kev tiv thaiv. Nws tuaj yeem hloov pauv lub zog tiv thaiv kab mob los ntawm kev sib cuam tshuam nrog ntau tus tswv tsev, thiab cuam tshuam cytokine ntau lawm.

Nws yog muab tau los ntawm cleavage ntawm cathelicidin, ib tug precursor protein, thiab nws yog ib qho tseem ceeb tivthaiv ntawm lub innate tsis muaj zog tiv thaiv kab mob. Nws cov dav dav-spectrum antimrichial kev ua kom nws tseem ceeb ntawm lub cev tiv thaiv kab mob. Ib qho ntxiv, kev tshawb fawb qhia tau hais tias ll -37 tej zaum muaj peev xwm kho tau rau kis mob, suav nrog kho kom zoo thiab qee yam kev tsis zoo.

Tsev tsim khoom

1. Xi'an Sonwu muaj lub Hoobkas nrog Tshuag txaus. Ib qho ntxiv, Xi'an Sonwu muaj cov chaw ua haujlwm huv thiab huv si nrog cov cuab yeej siv siab heev. Nyob rau hauv lub tuam txhab cov thawj coj kev coj ua, cov neeg tshawb nrhiav txuas ntxiv tsim cov khoom lag luam tshiab kom tau raws li cov neeg siv khoom xav tau.

2. Xi'an Sonwu muaj cov cuab yeej ntsuas siab thiab cov kws tshaj lij kev sim ua haujlwm, txhua yam uas qhia tau tias Xi'an Sonwu lub hom phiaj los muab cov ntaub ntawv raug thiab cov kev pabcuam zoo.

Daim ntawv muaj cai

Lub thawv

Hloov tshiab cov qauv hloov tshiab

Ntxiv rau kev lav cov khoom zoo, lwm yam tseem ceeb tshaj plaws yog cov neeg siv khoom tuaj yeem tau txais cov khoom kom yooj yim. Yog li, Xi'an Sonwu cov khoom siv txhua hom ntawm cov kws qhia ntawv raws li cov kev xav tau sib txawv.

Tuam Txhab Cov Ntaub Ntawv

Xi'an Songwu Biotech Co., Ltd yog cov kws tsim khoom lag luam suav thiab khoom siv. Nws tau tsim tsa hauv xyoo 2012 thiab yog nyob hauv Hi-Tech Industrial Zone, Xi'an City, xeev Shannxi, Suav. Nws them txhua qhov kev txhim kho, kev tshawb fawb, thiab kev tsim khoom noj khoom haus ntxiv, cov nroj tsuag, thiab lwm yam khoom xyaw ntawm cov khoom lag luam kho mob. Lub tuam txhab khoom siv tsib hom khoom siv raw khoom: anti-plaub hau poob hmoov, nooropic, api, cov leeg cov leeg khoom, thiab cov leeg cov leeg. Xi'an Sonwu ua tsaug rau qhov tseeb ntawm kev koom tes zoo yog qhov kev pabcuam zoo tshaj plaws thiab cov txiaj ntsig zoo. Yog li, txais tos koj qhov kev nug.

Thiab yog tias koj xav paubLl -37 hmoovNqe lossis koj xav tau ll {{{{{{{}} txhad ntxiv, thov hu rau Xi'an Sonwu.

Email:sales@sonwu.com

Cim npe nrov: ll -37 hmoov, Tuam Tshoj, Tuam Tshoj chaw tsim khoom, chaw tsim khoom, yuav khoom, tus nqi, ntshiab, muab khoom, kev muag khoom