Puas yog koj tab tom nrhiav rau ntau yam tshuaj excipient uas tuaj yeem txhim kho cov tshuaj solubility thiab stability? Xav txog meglumine. Kab lus no yuav tshawb txog nws cov kev siv thiab nws lub luag haujlwm hauv kev kho tsiaj.
Meglumine yog dab tsi
Meglumine hmoov(tshwj xeeb npe N-methyl-D-glucosamine) yog ib qho amino qab zib tau los ntawm qabzib.
Yooj yim muab tso, nws yog "tus pab" molecule siv hauv kev lag luam kws tshuaj los hloov cov tshuaj tsis zoo rau hauv daim ntawv tshiab. Thaum tsis tshua siv ib leeg los ua tshuaj, koj yuav pom nws nyob rau hauv cov npe ntawm cov khoom sib txawv (dyes siv hauv MRI thiab CT scans) thiab qee cov tshuaj noj.
Ntau cov tshuaj siv tau zoo yog acidic thiab tsis zoo soluble hauv dej. Yog tias cov tshuaj tsis tuaj yeem yaj, nws tsis tuaj yeem txhaj rau hauv cov hlab ntsha. Yog li ntawd, nws kuj yog ib tug organic puag. Thaum nws yog tov nrog ib tug acidic tshuaj, ob reacts tsim ib tug meglumine ntsev. Daim ntawv tshiab "ntsev" ntawm cov tshuaj no yog dej heev -soluble, ruaj khov, thiab nyab xeeb. Cov tshuaj tsis muaj meglumine yuav ntab hauv dej zoo li xuab zeb. Cov tshuaj uas muaj meglumine yuav yaj tag thiab xa mus rau hauv koj lub cev.
Nws yog ib qho tseem ceeb kom paub qhov txawv ntawm meglumine (tus cab kuj) thiab cov tshuaj nquag (cov tshuaj).
Meglumine nws tus kheej feem ntau suav hais tias yog kev lom zem thiab muaj kev nyab xeeb. Nws yog maj mam metabolized nyob rau hauv lub cev, yog li nws yog feem ntau excreted unchanged. Cov kev tshawb fawb tau pom tias nws tsis yog - tshuaj lom txawm tias thaum noj ntau heev.
Feem ntau ntawm cov "kev mob tshwm sim" koj tau nyeem txog nrog meglumine yog qhov tshwm sim ntawm cov tshuaj uas nws nqa. Piv txwv li, yog tias tus neeg mob hnov mob rau meglumine antimonate, nws feem ntau yog cov tshuaj tiv thaiv rau cov hlau hnyav antimony, tsis yog rau meglumine nws tus kheej. Ib yam li ntawd, tus nees tsim mob plab tom qab noj flunixin meglumine yog tshwm sim los ntawm flunixin (ib qho tshuaj tiv thaiv nonsteroidal - mob), tsis yog los ntawm meglumine. Yog tias koj txaus siab rau meglumine, thov hu rau Xi'an Sonwu.
Dab tsi yog kev siv meglumine hauv kev lag luam kws tshuaj
Nws feem ntau yog siv los ua cov khoom siv tshuaj kho mob -ib qho "cov khoom siv" uas pab lwm cov khoom xyaw tshuaj nquag (APIs) ua haujlwm tau zoo. Nws lub luag haujlwm tshwj xeeb nyob ntawm seb nws puas siv los ua tshuaj lom neeg hauv kev tsim lossis ua ib feem ntawm kev kho tshuaj tshwj xeeb.
1. Lub luag haujlwm "Auxiliary" (Chemical Function)
Hauv kev siv tshuaj feem ntau, meglumine yog siv los ua cov kuab tshuaj thiab stabilizer. Ntau cov tshuaj siv tshuaj muaj kua qaub thiab tsis zoo soluble hauv dej, ua rau lawv nyuaj rau txhaj rau hauv cov hlab ntsha lossis nqus hauv plab.
Txhim kho Tshuaj Solubility: Meglumine yog ib yam khoom tseem ceeb. Thaum ua ke nrog cov tshuaj acidic, nws tsim cov ntsev (meglumine ntsev). Qhov kev hloov pauv no ua rau cov tshuaj ntau dua soluble hauv dej / ntshav.
Txhim kho kev ruaj ntseg: Nws pab kom ruaj khov cov tshuaj rhiab heev, tiv thaiv lawv cov degradation ua ntej siv.
Piv txwv li, tej zaum koj yuav pom tias nws yog ib qho khoom tsis muaj zog hauv qee cov tshuaj uas nquag siv, xws li qee cov tshuaj kho cov kua qaub reflux lossis antihistamines, uas nws lub luag haujlwm yog los kho pH lossis txhim kho kev nqus.
2. Cov ntawv thov kev kho mob
Meglumine yog qhov dav tshaj plaws paub txog nws txoj kev siv los ua cov khoom xyaw hauv peb hom khoom kho mob:
A. Contrast agents (MRI thiab X-rays). Yog tias koj tau muaj MRI lossis CT scan uas siv cov tshuaj sib txawv, koj yuav tau txais meglumine-raws li cov neeg ua haujlwm sib txawv. Nws muaj kev nyab xeeb xa cov neeg ua haujlwm sib txawv (xws li gadolinium lossis iodine) rau hauv cov hlab ntsha kom cov kws kho mob tuaj yeem pom koj lub cev.
Nws yog ib qho tseem ceeb kom nco ntsoov tias meglumine nws tus kheej tsis yog tus neeg sawv cev sib txawv; Nws tsuas yog cov cab kuj ua kom cov hlau (gadolinium / iodine) yaj thiab ruaj khov hauv cov ntshav.
B. Veterinary analgesics (nonsteroidal anti-cov tshuaj tiv thaiv)
Yog tias koj yog tus tswv tsev tsiaj lossis ua haujlwm nrog nees / tsiaj txhu, koj yuav paub tias "meglumine" yog ib qho mob. Nws yog ib qho muaj zog uas tsis yog tshuaj steroidal los tiv thaiv -cov tshuaj tiv thaiv kab mob (NSAID) siv los kho qhov mob, ua npaws, thiab mob. Nws yog feem ntau siv hauv nees, nyuj, thiab npua (xws li, kho mob plab). Vim muaj kev txhawj xeeb txog kev nyab xeeb, nws feem ntau tsis siv rau tib neeg, txawm hais tias lwm yam meglumine ntsev NSAIDs muaj nyob hauv qee cov tib neeg kev lag luam kom nqus tau sai.
C. Kev kho cov kab mob cab: Qhov no yog thawj zaug - kab tshuaj rau leishmaniasis, ib hom kab mob parasitic tropical ( kis los ntawm cov xuab zeb ). Lub compound muab antimony (ib qho hlau hnyav) rau cov cab, cuam tshuam nrog nws lub zog tsim khoom thiab tua nws.
Meglumine siv hauv cov ntsiav tshuaj feem ntau suav tias muaj kev nyab xeeb thiab tsis muaj kev ua haujlwm lom neeg. Txawm li cas los xij, thaum siv los ua tus neeg sawv cev sib txawv lossis cov tshuaj tiv thaiv kab mob, cov kev mob tshwm sim feem ntau tshwm sim los ntawm cov tshuaj muaj zog (xws li gadolinium lossis antimony), tsis yog los ntawm glucosamine nws tus kheej.
Dab tsi yog kev siv meglumine hauv nees
Hauv equine veterinary tshuaj, meglumine, feem ntau yog xa mus rau flunixin meglumine, yog ib qho muaj zog nonsteroidal los tiv thaiv -cov tshuaj tiv thaiv kab mob (NSAID) feem ntau siv rau qhov mob nyem thiab kub taub hau. Ntawm no yog ib tug luv luv lub ntsiab lus ntawm nws cov thawj siv:
1. Relief ntawm colic: Qhov no yog nws cov feem ntau qhia. Nws zoo daws qhov mob tob tob uas tshwm sim los ntawm plab hnyuv plab, spasms, los yog kev cuam tshuam. Vim nws cov teebmeem tseem ceeb, kev ceev faj yog qhia raws li nws tuaj yeem npog cov tsos mob ntawm mob plab uas yuav tsum tau phais; yog li ntawd, nws yuav tsum tau siv nyob rau hauv kev taw qhia veterinary.
2. Ocular o: Nws yog NSAID ntawm kev xaiv rau kev kho mob intraocular o (xws li recurrent equine uveitis, tseem hu ua "moon blindness") vim tias nws cov ntaub so ntswg nkag mus tau zoo dua rau lwm yam tshuaj tua kab mob.
3. Txo kub taub hau: Nws muaj cov tshuaj tua kab mob zoo rau kev kub taub hau los ntawm kev ua pa lossis lwm yam kab mob.
4. Endotoxemia: Nyob rau hauv cov kab mob loj heev los yog plab hnyuv volvulus, endotoxins tso tawm los ntawm cov kab mob nkag mus rau hauv cov hlab ntsha. Flunixin tuaj yeem thaiv lub cev qhov txaus ntshai inflammatory teb rau cov co toxins.
5. Mob nqaij mos: Thaum phenylbutazone feem ntau siv rau cov pob txha thiab mob pob qij txha, flunixin kuj nquag siv los tswj cov nqaij mos raug mob lossis mob tom qab phais.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias, nrog rau tag nrho cov nonsteroidal anti-cov tshuaj tiv thaiv kab mob (NSAIDs), kev siv tsis raug lossis ntev ntawm kev siv flunixin meglumine tuaj yeem muaj qee yam kev pheej hmoo.
Yog xav paub ntxiv txog meglumine hmoov nqi, txaus siab rau Xi'an Sonwu, lossis lwm yam khoom siv -cov lus nug, thov hu rau Xi'an Sonwu ncaj qha.
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