NMN los tiv thaiv kev laus ntxiv, tsis ntev los no tau pom muaj txoj haujlwm tshiab --- txhawm rau txo qis thiab tiv thaiv daim siab.
1. Vim li cas cawv thiaj tsim kev puas tsuaj rau peb lub cev?
Muaj peb kauj ruam los rhuav tshem thiab metabolize cawv hauv tib neeg lub cev:
(1) Cawv (ethanol) yuav hloov mus rau hauv acetaldehyde raws li cov nyhuv ntawm aldehyde dehydrogenase (ADH) thiab NAD+;
(2) Acetaldehyde yuav hloov mus rau hauv ethanoic acid nyob rau hauv cov nyhuv ntawm acetaldehyde dehydrogenase 2 (ALDH2) thiab NAD+;
(3) Ethanoic acid yuav nkag mus rau lub voj voog tricarboxylic acid thiab hloov mus rau carbon dioxide thiab dej.
Acetaldehyde tuaj yeem tsis tsuas yog ua rau DNA puas tsuaj xwb, kuj yog ib qho mob qog noj ntshav. Nws kuj tseem cuam tshuam nrog lub hlwb puas, kev tiv thaiv kab mob, tawg thiab kev hloov pauv ntawm folic acid metabolism ( cuam tshuam rau tiam tom ntej). Qhov chaw tseem ceeb rau metabolize cawv yog daim siab, uas yuav tau txais kev phom sij tshaj plaws los ntawm kev haus ntau dhau. Cov neeg uas muaj cov noob ALDH2 li qub tuaj yeem decompose acetaldehyde hauv lub sijhawm. Txawm li cas los xij, cov neeg muaj ALDH tsis muaj peev xwm ua tsis tau. Lub sijhawm ntawd, acetaldehyde yuav ntim rau hauv daim siab thiab yuav maj mam oxidized thiab metabolized los ntawm oxidase P450 hauv daim siab, ua rau lub ntsej muag tawm, lub plawv dhia ceev, kiv taub hau, xeev siab thiab ntuav. Qhov phem tshaj yog tias nws yooj yim heev los ua mob rau hauv nruab nrog cev. Qhov tseem ceeb tshaj plaws yog yuav luag 30% mus rau 50% cov neeg yog ALDH tsis txaus.
2. NMN pab daws qhov hangover thiab tiv thaiv daim siab li cas?
Los ntawm saum toj no, peb tuaj yeem pom tias NAD+ koom nrog txhua kauj ruam ntawm cov metabolism hauv cawv. Yog li, cov kws tshawb fawb ntseeg tias nws tuaj yeem ua kom cov metabolism ntawm alicohol nce qib NAD+ hauv tib neeg lub cev.
NAD{{3}} +CH3CH2OH → NADH+H++CH3CHO
NAD{{2}} {{4}}CH3CHO+H2O →NADH+H++CH3COOH
NMN ntxiv tuaj yeem txhim kho qib ntawm NAD + sai sai hauv tib neeg lub cev. Cov kev tshawb fawb kuj tau pom tias NMN tuaj yeem tsis tsuas yog txo qis qis, tab sis kuj tuaj yeem tiv thaiv daim siab. NMN ntxiv tuaj yeem tiv thaiv qhov nce ntawm ALT thiab AST induced los ntawm ethanol. ALT thiab AST yog cov cim biomarkers ntawm daim siab puas. Lub caij no, cov kev tshawb fawb kuj pom tias ethanol hloov pauv qhov kev qhia ntawm 1778 noob, thiab kev kho NMN tuaj yeem txo cov nyhuv ethanol ntawm 437 noob (kwv yees 25%).
Xav paub ntau ntxiv lossis xaj rnmn? Nyemntawm nolos yog tiv tauj kuv.
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