Dab tsi yog Mechanism Ntawm Kev Ua Ntawm Masitinib
AB 1010 Powder(masitinib) yog ib qho kev xaiv tyrosine kinase inhibitor, feem ntau yog siv los kho cov kab mob cytopathic thiab inflammatory. Nws cuam tshuam nrog kev loj hlob thiab kev loj hlob ntawm cov kab mob los ntawm inhibiting ntau tyrosine kinases, suav nrog KIT, PDGFR, thiab CSF1R, thiab ua lub luag haujlwm hauv qee yam kab mob thiab kev tiv thaiv kab mob. Nws tau pib tsim los kho cov kab mob cytopathic, tshwj xeeb tshaj yog cov cuam tshuam nrog kev ua haujlwm txawv txav ntawm tyrosine kinases, los ntawm kev sib tw inhibiting kev ua ntawm cov enzymes thiab thaiv cov teeb liab transduction txoj kev, yog li inhibiting kev loj hlob thiab kis ntawm cov kab mob. Tam sim no, masitinib yog nyob rau hauv ntau theem kev soj ntsuam, nrog rau cov chaw tseem ceeb xws li kev kho mob ntawm cytopathic kab mob xws li gastrointestinal stromal qog (GIST) thiab pancreatic cytopathic kab mob; neurodegenerative kab mob xws li amyotrophic lateral sclerosis (ALS) thiab Alzheimer's kab mob; thiab inflammatory kab mob xws li ntau yam sclerosis (MS) thiab systemic lupus erythematosus (SLE). Cov kev mob tshwm sim zoo ib yam li lwm cov tshuaj tyrosine kinase inhibitors, thiab cov uas muaj xws li cov kab mob hauv plab hnyuv, lub siab ua haujlwm tsis zoo, cov tshuaj tiv thaiv ntawm daim tawv nqaij, thiab hematological toxicity. Txawm hais tias muaj kev phiv tshwm sim ntau, cov neeg mob feem ntau tuaj yeem zam tau rau lawv thiab tuaj yeem tswj tau nrog kev hloov tshuaj. Thaum siv, cov neeg mob lub siab ua haujlwm thiab kev kuaj ntshav yuav tsum tau saib xyuas tsis tu ncua txhawm rau txheeb xyuas thiab tswj cov kev mob tshwm sim sai. Nws qhia tau hais tias muaj peev xwm kho tau dav dav raws li ntau lub hom phiaj tyrosine kinase inhibitor, tab sis nws txoj kev loj hlob tsis tau du. Cov teeb meem tseem ceeb suav nrog kev ua kom nws txoj kev nyab xeeb thiab kev ua tau zoo thiab nws cov kev hloov pauv tau yooj yim hauv cov cim sib txawv. Txawm li cas los xij, nws ntau lub tswv yim ntawm kev ua haujlwm ua rau nws yog tus neeg sib tw tseem ceeb rau kev txhim kho tshuaj yav tom ntej. Nrog rau kev tshawb fawb ntxiv thiab kev sim tshuaj, masitinib yuav tsum yog ib qho ntawm cov kev xaiv tseem ceeb rau kev kho cov kab mob cytopathic thiab cov kab mob inflammatory. Txawm li cas los xij, kev saib xyuas yuav tsum tau them rau nws cov kev mob tshwm sim, thiab kev saib xyuas kev kho mob yuav tsum tau ua.
Cov txiaj ntsig ntawm Masitinib yog dab tsi
Hauv kev kho cov kab mob cytopathic, masitinib tau qhia txog qhov muaj peev xwm ua kom muaj sia nyob tsis muaj sia nyob hauv cov neeg mob uas muaj cov qog nqaij hlav plab (GIST) tiv taus imatinib. Tsis tas li ntawd, cov txiaj ntsig ua ntej ntawm cov neeg mob uas muaj kab mob siab lossis metastatic pancreatic cytopathic cov kab mob tau pom tias nws tuaj yeem txhim kho kev ciaj sia thaum siv nrog rau kev siv tshuaj khomob, tab sis yuav tsum tau kuaj xyuas ntxiv. Hauv thaj tsam ntawm cov kab mob neurodegenerative, kev siv nws hauv amyotrophic lateral sclerosis (ALS) thiab Alzheimer's kab mob tau pom tias muaj txiaj ntsig zoo. Cov kev sim tshuaj ntsuam xyuas tau pom tias nws tuaj yeem ua rau qeeb tus kab mob ntawm ALS los ntawm inhibiting inflammatory pathways thiab txhim kho cov neeg mob txoj kev ua haujlwm thiab lub neej zoo; nyob rau hauv Alzheimer's kab mob, cov ntaub ntawv ua ntej qhia tau hais tias nws yuav ncua kev poob ntawm kev txawj ntse, tab sis xav tau kev tshawb fawb ntxiv kom paub meej. Cov kab mob ua rau mob xws li ntau yam sclerosis (MS) thiab kab mob lupus erythematosus (SLE) feem ntau ua haujlwm los ntawm nws cov tshuaj tiv thaiv kab mob thiab kev tiv thaiv kab mob. Cov txiaj ntsig ua ntej qhia tau tias nws tuaj yeem txo tus nqi rov qab los ntawm MS thiab ncua kev kis kab mob. Nyob rau tib lub sijhawm, kev tshawb fawb hauv SLE lub hom phiaj txhawm rau txo qhov mob thiab tiv thaiv kab mob los ntawm kev cuam tshuam txog tyrosine kinases, thiab kev sim tshuaj tau pib. Txawm li cas los xij, masitinib kuj tseem nrog qee qhov kev mob tshwm sim, feem ntau suav nrog kev mob plab hnyuv xws li xeev siab, ntuav, thiab raws plab, ua haujlwm tsis zoo ntawm lub siab xws li nce siab enzymes, tawv nqaij ua pob khaus thiab khaus, thiab hematological toxicity xws li leukopenia thiab thrombocytopenia. Tsis tas li ntawd, qaug zog thiab tsis qab los noj mov kuj tshwm sim tshwm sim. Cov neeg mob feem ntau muaj peev xwm zam tau cov kev mob tshwm sim no, uas tswj tau zoo los ntawm kev hloov kho koob tshuaj thiab kho cov tsos mob. Txawm li cas los xij, txij li nws tseem nyob rau theem kev sim tshuaj rau ntau qhov kev qhia, nws txoj kev nyab xeeb mus sij hawm ntev thiab cov kev mob tshwm sim dav dav tseem xav tau kev tshawb fawb ntxiv thiab kev pom zoo. Zuag qhia tag nrho, masitinib tau pom tias muaj txiaj ntsig kho mob hauv thaj chaw xws li kab mob cytopathic thiab kab mob neurodegenerative. Txawm li cas los xij, nws txoj kev ua tau zoo thiab kev nyab xeeb tseem yuav tsum tau txais kev txhawb nqa los ntawm cov ntaub ntawv soj ntsuam ntau dua. Nws tsis tau txais kev pom zoo dav dav rau kev kho mob niaj hnub, thiab nws cov ntawv thov yav tom ntej yuav yog nyob ntawm cov txiaj ntsig ntawm kev tshawb fawb tsis tu ncua thiab kev pom zoo ntawm cov koom haum tswj hwm.
Dab tsi yog cov teebmeem ntawm Masitinib
Qhov koob tshuaj ntawm masitinib txawv nyob ntawm qhov qhia tshwj xeeb thiab tus neeg mob tus mob. Gastrointestinal stromal qog (GIST): Qhov pib koob tshuaj ib txwm yog 7.5 mg / kg / hnub, noj qhov ncauj hauv ob koob tshuaj. Yog tias tus neeg mob tuaj yeem zam tau nws, koob tshuaj yuav maj mam nce mus rau qib siab dua, tab sis qhov kev hloov kho tshwj xeeb yog nyob ntawm tus neeg mob lub siab ntev thiab kev kho mob. Cov kab mob siab tshaj lossis metastatic pancreatic cell: Hauv qee qhov kev tshawb fawb, masitinib tau ua ke nrog cov tshuaj khomob, thiab cov koob tshuaj feem ntau yog teem rau ntawm 9 mg / kg / hnub, noj qhov ncauj hauv ob koob tshuaj. Amyotrophic lateral sclerosis (ALS): Tus qauv koob tshuaj hauv kev sim tshuaj yog 4.5 mg / kg / hnub, noj qhov ncauj hauv ob koob tshuaj. Cov koob tshuaj yuav raug kho raws li tus neeg mob cov lus teb thiab cov kev mob tshwm sim. Alzheimer's disease: Hauv qee qhov kev tshawb fawb, nws yog 4.5 mg / kg / hnub, noj qhov ncauj hauv ob koob tshuaj. Nws yuav tsum raug sau tseg tias kev hloov kho koob tshuaj ntawm masitinib yuav tsum tau ua kom ceev faj thiab raws li kev qhia ntawm cov kws kho mob cov kws kho mob. Vim tias nws cov kev mob tshwm sim tuaj yeem suav nrog kev mob plab hnyuv, lub siab ua haujlwm tsis zoo, kev cuam tshuam ntawm daim tawv nqaij, thiab hematological toxicity, cov neeg mob yuav tsum tau saib xyuas tsis tu ncua thaum noj tshuaj txhawm rau txhawm rau txheeb xyuas thiab cuam tshuam nrog cov tshuaj tiv thaiv sai. Tus kws kho mob yuav tsum tau tsim ib txoj kev kho mob tshwj xeeb raws li tus neeg mob qhov xwm txheej tshwj xeeb, thiab kev siv tshuaj thiab kev hloov tshuaj yuav tsum tau ua raws li kev qhia kws kho mob.
Nyob rau tib lub sijhawm, nws yog ib qho tseem ceeb los xaiv cov khoom uas muaj kev ntseeg tau zoo. Xi'an Sonwu Biotech Co. Ltd. muaj kev paub dhau los hauv kev lag luam thoob ntiaj teb thiab kev lag luam kev noj qab haus huv. Insisting rau txoj kev ntseeg raws li kev ntseeg thiab zoo ua ntej yog peb lub tuam txhab txoj cai. Peb nruj me ntsis tswj cov khoom zoo, uas txhais tau tias kev xaiv pib los ntawm raw khoom. Tsis tas li ntawd, peb tswj txhua qhov kev nthuav dav thiab txo cov nqi kom siab tshaj plaws kom peb cov neeg siv khoom tuaj yeem tau txais cov khoom lag luam zoo. Raws li cov no, cov neeg siv khoom tau muab ntau cov lus pom zoo txog peb cov khoom.
Yog tias koj xav yuav masitinib, thov hu rau Xi'an Sonwu.
E-mail:sales@sonwu.com