Dab tsi yog Kev Ua Haujlwm Ntawm Iodixanol
Iodixanol hmoovyog ib tug radiopaque contrast agent feem ntau siv hauv cov txheej txheem kho mob, tshwj xeeb tshaj yog hauv kev suav tomography (CT) scans thiab angiography. Nws lub luag haujlwm tseem ceeb yog txhawm rau txhim kho qhov sib piv ntawm cov hlab ntsha, lub cev, thiab cov ntaub so ntswg hauv cov duab, tso cai rau cov kws kho mob kom pom cov qauv sab hauv zoo dua. Nws cov txheej txheem ntawm kev ua haujlwm yog ua raws li nws lub peev xwm los ua kom cov xov tooj cua ntawm cov hlab ntsha thiab cov ntaub so ntswg thaum lub sij hawm ntsuas cov txheej txheem. Thaum txhaj rau hauv lub cev, iodixanol ua tus neeg sawv cev sib txawv los ntawm kev nqus X-rays zoo dua li cov ntaub so ntswg nyob ib puag ncig, uas tso cai rau kev pom ntawm cov qauv sab hauv thaum CT scans, angiography, lossis lwm yam kev siv duab. Raws li koj tuaj yeem pom, cov khoom no muaj ntau yam kev siv. Yog tias koj txaus siab rau Iodixano, thov hu rau Xi'an Sonwu.
Lub luag haujlwm tseem ceeb thiab kev siv iodixanol suav nrog:
Contrast in Imaging: Cov khoom no pab tsim kom muaj qhov sib txawv ntawm cov ntaub so ntswg sib txawv thiab cov qauv ntawm cov duab scans. Nws absorbs X-rays mus rau qib siab dua li cov ntaub so ntswg ib puag ncig, muab kev pom zoo ntawm cov hlab ntsha, cov ntaub so ntswg, thiab cov kabmob.
Tsawg Osmolarity: nws yog cais raws li cov tsis-ionic, low-osmolar contrast tus neeg saib xyuas, uas txhais tau hais tias nws muaj tsawg cov kev phiv (xws li tsis xis nyob los yog tsis haum tshuaj) piv rau cov laus, high-osmolar agents. Qhov no ua rau nws muaj kev nyab xeeb dua rau cov neeg mob, tshwj xeeb tshaj yog cov uas muaj teeb meem raum lossis lwm yam mob uas twb muaj lawm.
Cardiovascular Imaging: Nws nquag siv rau hauv cov txheej txheem xws li angiograms, qhov uas nws pab pom cov ntshav ntws tuaj yeem kuaj pom cov hlab ntsha anomalies lossis blockages.
Neuroimaging: Nws kuj tseem siv tau rau hauv CT angiography thiab lwm yam kev yees duab los tshuaj xyuas lub hlwb thiab cov hlab ntsha hauv lub taub hau thiab caj dab.
Kev nyab xeeb thiab kam rau ua: nws feem ntau suav hais tias muaj qhov tsawg zaus ntawm cov xwm txheej tsis zoo thiab raug zam zoo piv rau cov neeg ua haujlwm sib txawv qub. Nws yog qhov tshwj xeeb tshaj yog nyiam rau cov neeg mob uas muaj keeb kwm ntawm lub raum teeb meem lossis cov neeg muaj kev pheej hmoo rau qhov sib txawv-induced nephropathy.
Chemical Properties:
Nws yog ib qho uas tsis yog-ionic, iso-osmolar contrast tus neeg sawv cev, uas txhais tau hais tias nws cov Osmolarity zoo ib yam li cov ntshav, txo qhov kev pheej hmoo ntawm kev hloov ntshav ntim lossis electrolyte tshuav.
Hauv cov ntsiab lus, cov khoom lag luam ua tus neeg sawv cev tseem ceeb rau ntau yam kev kuaj pom cov txheej txheem, txhim kho qhov tseeb thiab qhov tseeb ntawm X-ray thiab CT scans nrog cov kev mob tshwm sim tsawg.
Qhov txawv ntawm iodixanol thiab iohexol yog dab tsi
Iodixanol thiab Lohexol yog ob qho tib si iodinated contrast agents siv hauv kev kho mob duab, tshwj xeeb hauv CT scans thiab angiography, tab sis lawv txawv ntawm lawv cov tshuaj muaj pes tsawg leeg, Osmolarity, thiab lwm yam khoom. Nov yog qhov sib txawv tseem ceeb ntawm ob:
Chemical Structure thiab Composition
Nws yog non-ionic, iso-osmolar contrast agent. Qhov no txhais tau hais tias nws Osmolarity zoo ib yam li cov ntshav, ua rau nws tsis tshua muaj kev cuam tshuam tsis zoo hauv lub cev.
Lohexol, ntawm qhov tod tes, yog cov tsis-ionic, qis-osmolar contrast tus neeg sawv cev. Nws muaj qhov qis osmolarity dua li cov khoom, tab sis nws tseem siab dua li cov ntshav plasma.
Osmolarity
Nws yog iso-osmolar nrog osmolarity ntawm 290 mOsm / L (tib yam li ntshav), uas ua rau nws tsis tshua muaj peev xwm ua rau muaj kev hloov pauv ntawm cov kua dej sib npaug thaum txhaj rau hauv cov hlab ntsha.
Lohexol muaj qhov qis osmolarity ntawm kwv yees li 320-350 mOsm / L, uas yog siab dua li ntawm cov khoom thiab cov ntshav ntshav tab sis tseem qis dua cov laus-osmolar contrast agents. Qhov no tuaj yeem ua rau muaj qhov tshwm sim ntau dua qhov tshwm sim tsis zoo, tshwj xeeb tshaj yog rau cov tib neeg uas muaj teeb meem raum.
Sab nrauv Profile
Nws yog feem ntau zam tau zoo, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas muaj lub raum ua ntej, raws li nws cov iso-osmolarity txo qhov muaj peev xwm ntawm cov kev mob tshwm sim tsis zoo nrog rau kev sib piv-induced nephropathy (CIN) thiab kev tsis haum tshuaj.
Lohexol, ua qis osmolar, kuj tseem muaj qhov tshwm sim qis dua ntawm cov kev mob tshwm sim piv rau cov neeg ua haujlwm siab osmolar, tab sis nws tseem yuav ua rau muaj kev cuam tshuam me ntsis ntxiv piv rau nws vim nws cov Osmolarity siab dua. Txawm li cas los xij, nws tseem suav tias muaj kev nyab xeeb dua li cov neeg ua haujlwm sib txawv qub.
viscosity
nws feem ntau muaj qis dua viscosity dua li ntau lwm tus neeg ua haujlwm sib txawv, suav nrog iohexol, uas tuaj yeem ua rau nws yooj yim rau txhaj, tshwj xeeb tshaj yog nyob rau hauv siab. Qhov no yuav pab txo cov neeg mob tsis xis nyob thaum txhaj tshuaj.
Lohexol nyiam muaj viscosity ntau dua li iodixanol, uas yuav ua rau nws yooj yim dua rau txhaj tshuaj, tshwj xeeb tshaj yog nyob rau hauv high concentrations los yog qis kub.
Kev siv tshuaj kho mob
Ob leeg iodixanol thiab lohexol yog siv rau cov hom phiaj zoo sib xws, xws li CT imaging, angiography, thiab intravenous urography. Lawv ob qho tib si muab qhov sib txawv zoo dua los pab pom cov hlab ntsha, lub cev, thiab cov ntaub so ntswg thaum lub sijhawm ua cov txheej txheem.
Iodixanol, vim nws cov iso-osmolarity, feem ntau nyiam rau cov tib neeg uas muaj kev cuam tshuam ntau dua rau cov teebmeem tsis zoo (xws li cov neeg muaj lub raum tsis zoo lossis cov uas tab tom mob coronary angiography).
Lohexol, thaum tseem muaj kev nyab xeeb rau cov neeg mob feem ntau, tej zaum yuav raug xaiv nyob rau hauv qee lub sijhawm uas tus nqi lossis qhov muaj muaj kev txhawj xeeb, lossis rau cov neeg mob uas tsis muaj kev pheej hmoo siab ntawm lub raum teeb meem.
Hauv kev xaus, ob qho tib si iodixanol thiab lohexol yog cov neeg ua haujlwm zoo sib xws, nrog iodixanol feem ntau pom zoo rau cov neeg mob uas muaj kev pheej hmoo siab dua vim nws cov iso-osmolarity thiab kev nyab xeeb zoo dua, thaum lohexol yog qhov kev xaiv pheej yig dua uas tseem yuav nyiam nyob rau hauv cov xwm txheej qis dua.
Dab tsi ntawm qhov sib txawv yog Iodixanol
Nws yog non-ionic, iso-osmolar contrast agent. Non-ionic txhais tau hais tias nws tsis cuam tshuam rau hauv cov khoom siv hluav taws xob (ions) thaum yaj hauv dej, uas txo qhov kev pheej hmoo ntawm qee yam kev mob tshwm sim piv rau cov laus ionic contrast agents. Iso-osmolar txhais tau hais tias nws cov Osmolarity zoo ib yam li cov ntshav (kwv yees li 290 mOsm / L), uas yuav pab txo qis kev pheej hmoo ntawm cov kua dej tsis txaus thiab cov kev cuam tshuam tsis zoo, tshwj xeeb tshaj yog rau cov neeg mob rhiab heev (xws li cov mob raum lossis teeb meem plawv). . Qhov kev sib xyaw ua ke ntawm cov khoom no (tsis yog-ionic thiab iso-osmolar) ua rau nws muaj kev nyab xeeb dua thiab feem ntau ua kom zoo dua qub piv rau cov neeg ua haujlwm zoo sib xws, uas yog ionic lossis muaj Osmolarity siab dua.
Dab tsi yog Qhov Tseem Ceeb Ntawm Iodixanol
Nws cov concentration yog feem ntau qhia nyob rau hauv cov nqe lus ntawm tus nqi ntawm iodine ib milliliter ntawm kev daws. Feem ntau cov concentrations rau nws cov contrast agents yog:
- 270 mg iodine ib milliliter (mg I/mL)
- 320 mg iodine ib milliliter (mg I/mL)
Cov concentrations no yog siv nyob ntawm seb tus txheej txheem imaging tshwj xeeb thiab tus neeg mob tus mob. Qhov 270 mg I / mL concentration feem ntau yog siv rau qhov kev xav pom tsawg dua, thaum lub 320 mg I / mL concentration yuav siv tau rau cov duab ntxaws lossis siab dua, xws li hauv CT scans.
Hauv cov ntsiab lus, nws feem ntau tuaj nyob rau hauv qhov ntau ntawm 270 mg I / mL lossis 320 mg I / mL, nrog rau kev xaiv tshwj xeeb nyob ntawm kev xav tau kev kho mob.
Yog tias koj xav paub tus nqi Iodixanol hmoov, xav txog Xi'an Sonwu, lossis muaj lwm yam lus nug txog cov khoom, tsis txhob yig tiv tauj Xi'an Sonwu.