Zyvox
Linezolid hmoovyog ib qho tshuaj tua kab mob tshiab, tshuaj tua kab mob oxidized phosphate amide nrog broad-spectrum antibacterial kev ua. Xyoo 2000, FDA tau pom zoo rau kev kho mob hauv zej zog tau txais thiab mob ntsws hauv tsev kho mob. Nws yog ib tug B-amino methyl acid derivative, ib tug structurally tshiab tshuaj tua kab mob tshwm sim los ntawm ib tug tricyclic tetrahydrofuran nplhaib thiab ib tug vinyl thiazole nplhaib. Linezolid muaj broad-spectrum tshuaj tua kab mob tiv thaiv feem ntau Gram-zoo thiab qee cov kab mob Gram-negative. Nws inhibits thawj kauj ruam ntawm cov kab mob protein synthesis, sib dhos ntawm 30S thiab 50S subunits. Nws inhibits protein sib dhos los ntawm kev khi rau 23S rRNA thiab tiv thaiv nws los ntawm kev khi rau 50S subunit. Tsis tas li ntawd, nws inhibits kev loj hlob ntawm cov kab mob los ntawm kev thaiv qhov kev txiav txim ntawm thawj metabolic enzyme aromatic amino acid decarboxylase los tsim cov molecules me.
Raws li tshuaj tua kab mob, nws yog siv los kho ntau yam kab mob, tshwj xeeb tshaj yog cov kab mob Gram-positive. Zyvox tuaj yeem kho cov mob xws li mob ntsws, kab mob ntawm daim tawv nqaij thiab cov nqaij mos, sepsis, thiab lwm yam. Yog li yog tias koj txaus siab rau linezolid thiab xav nrhiav cov ntshiab linezolid, thov hu rau Xi'an Sonwu online.
Linezolid zyvox ua haujlwm li cas
Linezolid belongs rau ox aziridine chav kawm ntawm cov tshuaj uas muaj cov kab mob dav dav. Nws lub hauv paus ntsiab lus ntawm kev ua yog kom ua tiav cov kab mob bactericidal los ntawm inhibiting cov protein synthesis ntawm Gram-zoo kab mob. Protein synthesis yog cov txheej txheem nyuaj hauv cov kab mob uas muaj ntau yam sib txawv thiab cov molecules. Ib qho ntawm cov hom phiaj tseem ceeb yog cov kab mob 50S ribosome, lub tshuab tsim cov protein hauv cov kab mob. 50S ribosome suav nrog 23S, 5S, thiab 16S RNAs thiab 34 proteins thiab yog qhov tseem ceeb rau cov kab mob los tsim cov proteins. Thaum lub sij hawm synthesis, RNA thiab cov proteins pheej sib sau ua ke rau hauv cov hlau nplaum zoo li hu ua peptide chains.
Lub hom phiaj ntawm linezolid yog cov saw peptide no. Nws tuaj yeem khi rau sab nraub qaum ntawm 50S ribosome thiab tiv thaiv kev loj hlob ntawm peptide saw, yog li tiv thaiv kev sib txuas ntawm cov protein. Tshwj xeeb, nws thawj khi rau ribosome. Tom qab ntawd nws txuas mus rau A qhov chaw ntawm 23S rRNA, tiv thaiv cov saw peptide los ntawm kev txav los ntawm qhov chaw A kom cov kab mob protein synthesis nres ua ntej cov amino acid tshiab sib txuas ntxiv rau cov saw peptide. Nws tsis ua rau cov kab mob ntawm cov phab ntsa lossis cov hlab ntsha zoo li lwm cov tshuaj tua kab mob lossis tua cov kab mob los ntawm kev cuam tshuam nrog cov protein synthesis xws li penicillin. Hloov chaw, nws yog ib qho protein synthesis inhibitor uas tiv thaiv cov protein synthesis los ntawm inhibiting cov kab mob txhais lus, ua rau cov kab mob tuag.
Txij li lub hom phiaj ntawm linezolid yog 50S ribosome, cov tshuaj muaj qhov cuam tshuam ntau ntxiv ntawm cov kab mob Gram-zoo. Qee cov tshuaj tiv thaiv kab mob Gram-zoo, xws li MRSA thiab VRE, yog cov kab mob hu ua linezolid. Txawm li cas los xij, rau cov kab mob Gram-negative, linezolid cov tshuaj tua kab mob yog qhov tsis muaj zog.
Dab tsi yog linezolid siv los kho
Qee qhov xwm txheej uas linezolid feem ntau siv los kho muaj xws li:
Kab mob ntawm daim tawv nqaij: Linezolid kho cov kab mob ntawm daim tawv nqaij xws li cellulitis lossis kab mob rwj.
Pneumonia: Linezolid kho mob ntsws los ntawm qee cov kab mob, suav nrog methicillin-resistant Staphylococcus aureus (MRSA).
Intra-abdominal infections: Linezolid tuaj yeem siv los kho cov kab mob hauv plab xws li peritonitis lossis abscesses.
Cov kab mob pob txha thiab pob txha: Linezolid kho cov pob txha lossis cov mob xws li osteomyelitis lossis septic mob caj dab.
Cov kab mob hauv cov hlab ntshav: Linezolid kho cov kab mob uas kis tau los ntawm cov hlab ntsha, xws li bacteremia lossis sepsis.
Dab tsi yog qhov kev phiv tsis zoo ntawm linezolid
1. ntuav thiab xeev siab
Cov kev sim tau pom tias thaum linezolid nkag mus rau hauv lub cev, nws tuaj yeem ua rau muaj cov receptors tshwj xeeb hauv cov hnyuv, ua rau xeev siab thiab ntuav.
2. Mob taub hau
Lwm qhov tshwm sim tshwm sim yog mob taub hau. Qhov mob taub hau no tuaj yeem yog vim muaj kev cuam tshuam ntawm cov tshuaj los yog lub cev rhiab heev.
3. Tsis xis nyob thiab qaug zog
Cov neeg mob yuav muaj kev tsis xis nyob lossis xav tias nkees tom qab siv linezolid. Nws yog vim cov tshuaj cov txheej txheem ntawm kev ua, uas ua rau kom lub cev siv zog. Cov kev mob tshwm sim no feem ntau tsis xav tau kev kho mob tshwj xeeb, tab sis tus kws kho mob yuav tsum tau sab laj rau kev kuaj mob.
4. Cov ntshav siab
Qee tus neeg yuav muaj kev nce ntshav siab tom qab siv nws. Qhov ntawd yog qhov tshwm sim ntawm lub cev rhiab heev rau cov tshuaj.
5. Myelosuppression
Lwm qhov kev mob tshwm sim loj heev yog pob txha pob txha. Linezolid tuaj yeem cuam tshuam nrog hematopoiesis hauv lub cev thaum siv mus ntev. Nws txhais tau hais tias cov qe ntshav dawb thiab platelets hauv lub cev poob qis, ua rau tus neeg muaj kab mob. Qhov kev mob tshwm sim no feem ntau tuaj yeem tshwm sim nrog kev siv mus ntev lossis siv ntau dhau.
6.5-HT syndrome
Linezolid tuaj yeem cuam tshuam nrog lwm cov tshuaj ua rau muaj kev phom sij hu ua serotonin syndrome, uas ua rau cov tsos mob xws li kev ntxhov siab, tsis meej pem, ntshav siab, plawv dhia ceev, thiab kub taub hau.
Leej twg yuav tsum tsis txhob noj Zyvox
Nws yog ib qho tseem ceeb mus ntsib kws kho mob ua ntej noj Zyvox, tab sis ntawm no yog qee cov neeg uas yuav tsum tsis txhob noj cov tshuaj no:
Cov neeg uas tsis haum rau linezolid lossis ib yam ntawm nws cov khoom xyaw.
Cov neeg uas tau noj qee yam tshuaj (xws li MAO inhibitors) hauv 14 hnub dhau los.
Cov neeg mob ntshav siab uas tswj tsis tau.
Cov neeg uas muaj qog adrenal.
Cov neeg muaj kab mob siab heev.
Cov neeg uas raug kev txom nyem los yog muaj keeb kwm ntawm serotonin syndrome.
Cov poj niam cev xeeb tub los yog lactating.
FAQ
Rau kev kho mob ntawm daim tawv nqaij lossis tawv nqaij thiab cov nqaij mos, cov neeg laus noj 400 mg ntawm qhov ncauj txhua 12 teev, thiab cov tub ntxhais hluas noj 600 mg ntawm qhov ncauj txhua 12 teev. Cov menyuam yaus<5 years old take 10mg/kg orally every 8 hours; 5-11 years old take 10mg/kg orally every 12 hours.
Cov neeg laus uas muaj cov kab mob methicillin-resistant Staphylococcus aureus tau kho nrog linezolid 600 mg txhua 12 teev.
Txhua tus menyuam mos yuav tsum tau txhaj tshuaj ntawm 10mg / kg txhua 8 teev rau xya hnub sib law liag.
Yog tias koj xav paub lub chaw tsim khoom Bakuchiol, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email ces koj tau txais cov hmoov zoo DIM.
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