Yam tshuaj twg yog Urokinase
Urokinase hmoovyog ib qho enzyme uas tshwm sim hauv lub cev uas ua rau cov ntshav txhaws. Nws yog tus neeg sawv cev thrombolytic uas ua rau cov ntshav txhaws hauv cov hlab ntsha. Lub raum tsim thiab tso tawm, yog li lub npe "euro," lub ntsiab lus " zis." Nws muaj ob feem nrog molecular luj ntawm 33000 (LMW-tcu-PA) thiab 54000 (HMW-tcu-PA). Nws yog tsuas yog siv los ua cov tshuaj thrombolytic, ncaj qha ua haujlwm ntawm endogenous fibrinolytic system, thiab tuaj yeem ua rau fibrinolysis. Lub zymogen dhau los ua plasmin, uas tuaj yeem tsis tsuas yog degrade fibrin clots tab sis kuj degrade fibrinogen, coagulation factor V, thiab coagulation factor VIII nyob rau hauv cov ntshav ncig, li no exerting ib tug thrombolytic nyhuv thiab muaj kev cuam tshuam sai rau cov tshiab tsim thrombi. , suab nyhuv, kuj tuaj yeem ua rau cov hlab ntsha ADP enzyme ua haujlwm, inhibit ADP-induced platelet aggregation, thiab tiv thaiv thrombosis.
Nws ua haujlwm los ntawm kev ua kom plasminogen (lub precursor ntawm plasmin). Fibrin, cov protein tsim nyog uas tsim cov ntshav txhaws, yog tawg los ntawm plasmin. Urokinase pab nyob rau hauv lub dissolution ntawm fibrin thiab rhuav tshem ntawm cov hlab ntsha los ntawm txhawb kev hloov ntawm plasminogen rau plasmin. Hauv kev kho mob, nws feem ntau yog siv los kho cov mob uas muaj cov ntshav txhaws, xws li mob myocardial infarction (lub plawv nres), pulmonary embolism, thiab ischemic stroke. Nws yog muab tso rau hauv cov hlab ntsha nyob rau hauv kev saib xyuas ntawm tus kws kho mob. Tsis tas li ntawd, nws tuaj yeem siv rau hauv cov txheej txheem kho mob tshwj xeeb, xws li catheter-directed thrombolysis, txhawm rau tsom ncaj qha thiab yaj cov ntshav hauv cov hlab ntsha tshwj xeeb. Txawm hais tias koj xav tau vincristine sulfate raw lossis lwm yam khoom nyoos, koj tuaj yeem tiv tauj Xi'an Sonwu.
Kev siv urokinase
Kev Kho Mob Pulmonary Embolism: Nws daws cov mob ntsws loj heev. Tus kab mob no feem ntau tshwm sim los ntawm cov ntshav txhaws los ntawm ob txhais ceg lossis lwm yam hauv lub cev mus rau lub ntsws. Nws kuj tseem hu ua qhov txhaws ntawm lub ntsws pulmonary artery.
Kev tswj hwm ntawm Mob Myocardial Infarction (AMI): Nws tuaj yeem siv rau qee qhov mob plawv (mob myocardial infarction) kom yaj cov ntshav txhaws hauv cov hlab ntsha coronary, txhim kho cov ntshav txaus thiab txo qis ntawm cov leeg mob plawv.
Clearing Blocked Catheters: Nws kuj yog siv los tshem tawm cov catheters, muab tshuaj los yog kua, sau cov ntshav, los yog tso cov hlab rau hauv cov hlab ntsha hauv nruab nrab hauv pliaj, caj dab, lossis hauv siab.
Peripheral Arterial Occlusion: Nws tuaj yeem siv los kho peripheral arterial occlusion, uas yog qhov txhaws ntawm cov ntshav ntws hauv cov hlab ntsha ntawm cov ceg, tshwj xeeb tshaj yog ob txhais ceg, yog li pab kho cov ntshav ntws.
Ocular Conditions: Hauv qee qhov tshwj xeeb, urokinase tau siv los kho cov kab mob ntawm lub qhov muag uas muaj cov ntshav txhaws.
Dab tsi yog Cov Lus Ceeb Toom Rau Urokinase
Urokinase yuav tsum tau siv nrog ceev faj.
1. (1) Alanine aminotransferase (ALT) tuaj yeem nce siab; (2) Qee cov neeg mob yuav muaj qhov txo qis hauv hematocrit tab sis tsis muaj cov tsos mob los ntshav.
2. Lub sij hawm los ntshav, ib nrab thromboplastin tiam sij hawm, prothrombin lub sij hawm, thrombin lub sij hawm, platelet suav, hemoglobin, hematocrit, thiab lwm yam, yuav tsum tau kuaj ua ntej siv los txiav txim los ntshav txoj cai.
3. Kev pib noj kom txaus yuav tsum tau muab luv luv (15–30 feeb) kom tsis txhob muaj cov tshuaj tiv thaiv urokinase hauv lub cev. Txawm li cas los xij, koob tshuaj ntau dhau tuaj yeem ua rau lub cev plasminogen pas dej ua ke thiab coagulation yam Ⅰ, Ⅴ, thiab Ⅷ, yog li cuam tshuam rau cov nyhuv thrombolytic.
4. Cov tshuaj antiplatelet thiab anticoagulant yuav tsum tau siv tom qab kev kho mob thrombolytic los tiv thaiv thrombosis los ntawm tej zaum yuav tshwm sim. Yog li ntawd, kev sib xyaw ua ke nrog cov tshuaj aspirin qis (160 mg) yog qhov pom zoo thaum pib ntawm kev kho mob thrombolytic. Kev siv tshuaj aspirin rau ib hlis tom qab thrombolysis tuaj yeem txo qis kev tuag ob qho tib si thaum lub sijhawm mob hnyav thiab tom qab 15 lub hlis, txawm hais tias nws yuav ua rau muaj kev pheej hmoo los ntshav.
5. Cov ntshav ntau dhau los ntawm nws txoj kev siv tuaj yeem tswj tau qhov tsim nyog; los ntshav hnyav yuav tsum tau nres tam sim ntawd; thiab nyob rau hauv cov kev tshwm sim ntawm cov ntshav poob, tag nrho cov ntshav hloov (zoo tagnrho siv cov ntshav, tsis hloov ntshav plasma) tuaj yeem tswj tau zoo. Xav txog kev siv aminocaproic acid lossis aminotoluic acid los tiv thaiv nws cov teebmeem thaum muaj xwm txheej ceev.
6. Yog tias kub taub hau tshwm sim thaum siv tshuaj, acetaminophen tuaj yeem siv los kho cov tsos mob thiab tshuaj tua kab mob, tab sis cov tshuaj aspirin lossis lwm yam tshuaj tua kab mob uas muaj cov nyhuv antiplatelet siv tsis tau.
7. Hemodynamic hloov feem ntau nrog rau kev sib cais ntawm pulmonary embolism, yog li yuav tsum tau ceev faj txog kev tswj ntshav siab.
8. Rau cov hlab ntsha sib sib zog nqus, kev kho mob thrombolytic tuaj yeem ua kom nrawm thrombolysis thiab txhawb kom rov ua kom cov ntshav ntws sai. Hauv txoj kev xav, nws yog ib qho kev kho mob zoo dua li kev tiv thaiv coagulation. Txawm li cas los xij, qhov tshwm sim ntawm cov ntshav loj yog siab dua nrog kev kho thrombolytic dua li nrog heparin anticoagulation. Yog li, kev kho thrombolytic tsis yog niaj hnub rau cov neeg mob uas muaj cov hlab ntsha sib sib zog nqus.
Cov kev sim tsiaj txhu pom tias cov khoom no tsis ua rau cov nas poj niam muaj peev xwm tsim tau los yog fetuses thiab ras ntawm 1, 000 zaug ntawm tib neeg koob. Tsis muaj kab mob ua rau muaj teeb meem
tau tshaj tawm nrog kev siv mus ntev. Tsis muaj ntaub ntawv qhia txog kev siv rau cov poj niam cev xeeb tub nrog cov pab pawg tswj nruj. Yog li ntawd, cov poj niam cev xeeb tub yuav tsum tsis txhob siv cov khoom no tshwj tsis yog tias muaj kev xav tau ceev. Txawm hais tias cov khoom no tuaj yeem raug tso tawm hauv cov kua mis niam tseem tsis tau tshaj tawm. Yog li ntawd, cov poj niam lactating yuav tsum siv cov khoom no nrog ceev faj.
Yog tias koj xav paub cov chaw tsim khoom urokinase, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email, thiab tom qab ntawd koj tau txais cov ntaub ntawv zoo.
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