Coluracetam (BCI-540) yog dab tsi?
Coluracetam hmoovkuj yog BCI-540 hmoov, CAS TSIS yog 135463-81-9, Molecular Formula: C19H23N3O3, Molecular Luj: 341.4 g/mol, thiab hmoov dawb. Nws lub npe tshuaj yog N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,{16}}Chemicalbookb]quinolin-4-yl){ {18}}(2-oxopyrrolidine)-1-yl)acetamide, yog ib chav kawm ntawm racetam derivatives. Sib txawv ntawm racetams, coluracetam nce tus nqi-txheej kauj ruam ntawm synaptic choline kom tsawg los ua ke cov neurotransmitter acetylcholine los ntawm kev koom nrog hauv HACU txheej txheem, thiab ua kom cov haujlwm ntawm cholinergic neurons kom ua tiav kev paub zoo, tom qab ntawd ua tiav cov nyhuv nootropic.
Coluracetam siv rau dab tsi?
1.Coluracetam (BCI-540, MKC-231) yog ib qho nootropic nrog kev paub txog kev txawj ntse thiab kev tiv thaiv kab mob. Nws txhim kho kev nco los ntawm kev txhawb nqa kev kho cov hlwb hlwb. BCI-540 tuaj yeem siv los kho kev nco thiab kev txawj ntse uas tshwm sim los ntawm senile dementia, me me mus rau nruab nrab vascular dementia, raug mob, thiab lwm yam kab mob thiab txhawb kev loj hlob ntawm kev txawj ntse ntawm cov menyuam yaus.
2.Nws muaj txiaj ntsig zoo rau kev nyuaj siab los ntawm kev txhawb nqa kev sib kis ntawm cov paj hlwb. Hauv theem 2A kev soj ntsuam ntawm coluracetam, muab tshuaj ntawm 80 mg peb zaug hauv ib hnub rau rau lub lis piam, coluracetam txhim kho cov ntaub ntawv kev ntxhov siab hauv cov neeg mob uas muaj kev nyuaj siab thiab ntxhov siab tom qab rau lub lis piam, uas ua pov thawj tias qhov koob tshuaj no noj coluracetam zoo rau kev nyuaj siab thiab ntxhov siab vim.
3.In degenerative retinal kab mob, coluracetam txhawb cov paj hlwb. Qee cov neeg siv hais tias coluracetam tuaj yeem txhim kho lub zeem muag xim, pom cov duab, thiab qhov muag pom, uas txhais tau tias nws muaj txiaj ntsig zoo rau kev txhim kho tib neeg lub zeem muag. Cov neeg siv piav qhia txog cov txiaj ntsig ntawm kev txhim kho cov xim tsis pom kev, pom cov duab, thiab qhov muag pom kev zoo li "lub zeem muag siab", thaum lwm tus hais tias nws ua kom lub teeb ci thiab txhim kho qhov sib txawv.
Ua Haujlwm li cas?
Hauv kev sim kawm txog hippocampus ntawm bulk coluracetam, kev noj ntawm AF64A hauv hippocampus tau txo qis ntawm koob tshuaj 0.3 mg / kg thiab 1 mg / kg. Cov kws sim kuj tau pom tias Coluracetam ua rau tsis muaj cov tshuaj neurochemicals. Tom qab kev tswj hwm ntawm Coluraracetam, hippocampal high-affinity choline uptake (HACU) concentrations raug txo, thiab high-potassium stimulation-induced acetylcholine (ACh) tso tawm tuaj yeem rov qab mus rau qib qub.
Cov txheej txheem ntawm kev txiav txim ntawm coluracetam tuaj yeem txiav txim siab hauv ob txoj hauv kev kom ua tiav cov nyhuv. Thawj thiab tseem ceeb tshaj plaws, nws ua qhov no los ntawm kev xaiv cuam tshuam kev nco los ntawm kev txhim kho kev sib raug zoo rau choline uptake (HACU). Raws li ib txwm muaj, racetams feem ntau ua rau muaj qhov tshwm sim ntawm acetylcholine los ntawm kev txhawb nqa receptors, thaum coluracetam nce qib ntawm cov neurotransmitter acetylcholine los ntawm kev ua kom muaj kev sib raug zoo ntawm choline uptake los muab ntau choline. Affinity choline uptake yog tus nqi txwv cov kauj ruam hauv kev sib txuas ntawm acetylcholine (ACh), cov neurotransmitter feem ntau cuam tshuam nrog kev nco thiab kev paub. Nyob rau hauv qhov kev txiav txim ntawm coluracetam, qhov ceev uas choline nqus tau rau hauv cov hlab ntsha hlwb hauv tib neeg lub cev yog nce, thiab theem ntawm cov accompanying high-affinity choline transporter molecule CHT1 yog nce kom qhov nqus ceev thiab qib ntawm acetylcholine nce. Cov qib siab ntawm acetylcholine tshwm sim los ntawm cov kev sib xyaw ua ke no txhim kho kev nco thiab kev paub. Coluracetam cov nyhuv ntawm tus cwj pwm ntawm acetylcholine yog xav tias yog qhov laj thawj tseem ceeb rau kev ua yeeb yam zoo li nootropic ntxiv.
Cov kev tshawb fawb kuj tau pom tias cov nas raug rau choline neurotoxins tau txhim kho kev kawm tom qab ib koob tshuaj coluracetam. Coluracetam tseem tuaj yeem ua rau muaj kev paub ntev ntev hauv cov nas los ntawm kev hloov choline transporter regulatory system.
Qhov thib ob coluracetam kuj zoo nkaus li muaj cov txiaj ntsig zoo ntawm AMPA receptors. AMPA receptors mediate synaptic kis tau tus mob sai sai nyob rau hauv lub hauv nruab nrab lub paj hlwb, uas yog koom nyob rau hauv cov kev cai ntawm kev kawm thiab nco kev ua ub no. Cov lej txawv txav thiab kev ua haujlwm ntawm AMPA receptors tuaj yeem ua rau Alzheimer's tus kab mob. AMPA receptors feem ntau ua rau lub hlwb thiab lub hauv nruab nrab lub paj hlwb, txhim kho lub hlwb alertness thiab kev paub. Coluracetam yog ib qho tshwj xeeb zoo nootropic ntxiv, xav tau koob tshuaj me me dua li lwm cov racetams.
Coluracetam vs Aniracetam
Cov tshuaj nootropics ntawm cov racetams feem ntau suav nrog Piracetam, Aniracetam, Nefiracetam, Pramiracetam, Fasoracetam, thiab Oxiracetam, thiab lwm yam. Tab sis kev sib piv feem ntau yog ua los ntawm coluracetam thiab aniracetam.
Raws li coluracetam thiab aniracetam, uas yog nyob rau tib chav kawm ntawm nootropics, ob qho tib si muaj qhov zoo ntawm qhov tseem ceeb curative teebmeem thiab tsis tshua muaj toxicity. Tab sis qhov txawv yog tias coluracetam txhim kho kev nco qab los ntawm kev txhim kho choline affinity, thaum aniracetam yog kho los ntawm kev sib cuam tshuam ntawm dopaminergic, cholinergic, thiab serotonergic systems.
Hais txog kev ua haujlwm, coluracetam tsuas yog txhawb kev kho cov hlwb hlwb thiab txhim kho kev nco; thaum aniracetam txhim kho kev nco, lub hlwb ua haujlwm, kev kho mob Alzheimer's kab mob, kev kawm muaj peev xwm, thiab txhim kho kev xav. Ob yam khoom Xi'an Sonwu tuaj yeem muab cov hmoov thiab tshuaj ntsiav rau koj, yog tias koj xav tau tus nqi coluracetam, tsuas yog hu rau Xi'an Sonwu.
Kev siv Coluracetam
Coluracetam tuaj yeem noj raws li ntshiab Coluracetam hmoov, tshuaj ntsiav, lossis hauv cov tshuaj sib xyaw nrog lwm cov tshuaj nootropics. Zoo li lwm yam racetam nootropics, coluracetam tuaj yeem sib xyaw nrog alpha GPC los txhim kho kev nco thiab kev paub; nws tuaj yeem sib xyaw nrog CDP.
Rau cov hmoov coluracetam, Xi'an Sonwu tuaj yeem muab cov hmoov thiab cov tshuaj ntsiav, Yog tias koj xav yuav coluracetam, lossis muaj lwm yam lus nug txog cov khoom, yog tias koj muaj lus nug, thov nias rau ntawm lub thawv, Kuv yuav muab cov lus qhia zoo lossis daws koj cov teeb meem. .
Email:sales@sonwu.com