Dab tsi yog Cov Qauv Rau N4 Hydroxyphenyl Acetamide
4 Maleimidophenol hmoovLub npe tshuaj yog N 4 hydroxyphenyl acetamide. Nws cov qauv muaj ib pab pawg neeg txiv neej thiab lub nplhaib benzene nrog ib pawg hydroxyl (OH) txuas ntawm para txoj hauj lwm (4). Cov pab pawg neeg maleimide yog ib pawg tshuaj tseem ceeb ua haujlwm nrog ob pawg carbonyl (C=O) thiab ob daim ntawv cog lus ua ib lub nplhaib tsib-tus tswv cuab. Qhov ntawd yog cov organic compound nrog cov pab pawg neeg maleimide txuas rau pawg hydroxyl ntawm lub nplhaib benzene. Cov khoom sib xyaw no tuaj yeem ua lub luag haujlwm hauv cov khoom siv science lossis tshuaj synthesis. Cov pab pawg neeg maleimide yog tshuaj lom neeg heev, tshwj xeeb tshaj yog nrog sulfhydryl (-SH) pawg. Cov cuab yeej no ua rau 4-Maleimidophenol tau siv dav hauv biochemistry thiab cov ntaub ntawv tshawb fawb. Cov pab pawg txiv neej tuaj yeem hnov mob nrog sulfhydryl-muaj cov khoom sib txuas (xws li cysteine residues hauv cov proteins) los tsim ib daim ntawv cog lus ruaj khov thioether. Cov tshuaj tiv thaiv no ua haujlwm zoo tshaj plaws nyob rau hauv nruab nrab rau me ntsis alkaline tej yam kev mob, feem ntau ntawm pH 6.5 thiab 7.5. Cov cuab yeej reactive no ua rau 4-Maleimidophenol yog ib qho tseem ceeb reagent rau protein labeling thiab hloov kho. Nws pab cov kws tshawb fawb hauv kev kawm paub ntau ntxiv txog kev sib raug zoo thiab kev ua haujlwm ntawm cov proteins los ntawm kev ua cov cuab yeej rau kev sau cov protein thiab hloov kho. Raws li tus ntoo khaub lig-linker rau polymers thiab cov ntaub ntawv, nws txhim kho cov ntaub ntawv 'mechanical zog thiab tshuaj tiv thaiv. Yog li, yog tias koj txaus siab rau cov neeg nruab nrab, koj tuaj yeem tiv tauj Xi'an Sonwu, uas tuaj yeem muab cov hmoov nyoos rau koj.
N4 Hydroxyphenyl Acetamide siv
1. Kev siv biochemical
Protein Labeling thiab Hloov Kho
4-Maleimidophenol tuaj yeem sau npe thiab hloov kho cov proteins los ntawm kev ua haujlwm nrog cysteine residues hauv cov protein. Nws tuaj yeem txuas cov fluorescent dyes, tshuaj molecules, lossis lwm yam khoom siv rau cov proteins, ua kom yooj yim rau kev kawm txog cov protein ua haujlwm, thaj chaw, thiab kev sib cuam tshuam. 4-Maleimidophenol tuaj yeem ua hauj lwm hauv biosensors los immobilize enzymes lossis tshuaj tiv thaiv rau lub sensor nto, ua rau lub sensor rhiab heev thiab tshwj xeeb.
Biomolecule Cross-linking
4-Maleimidophenol tuaj yeem siv los ua tus sib txuas sib txuas los txuas ob lossis ntau dua cov proteins los ua ntau txoj haujlwm. Qhov kev sib txuas ntawm kev sib txuas sib txuas no yog qhov muaj txiaj ntsig zoo hauv kev kawm txog cov qauv thiab kev ua haujlwm ntawm cov protein complexes. Nws tuaj yeem tsim cov tshuaj tiv thaiv kab mob sib txuas (ADCs) los ntawm kev sib txuas cov tshuaj molecules rau cov tshuaj tiv thaiv kab mob tshwj xeeb rau cov qog nqaij hlav cancer lossis lwm cov kab mob thiab txo cov tshuaj lom rau cov hlwb noj qab haus huv.
Nucleic Acid Hloov Kho
4-Siv cov tshuaj fluorescent los yog lwm yam kev tshawb nrhiav cov molecules los khi cov nucleic acid molecules rau fluorescence nyob rau hauv situ hybridization (FISH) thiab lwm yam molecular biology txheej txheem yog ib txoj kev uas nws muaj peev xwm sau thiab hloov oligonucleotides.
2. Cov ntawv thov hauv Materials Science
Polymer Synthesis
Hauv polymer chemistry, 4-Maleimidophenol yog siv los ua tus sib txuas sib txuas los tsim cov qauv sib txuas sib txuas los ntawm kev ua haujlwm nrog thiol pawg hauv cov saw hlau polymer. Qhov ntawd tuaj yeem txhim kho cov khoom siv hluav taws xob zoo, lub zog thermal stability, thiab tshuaj lom neeg tsis kam. Los ntawm kev qhia 4-Maleimidophenol ntawm cov pob txha polymer, cov khoom siv ua haujlwm tau zoo tuaj yeem npaj los tsim cov ntaub ntawv ntse thiab teb.
Coatings thiab Adhesives
Ntxiv 4-Maleimidophenol rau cov txheej thiab cov nplaum tuaj yeem txhim kho lawv cov adhesion thiab durability. Nws cov pab pawg reactive tuaj yeem ua rau cov tshuaj tiv thaiv nrog cov txheej txheem los yog cov txheej txheem ntawm lub substrate kom ntxiv dag zog thiab ruaj khov ntawm txheej txheej. Thaum siv nyob rau hauv cov khaub ncaws tiv thaiv corrosive, tus ntoo khaub lig-txuas cov txheej txheem ntawm cov xov xwm kev tiv thaiv zoo thiab txuas ntxiv cov khoom siv ua haujlwm.
Nanomaterials
4-Maleimidophenol tuaj yeem siv rau kev ua haujlwm saum npoo ntawm nanoparticles kom muab lawv cov biocompatibility tshwj xeeb thiab lub hom phiaj. Piv txwv li, hauv kev xa tshuaj, cov khoom siv nanoparticles ua haujlwm tau zoo dua rau cov ntaub so ntswg lossis cov hlwb thiab ua rau muaj kev kho mob ntxiv.
3. Lwm yam kev siv
Cov khoom siv photosensitive
Hauv microelectronics thiab optoelectronics, nws tuaj yeem siv los npaj photoresists. Cov irradiation ntawm ultraviolet rays los yog lwm yam teeb pom kev zoo undergoes cross-linking cov tshuaj tiv thaiv los tsim ilv qauv siv nyob rau hauv semiconductor manufacturing thiab micromachining technology.
Cov khoom siv catalyst
4-Maleimidophenol tuaj yeem siv los tiv thaiv cov catalysts. Cov catalyst molecules yog tsau rau ntawm cov khoom txhawb nqa los ntawm cov tshuaj tiv thaiv tshuaj los txhim kho qhov ruaj khov thiab rov siv tau ntawm cov catalyst.
N4 Hydroxyphenyl Acetamide Toxicity
4-Maleimidophenol yog ib qho organic compound nrog ntau daim ntawv thov hauv biochemistry thiab cov ntaub ntawv tshawb fawb. Txawm li cas los xij, zoo li txhua yam tshuaj, nws muaj peev xwm toxicity thiab cov kev mob tshwm sim yuav tsum raug sau tseg thaum siv.
Toxicity
Mob toxicity
Kev nqus pa: Kev nqus pa ntawm 4-Maleimidophenol plua plav lossis vapor tuaj yeem ua rau ua pa ua pa, nrog cov tsos mob xws li hnoos, mob caj pas, thiab ua pa nyuaj.
Kev sib cuag ntawm daim tawv nqaij: Cov tawv nqaij khaus tuaj yeem tshwm sim los ntawm kev sib cuag ncaj qha rau ntawm daim tawv nqaij thiab tshwm sim xws li kub hnyiab, khaus, thiab liab.
Kev sib cuag qhov muag: mob qhov muag hnyav tuaj yeem tshwm sim los ntawm kev sib cuag nrog lub qhov muag; Cov tsos mob muaj xws li liab, kua muag, thiab qhov muag tsis pom kev.
Noj: Thaum noj, nws yuav ua rau mob plab, xeev siab, thiab ntuav, thiab lwm yam teeb meem digestive.
Mob toxicity
Kev kis mus ntev rau 4-Maleimidophenol tuaj yeem ua rau tawv nqaij ua xua, tshwm sim raws li kev sib cuag dermatitis. Kev rov ua dua lossis ntev mus ntev yuav ua rau muaj teeb meem kev noj qab haus huv hnyav dua.
Kev mob tshwm sim
Cov tawv nqaij ua xua
4-Maleimidophenol tuaj yeem ua rau tawv nqaij ua xua, tshwj xeeb tshaj yog rau cov neeg rhiab heev. Kev sib cuag ntev lossis rov ua dua tuaj yeem ua rau cov tsos mob ua xua xws li tawv nqaij liab, khaus, thiab pob khaus.
Qhov muag khaus
Qhov muag khaus zoo li liab, kua muag, thiab mob. Thaum mob hnyav, kev pom kev yuav raug cuam tshuam.
Ua pa kab mob ua npaws
Kev nqus plua plav lossis vapor tuaj yeem ua rau mob ua pa sab sauv nrog cov tsos mob xws li hnoos, mob caj pas, thiab ua pa nyuaj. Kev kis mus ntev yuav ua rau muaj teeb meem ua pa ntev.
Yog tias koj xav tau 4 Maleimidophenol tus nqi, txaus siab rau Xi'an Sonwu, lossis muaj lwm yam lus nug txog cov khoom, tsis txhob yig tiv tauj Xi'an Sonwu.
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