Lub Npe Lub Npe Rau Zuprevo yog dab tsi
Tildipirosin hmoovyog lwm lub npe rau Zuprevo, cov tshuaj muaj npe nrov hauv cov kws kho tsiaj, uas yog qhov tseem ceeb rau nws siv los kho cov kab mob bovine respiratory (BRD). Ib qho teeb meem kev noj qab haus huv tshaj plaws thiab kim tshaj plaws uas ntsib thoob ntiaj teb kev lag luam mis nyuj thiab nqaij yog kab mob ua pa ntawm bovine. Kev ntxhov siab ib puag ncig, tus tswv tsev, thiab cov kab mob thiab cov kab mob kis kab mob sib cuam tshuam los tsim nws. Los ntawm tshwj xeeb tsom thiab tiv thaiv cov synthesis ntawm cov kab mob protein tsim nyog rau txoj kev loj hlob thiab ciaj sia ntawm cov kab mob pathogenic, Zuprevo txo qhov cuam tshuam ntawm cov kab mob ntawm nyuj.
Cov khoom no yog tsim los tawm tsam cov kab mob tshwj xeeb uas ua rau BRD, kho thiab tswj tus kab mob zoo. Tom qab siv, cov tshuaj muaj txiaj ntsig tuaj yeem khaws cia hauv lub cev nyuj rau lub sijhawm ntev dua, uas yuav pab txo qhov zaus ntawm kev tswj hwm thaum ua kom muaj txiaj ntsig zoo. Kev kho mob zoo ntawm BRD txo qis kev sib kis ntawm cov nyuj thiab pab txhim kho kev noj qab haus huv thiab tsim khoom ntawm tag nrho pab tsiaj. Yog tias koj xav tau cov khoom nyoos macrolide tshuaj tua kab mob, hu rau Xi'an Sonwu.
Tildipirosin ua haujlwm li cas hauv Tsiaj txhu
Cov tshuaj tua kab mob ntawm Tildipirosin yog tib yam li cov tshuaj macrolide. Nws tuaj yeem txuas nws tus kheej mus rau cov kab mob rhiab heev ribosome's 50S subunit thiab tiv thaiv kev tsim cov nucleoprotein peptide chains, cuam tshuam cov synthesis ntawm cov protein hauv cov kab mob. Ribosomes yog qhov tseem ceeb hauv kev txiav txim siab tus xa xov RNA (mRNA) los tsim cov proteins raws li nws cov lus qhia. Kev sib cuam tshuam nrog ribosomes zoo thaiv lub qhov ribosome los ntawm qhov uas tau tsim tshiab cov protein chains feem ntau tawm. Tom qab khi rau 50S ribosomal subunit, nws tiv thaiv cov amino acids tshiab los ntawm kev ntxiv rau cov saw hlau nascent protein, halting protein ntau lawm. Nws qhov tshwj xeeb kev sib cuam tshuam ntawm ob lub piperidine Cheebtsam ua rau cov tshuaj no cov txheej txheem ntawm kev ua txawv ntawm tylosin thiab tilmicosin. Lub 20-piperidine yog coj mus rau hauv lub lumen los cuam tshuam nrog kev loj hlob ntawm nascent peptides. Vim tias nws muaj peb pawg thawj amino, nws tuaj yeem tsim cov ntawv them nqi raws li ntau yam pH. Tus nqi yog qhov tseem ceeb hauv kev rhuav tshem cov solubility ntawm cov kab mob lipids thiab nkag mus rau sab nrauv ntawm cov kab mob Gram-negative, yog li nws cov tshuaj tua kab mob hauv vitro cuam tshuam zoo heev los ntawm pH. Tildipirosin cov tshuaj tua kab mob txo qis hauv qhov chaw acidic vim yog protonation ntawm cov amino pawg; Hauv cov chaw alkaline, txawm li cas los xij, nws nthuav tawm ntau cov tshuaj tua kab mob.
Macrolides nthuav tawm cov tshuaj tiv thaiv kab mob ntawm neutrophils thiab macrophages los ntawm kev ua phospholipase, leukotriene tso tawm, thiab proinflammatory cytokine secretion inhibition. Nws txo cov inflammatory mediators uas tsim thaum lub sij hawm tshwj xeeb o lossis kev ntxhov siab. Cov kab mob uas nws lub hom phiaj suav nrog tab sis tsis txwv rau, Mycoplasma bovis, uas paub txog nws lub luag haujlwm hauv BRD thiab nyuaj rau kev kho mob vim muaj ntau yam tshuaj tua kab mob. Txawm hais tias dioxin muaj txiaj ntsig tshwj xeeb rau cov kab mob tshwj xeeb uas koom nrog hauv cov kab mob ua pa, nws kuj nthuav tawm cov haujlwm dav dav tawm tsam cov kab mob sib txawv. Qhov ntawd txhais tau tias nws tuaj yeem kho ntau yam kab mob kab mob hauv cov kws kho tsiaj, tsis yog ua pa yooj yim.
Kev siv Tildipirosin
1. Kev Kho Kab Mob Bovine Respiratory Disease (BRD)
Tildipirosin yog dav siv los kho thiab tswj kab mob bovine respiratory disease (BRD), ib tug complex multifactorial kab mob cuam tshuam rau nyuj. BRD yog tshwm sim los ntawm kev sib xyaw ntawm cov kab mob thiab kab mob, suav nrog tab sis tsis txwv rau Mannheimia haemolytica, Pasteurella multocida, thiab Histophila somnifera. Cov khoom no tshwj xeeb tshaj yog tiv thaiv Mycoplasma bovis, cov kab mob nyuaj uas cuam tshuam nrog BRD, vim tias nws tiv taus ntau lwm yam tshuaj tua kab mob.
2. Kev Tiv Thaiv BRD
Ntxiv nrog rau kev kho cov kab mob nquag, digoxin yog siv los tiv thaiv kev loj hlob ntawm BRD hauv cov tsiaj txhu uas muaj kev pheej hmoo, feem ntau yog thaum cov tsiaj muaj kev ntxhov siab, xws li kev txiav, thauj, lossis sib xyaw nrog cov tsiaj tshiab; Tag nrho cov no tuaj yeem ua rau lawv mus rau BRD kab mob ua pa.
3. Swine dysentery thiab mob ntsws
Thaum nws thawj daim ntawv thov yog kho BRD hauv nyuj, kev tshawb fawb thiab kev siv tshuaj kho mob tau txuas ntxiv mus kho cov kab mob hauv npua, xws li swine dysentery thiab mob ntsws. Cov mob no, tshwm sim los ntawm cov kab mob sib txawv, tuaj yeem cuam tshuam rau npua kev noj qab haus huv thiab kev tsim khoom.
4. Veterinary tshuaj zoo
Tildipirosin yog tsim los ua haujlwm ntev, txhais tau tias nws tseem siv tau rau lub sijhawm ntev dua tom qab ib koob tshuaj. Qhov ntawd txo qhov kev xav tau ntawm kev tuav thiab kho tsiaj, txo qis kev ntxhov siab thiab nqi zog. Nws lub peev xwm tshwj xeeb rau lub hom phiaj thiab inhibit protein synthesis hauv cov kab mob ua rau nws muaj kev xaiv zoo rau cov kab mob uas ua rau cov kab mob tseem ceeb hauv cov tsiaj txhu. Tsis tas li ntawd, nws tau raug soj ntsuam rau kev nyab xeeb hauv hom hom phiaj thiab tau pom tias muaj kev nyab xeeb zoo thaum siv raws li cov lus qhia.
Zuprevo Cov Teeb Meem Hauv Cov Nyuj
1. Cov kab mob digestive tsis xis nyob
Qee cov tsiaj kuj yuav ntsib kev tsis xis nyob hauv plab, nrog rau kev tsis qab los noj mov, raws plab, ntuav, lossis mob plab. Cov tsos mob no feem ntau yog ib ntus thiab ploj mus tom qab kev kho mob xaus.
2. Kev ua xua
Muaj qee zaus, tsiaj txhu tuaj yeem tsim kev tsis haum rau Zuprevo, nrog rau cov pob khaus, khaus, o ntawm lub qhov muag lossis lub ntsej muag, ua pa nyuaj, ntuav, raws plab, lossis lwm yam kev hloov pauv. Anaphylaxis tuaj yeem ua rau mob hnyav thiab xav tau kev pab kho tsiaj tam sim ntawd.
3. Cov lus teb zoo
Tsis tshua muaj, kev cuam tshuam rau Zuprevo tuaj yeem suav nrog kub taub hau, qaug dab peg, qaug zog, lossis lwm yam tsos mob ntawm lub cev tsis zoo. Tus kws kho tsiaj yuav tsum hu rau tam sim ntawd vim tias cov tshuaj tiv thaiv no yuav hnyav heev.
4. cuam tshuam rau kev tsim tawm
Tsis tau muaj cov lus ceeb toom dav dav, tab sis Zuprevo tej zaum yuav muaj kev cuam tshuam kev loj hlob ntawm cov nyuj, uas yuav muaj xws li kev xeeb tub, rho menyuam, lossis lwm yam teeb meem kev loj hlob.
Yog tias koj xav paub cov chaw tsim khoom tildipirosin, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email, thiab tom qab ntawd koj tau txais cov hmoov zoo.
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