7,8-Dihydroxyflavone yog dab tsi thiab nws ua haujlwm li cas
7,8-Dihydroxy Flavone hmoovyog ib qho tshwm sim flavonoid qauv uas muaj ob pawg hydroxyl ntawm 7 thiab 8 txoj haujlwm ntawm nws cov pob txha flavone. Nws cov mis molecular yog C15H10O4, nrog rau qhov hnyav molecular kwv yees li 254.24 g / mol. Nws tseem paub los ntawm cov npe xws li 7,8-DHF thiab 7,8-dihydroxy-2-phenylchromen-4-one.
Lub ntsiab yog vim li cas cov kws tshawb fawb kawm 7,8-DHF yog nws cov lus tshaj tawm kev sib raug zoo nrog cov BDNF/TrkB signaling txoj kev. BDNF yog ib qho tseem ceeb neurotrophin koom nrog hauv kev txhim kho neuronal, ciaj sia taus, synaptic plasticity, thiab lwm yam txheej txheem hauv lub paj hlwb. Feem ntau, BDNF ua rau ntau qhov teebmeem no los ntawm kev khi rau TrkB receptor.
Kev tshawb fawb thaum ntxov tau txheeb xyuas 7,8-DHF ua ib qho me me-molecule TrkB agonist. Cov kev tshawb fawb tshawb fawb tau tshaj tawm tias qhov sib xyaw ua ke tuaj yeem qhib TrkB thiab txhawb nqa cov kev taw qhia hauv qab uas cuam tshuam nrog kev ua haujlwm neuronal. Hauv cov qauv tsiaj, kev tswj hwm ntawm 7,8-DHF kuj tseem cuam tshuam nrog TrkB ua kom lub hlwb.
Kev tshawb fawb biochemical ntxiv tau tshuaj xyuas seb 7,8-DHF cuam tshuam nrog TrkB li cas. Ib txoj kev tshawb fawb qhia txog kev sib cuam tshuam ntawm 7,8-DHF thiab cov extracellular domain ntawm receptor thiab txheeb xyuas qhov sib txawv ntawm 7,8-DHF thiab BDNF hauv lawv cov qauv ntawm TrkB ua kom. Cov kev tshawb pom no tau pab cov kws tshawb fawb kom nkag siab zoo dua yog vim li cas ib qho me me flavonoid molecule tuaj yeem cuam tshuam txoj hauv kev ib txwm ua los ntawm cov protein ntau ntau dua neurotrophic.
Qhov tseem ceeb, 7,8-DHF yuav tsum tsis yog tsuas yog piav raws li "BDNF." Nws yog ib qho me me molecule uas tau tshawb xyuas raws li BDNF mimetic lossis TrkB agonist. Nws cov chaw muag tshuaj, kev sib cuam tshuam ntawm receptors, cov metabolism, thiab cov teebmeem lom neeg tsis zoo ib yam rau cov uas tshwm sim BDNF.
Cov txiaj ntsig muaj peev xwm ntawm 7,8-Dihydroxyflavone yog dab tsi
Kev txaus siab hauv 7,8-DHF tau loj hlob ntau vim qhov kev tshawb pom los ntawm kev tshawb fawb preclinical. Tsis yog ua kom pom cov txiaj ntsig kho mob, cov kev tshawb fawb no muab cov lus qhia txog kev lom neeg uas yuav tsim nyog tshawb xyuas ntxiv.
Ib qhov chaw tshawb fawb loj yog kev tiv thaiv neuronal. Cov kev sim thaum ntxov tau tshaj tawm tias 7,8-DHF tiv thaiv cov neurons los ntawm qee hom kev ntxhov siab ntawm tes hauv ib qho TrkB-dependent. Cov kev tshawb fawb tsiaj tom qab tau tshawb xyuas qhov sib xyaw hauv cov qauv uas cuam tshuam txog kev raug mob ntawm lub paj hlwb thiab neurodegeneration, suav nrog cov qauv Parkinsonian.
Lwm thaj chaw txaus siab yog synaptic plasticity thiab nco-kev tshawb fawb txog. Vim tias BDNF/TrkB signaling yog sib txuas nrog synaptic muaj nuj nqi, cov kws tshawb fawb tau tshuaj xyuas seb puas ua kom TrkB nrog 7,8-DHF tuaj yeem cuam tshuam kev kawm thiab kev nco txog cov txheej txheem. Piv txwv li, cov kev tshawb fawb hauv cov nas hnub nyoog tau tshaj tawm txog kev hloov pauv hauv TrkB ua kom muaj zog, txha nraub qaum, synaptic plasticity, thiab kev ua tau zoo hauv cov haujlwm tshwj xeeb nco qab tom qab kev sim kho.
7,8-DHF kuj tau kawm hauv cov qauv uas muaj oxidative stress thiab neuronal raug mob. Kev tshawb fawb siv cov hlwb retinal thiab cov qauv tsiaj pom tau tias 7,8-DHF tuaj yeem qhib BDNF / TrkB-txog kev taw qhia thiab cuam tshuam rau txoj hauv kev hauv qab uas cuam tshuam nrog kev ciaj sia ntawm tes. Cov kev tshawb pom no tau nthuav dav txaus siab rau qhov sib txuas tshaj li kev tshawb fawb txog kev txawj ntse.
Cov txiaj ntsig no yog kev nthuav dav, tab sis lawv yuav tsum tau txhais kom zoo. Ib qho txiaj ntsig zoo hauv tus qauv nas lossis kab lis kev cai ntawm tes tsis tsim kom muaj cov txiaj ntsig zoo ib yam yuav tshwm sim hauv tib neeg. Cov yam ntxwv xws li ntau npaum li cas, cov metabolism, bioavailability, ntev - lub sij hawm raug, thiab qhov sib txawv ntawm tsiaj thiab tib neeg biology tag nrho yuav tsum tau tshawb nrhiav ntxiv.
Vim li no, 7,8-DHF yog qhov zoo dua saib raws li kev tshawb fawb sib xyaw nrog cov kev ua haujlwm neurotrophic es tsis yog kev kho mob rau kev puas hlwb lossis kev txawj ntse.
Koj Yuav Tsum Paub Dab Tsi Txog 7,8-Dihydroxyflavone Powder
Rau cov chaw soj nstuam thiab cov kws tshawb fawb ua haujlwm nrog 7,8-DHF, cov yam ntxwv ntawm lub cev thiab tshuaj lom neeg ntawm cov khoom tuaj yeem yog qhov tseem ceeb raws li nws cov haujlwm lom neeg tau tshaj tawm.
PubChem teev 7,8-DHF raws li daj ntseg daj cov compound thiab tshaj tawm tias nws yog me ntsis soluble, uas txhais tau hais tias hnyav xaiv thiab kev sim formulation tuaj yeem yog qhov tseem ceeb rau kev txiav txim siab thaum tsim cov kev tshawb fawb hauv chav kuaj.
Thaum ntsuas 7,8-Dihydroxyflavone hmoov, cov kws tshawb fawb yuav xav txog ntau yam zoo- cuam tshuam. Cov no tuaj yeem suav nrog kev lees paub tus kheej, kev tshuaj xyuas lossis kev ua kom huv, batch-rau-batch zoo ib yam, zoo li, khaws cia, thiab cov ntaub ntawv txheeb xyuas tsim nyog. Nyob ntawm qhov kev sim npaj, kev tshuaj ntsuam xyuas xws li HPLC thiab huab hwm coj spectrometry kuj tseem yuav pab tau kom paub meej tias tus kheej thiab qhov zoo.
Purity yog tshwj xeeb tshaj yog muaj feem xyuam rau thaum ib tug compound yog siv nyob rau hauv cell -raws li los yog biochemical thwmsim. Cov impurities tuaj yeem cuam tshuam rau cov txiaj ntsig kev sim, tshwj xeeb tshaj yog thaum cov kws tshawb fawb tab tom tshuaj xyuas kev ua kom receptor, kev taw qhia txoj hauv kev, lossis kev xav ntau ntxiv - cov lus teb nyob ntawm. Cov ntaub ntawv qhia meej meej tuaj yeem ua rau nws yooj yim dua los sib piv cov txiaj ntsig ntawm kev sim thiab cov khoom sib txawv.
Kev khaws cia yog lwm qhov kev xav tau. Raws li nrog rau lwm cov tshuaj tshawb fawb, cov kws tshawb fawb yuav tsum ua raws li tus neeg muag khoom tau pom zoo rau cov xwm txheej khaws cia thiab sab laj nrog daim ntawv pov thawj cuam tshuam ntawm kev soj ntsuam thiab cov ntaub ntawv kev nyab xeeb ua ntej siv. Txoj kev hnyav thiab kev npaj tsim nyog yuav tsum tau txiav txim siab raws li cov txheej txheem kev sim tshwj xeeb es tsis yog xav tias txhua daim ntawv thov yuav tsum tau ua tib yam.
Kev Tshawb Fawb Txog Kev Tshawb Fawb rau 7,8-Dihydroxyflavone
Qhov kev txaus siab txuas ntxiv hauv 7,8-DHF los ntawm nws txoj kev sib txuas nrog BDNF / TrkB txoj hauv kev, yog ib qho tseem ceeb ntawm cov cim qhia kev tshawb fawb hauv neuroscience. Kev tshawb fawb tau tshawb nrhiav nws qhov muaj feem cuam tshuam rau kev muaj sia nyob ntawm neuronal, synaptic plasticity, oxidative kev nyuaj siab, thiab ntau yam kev sim ua qauv ntawm neurological dysfunction.
Nyob rau tib lub sijhawm, qhov sib xyaw tseem yog thaj tsam ntawm kev tshawb fawb preclinical es tsis yog kev kho tib neeg. Cov kev tshawb fawb yav tom ntej yuav xav tau kom meej cov lus nug nyob ib puag ncig cov tshuaj pharmacokinetics, cov metabolism, kev tsim, kev nyab xeeb ntev - lub sij hawm kev nyab xeeb, receptor selectivity, thiab rov tsim dua nyob rau hauv ntau yam kev sim.
Rau cov kws tshawb fawb soj ntsuam 7,8-Dihydroxyflavone hmoov, kev nkag siab ob qho tib si biology ntawm cov khoom sib xyaw thiab qhov zoo ntawm cov khoom uas tau kawm yog qhov tseem ceeb. Cov ntaub ntawv tshawb fawb muaj txiaj ntsig zoo tuaj yeem muab lub hauv paus txhim khu kev qha ntxiv rau kev tshawb xyuas TrkB signaling thiab lwm txoj hauv kev lom neeg.
Xav paub ntau ntxiv txog 7,8-DHF hmoov? Tshawb xyuas peb cov ntaub ntawv khoom thiab kev tshawb fawb-qib specifications, lossis hu rau xi'an sonwu pab pawg los tham txog koj cov kev xav tau tshwj xeeb.
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