Dab tsi yog Qhov Chaw ntawm Wogonin
Wogonin hmoovyog flavonoid compound nrog ntau yam txiaj ntsig kev noj qab haus huv. Ib qho tshuaj tshwm sim feem ntau tuaj yeem tau los ntawm lub hauv paus ntawm cov nroj tsuag hu ua Scutellaria baicalensis, feem ntau hu ua Suav pob txha taub hau.
Scutellaria baicalensis yog cov txuj lom uas muaj sia nyob uas muaj qhov chaw nyob hauv tsev neeg Lamiaceae. Lub hauv paus ntawm cov nroj tsuag no tau siv sijhawm ntev heev hauv cov tshuaj suav tshuaj vim nws muaj ntau yam kev kho mob. Wogonin yog ib qho tseem ceeb ntawm cov hauv paus hniav ntawm Scutellaria baicalensis.
Cov hauv paus hniav ntawm Scutellaria baicalensis yog muab rho tawm thiab ntxuav kom tau wogonin. Lub extraction muaj xws li crushing lub plawv mus rau hauv ib tug hmoov los yog txiav mus rau hauv me me pieces thiab siv cov tswv yim xws li soaking nyob rau hauv ib tug tsim nyog dissolvable, xws li ethanol los yog dej. Wogonin thiab lwm yam bioactive compounds tuaj yeem muab rho tawm los ntawm cov khoom cog ua tsaug rau qhov no.
Thaum cov extraction tiav lawm, cov khoom nyoos extract yog raug rau ntxiv purification rau cais wogonin. Cov tswv yim sib txawv tuaj yeem siv tau, xws li chromatography, crystallization, los yog cov fractionation dissolvable. Cov tswv yim no pab cais wogonin los ntawm kev sib txawv ntawm cov hauv paus extricate, tsim kom muaj ntau hom wogonin thiab lucid.
Hauv cov tshuaj suav tshuaj, Scutellaria baicalensis cag, suav nrog wogonin, yog siv los tsim cov tshuaj ntsuab los kho ntau yam mob. Cov khoom siv tau txais tuaj yeem pab txo cov kev mob tshwm sim ntawm kev ua pa, mob siab, thiab kab mob plawv, thiab qhov ntawd yog qhov pib xwb.
Wogonin tau txais los ntawm lub hauv paus ntawm Scutellaria baicalensis, ib tsob nroj tseem ceeb feem ntau hu ua Suav pob txha taub hau. Los ntawm kev rho tawm thiab tshem tawm cov voj voog, wogonin tuaj yeem raug tshem tawm thiab siv rau ntau lub hom phiaj, suav nrog kev tshawb fawb thiab tshuaj noj.
Dab tsi yog Mechanism of Action ntawm Wogonin
Ib qho ntawm cov txheej txheem tseem ceeb los ntawm Wogonin siv nws cov khoom yog ntsuas txoj hauv kev fiery. Nws tau tshwm sim los txwv qhov kev lees paub ntawm atomic variable kappa B (NF-κB), qhov tseem ceeb ntawm cov ntaub ntawv tseem ceeb hauv kev pib cov kev xav. Los ntawm impeding NF-κB, wogonin tuaj yeem txo qis kev loj hlob ntawm incendiary mus-nruab nrab xws li cytokines, chemokines, thiab prostaglandins. Qhov kev ua kom calming no tuaj yeem ntxiv rau nws cov txiaj ntsig kho tau zoo hauv cov xwm txheej provocative.
Wogonin kuj tseem tau pom los txuas nrog -aminobutyric corrosive (GABA) receptor channels, uas yog qhov tseem ceeb rau kev tswj hwm cov tshuaj tiv thaiv neurotransmission hauv focal sensory system. Los ntawm kev kho dua tshiab GABAergic chij, wogonin tuaj yeem ua rau muaj kev ntxhov siab thiab kev siv tshuaj yeeb, tejzaum nws ntxiv rau nws cov kev siv tshuaj rau cov xwm txheej uas cuam tshuam nrog kev ntxhov siab thiab pw tsaug zog tsis zoo.
Tsis tas li ntawd, wogonin tau tshwm sim los txuas nrog cov tshuaj thiab cov receptors cuam tshuam nrog cov txheej txheem ntawm tes sib txawv. Piv txwv li, nws tuaj yeem cuam tshuam kev txav ntawm lub moj khaum metalloproteinases (MMPs), cov tebchaw cuam tshuam nrog kev kho cov ntaub so ntswg thiab ua rau hnyav dua. Los ntawm kev cuam tshuam MMPs, wogonin tuaj yeem pab txo qis cov nqaij mos thiab khaus khaus cuam tshuam nrog cov mob xws li mob pob qij txha thiab kab mob metastasis.
Tsis tas li ntawd, wogonin tau tshwm sim los txuas nrog cov tshuaj thiab cov receptors cuam tshuam nrog cov txheej txheem ntawm tes sib txawv. Piv txwv li, nws tuaj yeem cuam tshuam kev txav ntawm lub moj khaum metalloproteinases (MMPs), cov tebchaw cuam tshuam nrog kev kho cov ntaub so ntswg thiab ua rau hnyav dua. Los ntawm kev cuam tshuam MMPs, wogonin tuaj yeem pab txo qis cov nqaij mos thiab khaus khaus cuam tshuam nrog cov mob xws li mob pob qij txha thiab kab mob metastasis.
Los ntawm tweaking liab kub lem, thwarting mixs, tswj GABAergic neurotransmission, thiab cuam tshuam cov txheej txheem ntawm tes sib txawv, wogonin qhia alleviating, malignant loj hlob zam tshwj xeeb, neuroprotective, cytoprotective, anxiolytic, thiab anticancer teebmeem.
Dab tsi yog Kev Siv Wogonin
Wogonin, flavonoid compound tau los ntawm lub hauv paus ntawm Scutellaria baicalensis, tau pom muaj peev xwm rau cov hom phiaj sib txawv vim nws cov khoom siv tshuaj ntau yam. Thaum kev tshawb nrhiav ntxiv yuav tsum tau tso tawm nws txoj kev muaj peev xwm thiab kev nyab xeeb tag nrho, ntawm no yog ib feem ntawm cov hom phiaj ntawm Wogonin:
Anti-inflammatory teebmeem: Wogonin tau nthuav tawm cov haujlwm tseem ceeb los tiv thaiv kab mob los ntawm inhibiting zus tau tej cov pro-inflammatory cytokines thiab enzymes. Cov teeb meem provocative, nrog rau mob rheumatoid pob qij txha, mob hawb pob, mob plab hnyuv, thiab dermatitis, tau lees paub hauv lawv txoj kev kho mob.
Antioxidant kev ua ub no: Wogonin muaj zog antioxidant zog, tso cai rau nws tshem tawm cov dawb radicals thiab txo oxidative kev nyuaj siab. Qhov no ua rau nws tseem ceeb rau cov xwm txheej cuam tshuam txog kev puas tsuaj oxidative, xws li mob neurodegenerative, kab mob plawv, thiab hnub nyoog cuam tshuam.
Cov teebmeem ntawm Neuroprotective: Wogonin tau pom tias muaj cov khoom tiv thaiv neuroprotective los ntawm kev txo qhov mob, oxidative kev nyuaj siab, thiab neurotoxicity. Nws yuav muaj peev xwm siv tau los kho cov kab mob neurodegenerative, suav nrog Alzheimer's thiab Parkinson's.
Antimicrobial kev ua si: Wogonin tau nthuav tawm cov tshuaj tua kab mob tiv thaiv ntau yam kab mob, fungi, thiab kab mob. Nws tau pom tias inhibitory txav tawm tsam tiv thaiv kab mob-kev nyab xeeb kab mob thiab muaj peev xwm ua tus yam ntxwv lwm yam kev xaiv los yog adjuvant rau kev kho mob antimicrobial tsis tu ncua.
Kev cuam tshuam los tiv thaiv kab mob: Qee yam kab mob, xws li kab mob siab B, kab mob siab C, herpes simplex, thiab mob khaub thuas, tau pom tias yuav teb rau wogonin compound. Nws tau raug tshawb xyuas raws li tus neeg sawv cev tiv thaiv kab mob thiab tej zaum yuav raug siv los tsim cov tshuaj tshiab.
Ua kom muaj kev ntxhov siab thiab txo kev ntxhov siab: Wogonin tau qhia txog kev cuam tshuam ntawm kev ntxhov siab thiab narcotic los ntawm kev txhim kho lub peev xwm ntawm -aminobutyric corrosive (GABA) receptors hauv focal sensory system. Tej zaum nws yuav yog nyob rau hauv kev tswj xyuas cov teeb meem nervousness thiab pw tsaug zog.
Immunomodulatory teebmeem: Wogonin tau pom los hloov kho lub cev tiv thaiv kab mob los ntawm kev tswj cov cytokine ntau lawm, inhibiting immuno cell activation, thiab suppressing allergic reactions.
Cov kab mob plawv zoo: Wogonin muaj txiaj ntsig cuam tshuam rau cov hlab plawv, nrog rau kev txo qis, ua haujlwm ntawm endothelial muaj peev xwm, thiab cuam tshuam cov platelet conglomeration. Nws tuaj yeem saib xyuas cov kab mob plawv xws li ntshav siab thiab atherosclerosis.
Wogonin yuav tsum tsis txhob siv los hloov kev kho mob, thiab kev sab laj tus kws kho mob yog ib lub tswv yim zoo ua ntej txiav txim siab nws siv rau ib qho kev mob tshwj xeeb.
Yog koj xav paub covWogonin hmoovnqe, thov tsis txhob yig tiv tauj peb ntawm:
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