Peptide Hmoov Teriparatide

Teriparatide yog dab tsi
Peptide hmoov teriparatide, TPTD, yog ib qho khoom siv hluavtaws polypeptide ntawm txoj haujlwm 1 txog 34 ntawm parathyroid hormone (PTH), uas txhawb nqa pob txha anabolism thiab kev tswj hwm kev tiv thaiv kab mob. Nws tuaj yeem txhim kho rau kev mob caj dab caj dab. Nws yog ib qho hluavtaws polypeptide hormone tsim los ntawm endogenous parathyroid hormone, uas tuaj yeem tswj cov pob txha metabolism, txhawb nqa osteoblasts 'kev ua haujlwm, thiab ua kom cov pob txha calcium deposition. Teriparatide yog cov tshuaj sab hnub poob uas tuav dej, electrolyte, thiab acid-base tshuav tshuaj thiab electrolyte tshuav. Nws tuaj yeem ua kom cov pob txha ceev thiab ntxiv dag zog rau cov pob txha tawv, txhim kho pob txha. Cov neeg mob kuj tuaj yeem sib xyaw nrog cov tshuaj vitamin D, tshuaj calcium, thiab lwm yam tshuaj rau kev kho mob thiab lwm yam kev kho mob hauv kev kho mob. TPTD txhawb cov pob txha tsim thiab resorption, txo qhov tshwm sim ntawm pob txha nyob rau hauv cov poj niam postmenopausal, thiab nce los yog txo cov pob txha ntxhia pob txha, nyob ntawm seb hom kev tswj hwm. Tsis tas li ntawd, cov tshuaj no tsis cuam tshuam cov platelet aggregation teb ntawm ADP- los yog collagen-induced txoj kev. Teriparatide yog thawj zaug thiab tsuas yog FDA pom zoo kev kho mob biosynthetic rau osteoporosis, uas tuaj yeem nce tus naj npawb thiab kev ua haujlwm ntawm osteoblasts, yog li txhawb kev tsim cov pob txha tshiab. Nws tuaj yeem tsis tsuas yog ua kom cov pob txha ceev xwb tab sis kuj ua tiav rov tsim cov pob txha microstructure, Ua kom cov pob txha muaj zog thiab txo qhov tshwm sim ntawm pob txha hauv cov neeg mob osteoporosis. Yog tias koj txaus siab rau osteoporosis teriparatide hmoov, hu rau Xi'an Sonwu. Xi'an Sonwu tuaj yeem muab koj cov ntshiab teriparatide.

Certificate Of Analysis

Qhov Yuav Yuav Teriparatide
Xi'an Sonwu Biotech Co., Ltd. yog ib tug distributor thiab chaw tsim tshuaj paus nrog ntau tshaj kaum xyoo ntawm kev paub. Xi'an Sonwu muaj kev koom tes ruaj khov nrog cov teb chaws thoob ntiaj teb hauv Asia, Europe, Asmeskas, thiab Oceania. Xi'an Sonwu ib txwm hais kom ua haujlwm thiab txaus siab rau txhua tus neeg siv khoom zoo. Tsis tas li ntawd, Xi'an Sonwu siv zog ua haujlwm zoo hauv txhua qhov kev nthuav dav kom txo cov nqi kom cov neeg siv khoom tau txais cov khoom lag luam zoo. Raws li cov no, cov neeg siv khoom tau muab cov lus pom zoo ntawm cov khoom. Yog li yog tias koj xav tau osteoporosis teriparatide hmoov, thov hu rau Xi'an Sonwu.
Xi'an Sonwu thaum kawg ua rau qee yam khoom zoo thiab muab cov qauv. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'Cov lus pom zoo

Teriparatide ua haujlwm li cas
Peptide hmoov teriparatideyog tib neeg PTH analog nrog cov qauv tib yam li 34 amino acid sequences ntawm N-terminus ntawm ntuj PTH. Nws tuaj yeem khi rau qhov tshwj xeeb ntawm kev sib raug zoo ntawm tes ntawm tes receptors kom ua rau muaj kev cuam tshuam lom. Piv txwv li, nws tuaj yeem khi rau PIH1 receptors thiab ua si PIH lub luag haujlwm ntawm lub cev hauv cov pob txha thiab lub raum, thiab tsis muaj qhov cuam tshuam ntawm C-terminal peptide ntawm cov pob txha metabolism. Tib neeg PTH yog secreted los ntawm cov thawj parathyroid hlwb thiab muaj 84 amino acid ib leeg-chain polypeptide proteins. Nws muaj cov haujlwm tseem ceeb ntawm kev nce ntshav calcium, txo cov ntshav phosphorus, thiab tswj xyuas qhov chaw sab hauv ntawm cov kua dej ntxiv. Nyob rau tib lub sijhawm, PTH muaj ob txoj kev tswj hwm ntawm cov pob txha hloov pauv.
TPTD tuaj yeem kho cov pob txha metabolism los ntawm inhibiting osteoblast apoptosis, ua kom cov pob txha hauv ob sab phlu, thiab txhim kho osteoblast sib txawv. Los ntawm kev tswj cov adenylate cyclase-cyclic adenosine phosphate protein kinase A txoj hauv kev, PHT-I receptors nyob rau saum npoo ntawm osteoblasts, cov pob txha hauv ob sab phlu, thiab cov pob txha pob txha stromal qia hlwb tau cuam tshuam los txhawb kev sib txawv ntawm osteoblasts thiab ntev lub neej ntawm osteoblasts. Stimulates osteoblast cell kab proliferation los ntawm phosphate C-cytoplasmic calcium ion-protein kinase C signaling txoj kev. Los ntawm inhibiting lub transactivation kev ua ntawm PPAR, nws txo qhov sib txawv ntawm stromal hlwb mus rau hauv adipocyte kab mob thiab ua rau kom cov osteoblasts. Tsis tas li ntawd, nws ncaj qha tswj cov pob txha loj hlob los ntawm kev tswj cov cytokines, xws li inducing iGF-1 los ua ke nrog osteoblasts, yog li txhawb kev tsim cov pob txha. Tswj cov txheej txheem ntawm cov pob txha tsim los ntawm Wnt signaling txoj kev, yog li ua kom cov pob txha tsim. Tom qab ib lub lim tiam ntawm daim ntawv thov ntawm PTH, osteoblast progenitor hlwb thiab osteoblasts tsis paub qab hau proliferated thiab txawv, inhibiting osteoblasts 'apoptosis. Nws ntseeg tau tias kev tswj hwm tsis tu ncua ntawm PTH hauv cov koob tshuaj me me tuaj yeem txhawb kev tsim cov pob txha, thiab cov nyiaj ntau tuaj yeem txhawb cov pob txha resorption. Cov kev tshawb fawb tau pom tias N-terminal ntawm PIH tuaj yeem khi rau PTH-I receptors faib rau cov pob txha thiab ob lub raum, cuam tshuam rau osteogenesis; C-terminal tuaj yeem khi rau lwm hom receptor, siv lwm yam kev ua haujlwm lom neeg, thiab tseem txhawb kev tsim cov osteocytes apoptosis.

Kev kho Teriparatide yog dab tsi
1. Kev kho mob pob txha pob txha
Tam sim no, cov tshuaj siv tshuaj kho mob rau thawj pob txha, xws li bisphosphonates, calcitonin, thiab pawg tshuaj hormones, txhua yam ua tiav cov txiaj ntsig ntawm Teriparatide ib leeg lossis ua ke tuaj yeem ua kom cov pob txha pob txha pob txha, txhim kho pob txha microstructure, thiab txo kev pheej hmoo ntawm pob txha. Feem ntau cov kev tshawb fawb soj ntsuam tau ua pov thawj tias teriparatide ua rau cov pob txha pob txha pob txha ntom ntom ntom ntom ntom nti.
2. Kev kho mob osteoporosis theem nrab
Tag nrho ntawm 437 tus txiv neej cov neeg mob uas muaj thawj lossis theem nrab osteoporosis los ntawm hypogonadism raug tshuaj xyuas los ntawm kev kuaj pob txha. Lawv tau muab faib rau hauv pawg placebo, teriparatide ib pawg qis, thiab teriparatide 1 pawg. Hauv peptide ob pawg neeg siab, txhua tus neeg mob tau txais cov tshuaj calcium thiab vitamin D rau kev tshawb fawb thiab tshuaj xyuas. Tom qab 11- lub hlis soj ntsuam, BMD ntawm lub lumbar qaum tau nce 5.9 feem pua ​​​​thiab 9.0 feem pua ​​​​hauv teriparatide pawg 1 thiab 2 pawg, feem. BMD ntawm lub caj dab femoral nce 1.5 feem pua ​​​​thiab 2.9 feem pua ​​​​, thiab cov kev phiv tshwm sim hauv ob pawg tau siab hauv pawg 1. Hauv kev tshawb nrhiav tom qab, 350 tus txiv neej osteoporosis tau ua raws li rau 30-42 hli. Qhov tshwm sim ntawm pob txha pob txha hauv pawg teriparatide yog 51 feem pua ​​​​qis dua li cov placebo pawg. Yog li, cov khoom no yog ib qho tshuaj zoo heev rau kev kho mob glucocorticoid Secondary osteoporosis.

Cov teebmeem ntawm Teriparatide
1. Cov kab mob plawv: Ntshav siab tuaj yeem pom. Cov tsos mob no feem ntau tshwm sim nyob rau thawj ob peb qhov kev tswj hwm, thiab cov tsos mob tuaj yeem txo qis tom qab noj cov tshuaj, uas tsis cuam tshuam rau kev kho mob txuas ntxiv.
2. Central paj hlwb: cov tsos mob xws li kiv taub hau, kev nyuaj siab, thiab mob taub hau tuaj yeem pom.
3. Metabolic/endocrine system: nce ntshav calcium, nce ntshav uric acid, thiab hypoparathyroidism yuav tshwm sim.
4. Musculoskeletal system: ob txhais ceg cramps thiab arthralgia tej zaum yuav tshwm sim thaum cov tshuaj no kho osteoporosis. 5. Kab mob plab: xeev siab tshwm sim.

Hoobkas
1. Xi'an Sonwu Biotech Co., Ltd muaj nws lub Hoobkas los tsim, tsim thiab khaws cov khoom, yog li nws muaj Tshuag zoo heev. Xi'an Sonwu muaj lub chaw tsim khoom kom zoo thiab huv si. Nyob rau hauv Xi'an Sonwu, cov kws tshawb fawb tuaj yeem tsim cov khoom tshiab zoo.
2. Xi'an Sonwu Biotech Co., Ltd nruj me ntsis xyuas txhua kauj ruam, los ntawm kev xaiv cov khoom siv, kev tsim khoom, kev kuaj cov qauv, cov neeg ua haujlwm tshaj lij, thiab lwm yam kev sib txuas, los ntawm kev xaiv cov khoom siv raw mus rau cov khoom zoo. Txhawm rau kom ntseeg tau tias txhua yam khoom escort, muab cov ntaub ntawv nruj thiab kev pab cuam tom qab muag.

Daim ntawv pov thawj

Ntim

Logistics

Dhau li kev lees paub cov khoom zoo, lwm qhov tseem ceeb tshaj plaws yog pab cov neeg siv khoom kom tau txais cov khoom zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ
Txawm hais tias muaj ntau yam tshuaj rau kev kho mob pob txha, tsis muaj pov thawj txaus los qhia tias cov tshuaj twg zoo dua ntawm kev ua tau zoo thiab kev nyab xeeb. Osteoporosis teriparatide hmoov, nrog nws cov txheej txheem tshwj xeeb ntawm kev txhawb nqa pob txha. Qhov tseeb cov nyhuv ntawm nce pob txha pob txha ceev thiab qhov kev pheej hmoo ntawm pob txha caj txha pob txha caj qaum tau nqa ib qho kev kho kom zoo los kho cov tshuaj tiv thaiv kab mob osteoporosis. Teriparatide tuaj yeem siv los ua thawj qhov kev xaiv tshuaj thiab ua ke nrog raloxifene thiab vitamin D los txhim kho cov nyhuv curative. Nrog rau kev tshawb fawb ntxiv, teriparatide yuav dhau los ua riam phom muaj zog hauv kev kho mob pob txha.
Yog tias koj txaus siab rau teriparatide tsum, tsuas yog hu rau Xi'an Sonwu. Nyem rau email ces koj tau txais high-zoopeptide hmoov teriparatide.
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