Dab tsi yog 7 hydroxy 4 methylcoMarin siv rau
7 Hydroxy 4 Methyl Coumarin HmoovYog cov tshuaj sib txuas ua ke uas yog cov chav qhia ntawm Coumarins, uas yog cov duab sib txuas uas muaj ntxhiab nrog lub nplhaib benzene nrog lub nplhaib benzene. Qhov tshwj xeeb tshaj plaws ntawm Coumalin muaj ob peb yam ntawv siv thiab cov ntawv thov, feem ntau ntawm cov chaw ntawm chaw muag tshuaj, biochemistry, thiab tshuaj pleev ib ce. Yog tias koj txaus siab rau 7 Mthroxy 4 MethylcoMarin, thov koj xav tiv tauj Xi'an Soniau.
Ntawm no yog kev tawg ntawm nws thawj siv:
1. Fluorescent sojntsuam hauv Biochemistry
Nws yog feem ntau siv los ua fluorescent sojntsuam hauv biochemical kev tshawb fawb. Qhov compound ua tej yam fluorescence cov khoom, uas ua rau nws muaj nuj nqis rau fluorescence spectroscopy. Nws tuaj yeem siv los kawm ntau cov txheej txheem roj lom xws li kev ua si enzyme, protein khi, thiab txoj haujlwm cellular. Cov cuab yeej fluorescence no tshwj xeeb tshaj yog muaj txiaj ntsig tshwj xeeb hauv kev kuaj mob thiab cov kev kuaj mob lossis cov kev hloov pauv ntawm qhov chaw, xws li cov pheeb suab lossis lub xub ntiag ntawm cov ions.
2. Antioxidant kev ua si
Nws tau qhia antioxidant kev ua si hauv qee qhov kev tshawb fawb, lub ntsiab lus nws tuaj yeem pab neutralize dawb radicals thiab txo kev ntxhov siab oxidative hauv kev siv tshuaj lom neeg. Cov cuab yeej no ua rau nws muaj txiaj ntsig zoo nyob rau hauv kev txhim kho kev laus thiab tiv thaiv cov khoom lag luam, kev ntxhov siab yog txuas rau kev laus thiab ntau yam kab mob.
3. Kev siv tshuaj pleev ib ce
Hauv cov tshuaj pleev ib ce, nws qee zaum siv los ua cov tawv nqaij kom txias. Nws tuaj yeem suav nrog hauv cov khoom tu tawv nqaij vim nws cov tshuaj tiv thaiv tawv nqaij thiab cov tshuaj tiv thaiv kab mob, uas tuaj yeem pab tiv thaiv cov tawv nqaij los ntawm ib puag ncig kev laus thiab txo cov cim kev laus. Tsis tas li ntawd, nws cov ntxhiab tsw ntxhiab tsw qab (feem ntau ntawm cov coumarins) tuaj yeem yog cov txiaj ntsig ntxiv hauv qee cov tshuaj tsw qab.
4. Raws li ib qho sib xyaw ua ke
Qee qhov Coumarin derivatives, suav nrog nws, yog siv hauv kev lag luam thiab dej haus uas yog tsw ntxhiab tsw vim lawv qab zib, cov khoom muaj ntxhiab. Txawm li cas los xij, nws siv los ua cov zaub mov ntxiv yog nruj me ntsis tswj hwm hauv ntau lub teb chaws vim tias muaj peev xwm txaus ntshai muaj feem cuam tshuam nrog kev sib txuas lus zoo.
5. Cov ntawv thov pharcological
Hauv chaw muag tshuaj, nws qee zaum tshawb xyuas rau nws cov khoom tiv thaiv thiab cov tshuaj tua kabmob. Thaum lub sij hawm cov compound tsis yog siv los ua tus neeg sawv cev ncaj qha, nws muaj teebmeem tuaj yeem pab txhawb cov neeg sib raug zoo tshiab uas muaj mob, lossis lwm yam mob.
6. UV-nqus tus neeg sawv cev
Qee lub coumarins, suav nrog cov derivatives zoo li nws, tuaj yeem nqus cov ultraviolet (UV) lub teeb. Cov cuab yeej no ua rau nws muaj txiaj ntsig UV lim hauv qee cov tawv nqaij ua kom zoo nkauj, pab tiv thaiv cov tawv nqaij ntawm UV-kev puas tsuaj uas tuaj yeem ua rau muaj kev ua haujlwm laus lossis mob qog nqaij hlav.
Tag
7 Hydroxy 4 Methyl Coumarin yog ib qho kev sib txuas nrog cov ntawv thov feem ntau hauv fluorescence thiab anticancer formulations, thiab pharmetication, thiab chaw muag tshuaj. Nws cov khoom ua rau nws muaj txiaj ntsig zoo hauv ntau qhov kev tshawb fawb thiab kev ua lag luam, tshwj xeeb hauv cov cheeb tsam tau tsom rau kev noj qab haus huv, kev noj qab haus huv, thiab kuaj mob.
Yog 7 hydroxy 4 methylcoMarin lom
Nws zoo li ntau cov tshuaj sib xyaw ua ke, muaj peev xwm ua kom pom kev lom zem nyob ntawm nws txoj kev xav tau, thiab ntev ntawm kis. Ntawm no yog cov ntsiab lus ntxaws ntxaws ntxiv raws li cov ntaub ntawv muaj:
1. Toxicity nyob rau hauv cov tsiaj hauv kev tshawb fawb
Hauv kev tshawb fawb tsiaj, qee qhov kev ua yeeb yaj kiab coumarin (suav nrog nws) tau pom tias yuav tsum tau pom tias yuav tsum tau pom tias nthuav tawm cov tshuaj lom tsawg thaum siv rau hauv cov nyiaj tsis muaj txiaj ntsig. Txawm li cas los xij, qee qhov coumarins paub ua rau lub siab puas tsuaj rau hauv cov koob tshuaj tiv thaiv cov tshuaj ntau, tshwj xeeb tshaj yog thaum tswj tau ncua sijhawm ntev. Cov tshuaj lom ntawm nws tshwj xeeb yuav tsum tau ntsuas hauv cov kev tshawb fawb ntxiv, raws li nws txoj kev nyab xeeb profile tsis zoo raws li qee qhov coumarins zoo.
2. Cov tawv nqaij khaus thiab rhiab
Xws li muaj ntau yam tshuaj lom neeg, tawv nqaij tawv nqaij lossis cov teeb meem tuaj yeem tshwm sim yog tias cov kab ke raug rau cov tawv nqaij hauv lub sijhawm ntev lossis ntau dua lub sijhawm ntev. Nws suav nrog cov tshuaj pleev xim kom zoo yog li cas thiaj ua raws txoj kev tswj hwm nruj raws li kev nyab xeeb rau cov neeg siv, nrog kev ntsuas kom paub tseeb tias tsis muaj kev phom sij.
3. Kev noj tshuaj lom
Txawm hais tias nws qee zaum tau siv los ua tus neeg sawv cev tsw qab lossis hauv cov zaub mov hauv qee qhov ntau ntawm 7 hydroxy 4 Mthyl Coumarin lossis lwm tus coumrains tej zaum yuav muaj kev phom sij. Muaj cov ntaub ntawv zoo txog kev txhawj xeeb txog cov peev xwm muaj kev lom zem ntawm qee qhov Coumarin cov tebchaw thaum noj ntau lub sijhawm, tshwj xeeb hauv cov tsiaj. Vim li no, ntau lub cooj sib txuas teb yog tswj hwm thiab lawv cov kev siv tau txwv hauv cov zaub mov thiab dej haus.
Koj yuav npaj li cas 7 Hydroxy 4 Methyl Coumarin los ntawm Resorcinol
Qhov kev npaj ntawm resorcinol cuam tshuam nrog cov tshuaj tiv thaiv kab ib uas qhia cov pab pawg tsim nyog los ua tus thawj Coumarin nplhaib qauv. Txoj kev ua kom dav dav yuav xav tau methylation ntawm resorcinol, ua raws los ntawm Cyclization los ua tus lej Coumarin. Ntawm no yog ib qib zuj zus ntawm-kauj ruam qhia seb yuav ua li cas qhov no:
Kauj ruam 1: Methylation ntawm resorcinol
Txhawm rau pib, koj yuav tsum tau txais methylate resorcinol (1, 3-}}} {} txoj haujlwm ntawm lub nplhaib uas muaj ntxhiab. Qhov no tuaj yeem ua tiav los ntawm methylation cov tshuaj uas siv lub tswv yim methylating li methyl iodide (DMS) lossis dimethyl sulfate (K₂CO₃).
Cov tshuaj tiv thaiv yuav mus raws li hauv qab no:
Resorcinol (1, {3-}} Methyl iodide (2, {{}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} mehlyylenzene).
Kauj ruam 2: Cyclization los ua cov nplhaib Coumarin
Tom ntej no, cov methylated resorcinol (4- methyl resororcinol) undergoes txoj kev xav tau los ntawm kev cai los ua tus thawj Coumarin nplhaib qauv (Benzopyrone). Txoj kev ua yeeb yam no tuaj yeem ua tiav los ntawm kev kho mob nrog lub cev qhuav dej, xws li acetic anhydride lossis phosphorus oxychloride (pocl₃).
Cov tshuaj tiv thaiv tuaj yeem sau tau hais tseg raws li hauv qab no:
4- methylresorcinol + Acetic anhydride (c₄h₆o₃) lossis pocl₃ → 7 methroxy 4 methylcarin.
Kev ua kom cov tshuaj tiv thaiv Cyclization koom nrog kev tsim ntawm lub nplhaib lactone, uas yog tus yam ntxwv ntawm Coumarin derivatives. Cov pab pawg hydroxyl ntawm txoj haujlwm 7 yog khaws cia, thiab cov pab pawg methyl tau qhia ntawm txoj haujlwm 4.
Cov ntsiab lus dav dav ntawm cov txheej txheem hluavtaws
Methylation ntawm Resorcinol: Siv cov methyl iodide thiab potassium carbonate kom ntxiv cov methyl pawg rau cov resorcinol, ua {{}} methyl resorcinol.
Cyclization: Resure 4- methyl resororcinol nrog acetic anhydoride los ua 7 metylcymarin.
Yog tias koj xav paub tus nqi ntawm 7 hydroxy 4 methylcoumarin hmoov, xav nrog Xi'an Sonwu, lossis muaj lwm cov lus nug txog cov khoom, tsis txhob ua siab deb ntawm cov khoom, tsis txhob ua siab deb hu rau Xi'an Sonwu.