Dab tsi yog Qhov Chaw ntawm Dioscin
Dioscin hmoov yog ib tug natural compound teej tug mus rau tsev neeg ntawm steroidal saponins. Nws muaj nyob rau hauv ntau qhov chaw cog, yeej nyob rau hauv unambiguous hom nroj tsuag nyob rau hauv Dioscorea. Dioscorea yog ib hom ntawm cov nroj tsuag sprouting, los ntawm thiab loj lub npe hu ua yams, thiab muaj thoob plaws thoob plaws ntiaj teb cov cheeb tsam, xws li Asia, Africa, thiab Americas.
Ib qho ntawm cov paub zoo tshaj plaws ntawm dioscin yog Suav yam, tseem hu ua Dioscorea opposita lossis Shan Yao hauv Suav. Cov qos yaj ywm no yog nyob rau hauv Suav teb, tsim dav rau nws cov tubers, thiab devoured ua zaub mov. Cov tubers ntawm Suav yam muaj ntau npaum li cas ntawm dioscin thiab lwm yam bioactive compounds.
Sib nrug los ntawm Suav yam, ob peb lwm hom ntawm Dioscorea nroj tsuag kuj tau txheeb xyuas raws li qhov chaw ntawm dioscin. Dioscorea nipponica, Dioscorea zingiberensis, Dioscorea septemloba, thiab Dioscorea bulbifera yog qee yam piv txwv ntawm Dioscorea hom uas tau tshaj tawm tias muaj dioscin.
Sib nrug los ntawm Suav yam, ob peb lwm hom ntawm Dioscorea nroj tsuag kuj tau txheeb xyuas raws li qhov chaw ntawm dioscin. Dioscorea nipponica, Dioscorea zingiberensis, Dioscorea septemloba, thiab Dioscorea bulbifera yog qee yam piv txwv ntawm Dioscorea hom uas tau tshaj tawm tias muaj dioscin.
Kev rho tawm ntawm dioscin los ntawm cov nroj tsuag no muaj ntau txoj hauv kev. Cov txheej txheem siv feem ntau suav nrog kev tshem tawm cov kuab tshuaj, maceration, thiab chromatographic sib cais. Cov ntaub ntawv cog qoob loo qhuav thiab hmoov yog feem ntau kho nrog cov kuab tshuaj uas tsim nyog, xws li ethanol lossis methanol, kom tshem tawm cov ntsiab lus xav tau. Cov extract yog ces concentrated thiab purified kom tau dioscin nyob rau hauv ib tug ntau refined daim ntawv.
Tag nrho hauv tag nrho, Dioscin tau taug qab hauv cov nroj tsuag ntawm Dioscorea chav kawm, nrog Suav qos yaj ywm (Dioscorea opposita) tej zaum yog qhov pom tseeb tshaj plaws. Lwm hom Dioscorea thiab ob peb hom nroj tsuag uas tsis yog Dioscorea kuj tau tshaj tawm tias muaj cov khoom xyaw ntuj no. Cov txheej txheem rho tawm uas muaj cov kuab tshuaj feem ntau yog ua haujlwm los cais cov dioscin los ntawm cov nroj tsuag no.
Dab tsi yog Lub Mechanism ntawm Kev Ua ntawm Dioscin
Cov cuab yeej ntawm kev ua si ntawm dioscin, steroidal saponin, muaj ntau yam thiab ntau txheej, qhia txog kev cuam tshuam ntawm ntau yam ntawm tes thiab sub-atomic lub hom phiaj. Txawm hais tias kev tshawb nrhiav ntau dua yuav tsum nkag siab txog nws cov cuab yeej ua tiav, qee qhov kev ua haujlwm tseem ceeb tau raug npaj los muab cov kev xeem uas twb muaj lawm.
1. Anti-inflammatory Effects: Dioscin nthuav tawm cov tshuaj tiv thaiv kab mob los ntawm kev tsim cov cytokines pro-inflammatory xws li TNF- , IL-1 , thiab IL-6. Nws tseem tuaj yeem cuam tshuam qhov ua kom muaj zog ntawm cov khoom siv hluav taws xob nuclear-kappa B (NF-κB), qhov tseem ceeb ntawm kev hloov pauv hauv qhov mob. Los ntawm kev txo qhov mob, dioscin tuaj yeem txo cov tsos mob hauv ntau yam mob.
2. Antioxidant Activity: Dioscin ua cov tshuaj antioxidant los ntawm kev tshem tawm cov dawb radicals thiab txo oxidative kev nyuaj siab. Nws tuaj yeem txhim kho qhov kev qhia ntawm cov enzymes antioxidant, xws li superoxide dismutase (SOD) thiab catalase, txhawm rau tiv thaiv oxidative puas tsuaj. Qhov kev ua haujlwm antioxidant no tuaj yeem ua rau muaj kev tiv thaiv ntawm dioscin tiv thaiv cov kab mob oxidative kev nyuaj siab.
3. Anti-diabetic Effects: Dioscin tau tshaj tawm tias muaj txiaj ntsig zoo hauv kev tswj ntshav qab zib. Nws tuaj yeem txhim kho txoj hauv kev ntawm cov tshuaj insulin, txhim kho cov piam thaj ntxiv, thiab nce glycogen ua ke. Tsis tas li ntawd, nws tiv thaiv kev cuam tshuam rau pancreatic beta hlwb, ntxiv rau lawv qhov tsis muaj zog thiab muaj peev xwm. Cov kev ua ub no nce nws cov yeeb ncuab tiv thaiv kev txhim kho cov ntshav qab zib thiab ntxiv dag zog ntxiv nws lub peev xwm tiag tiag li cov kws kho mob ntshav qab zib.
4. Kev tiv thaiv kab mob plawv: Dioscin tau qhia txog kev tiv thaiv kab mob plawv los ntawm kev txo cov ntshav siab, txo qis oxidative kev nyuaj siab, thiab txhim kho endothelial muaj nuj nqi. Tsis tas li ntawd, nws tuaj yeem tiv thaiv kev tsim ntawm thrombus thiab platelet aggregation, ob qho tseem ceeb rau kev mob plawv.
Nws txhais tau hais tias me ntsis yuav tsum nco ntsoov tias cov txheej txheem tiag tiag ntawm dioscin tuaj yeem hloov pauv raws li qhov tshwj xeeb ntawm tes, feem, thiab kev tshawb nrhiav tau siv.
Dab tsi yog Dioscin siv rau
1. Cov nyhuv Neuroprotective: Dioscin lub peev xwm los tiv thaiv cov kab mob neurodegenerative tau raug kawm. Raws li kev tshawb fawb, nws tuaj yeem txo cov amyloid txoj kev loj hlob, oxidative siab, thiab neuroinflamation, tag nrho cov uas txhawb kev tuav pov hwm ntawm paj hlwb. Nws tuaj yeem qhia txog kev cog lus ntawm cov tshuaj neuroprotective hauv kev kho mob xws li Parkinson's thiab Alzheimer's.
2. Kev Noj Qab Haus Huv Kab Mob: Dioscin tau pom tias muaj kev tiv thaiv kab mob plawv. Nws tuaj yeem pab txo qis ntshav siab, txo oxidative kev nyuaj siab, txhim kho endothelial muaj nuj nqi, thiab inhibit platelet aggregation thiab thrombus tsim. Cov khoom zoo li no yuav muaj feem cuam tshuam rau kev tiv thaiv thiab kho cov kab mob plawv.
3. Nws tsim nyog sau cia tias thaum dioscin tau pom muaj peev xwm nyob rau hauv cov cheeb tsam no, yuav tsum muaj kev tshawb fawb ntxiv los tsim kom muaj kev ua tau zoo, kev nyab xeeb, thiab kev siv tshuaj zoo. Daim ntawv thov ntawm dioscin hauv chaw kho mob tseem tab tom tshawb nrhiav, thiab kev sab laj nrog tus kws kho mob tseem ceeb ua ntej txiav txim siab nws siv rau ib qho xwm txheej tshwj xeeb.
Nws txhais tau hais tias muaj ntau yam uas yuav tsum nco ntsoov tias thaum dioscin qhia tau hais tias muaj kev lav phib xaub hauv kev kuaj mob preclinical, nws cov ntaub ntawv tseem ceeb hauv tib neeg tsis tau daws tag nrho. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tau tham nrog cov kws kho mob cov kws kho mob thiab nyob ntawm seb cov tshuaj muaj pov thawj ua ntej siv dioscin los yog lwm yam kev sib xyaw ua ke rau kev kho mob.
Yog koj xav paub covDioscin hmoovnqe, thov tsis txhob yig tiv tauj peb ntawm:
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