MOTS C hmoov

MOTS-C Peptide yog dab tsi

MOTS C hmoov,Lub npe tag nrho yog mitochondria qhib-nyeem-them ntawm kaum ob S rRNA-C, ib qho mitochondria-derived peptide thiab ib hom tshuaj hormones tshiab uas muaj kev lom zem tshwj xeeb. Nws yog tshwj xeeb vim hais tias nws yog encoded los ntawm mitochondrial noob es tsis yog nuclear noob, zoo li feem ntau cov tshuaj hormones. Nws yog ib qho polypeptide uas tsuas muaj 16 amino acids, thiab kev tshawb fawb tau pom tias nws tuaj yeem kho mitochondrial kev tswj hwm ntawm insulin los ntawm txoj kev folate-purine-AMPK. Kev tshawb pom ntawm cov tshuaj no muab cov tswv yim tshiab rau kev kho mob ntshav qab zib, kev noj zaub mov kom rog, thiab lwm yam kab mob. Thiab kev ua haujlwm ntawm cov tshuaj hormones tau raug lees paub qee qhov los ntawm kev sim nas. Xi'an Sonwu tuaj yeem muab cov tshuaj-qib peptides thiab tshuaj pleev ib ce-qib peptides. Yog tias koj xav nrhiav tus neeg muag khoom MOTS-C, Xi'an Sonwu yuav tsum yog qhov kev xaiv zoo.

Certificate Of Analysis

Qhov Yuav Yuav MOTS-C

Xi'an Sonwu Biotech Co., Ltd. yog ib lub chaw muag khoom thiab distributor nrog ntau tshaj kaum xyoo ntawm kev paub. Nws muaj kev koom tes dav thiab ruaj khov nrog cov teb chaws hauv Asmeskas, Asia, Europe, thiab Oceania thoob ntiaj teb. Xi'an Sonwu yeej ib txwm hais rau cov khoom zoo ua ntej. Pab txhua tus neeg siv khoom zoo thiab txaus siab rau txhua tus neeg siv khoom yog Xi'an Sonwu txoj kev nrhiav. Xi'an Sonwu nruj me ntsis tswj txhua kauj ruam, los ntawm kev xaiv cov khoom siv raw, thiab nrhiav cov khoom zoo los ntawm txhua yam, xws li kev xaiv cov khoom siv, kev tsim khoom, kev kuaj cov qauv, thiab cov neeg ua haujlwm tshaj lij. Tsis tas li ntawd, Xi'an Sonwu siv zog ua txhua yam kom txo tau cov nqi thiab tso cai rau cov neeg siv khoom kom tau txais cov khoom lag luam nrog cov nqi siab. Raws li cov khoom lag luam zoo thiab kev pabcuam, cov neeg siv khoom tau muab cov lus pom zoo rau cov khoom. Yog li yog tias koj xav tau MOTS-C, tsis txhob yig tiv tauj Xi'an Sonwu.

Xi'an Sonwu thaum kawg ua kom cov khoom zoo thiab muab cov qauv. Thov xyuas kom muaj nuj nqis.

Cov neeg siv khoom 'Cov lus pom zoo

Cov txiaj ntsig ntawm MOTS-C yog dab tsi

1.Cytoprotective nyhuv ntawm MOTSc

Mitochondria, lub hauv paus ntawm cellular zog metabolism, yog "lub cav" uas tswj lub cev metabolism thiab feem ntau exerts lom. Mitochondria tuaj yeem tswj hwm ntau yam txheej txheem physiological thiab txawm cuam tshuam rau kev qhia ntawm nDNA. MOTS c, polypeptide encoded los ntawm mtDNA sORF, yog ib tug tswv cuab tshiab ntawm mitochondrial signaling system. MOTSc tuaj yeem cuam tshuam nrog nDNA kev tswj hwm cov ntsiab lus thiab cov txheej txheem hloov pauv kom ncaj qha tswj qhov kev qhia ntawm nDNA. Thaum HEK293 hlwb kab lis kev cai nyob rau hauv vitro raug txhawb los ntawm oxidative kev nyuaj siab, extranuclear MOTS-c tuaj yeem hloov pauv mus rau lub nucleus los ntawm AMP-activated protein kinase txoj hauv kev teb rau kev ntxhov siab metabolic, yog li khi rau thaj tsam txhawb nqa ntawm cov khoom nuclear E{{3} }txog qhov tseem ceeb 2 lub hom phiaj cov noob los txhawb qhov kev qhia ntawm cov noob caj noob ces. Qhov kev ntxhov siab no tswj cov kev qhia ntawm ntau yam tshuaj tiv thaiv oxidative kev nyuaj siab enzymes, tsub kom cell resistance, tswj cell metabolic homeostasis, thiab plays lub luag hauj lwm nyob rau hauv lub cell tiv thaiv. Kev qhia qis ntawm MOTSc hauv cov leeg pob txha los ntawm cov neeg mob uas muaj kab mob raum ntev 5 ua ke nrog kev txo qis ntawm cov khoom siv hluav taws xob E2- cuam tshuam txog 2 noob. Lub cytoprotective mechanism ntawm MOTS-c nyob rau hauv metabolic kev nyuaj siab tej zaum yuav koom nyob rau hauv ntau yam pathophysiological txheej txheem.

2. MOTS- tswj cov piam thaj thiab lipid metabolism

MOTS-c tuaj yeem koom nrog hauv kev tswj hwm cov piam thaj homeostasis thiab fatty acid synthesis los ntawm txoj kev AMPK. Cov kev tshawb fawb tau pom tias MOTS-c tuaj yeem cuam tshuam lub voj voog folate-methionine, ncaj qha thaiv cov de novo synthesis ntawm purine, txo cov 5-methyltetrahydrofolate, nce qib ntawm 5-aminoimidazole-4-carboxamide nucleotide. , Nws ua lub luag haujlwm hauv kev tswj hwm homeostasis ntawm qabzib thiab lipid metabolism los ntawm kev ua kom AMPK. Hauv qee qhov kev sim nas mus txog 12 lub hlis, cov hnub nyoog ntawm cov leeg pob txha insulin tsis kam tau ua tiav rov qab los ntawm MOTS-c supplementation, qhia tias qib MOTS-c hauv nas pob txha pob txha thiab cov hlab ntsha muaj feem cuam tshuam nrog cov hnub nyoog ntsig txog cov tshuaj insulin. " Hauv cov nas uas muaj cov rog rog uas ua rau cov tshuaj insulin tsis kam, cov lus qhia ntawm AMPK thiab cov piam thaj hauv qab qis thauj mus rau plaub tau nce ntxiv hauv nas cov leeg nqaij pob txha, qhia tias MOTS-c tuaj yeem tiv thaiv kev noj zaub mov muaj roj ntau vim insulin-qabzib siab. Clamp cov tswv yim qhia tias MOTS-c tswj cov piam thaj hauv tsev los ntawm kev ua haujlwm ntawm cov leeg pob txha txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm los ntawm anaerobic glycolysis, tawm tswv yim tias MOTS-c tsis hloov tus nqi ntawm cov piam thaj hauv siab.

MOTS-c kuj koom nrog hauv lipid metabolism. MOTS-c nce lipid siv thiab -oxidation qib los ntawm kev txhawb nqa carnitine shuttling. Fatty acid oxidation nce thaum 5-aminoimidazole-4-carboxamide nucleotides accumulates. Hauv cov nas uas muaj tshuaj insulin-tiv thaiv tau noj cov zaub mov muaj roj ntau, MOTS-c hauv cov leeg pob txha tuaj yeem tiv thaiv kev rog rog vim kev rog dhau los ntawm kev ua kom muaj zog AMPK thiab txhawb kev qhia txog cov piam thaj hauv qab 4.

Ntxiv rau,MOTS C hmoovtuaj yeem tiv thaiv insulin tsis kam, rog deposition, thiab inflammatory aggression induced los ntawm ovariectomy.

3. MOTS-c tswj kev txav mus los

Kev tawm dag zog tuaj yeem qhib AMPK hauv cov leeg pob txha, ua rau cov roj ntsha oxidation thiab mitochondrial biosynthesis, kho cov leeg, thiab txhim kho lub cev endurance thiab metabolism. AMPK plays lub luag haujlwm tseem ceeb hauv kev txav mus los cuam tshuam txog kev hloov pauv. Cov kev tshawb fawb tau pom tias MOTS-c tuaj yeem qhib AMPK hauv nas pob txha pob txha. MOTS-c tuaj yeem txuas ncaj qha mus rau mitochondria nrog kev tawm dag zog lub cev los ntawm kev ua kom AMPK, yog li koom nrog kev tswj hwm kev tawm dag zog. MOTS-c tej zaum yuav yog ib qho kev simulant. Nyob rau hauv lub neej yav tom ntej, kev noj haus ntawm exogenous MOTS-c tuaj yeem ua lub luag haujlwm zoo ib yam li "kev tawm dag zog" los txhawb lub cev. Tsis tas li ntawd, MOTS-c, raws li ib tug tswv cuab ntawm lub mitochondrial teeb liab kis tau tus mob, kho kom haum xeeb-induced mitosis thiab txhim khu kev zam rau kev tawm dag zog.

4. MOTS-c ncua kev laus

The level of MOTS-c decreases with age, implying that the loss of MOTS-c is associated with the pathophysiological processes of aging and age-related diseases. The m.1382A>C hloov pauv hauv mtDNA encoding MOTS-c ua rau kev hloov pauv ntawm 14th amino acid lysine hauv MOTS-c nrog glutamine, uas tuaj yeem ncua kev laus. MOTS-c tuaj yeem nce qib ntawm intracellular nicotinamide adenine dinucleotide. Tsis tas li ntawd, MOTS-c tuaj yeem cuam tshuam lub voj voog folate-methionine, ua rau txo qis hauv methionine metabolism. Kev tshem tawm ntawm methionine tuaj yeem txuas ntxiv lub neej ntawm cov nas los ntawm kwv yees li 45 feem pua, txo cov kab mob uas muaj hnub nyoog, thiab ncua lub lens deterioration. Txo cov roj visceral thiab nce qib ntawm cov tshuaj antioxidant tseem ceeb glutathione. Cov kev tshawb fawb tau pom tias MOTS-c nce qhov kev qhia ntawm senescence-associated secretory phenotypes hauv senescent hlwb, ua rau lawv yooj yim dua nrhiav tau thiab tshem tawm los ntawm lub cev tsis muaj zog.

5. MOTS-c tswj cov lus teb inflammatory

Kev mob plab yog thawj txheej txheem pathological ntawm ntau yam kab mob. MOTS-c txo cov proinflammatory cytokines xws li interleukin -6 thiab IL-1 los ntawm kev txo cov phosphorylation ntawm MAPK, upregulating cov kev qhia ntawm aryl hydrocarbon receptors thiab teeb liab transduction thiab transcription nyob rau hauv macrophages, li no activating theem ntawm yam 3. s qib. Hauv MRSA-mob nas, kev tswj hwm ntawm MOTS-c ua rau muaj qhov nce ntxiv ntawm cov peritoneal macrophages thiab txo cov kab mob hauv ntau lub cev. Txoj kev tshawb no ntseeg tias MOTS-c nce qhov kev qhia ntawm cov teeb liab transducer thiab activator ntawm transcription peb thiab aryl hydrocarbon receptor los ntawm inhibiting MAPK txhim kho cov kab mob muaj peev xwm ntawm macrophages, thiab tswj qhov sib npaug ntawm proinflammatory cytokines thiab anti-inflammatory cytokines tib lub sijhawm.

6. MOTS-c tswj vascular endothelial muaj nuj nqi

MOTS-c tuaj yeem koom nrog hauv mitochondrial signal transduction ntawm vascular endothelium, qhia nws lub luag haujlwm hauv kev tswj hwm kev ua haujlwm endothelial. Txoj kev tshawb nrhiav pom tias plasma MOTS-c qib qis dua hauv cov neeg mob endothelial dysfunction dua li cov neeg uas muaj kev ua haujlwm endothelial. Txoj kev tshawb fawb ntawm cov aortic rings ntawm nas thiab nas nrog rau lub raum hlab ntsha stenosis pom tau hais tias txawm hais tias MOTS-c tsis muaj qhov ncaj qha vasoactive nyhuv, cov hlab ntsha ntawm nas nrog MOTS-c los yog nas nrog lub raum hlab ntsha stenosis pretreated nrog MOTS-c tau txhim kho cov lus teb rau. acetylcholine tshuaj. Cov kev tshawb pom no qhia txog lub luag haujlwm ntawm MOTS-c hauv ameliorating endothelial dysfunction, tab sis qhov tseeb mechanism tseem tsis meej. Cov ntaub ntawv pov thawj qhia tias kev ua kom muaj zog ntawm cov khoom siv hluav taws xob kB tuaj yeem ua rau lub cev tsis muaj zog ntawm endothelial kev ua haujlwm los ntawm kev hloov cov kev qhia ntawm proinflammatory cytokines, adhesion molecules, thiab inducing enzymes. Tsis tas li ntawd, MAPKs, txoj hauv kev ntws ntawm NF-κB, kuj tseem tuaj yeem tswj hwm qhov kev nthuav qhia ntawm adhesion molecules xws li vascular cell adhesion molecule ib thiab intercellular adhesion molecule thiab koom nrog qhov tshwm sim thiab kev loj hlob ntawm endothelial dysfunction los ntawm kev tswj. MOTS-c tuaj yeem cuam tshuam qhov kev qhia ntawm proinflammatory cytokines los ntawm inhibiting MAPK teeb liab txoj kev. Cov kev tshawb fawb saum toj no qhia ncaj qha tias MOTS-c tuaj yeem tiv thaiv kev ua haujlwm tsis zoo ntawm endothelial los ntawm inhibiting MAPK / NF-κB txoj hauv kev.

7. MOTS-c anti-osteoporosis

Osteoporosis yog ib qho kab mob ntawm cov pob txha degenerative nrog qhov tsis txaus ntawm cov pob txha resorption thiab kho pob txha, thiab nws qhov tshwm sim yog siab heev rau cov poj niam postmenopausal thiab cov neeg laus. Cov kev tshawb fawb tau pom tias ntxiv MOTS-c rau osteoclast sib txawv ntawm macrophages tuaj yeem cuam tshuam kev sib txawv ntawm osteoclast; ntxiv MOTS-c thiab tom qab ntawd ntxiv AMPK blocker Compound c tuaj yeem ua rau tsis muaj zog MOTS-c qhov inhibition ntawm osteoclasts. Lub luag haujlwm ntawm kev sib txawv. MOTS-c plays lub luag haujlwm tiv thaiv kab mob osteoporosis los ntawm kev ua kom AMPK, inhibiting osteoclast sib txawv, thiab alleviating postmenopausal pob txha los ntawm kev txo cov tshuaj estrogen. MOTS-c tuaj yeem txhawb cov pob txha pob txha mesenchymal qia hlwb thiab sib txawv rau hauv osteoblasts los ntawm kev hloov pauv txoj kev loj hlob, yog li txhim kho pob txha.

Hoobkas

1. Hais txog cov khoom zoo, Xi'an Sonwu Biotech Co., Ltd. Tsis tas li ntawd, Xi'an Sonwu muaj chav saib xyuas huv thiab huv nrog cov khoom siv siab heev los muab cov ntaub ntawv txhawb nqa rau txhua yam khoom. Raws li cov kev cai nruj ntawm Xi'an Sonwu, cov kws tshawb fawb txuas ntxiv tsim cov khoom tshiab thiab tsim cov khoom lag luam nrog cov ntsiab lus siab dua kom tau raws li cov neeg siv khoom xav tau.

2. Los ntawm qhov kev pabcuam ntawm qhov pom, Xi'an Sonwu Biotech Co., Ltd. muaj cov neeg ua haujlwm tsim khoom los xaiv cov khoom siv raw thiab tsim cov khoom, cov cuab yeej siv siab tshaj plaws, thiab cov neeg ua haujlwm kuaj xyuas cov khoom zoo. Cov neeg ua haujlwm nrog kev paub txog kev muag khoom txawv teb chaws los muag cov khoom thiab Xi'an Sonwu muaj cov kab tshwj xeeb rau kev thauj mus los hauv ntau lub teb chaws thiab nrhiav kom tau raws li qhov xav tau ntawm txhua tus neeg siv khoom.

Daim ntawv pov thawj

Pob

Logistics

Dhau li ntawm kev lees paub cov khoom, qhov tseem ceeb tshaj plaws yog los pab cov neeg siv khoom tau txais cov pob khoom kom zoo. Raws li qhov no, Xi'an Sonwu tuaj yeem muab txhua tus neeg xa khoom raws li qhov xav tau sib txawv.

FAQ

MOTS-C feem ntau muaj kev nyab xeeb heev, thiab tam sim no tsis muaj pov thawj tias nws muaj kev phiv. MOTS C feem ntau yog siv rau hauv kev noj qab haus huv thiab kev noj qab haus huv nrawm rau ntau txoj kev ua neej thiab kev noj haus. Tab sis cov khoom no tsuas yog tau sim rau nas, yog li tej zaum yuav muaj kev phiv, yog li nws yuav tsum tau kawm.

Puas yog MOTS-C ua haujlwm? Ntau tus neeg siv uas tau siv nws tau muaj kev sib xyaw ua ke. Thaum lawv kho, lawv lub cev hloov txawv. Thaum nws los txog rau ntau lub hom phiaj kev soj ntsuam, qee cov neeg siv tau ntsib tias tsis muaj qhov hloov pauv loj hauv lub cev hnyav. Txawm li cas los xij, qhov feem pua ​​​​ntawm lub cev rog, kev tawm dag zog lub cev, thiab kev ua haujlwm ntawm tus kheej txhua tus tau pom qhov hloov pauv loj. Dab tsi ntxiv, qee cov neeg siv tau tshaj tawm tias kev kho MOTS-C kuj tau pab lawv tsaug zog zoo dua. Lawv kuj tau kuaj pom tias lawv tsis muaj qab zib ntau npaum li cas thaum kho.

Yog koj xav paub covMOTS C hmoovnqe los yog xav nyob rau hauv Xi'an Sonwu, xav tiv tauj Xi'an Sonwu.

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