Cov kab mob uas muaj sia nyob feem ntau yog qhov xav tsis thoob, tab sis peb yuav ua li cas thiaj li nrhiav tau kev tawg thaum cov kab mob uas muaj kab mob ua rau muaj kev tiv thaiv tsis zoo rau cov kev kho mob ib txwm muaj? Qhov no peptide molecule, PNC-27, yog lub cuab yeej tshiab tsim los daws qhov kev sib tw no. Hauv txoj kev tshawb no, peb yuav tsom mus rau cov txheej txheem ntawm kev nqis tes ua, cov ntawv thov tseem ceeb, thiab lub peev xwm tshwj xeeb ntawm PNC-27 hauv kev kho mob.
Dab tsi yog PNC-27
PNC-27 hmoovyog ib qho tshuaj peptide uas tsom rau cov kab mob uas muaj kab mob thiab koom nrog thaj tsam ntawm kev tshawb fawb tshuaj tiv thaiv -cytopathic, ua rau nws tsim nyog rau kev kho mob tshwj xeeb. Nws yog ib qho tshwj xeeb peptide tsim los ntawm ntau cov amino acids, nthuav tawm cov kev xaiv muaj zog rau cov kab mob uas muaj kab mob thiab tsis muaj tshuaj lom rau lub cev. Nws txoj kev tshawb fawb tsom mus rau kev tsim cov tswv yim tshiab los kho cov kab mob cytopathic, tshwj xeeb tshaj yog nyob rau hauv hom cell uas tsis teb zoo rau cov kev kho mob xws li tshuaj tua kab mob thiab kev siv hluav taws xob. Nws yog luv peptide synthesized los ntawm tib neeg, kwv yees li 27 amino acid residues nyob rau hauv ntev. Nws cov yam ntxwv nta tso cai rau nws khi thiab lub hom phiaj receptors ntawm lub cell membrane ntawm cov kab mob, tshwj xeeb tshaj yog cov protein p53 ntawm lub xov tooj ntawm tes. p53 yog ib qho tseem ceeb ntawm cov qog nqaij hlav uas tswj lub voj voog ntawm tes, kho DNA, thiab apoptosis. Hauv ntau cov kab mob cytopathic, p53 noob kev hloov pauv ua rau poob ntawm kev ua haujlwm, tso cai rau cov kab mob kom tshem tawm cov cim kev tuag. Cov khoom lag luam tshwj xeeb khi rau daim ntawv hloov pauv ntawm p53 protein thiab ua kom muaj txoj hauv kev tuag ntawm tes los ntawm kev hloov kho nws cov kev sib raug zoo, thaum kawg ua rau apoptosis (programmed cell tuag) ntawm cov kab mob. Cov qauv tshuaj ntawm nws zoo ib yam li lub ntuj p53 protein. Txawm li cas los xij, nws qhov tshwj xeeb amino acid ib ntus tso cai rau nws nkag mus rau cov cell membranes thiab txuas mus rau p53 ntawm qhov chaw ntawm cytopathic hlwb. Cov kev sim tau pom tias nws tuaj yeem cuam tshuam qhov kev loj hlob ntawm cytopathic hlwb los ntawm kev tsom mus rau p53 protein ntawm lawv qhov chaw thiab, rau qee qhov, kov yeej cov teeb meem tshuaj tiv thaiv uas cov kev kho mob ib txwm tsis tuaj yeem daws tau. Tsis zoo li cov tshuaj kws khomob ib txwm siv, Cov tshuaj muaj qhov tshwj xeeb dua thiab muaj kev phiv tsawg dua. Yog tias koj txaus siab rau PNC-27, thov hu rau Xi'an Sonwu.
Dab tsi yog PNC-27 siv rau
PNC-27 feem ntau siv nws cov tshuaj tiv thaiv cytopathic los ntawm kev cuam tshuam nrog p53 protein. P53 protein ua lub luag haujlwm tseem ceeb hauv cov hlwb ib txwm, suav nrog kev tswj lub voj voog ntawm tes, kho DNA puas, thiab ua rau apoptosis thaum cov hlwb raug kev puas tsuaj loj. Txawm li cas los xij, hauv ntau lub hlwb cytopathic, p53 protein yog hloov pauv lossis tsis ua haujlwm, tiv thaiv nws los ntawm kev ua haujlwm zoo hauv inhibiting cov kab mob. Qhov no tso cai rau cytopathic hlwb kom dim txoj kev tuag thiab txhawb lawv txoj kev loj hlob thiab kev sib kis. Nws cov txheej txheem ntawm kev txiav txim yog raws li nws lub peev xwm los tsom thiab khi rau kev hloov pauv lossis tsis ua haujlwm p53 proteins. Nws cov qauv molecular zoo li cov cheeb tsam tseem ceeb ntawm p53, ua rau PNC-27 khi rau p53 receptors ntawm qhov chaw ntawm cytopathic hlwb. Qhov kev khi no ua rau muaj kev cuam tshuam ntawm molecular thiab lom neeg tuag, ua rau muaj kev puas tsuaj rau cov ntaub so ntswg thiab ua rau muaj kev phiv xws li kev tiv thaiv kab mob, plaub hau poob, thiab xeev siab. PNC-27, txawm li cas los xij, feem ntau ua haujlwm xaiv ntawm cytopathic hlwb nqa cov hloov pauv p53, yog li txo kev puas tsuaj rau cov ntaub so ntswg noj qab haus huv thiab ua rau muaj kev phiv tsawg. Tsis tas li ntawd, PNC-27 kuj tseem muaj peev xwm tiv thaiv cytopathic hlwb uas tau tsim kev tiv thaiv rau cov kev kho mob xws li tshuaj tua kab mob thiab xov tooj cua. Ntau lub hlwb cytopathic tau maj mam tsim kev tiv thaiv rau cov kev kho mob ib txwm vim p53 hloov pauv lossis tshem tawm.
PNC-27 ua dab tsi
Nws yog tsim los xaiv tua cov kab mob uas tsis muaj kev puas tsuaj rau lub cev.
Mechanism ntawm kev ua:
1. Targeting kab mob hlwb ntawm HDM-2 (MDM2): Cov peptide no khi rau HDM-2, ib qho protein ntau tshaj tawm rau ntawm ntau lub hlwb tab sis yuav luag tsis tuaj ntawm cov cell membranes.
2. cuam tshuam cov kab mob cell membranes: Raws li kev khi rau HDM-2, PNC-27 cov ntaub ntawv transmembrane pores ntawm cov kab mob cell membrane, ua rau poob sai ntawm cell membrane kev ncaj ncees.
3. Inducing nyob rau hauv vivo cell tuag (necrosis): Qhov no cell membrane cuam tshuam ua rau kom ncaj thiab ceev cell tuag, es tsis txhob cia siab rau txoj kev qeeb apoptosis.
4. P53-txoj kev ywj pheej: Txawm hais tias nws yog muab los ntawm p53 protein ib ntus, nws tsis tas yuav tsum muaj p53 ua haujlwm, thiab yog li ntawd tej zaum yuav zoo tiv thaiv cov kab mob uas nqa p53 hloov pauv.
Nws lub ntsiab tseem ceeb:
Nws nthuav tawm kev xaiv toxicity rau cov kab mob hauv lub cev.
Nws muaj txiaj ntsig zoo tiv thaiv ntau hom kab mob hauv lub cev (raws li kev lees paub los ntawm kev tshawb fawb preclinical).
Piv nrog rau cov tshuaj chemotherapy, nws ua rau muaj kev puas tsuaj tsawg rau cov hlwb noj qab haus huv.
Selectivity: Lawv feem ntau tsom rau cov hlwb tsis zoo lossis cov receptors nyob rau saum npoo ntawm cov qog nqaij hlav cancer.
Tsawg tsis kam: Lawv cov txheej txheem ntawm kev ua haujlwm feem ntau cuam tshuam rau lub cev kev puas tsuaj ntawm cov hlwb es tsis yog tsom rau cov txheej txheem metabolic, ua rau nws nyuaj rau cov kab mob los tsim kev tiv thaiv.
Multifunctionality: Lawv tuaj yeem siv los ua ib qho tshuaj lossis xa lwm cov tshuaj kho mob.
Qhov no peptide tam sim no nyob rau hauv kev tshawb nrhiav rau nws lub peev xwm los txo cov kev mob tshwm sim ntawm cov tshuaj chemotherapy.
Yog tias koj xav nug txog tus nqi ntawm PNC-27 hmoov lossis lwm yam ntaub ntawv khoom, thov hu rau Xi'an Sonwu ncaj qha.
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Siv:https://peptidehubs.com/articles/pnc-27-how-qhov no-peptide-selectively-targets-cancer-cells-12512.html?utm_source=chatgpt.com