Yam tshuaj twg yog Artesunate
Artesunate API hmoov, kuj hu ua Art, yog ib yam tshuaj uas belongs rau chav kawm ntawm artemisinin derivatives. Nws yog muab los ntawm Artemisia annua cog. Nws yog ib yam khoom uas muaj cov nyhuv tua cov asexual lub cev ntawm Plasmodium. Lub mechanism ntawm kev txiav txim ntawm artesunate yog tib yam li artesunate. Nws muaj zog tua cov nyhuv ntawm Plasmodium asexuals thiab tuaj yeem tswj tau cov kab mob malaria sai. Nws yog tsuas yog siv los kho malaria, tshwj xeeb tshaj yog mob malaria hnyav lossis nyuaj. Nws yog siv nyob rau hauv kev kho mob los kho cerebral malaria thiab cawm ntau yam mob malaria. Nws tuaj yeem tua Plasmodium asexuals thiab tswj qhov pib ntawm malaria. Cov nyhuv kho tau pom zoo, thiab cov tsos mob tuaj yeem kho sai. Kev kos duab tuaj yeem cuam tshuam rau cov qauv ntawm Plasmodium, ua rau nws raug hloov pauv ntawm cov qauv, cuam tshuam rau Plasmodium nkag mus rau cov as-ham, thiab ua rau Plasmodium poob cov as-ham thiab tuag.
Raws li ib tug semi-synthetic derivative ntawm artemisinin, Art nws tus kheej muaj ntau yam kev ua ub no xws li antimalarial, antioxidant, thiab anti-inflammatory, thiab nws kuj muaj zoo pharmacological kev nyab xeeb. Tsis tas li ntawd, cov kws tshawb fawb tau siv hauv vitro HaCaT cell thiab nas qauv los kawm txog cov nyhuv inhibitory ntawm Art ntawm daim tawv nqaij photoaging nyob rau hauv ultraviolet irradiation. Ntawm lawv, -catenin yog ze ze rau kev kho mob ntawm Art. Yog tias koj xav kawm artesunate thiab xav tau artesunate nyoos, koj tuaj yeem tiv tauj Xi'an Sonwu txhua lub sijhawm. Xi'an Sonwu tuaj yeem muab rau koj.
Dab tsi yog Artesunate siv rau
1. Kho malaria
Art yog siv los kho malaria. Nws muaj txiaj ntsig tshwj xeeb hauv kev mob malaria hnyav lossis nyuaj (qhov twg tus kab mob kis mus rau cov kabmob tseem ceeb lossis muaj pov thawj ntawm lub cev tsis ua haujlwm). Nws tuaj yeem tua Plasmodium Anaplasma los ntawm thaiv nws cov khoom noj khoom haus rau tus tswv tsev cov khoom siv ntshav liab. Nws ua tau sai thiab zoo tiv thaiv kab mob malaria multidrug. Nws muaj peev xwm tua tau sai thiab nrawm ntawm theem liab ntawm Plasmodium thiab tuaj yeem tswj xyuas cov kev tawm tsam thiab cov tsos mob tam sim ntawd. Nws yog tsuas yog siv nyob rau hauv kev kho mob los cawm cerebral malaria thiab ntau yam mob malaria. Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv (WHO) suav tias yog artesunate thawj kab tshuaj rau kev kho mob malaria hnyav. Nws feem ntau ua ke nrog lwm cov tshuaj tiv thaiv kab mob, xws li mefloquine, lumefantrine, lossis sulfadoxine-pyrimethamine, los muab kev kho mob sib xyaw ua ke.
Ntxiv rau nws siv los kho tus mob malaria hnyav, nws kuj tseem siv los kho tus mob malaria tsis yooj yim. Nyob ntawm thaj chaw tshwj xeeb thiab cov qauv kev tiv thaiv ntawm tus kab mob malaria parasite, nws tuaj yeem siv los ua monotherapy lossis ua ke nrog lwm cov tshuaj tiv thaiv kab mob. Txawm li cas los xij, nws tsis yog siv los tiv thaiv malaria. Lwm cov tshuaj tiv thaiv kab mob, xws li chloroquine, mefloquine, lossis atovaquone-proguanil, feem ntau raug muab rau cov hom phiaj tiv thaiv.
2. Txhim kho daim tawv nqaij photoaging
Hauv vitro HaCaT tus qauv ntawm tes thiab tus qauv nas, cov nyhuv inhibitory ntawm Art ntawm daim tawv nqaij photoaging nyob rau hauv ultraviolet irradiation tau kawm. UV-irradiated HaCaT hlwb txo cov cell senescence thiab intracellular ROS ntau lawm thiab nce SOD qhia.
Hauv kev sim los tiv thaiv kev yees duab, cov kws tshawb fawb tau piv cov kev hloov pauv hauv SA- -gal hauv HaCaT hlwb ua ntej thiab tom qab kho Art. Art pretreatment txo qis qhov kev qhia ntawm senescence factor SA- -gal nyob rau hauv HaCaT hlwb nyob rau hauv UV irradiation nyob rau hauv ib tug npaum li cas ntawm koob tshuaj. Yog li ntawd, Art pretreatment tuaj yeem tiv thaiv UVB hluav taws xob-induced cell senescence. Thaum cov qib ntawm intracellular ROS raug kuaj, nws tau pom tseeb tias pawg UVB irradiation muaj qib siab dua li pawg tswj hwm. Txawm li cas los xij, tom qab pretreatment nrog 5 thiab 20 ug / ml Art, intracellular ROS qib tau txo qis. Tsis tas li ntawd, pab pawg tshawb fawb kuj tau tshawb pom lub ntsiab endogenous antioxidant SOD thiab pom tias Art pretreatment ho nce nws cov lus qhia hauv hlwb tom qab UVB irradiation. Hauv cov ntsiab lus, Art pretreatment (tshwj xeeb tshaj yog 20 ug / ml) tuaj yeem txo qhov kev loj hlob ntawm HaCaT hlwb nyob rau hauv ultraviolet irradiation, txo cov zus tau tej cov intracellular ROS, thiab nce cov kev qhia ntawm intracellular SOD.
Cov kws tshawb fawb tau faib HaCaT hlwb rau hauv pawg tswj hwm, 20 ug/ml Art group, UVB irradiation pawg, thiab UVB + 20 ug/ml Art pawg. Cov txiaj ntsig tau pom tias 20 ug / ml Art pretreatment tau txhim kho kev loj hlob ntawm cov hlwb senescent thiab kev loj hlob ntawm cov hlwb ib txwm muaj. Tsis tas li ntawd, cell apoptosis tau nce ntxiv tom qab UVB irradiation, tab sis 20 ug / ml Art pretreatment inhibited cell apoptosis considerably. Tsis tas li ntawd xwb, 20 ug / ml Art pretreatment tuaj yeem txo cov apoptosis ntawm cov hlwb ib txwm. Hauv lwm lo lus, txawm tias lawv yog UVB-irradiated lossis cov hlwb ib txwm muaj, qhov feem pua ntawm cov hlwb puas tau txo qis tom qab Art pretreatment. Tsis tas li ntawd, kev txiav txim los ntawm cov cell senescence indicator SA- -gal staining results, 20 ug/ml Art pretreatment ho inhibited the senescence of UVB-irradiated cells and normal cells.
Tom ntej no, cov kws tshawb fawb tau siv tus qauv nas ntawm daim tawv nqaij photodamage los soj ntsuam cov teebmeem ntawm Art kho thiab -catenin silencing ntawm photoaging ntawm UV-irradiated nas daim tawv nqaij. Cov tawv nqaij ntawm nas nyob rau hauv pawg tswj tau du, tsis tu ncua ntawm cov xim, elastic, thiab tsis muaj wrinkles thiab sagging. Cov tawv nqaij ntawm nas raug UVB pom thaj tsam xim av, roughness, wrinkles, scaly ntawm daim tawv nqaij, thiab tsis muaj elasticity. Tom qab siv sh- -catenin, daim tawv nqaij ntawm nas irradiated los ntawm UVB shrank, wrinkles tob zuj zus, xim av thaj ua rau thaj thiab scaly protrusions tshwm, thiab ib tug tawv zoo li zoo li tshwm sim. Tom qab kev kho mob nrog Art, kev yees duab ntawm daim tawv nqaij nas tau txhim kho zoo. Hauv cov ntsiab lus, txoj kev tshawb no tau tsim cov ntaub ntawv ntxaws ntxaws, lees paub tias nws tuaj yeem txo cov duab ntawm daim tawv nqaij los ntawm UVB irradiation los ntawm kev txhim kho kev qhia ntawm -catenin.
Artesunate koob tshuaj
Qhov koob tshuaj ntawm artesunate nyob ntawm ntau yam, suav nrog qhov mob hnyav ntawm tus kab mob malaria, hnub nyoog thiab qhov hnyav ntawm tus neeg mob, thiab cov txheej txheem kev kho mob tshwj xeeb ua raws hauv ib cheeb tsam.
Rau mob malaria hnyav:
Rau cov neeg laus thiab cov menyuam uas hnyav 20 kilograms (kg) lossis ntau dua: Cov koob tshuaj thawj zaug pom zoo yog feem ntau 2.4 milligrams ib kilogram (mg / kg) ntawm lub cev qhov hnyav.
Rau qhov tsis sib xws malaria:
Kev kos duab feem ntau muab nrog lwm cov tshuaj tiv thaiv kab mob, xws li mefloquine lossis artemether-lumefantrine. Tus kws kho mob yuav txiav txim siab txog kev noj tshuaj tshwj xeeb raws li cov xwm txheej xws li tus neeg mob lub hnub nyoog, qhov hnyav, thiab cov qauv tiv thaiv hauv cheeb tsam.
Dab tsi yog Kev Sib Txuas Nrog Artesunate
Kev kos duab feem ntau ua ke nrog lwm cov tshuaj tiv thaiv kab mob malaria ua ib feem ntawm txoj hauv kev kho mob malaria. Kev sib xyaw ua ke muaj ntau yam zoo, suav nrog kev ua kom zoo dua qub, txo kev pheej hmoo ntawm kev tiv thaiv, thiab tshem tawm cov kab mob sai dua.
Artemether-lumefantrine (AL): Tshwj xeeb tshaj yog nyob rau hauv cheeb tsam uas tus kab mob no tiv taus lwm yam tshuaj tiv thaiv kab mob, qhov kev sib xyaw no nquag siv los ua thawj kab kev kho mob rau Plasmodium falciparum-ua rau tsis muaj kab mob malaria. Nws yog tsim los ntawm artemether, lwm yam artemisinin derivative, thiab lumefantrine. Kev kos duab feem ntau yog siv nyob rau hauv thawj theem kom sai txo cov cab cab, ua raws li artemether-lumefantrine kom tshem tau tus kab mob tag nrho.
Dihydroartemisinin-piperaquine: Kev sib xyaw ua ke no yog siv los kho tus mob malaria tsis yooj yim. Nws muaj dihydroartemisinin, cov metabolite ntawm artesunate, thiab piperaquine. Qhov kev sib xyaw no feem ntau yuav tsum tau siv sijhawm 3-hnub ntawm kev kho mob thiab muaj txiaj ntsig zoo tiv thaiv kab mob malaria uas tiv taus ntau yam kab mob.
Artesunate-Mefloquine: Kev sib xyaw ua ke no kho cov kab mob npaws tsis sib haum xeeb los ntawm chloroquine-resistant Plasmodium falciparum. Art tau muab thawj zaug, ua raws li mefloquine. Qhov kev sib xyaw ua ke no tau pom tias muaj txiaj ntsig zoo thiab feem ntau siv rau hauv thaj chaw uas tsis muaj tshuaj tiv thaiv mefloquine.
Yog tias koj xav paub cov chaw tsim khoom kos duab, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email, thiab tom qab ntawd koj tau txais cov hmoov zoo Art.
Email:sales@sonwu.com