Koj puas xav paub txog yuav ua li cas me me hluavtaws peptides zoo li pinealon cuam tshuam rau kev pw tsaug zog, tiv thaiv hlwb hlwb, thiab tseem cuam tshuam cov kev ua ntawm noob? Lawv tau txais kev saib xyuas ntau heev vim lawv muaj peev xwm tiv thaiv kab mob thiab lub hlwb ua haujlwm - tswj cov khoom. Cov kws tshawb fawb xav paub txog lawv lub luag haujlwm tseem ceeb hauv kev txhawb nqa kev paub, ua rau lub hlwb qeeb qeeb, txhim kho kev tiv thaiv antioxidant, thiab txhawb kev rov qab los tom qab kev raug mob neurological. Kab lus no yuav pib los ntawm kev tshawb nrhiav cov yam no.
Pinealon yog dab tsi
Pinealon peptideyog ib qho hluavtaws luv peptide, piv txwv zoo ntawm Lavxias "kev tswj hwm peptide" kev tshawb fawb. Nws lub npe muab los ntawm lub tswv yim ntawm "pineal caj pas + peptide," thawj zaug tau tsim los ntawm pab pawg tshawb fawb biomedical hauv St. Petersburg, Russia, kom ua raws li thiab cuam tshuam endogenous signaling peptides koom nrog hauv kev tswj hwm neural thiab kev tswj kev laus. Tsis zoo li ntau qhov ntev -chain bioactive peptides, EDR peptide yog luv heev, theoretically ua kom nws yooj yim rau nqus, diffuse, thiab cuam tshuam nrog cellular receptors los yog taw qhia txoj hauv kev hauv vivo.
Ntawm qib molecular, Pinealon yog ib qho tripeptide (luv luv amino acid sequence) nrog cov qauv yooj yim tab sis txoj haujlwm lom lom. Cov kws tshawb fawb ntseeg tias nws tuaj yeem hloov kho txoj hauv kev hauv lub paj hlwb, cuam tshuam cov metabolism hauv neuronal, synaptic plasticity, thiab cellular zog tshuav. EDR peptide yog cais raws li "neuroprotective / neuromodulatory peptide" vim qee qhov kev tshawb fawb pom tias nws tuaj yeem pab txhim kho lub hlwb kev ua siab ntev rau hypoxia, oxidative stress, lossis metabolic stress.
Hauv tebchaws Russia thiab qee lub tebchaws European sab hnub tuaj, cov khoom no tau raug tshawb xyuas los tshawb txog nws cov peev xwm siv hauv kev puas hlwb, kev paub tsis meej, thiab lub hlwb ua haujlwm. Piv txwv li, nws yog siv los ua ib qho kev kho mob ntxiv rau qee yam kab mob neurological, raws li kev kho mob rov qab los ntawm cov kab mob cerebrovascular, thiab raws li kev cuam tshuam rau hnub nyoog - cuam tshuam txog kev nco qab poob.
Cov khoom no ntseeg tau tias muaj kev cuam tshuam cov lus teb neuroinflammatory, txhim kho mitochondrial muaj nuj nqi, txo oxidative kev nyuaj siab, thiab tswj cov neurotransmitter tshuav nyiaj li cas. Nws tsis ncaj qha kho cov kab mob tshwj xeeb tab sis suav tias yog "kev ua kom zoo ib puag ncig" rau cov neurons. Hauv lwm lo lus, nws zoo li lub tshuab ua haujlwm zoo dua li cov tshuaj ib txwm siv tsom rau qhov laj thawj tshwj xeeb. Yog xav paub txog tus nqi lossis cov khoom lag luam, thov hu rau Xi'an Sonwu.
Dab tsi yog kev siv pinealon
Pinealon peptides luv luv -cov saw hluavtaws peptides tam sim no tau kawm feem ntau rau lawv cov teebmeem ntawm lub hlwb ua haujlwm thiab kev laus. Lawv tsuas yog siv rau hauv kev tshawb fawb lossis chaw kuaj mob. Yog li ntawd, lawv raug cais raws li kev tshawb fawb lossis kev sim sib txuas.
Nyob rau hauv cov nqe lus ntawm kev paub txog kev txhawb nqa, qhov sib xyaw no cuam tshuam nrog kev txhim kho hauv kev nco, kev kawm muaj peev xwm, kev mloog zoo, thiab kev paub meej meej tag nrho. Vim tias nws lub luag haujlwm tseem ceeb hauv kev txhawb nqa lub hlwb ua haujlwm thiab ncua hnub nyoog - cuam tshuam txog kev paub txog kev poob qis, qee zaum nws raug cais raws li nootropic peptide.
Hais txog kev pw tsaug zog thiab circadian rhythms, nws tau xav tias yuav ua rau lub caj pas pineal, uas tswj cov khoom melatonin. Los ntawm cov txheej txheem no, nws tuaj yeem pab txhim kho kev pw tsaug zog - lub voj voog ntawm kev pw tsaug zog tsis zoo, txawm hais tias nws tsis muaj cov nyhuv sedative ncaj qha.
Nyob rau hauv cov nqe lus ntawm neuroprotection, kev tshawb fawb thaum ntxov qhia tias nws yuav pab tiv thaiv neurons los ntawm kev puas tsuaj, txhawb lub hlwb kho, thiab cuam tshuam txoj kev lom neeg muaj feem xyuam nrog cellular aging. Cov teebmeem no ua rau muaj kev tshawb fawb txog nws lub luag haujlwm hauv kev tswj xyuas lub hlwb ntev ntev -.
Hauv thaj tsam ntawm kev tiv thaiv- kev laus, lub peev xwm ntawm melatonin los txhawb kev noj qab haus huv lub hlwb kev laus thiab tswj kev ua haujlwm neuroendocrine tau raug tshawb nrhiav. Txawm li cas los xij, cov teebmeem no tseem nyob rau theem theoretical thiab xav tau kev tshawb fawb nruj dua.
Yog li ntawd, melatonin feem ntau yog siv rau hauv kev sim lossis kev tshawb fawb chaw rau kev paub txog kev txawj ntse, kev tswj kev pw tsaug zog, neuroprotection, thiab tiv thaiv -aging.
Pinealon ua haujlwm li cas
Pinealon yog luv luv hluavtaws peptide xav ua feem ntau ntawm cov caj pas pineal thiab hlwb hlwb. Nws cov txheej txheem tsis muaj pov thawj tag nrho, tab sis kev tshawb fawb tam sim no qhia ob peb txoj hauv kev tseem ceeb uas nws yuav ua haujlwm:
1. Kev tswj ntawm Melatonin thiab Circadian Rhythm
Qhov kev sib xyaw no tau xav tias muaj feem xyuam nrog kev tswj hwm melatonin. Melatonin yog ib qho tseem ceeb cov tshuaj hormones secreted los ntawm pineal caj pas uas tswj kev pw tsaug zog -wake cycle. Melatonin tuaj yeem pab txhim kho circadian rhythms los ntawm kev txhawb nqa pineal gland kev ua si thiab melatonin signaling, txhawb kev pw tsaug zog ntau dua - qauv tsim, thiab tsis ncaj ncees lawm kev pw tsaug zog zoo. Qee cov kws tshawb fawb kuj ntseeg tias kev tswj hwm circadian atherosclerosis zoo dua tuaj yeem ua rau muaj kev cuam tshuam ntau dua ntawm lub zog, lub siab ruaj khov, thiab kev txawj ntse, txawm hais tias cov teebmeem no tseem muaj kev xav.
2. Kev cai ntawm Gene Expression
Ib qho tshwj xeeb (thiab tseem theoretical) mechanism ntawm melatonin yog nws lub peev xwm los khi rau cov cheeb tsam tshwj xeeb ntawm DNA, yog li tswj cov noob koom nrog hauv kev ua haujlwm ntawm tes, kev laus, thiab kho. Qhov no feem ntau yog los ntawm kev tshawb fawb hauv chav kuaj thaum ntxov.
3. Cov nyhuv Neuroprotective
Cov kev tshawb fawb qhia tias melatonin tuaj yeem pab tiv thaiv cov neurons los ntawm kev puas tsuaj lossis kev ntxhov siab, txhawb kev ciaj sia ntawm tes thiab kho cov txheej txheem, thiab txhim kho tag nrho lub hlwb resilience.
4. Kev them nyiaj yug Cellular Metabolic
Nws kuj tseem tuaj yeem cuam tshuam li cas hlwb hlwb siv lub zog, tiv thaiv oxidative kev nyuaj siab, thiab tswj kev ua haujlwm zoo. Nws ntseeg tau tias ua haujlwm los ntawm kev txhawb nqa pineal caj pas ua haujlwm, tswj melatonin, thiab cuam tshuam cov txheej txheem ntawm tes thiab caj ces hauv lub hlwb.
Yog tias koj xav nug txog tus nqi ntawm Pinealon peptide lossis lwm yam khoom siv, thov hu rau Xi'an Sonwu ncaj qha.
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