Urokinase (Peptidolytic) (9ci) Nqe lus piav qhia
Urokinase hmoov, paub nyob rau hauv cov tshuaj thiab kws tshuaj lub voj voog los ntawm nws lub npe scientific, "peptidolytic enzyme" (9CI), sawv cev rau ib tug fascinating thiab tseem ceeb tivthaiv nyob rau hauv kev kho mob teb, tshwj xeeb tshaj yog nyob rau hauv kev kho mob thrombolytic kab mob thiab kev tswj xyuas. Qhov no serine protease enzyme yog qhov tseem ceeb rau lub cev fibrinolytic system. Nws rhuav tshem cov ntshav txhaws thiab pab kom tsis txhob muaj kab mob ua rau tuag taus xws li kev sib deev stroke, sib sib zog nqus vein thrombosis, thiab pulmonary embolism.
Nws yog ib qho proteolytic enzyme uas lub hom phiaj meej meej thiab cleaves plasminogen (qhov tsis muaj zog ua ntej ntawm plasmin). Plasminogen circulates thoob plaws hauv cov hlab ntsha thiab tuaj yeem yaj cov hlab ntshav thaum qhib kom tsim plasmin. Fibrin yog cov txheej txheem tseem ceeb ntawm cov ntshav txhaws, thiab nws qhov kev puas tsuaj yog qhov tseem ceeb rau kev ua kom cov ntshav txhaws uas tsis xav tau lossis ua rau muaj kev phom sij rau kev noj qab haus huv los ntawm kev thaiv cov hlab ntsha. Qhov kev txiav txim ntawm urokinase cuam tshuam nrog kev khi rau plasminogen los ua ib qho nyuaj, uas tom qab ntawd dhau los ua kev hloov pauv uas txhawb kev hloov pauv ntawm plasminogen rau plasmin. Thaum tsim, plasmin tuaj yeem txo qis fibrin thiab lwm yam plasma proteins, ua rau thrombolysis. Cov txheej txheem no nruj nruj tswj hwm hauv lub cev kom ntseeg tau tias cov hlab ntsha tsis tawg sai dhau, uas tuaj yeem ua rau los ntshav ntau dhau, lossis lig dhau lawm, uas tuaj yeem ua rau cov ntshav txhaws. Lub peev xwm ntawm nws kom yaj cov ntshav txhaws ua rau nws yog ib qho tseem ceeb tshuaj nyob rau hauv kev kho mob ntawm ntau yam kab mob thrombotic. Nws yog qhov muaj txiaj ntsig zoo nyob rau hauv qhov chaw mob hnyav uas cov ntshav txhaws sai sai tuaj yeem cawm tau txoj sia, xws li mob ntsws pulmonary embolism lossis mob myocardial infarction. Hauv qee kis mob stroke, nws kuj tseem siv los kho cov hlab ntsha peripheral occlusions, rhuav tshem cov ntshav txhaws uas cuam tshuam cov ntshav ntws mus rau lub hlwb. Yog tias koj xav tau urokinase nyoos, hu rau Xi'an Sonwu.
Dab tsi yog Qhov Kev Ua Ntawm Urokinase
Lub hauv paus ntsiab lus ntawm kev ua thiab lub hom phiaj ntawm urokinase feem ntau koom nrog cov ntshav coagulation thiab fibrinolytic systems. Nws yog ib qho tseem ceeb ntawm plasminogen-activating enzyme uas tuaj yeem hloov pauv plasminogen (Plasminogen) hauv cov ntshav mus rau hauv plasmin (Plasmin), yog li txhawb kev sib cais ntawm thrombus. Nws ua ncaj qha rau plasminogen hauv plasma, ua kom nws mus rau hauv plasmin. Plasminogen yog cov protein uas muaj nyob rau hauv daim ntawv tsis muaj zog hauv cov ntshav, thiab nws ua kom nws los ntawm kev tshem cov peptide bonds hauv plasminogen. Activated plasmin tuaj yeem degrade fibrin, ib feem tseem ceeb ntawm thrombus. Fibrin yog cov protein tseem ceeb uas tsim cov thrombus. Plasmin cleaves fibrin, ua rau kev puas tsuaj ntawm cov thrombus thiab thaum kawg dissolving lub thrombus. Dissolving thrombus pab kho cov ntshav ntws mus rau cov hlab ntsha uas thaiv thiab txo lossis tshem tawm cov ntaub so ntswg ischemia los ntawm thrombus, uas yog qhov tseem ceeb hauv kev kho mob vascular obstructive kab mob xws li myocardial infarction thiab pulmonary embolism.
Lub hom phiaj ncaj qha ntawm nws yog plasminogen, uas ua los ntawm kev khi rau plasminogen thiab ua kom nws mus rau plasmin. Plasmin ntxiv ua rau fibrin thiab yog lub hom phiaj tsis ncaj ntawm nws. Cov tshuaj tiv thaiv kab mob no tsis txwv rau kev ua kom cov thrombus tsim, tab sis kuj tswj cov ntshav coagulation thiab anticoagulation tshuav nyiaj li cas los tswj cov hlab ntsha.
Dab tsi yog Cov txiaj ntsig ntawm Urokinase
1. Ua kom cov ntshav txhaws zoo
Urokinase ncaj qha pab yaj cov ntshav txhaws, rov ua kom cov ntshav ntws mus rau thaj tsam cuam tshuam. Qhov ntawd yog qhov tseem ceeb hauv cov xwm txheej xws li pulmonary embolism, mob myocardial infarction (lub plawv nres), thiab qee hom mob stroke, qhov twg cov ntshav rov qab sai tuaj yeem tiv thaiv kev puas tsuaj rau cov ntaub so ntswg thiab lub cev.
2. Txo qhov kev pheej hmoo ntawm cov teeb meem
Kev ua kom cov ntshav txhaws tau zoo pab txo qis kev pheej hmoo ntawm cov teeb meem tshwm sim los ntawm cov xwm txheej thrombotic. Piv txwv li, nyob rau hauv cov ntaub ntawv ntawm lub plawv nres los yog mob stroke, raws sij hawm kev tswj ntawm nws yuav txo tau lub plawv mob los yog lub hlwb puas, feem.
3. Kev kho mob tsawg kawg nkaus
Urokinase muab kev xaiv tsis yog phais rau kev kho mob ntawm cov kab mob thrombotic. Tsis zoo li txhua yam thrombectomy lossis phais, uas yuav tsum tau tshem tawm cov hlab ntsha, nws tuaj yeem muab tso rau hauv cov hlab ntsha. Txoj kev tsis tshua muaj kev cuam tshuam no ua rau muaj kev xa mus sai dua thaum muaj xwm txheej ceev thiab txo qis kev phom sij txuas nrog kev phais.
4. Kev siv ntau yam
Nws txoj kev siv tsis txwv rau kev kho mob rau lub neej xws li mob plawv lossis mob stroke; Nws kuj tseem siv los kho lwm yam mob uas cuam tshuam nrog cov ntshav txhaws, suav nrog cov hlab ntsha sib sib zog nqus thrombosis thiab qee yam kab mob peripheral artery. Nws versatility ua rau nws yog ib qho cuab yeej tseem ceeb hauv kev sib ntaus tawm tsam ntau yam kab mob thrombotic.
5. Muaj txiaj ntsig rau qee yam kab mob uas tsis yog thrombotic
Cov kev tshawb fawb tau tshawb fawb siv nws nyob rau hauv cov mob uas tsis yog-thrombotic, xws li pleural effusion (cov kua dej ntau dhau ntawm cov txheej pleural sab nraum lub ntsws) thiab qee qhov muag qhov muag, qhov twg nws cov txheej txheem thrombolytic yuav muaj txiaj ntsig.
6. Txhim kho cov txiaj ntsig ntawm tus neeg mob
Rau ntau tus neeg mob, nws cov kev tswj hwm tuaj yeem txhim kho cov txiaj ntsig tau los ntawm kev daws teeb meem sai sai ntawm thrombosis, yog li txo qhov kev pheej hmoo ntawm kev puas tsuaj mus ntev thiab txhim kho lub neej zoo tom qab kho.
Yog Urokinase Safe
Cov tshuaj tiv thaiv tsis zoo tshaj plaws ntawm cov khoom no yog los ntshav.
Los ntshav me: Cov kev mob tshwm sim feem ntau yog los ntshav me ntawm qhov chaw ntawm daim ntawv thov, uas feem ntau tsis loj. Ua raws li cov ntshav hauv cov ntaub so ntswg, qhov tshwm sim yog 5% -11%, feem ntau mob me, thiab mob hnyav tuaj yeem ua rau mob hlwb.
Los ntshav hnyav: Vim tias urokinase ua haujlwm los ntawm kev txhawb kev sib cais ntawm fibrin protein, qhov no tuaj yeem ua rau los ntshav nyob rau lwm qhov hauv lub cev, suav nrog los ntshav loj. Cov mob hnyav tshaj plaws yuav suav nrog intracranial hemorrhage, uas yog ib qho kev kho mob xwm txheej ceev uas yuav tsum tau saib xyuas tam sim ntawd.
kev tsis haum tshuaj
Txawm hais tias tsawg dua, tus neeg mob yuav tsim kev tsis haum rau nws lossis nws cov khoom sib xyaw. Cov tsos mob ntawm cov tshuaj tiv thaiv no yuav muaj xws li:
Ua pa nyuaj
Khaus khaus thiab khaus tawv nqaij
o ntawm caj dab, tus nplaig, daim di ncauj, lossis lub ntsej muag
Kev tsis haum tshuaj hnyav (anaphylactic shock)
Lwm yam kev mob tshwm sim
Ua npaws thiab ua daus no: Qee tus neeg mob yuav ua npaws thiab ua daus no.
Kev xeev siab thiab ntuav: Nws tuaj yeem ua rau digestive system tshwm sim raws li xeev siab thiab ntuav.
Thaum cov khoom no yog siv rau thrombolysis nyob rau hauv coronary artery recanalization, atrial los yog ventricular arrhythmias feem ntau tshwm sim tom qab lub nkoj recanalization, nrog ib tug tshwm sim ntawm ntau tshaj 70%, thiab nruj ECG xyuas yuav tsum tau.
Yog tias koj xav paub "peptidolytic enzyme" (9CI) cov chaw tsim khoom, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email, thiab tom qab ntawd koj tau txais cov ntaub ntawv zoo.
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