Chloroquine Diphosphate yog dab tsi?
Chloroquine diphosphate hmoovyog ib qho ntawm cov lag luam feem ntau hom chloroquine. Nws yog hu ua chloroquine diphosphate vim nws muaj ob phosphate anions. Tau kawg, nws mus los ntawm lwm lub npe, xws li chloroquine phosphate thiab keratin phosphate. Chloroquine diphosphate yog ib daim ntawv ntawm chloroquine. Chloroquine tuaj yeem muab faib ua chloroquine phosphate, Chloroquine sulfate, thiab Chloroquine hydrochloride los ntawm cov mis molecular, ntawm cov tshuaj chloroquine phosphate yog cov feem ntau. Chloroquine phosphate feem ntau tiv thaiv thiab kho malaria, ua rau nws lub luag haujlwm tseem ceeb hauv kev kho tshuaj. Raws li cov chaw tsim khoom ntawm chloroquine phosphate, Xi 'an Sonwu tau txais kev pom zoo los ntawm ntau tus neeg siv khoom rau nws cov khoom zoo thiab cov nqi sib tw. Yog tias koj xav yuav, tsis txhob yig tiv tauj nrog Xi'an Sonwu.
Chloroquine yog dab tsi?
Chloroquine yog ib hom kab mob malaria uas feem ntau siv los kho thiab tiv thaiv malaria los ntawm Plasmodium thiab Plasmodium vivax. Tab sis nws tsis yog siv rau Plasmodium falciparum vim nws tiv taus. Txawm li cas los xij, tsis yog txhua yam kab mob malaria tuaj yeem kho nrog chloroquine. Piv txwv li, cov tshuaj tiv thaiv kab mob yuav tsum tau kho ntxiv. Cov tshuaj no tuaj yeem metabolized hauv daim siab, thiab kev tshem tawm ib nrab-lub neej yog li ntawm ib mus rau ob lub hlis. Tib neeg tuaj yeem noj tshuaj ncaj qha los ntawm qhov ncauj. Qhov tseem ceeb, chloroquine tau siv dav rau kev tswj hwm loj, uas tuaj yeem ua rau muaj kev tshwm sim thiab kis ntawm tib neeg kev tawm tsam. Yog li ua ntej siv chloroquine, tib neeg yuav tsum tau kuaj xyuas tias chloroquine tseem muaj nyob hauv zos.
Chloroquine Sulfate yog dab tsi?
Chloroquine sulfate yog lwm hom tshuaj chloroquine tsawg dua. Cov khoom no muaj cov sulfate anion uas khi rau chloroquine molecule. Zoo li chloroquine phosphate, Chloroquine sulfate tuaj yeem noj hauv qhov ncauj thiab tseem ceeb heev rau kev tiv thaiv thiab kho malaria. Txawm hais tias nws muaj kev ua haujlwm zoo sib xws rau chloroquine diphosphate, nws tsis tshua muaj nyob hauv khw.
Qhov txawv ntawm Chloroquine Diphosphate & Chloroquine Sulfate yog dab tsi?
Ob leeg chloroquine phosphate thiab Chloroquine sulfate yog cov ntaub ntawv ntawm chloroquine, txawm hais tias chloroquine phosphate yog qhov ntau tshaj. Qhov sib txawv tshaj plaws ntawm ob hom yog cov qauv tshuaj sib txawv kiag li. Ob phosphate anions khi rau chloroquine molecule hauv chloroquine phosphate. Hauv chloroquine sulfate, sulfate anion khi rau chloroquine molecule. Cov slides tom ntej no qhia qhov txawv ntawm chloroquine diphosphate thiab chloroquine sulfate, uas koj tuaj yeem tshawb xyuas.
Cov txiaj ntsig ntawm Chloroquine Diphosphate
Chloroquine diphosphate hmoov yog dav siv hauv khw. Tib neeg siv nws los kho qee yam kab mob, suav nrog malaria, thiab nws ua haujlwm zoo heev. Muaj kwv yees li peb qhov zoo.
1. Nws yog ib qho tshuaj tua kab mob;
Chloroquine phosphate muaj cov tshuaj tiv thaiv kab mob rau qee tus kab mob. Nws tuaj yeem ua rau muaj kev puas tsuaj rau tus kab mob tso tawm los ntawm endosome lossis lysosome los ntawm kev nce pH ntawm endosome thiab lysosome. Vim tias pH qis uas xav tau rau kev tso tawm cov kab mob, cov kab mob tsis tuaj yeem tso lawv cov khoom siv caj ces rau hauv cov hlwb thiab rov ua dua. Txoj haujlwm no yuav tua tus kabmob.
2. Nws muaj txiaj ntsig zoo rau kev kho mob rau lwm yam kab mob;
Hauv rheumatoid mob caj dab, nws muaj kev kho mob ntawm tus kab mob los ntawm inhibiting lymphocyte proliferation thiab antigen nthuav qhia nyob rau hauv dendritic hlwb thiab tso reactive oxygen hom los ntawm macrophages.
3. Nws tuaj yeem kho malaria.
Chloroquine diphosphate yog qhov paub zoo tshaj plaws rau kev kho mob malaria. Cov plasmodium yuav tsum degrade hemoglobin hauv cov qe ntshav liab kom tau txais cov amino acids tseem ceeb. Qhov kev coj cwj pwm no yog qhov tsim nyog rau tus kab mob los tsim cov proteins thiab metabolize zog. Nyob rau hauv tus txheej txheem, tus kab mob tso tawm ib tug lom soluble molecule hu ua heme. Heme muaj ib lub nplhaib porphyrin ntawm Fe(II) -protoporphyrin IX (FP). Txhawm rau kom tsis txhob raug rhuav tshem los ntawm cov molecule no, cov kab mob ua rau heme crystals los ntawm heme.
Chloroquine diphosphate diffuses los ntawm cov hlwb mus rau hauv cov ntshav liab. Nws qhwv lub heme molecule thiab tiv thaiv kev hloov dua siab tshiab ntawm heme mus rau hauv heme biocrystals uas tuaj yeem ua rau tsub zuj zuj, uas yog tshuaj lom rau cov hlwb thiab cuam tshuam cov cell membrane ua haujlwm. Nws ua rau cov hlwb tawg thiab thaum kawg ua rau cov kab mob parasite tuag.
Dab tsi yog qhov cuam tshuam ntawm Chloroquine Diphosphate?
1. Kev siv ntau dhau yuav ua rau khaus lossis hloov xim ntawm daim tawv nqaij.
Hauv qhov sib piv, khaus los ntawm chloroquine diphosphate muaj ntau dua hauv cov neeg Asmeskas dub txog 70 feem pua ntawm lub sijhawm. Nws tsis tshua muaj tshwm sim hauv lwm haiv neeg. Qhov tshwm sim no yuav tshwm sim vim muaj qhov tshwm sim ntawm malaria hauv ib puag ncig hauv zos vim muaj yoov tshaj cum. Thiab qhov sib txawv ntawm plasmodium hauv tib neeg cov ntshav tuaj yeem ua rau muaj kev sib txawv ntawm qhov hnyav. Cov neeg uas xav tau ntau ntawm chloroquine diphosphate thiab nyob rau lub sij hawm kho mob malaria tej zaum yuav khaus lossis tawv nqaij.
2. Lub sij hawm ntev los yog koob tshuaj chloroquine diphosphate yuav ua rau muaj kev puas tsuaj loj rau lub retina. Yog siv tsis tu ncua, nws tuaj yeem ua rau tsis pom kev tsis pom kev hmo ntuj thiab tsis tuaj yeem kho dua.
3. Tsis txhob siv chloroquine diphosphate yog tias koj cev xeeb tub.
Tsis muaj teeb meem tshwm sim thaum chloroquine diphosphate tau siv los ntawm cov kws kho mob pom zoo kom tiv thaiv malaria. Tab sis cov kev tshawb fawb hauv nas tau pom tias cov xov tooj cua-labeled chloroquine diphosphate tuaj yeem hla cov placenta sai sai thiab sib sau ua ke hauv lub qhov muag fetal. Nws tseem nyob hauv fetus lub qhov muag rau tsib lub hlis tom qab tshem cov tshuaj los ntawm lub cev. Yog li ntawd, cov poj niam cev xeeb tub los yog npaj cev xeeb tub zoo dua tsis txhob mus rau thaj chaw uas muaj kab mob malaria siab.
4. Nws tsis haum rau cov neeg laus siv.
Lub cev metabolizes chloroquine diphosphate tsuas yog los ntawm ob lub raum, thiab lub raum kev ua haujlwm poob qis thaum muaj hnub nyoog. Yog tias cov neeg laus xav siv nws, lawv yuav tsum nug lawv tus kws kho mob ua ntej, siv nws raws li tus kws kho mob cov lus qhia, thiab ua tib zoo saib xyuas txhua lub sijhawm.
Xaus
Chloroquine diphosphate yog siv dav hauv kev kho mob malaria. Txawm li cas los xij, nws tseem yuav tsum tau ua tib zoo saib xyuas seb puas muaj kev tiv thaiv hauv cheeb tsam thiab ua cov tshuaj tiv thaiv tshuaj tiv thaiv ua ntej siv. Qhov tseem ceeb tshaj plaws, ib txwm siv nws raws li cov lus qhia thiab kev qhia ntawm koj tus kws kho mob.
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