Hederagenin Structure
Hederagenin hmoov(HD) yog ntuj pentacyclic triterpenoid compound. HD tau garnered ntau xim raws li ib tug nroj tsuag theem nrab metabolite vim nws ntau yam pharmacological kev ua si thiab muaj peev xwm noj qab haus huv zoo. Nws cov qauv tshuaj lom neeg feem ntau suav nrog lub cev pob txha triterpene nrog tsib lub nplhaib sib koom ua ke, uas muaj cov pab pawg ua haujlwm xws li hydroxyl thiab methyl, uas ua rau nws ua haujlwm lom. Cov qauv no tuaj yeem cuam tshuam nrog lwm cov molecules los ntawm ntau txoj hauv kev biotransformation los ua haujlwm rau nws txoj haujlwm. Nws feem ntau muaj nyob rau hauv daim ntawv ntawm saponins, uas yog complex molecules tsim los ntawm qab zib chains txuas rau sapogenins. Hederagenin feem ntau yog muab rho tawm los ntawm nplooj thiab cov hauv paus hniav ntawm ivy tab sis kuj tuaj yeem pom nyob rau hauv lwm cov nroj tsuag, xws li Gleditsia.
HD muaj ntau yam tshuaj ua haujlwm, suav nrog tshuaj tiv thaiv kab mob, tshuaj tua kab mob, tshuaj tiv thaiv kab mob hlwb, thiab cov teebmeem neuroprotective. Cov kev tshawb fawb tau pom tias nws tuaj yeem pab txo cov kab mob inflammatory, txo cov oxidative kev nyuaj siab, inhibit qhov kev loj hlob ntawm cov kab mob, muaj kev tiv thaiv ntawm paj hlwb, thiab muaj peev xwm kho tau ntau yam kab mob. Vim nws cov nqi tshuaj muaj peev xwm, hederagenin kuj tau muab tso rau hauv qee yam tshuaj thiab cov khoom noj qab haus huv. Cov neeg siv nws qhov ncauj los yog siv cov tshuaj pleev ib ce kom tau txais nws cov txiaj ntsig kev noj qab haus huv, xws li kev saib xyuas ntawm daim tawv nqaij, kev tiv thaiv kev laus, kev tiv thaiv kab mob, thiab lwm yam. Yog tias xav tau cov neeg nruab nrab, koj tuaj yeem tiv tauj Xi'an Sonwu, uas tuaj yeem muab cov hmoov nyoos.
Kev siv Hederagenin
1. Anti-inflammatory nyhuv
Hedera saponin tau pom tias muaj cov haujlwm tseem ceeb los tiv thaiv kab mob thiab tuaj yeem txo cov kab mob o, xws li mob caj dab rheumatoid, kab mob plab hnyuv, thiab lwm yam. ntawm inflammatory pathways.
2. Antioxidant nyhuv
Helexin muaj cov khoom antioxidant, pab tiv thaiv cov hlwb los ntawm kev puas tsuaj los ntawm oxidative kev nyuaj siab, ncua kev laus, thiab tej zaum yuav muaj kev tiv thaiv oxidative kev nyuaj siab cov kab mob xws li kab mob plawv.
3. Anti-lesion nyhuv
Kev tshawb fawb qhia tias HD muaj kev cuam tshuam rau cov kab mob tshwj xeeb thiab tuaj yeem pab kho cov kab mob loj. Nws tuaj yeem ua rau apoptosis, tiv thaiv kev loj hlob thiab kev sib kis ntawm cov mob hlwb, thiab txhim kho kev kho mob ntawm cov tshuaj tiv thaiv kab mob thaum ua ke nrog lawv.
4. Cov nyhuv neuroprotective
Kev tshawb fawb pom tau tias HD tiv thaiv lub paj hlwb thiab pab tiv thaiv cov kab mob neurodegenerative, xws li Alzheimer's kab mob, Parkinson's kab mob, thiab lwm yam. Nws yuav ua tau los ntawm antioxidant, anti-inflammatory, thiab neuroprotective mechanisms.
5. Kev kho tawv nqaij
HD yog siv rau hauv cov khoom tu tawv nqaij thiab muaj kev tiv thaiv kab mob, antioxidant, thiab moisturizing zog. Nws pab txo cov tawv nqaij o, txhawb qhov txhab kho, thiab txo cov cim ntawm daim tawv nqaij laus. Nws yog ib qho ntawm cov khoom xyaw tseem ceeb hauv ntau cov khoom siv tawv nqaij.
6. Immunomodulation
Dysregulation ntawm lub cev tiv thaiv kab mob yog ib qho tseem ceeb ntawm pathogenesis ntawm tej yam kab mob. Cov nyhuv immunomodulatory ntawm HD tuaj yeem pab sib npaug ntawm lub cev tiv thaiv kab mob, txhim kho lub cev tiv thaiv, thiab tiv thaiv thiab kho cov kab mob tiv thaiv kab mob.
Hederagenin Mechanism Ntawm Kev Ua
Mechanism ntawm kev ua
1. Antioxidant nyhuv
HD tuaj yeem txo qis oxidative kev nyuaj siab thiab tshem tawm cov dawb radicals. Los ntawm kev txhawb nqa kev ua haujlwm ntawm cov enzymes antioxidant (xws li catalase CAT thiab superoxide dismutase SOD), nws txo qhov kev puas tsuaj uas dawb radicals wreak rau hlwb hlwb.
2. Anti-inflammatory nyhuv
HD txo qhov kev puas tsuaj uas ua rau mob hlwb los ntawm kev tiv thaiv kev tso tawm ntawm cov kab mob sib kis xws li TNF- , IL-1 , thiab IL-6.
3. Inhibition ntawm cell apoptosis
HD tswj kev qhia ntawm Bcl-2 tsev neeg cov proteins, suav nrog Bcl-2 thiab Bax, uas tuaj yeem tiv thaiv kev tuag ntawm tes hauv txoj kev mitochondrial. Nyob rau tib lub sijhawm, nws tseem tuaj yeem cuam tshuam kev ua haujlwm ntawm caspase tsev neeg cov protein, yog li txo cov apoptosis ntawm paj hlwb.
4. Txhim kho cov kev tiv thaiv kab mob neuroprotective
PI3K/Akt signaling pathway, tseem ceeb rau cell ciaj sia taus thiab anti-apoptosis, tuaj yeem qhib tau los ntawm ivy sapogenin. Akt activation tuaj yeem cuam tshuam ntxiv rau kev ua haujlwm ntawm GSK-3, yog li tiv thaiv cov paj hlwb.
5. Tswj cov neurotransmitters
HD tuaj yeem txhim kho cov paj hlwb ua haujlwm thiab nyob ib puag ncig los ntawm kev tswj hwm cov tshuaj neurotransmitters 'kev tso tawm thiab rov ua dua.
Hom phiaj
1. Antioxidant enzymes
Superoxide dismutase (SOD)
Calatase (CAT).
2. Cov kab mob sib kis
TNF-
Interleukin -1 (IL-1)
Interleukin -6 (IL-6)
3. Apoptosis-related proteins
Bcl-2 tsev neeg cov proteins (Bcl-2, Bax)
Caspase tsev neeg cov proteins (caspase-3, caspase-9)
4. Kev taw qhia txoj hauv kev
PI3K/Akt signaling pathway
GSK-3
Hederagenin Toxicity
Gastrointestinal tsis xis nyob
Hederagenin tuaj yeem ua rau mob plab hnyuv, nrog rau xeev siab, ntuav, thiab raws plab, raws li kev tshawb fawb tshwj xeeb thiab cov ntawv ceeb toom.
Cov tawv nqaij ua xua
Qee tus neeg yuav ua xua rau hederagenin lossis cov khoom uas muaj cov khoom xyaw no thiab tej zaum yuav muaj kev tsis haum tshuaj xws li khaus tawv nqaij, pob khaus, lossis mob dermatitis tom qab siv.
Ua pa ua pa
Kev nqus ntawm hederagenin tuaj yeem ua rau ua pa ua pa, ua rau cov tsos mob xws li hnoos thiab caj pas tsis xis nyob.
Cov teebmeem rau lub siab
Qee qhov kev tshawb fawb tau pom tias kev siv tshuaj hederagenin ntev ntev los yog siv ntau yuav ua rau lub siab mob, yog li cov neeg mob siab yuav tsum siv ceev faj.
Kev sib cuam tshuam nrog tshuaj
Hederagenin tuaj yeem cuam tshuam nrog qee yam tshuaj, cuam tshuam rau cov metabolism thiab cov nyhuv ntawm cov tshuaj. Yog li ntawd, cov tib neeg noj lwm yam tshuaj yuav tsum sab laj nrog kws kho mob ua ntej siv cov khoom hederagenin.
Yog tias koj xav tau tus nqi HD, txaus siab rau Xi'an Sonwu, lossis muaj lwm yam lus nug txog cov khoom, tsis txhob yig tiv tauj Xi'an Sonwu.
Email:sales@sonwu.com