Nucleotides ua haujlwm raws li cov av uas tseem ceeb hauv lub neej, kev koom nrog cov txheej txheem tseem ceeb xws li genetic hloov chaw, thiab kev ntsuas ntawm tes. Ntawm cov no, uridine monophospate hydrate (UMP - h) sawv ntsug raws li tus tseem ceeb pyrimidine nucleotide thiab ib qho tseem ceeb ntawm RNA. Nws txhawb nqa tsis tsuas nucleic acid saptthesis thiab muaj protein txhais lus tab sis kuj ua rau muaj kev sib luag, glycogen cia, thiab kev ua haujlwm neural. Hauv tsab xov xwm no, peb tshuaj xyuas cov yam ntxwv kev ua haujlwm, kev nqus cov haujlwm, thiab ntau daim ntawv thov ntawm UMP {4} h ntawm kev ntsuas ntawm lub cev thiab kev tshawb fawb.
Dab tsi yog UMP - h
UMP - h hmoovyog cov kua qaub nrog cov tshuaj c9h12n207.h2oformula c9h12n2o7.h2o. Nws yog ib qho chaw ua yeeb yam ntawm RNA (Ribonucleic acid). Lub TA Cheebtsam ntawm nws suav nrog ib pab pawg. Nyob rau theem tshuaj, qhov tseem ceeb ntawm Uraclbase yog nws lub nucleotide qauv, tshwj xeeb uridically. Tus 3 'thiab 5' carbon atoms ntawm uridine tau sib txuas nrog pab pawg phosphathate, ua rau uridine acid. Cov hydrate no nyob rau hauv cov daim ntawv hydrate muaj cov khoom ntim dej ntxiv, uas feem ntau cuam tshuam rau nws cov khoom siv crystallization thiab solubility. Qhov no nucleotide plays lub luag haujlwm tseem ceeb hauv kev muaj sia thiab ua haujlwm raws li chav tsev ntawm RNA synthesis. Hauv cov hlwb, nws koom rau hauv cov kev sib txoos ntawm ribosomes thiab cov txheej txheem txhais lus ntawm cov protein. Nws pab pawg phosphate thiab RNA chains yog qhov tseem ceeb rau kev hloov caj ces. Hauv kev tshawb nrhiav thiab cov kws tshawb fawb thaij duab, cov khoom no feem ntau siv los ua cov hluavtaws nucleic acids rau cov kev tshawb fawb molecular. Nws ruaj khov thiab solubility ua nws muaj txiaj ntsig zoo hauv cov ntawv thov thiab cov khoom lag luam. Yog tias koj txaus siab rau UMP - h, thov tsis txhob yig tiv tauj Xi'an Soniau.
Dab tsi yog UMP - h siv rau hauv lub cev
Uridine Monophosphathate, ib qho tseem ceeb heev nucleotide, ua lub luag haujlwm tseem ceeb hauv ntau cov txheej txheem roj ntsha. Nws lub luag haujlwm tseem ceeb tshaj plaws yog qhov tseem ceeb hauv synthesis, ncaj qha rau kev tsim tawm, yog kev txhawb nqa protein biosynthesis thiab kev tswj hwm cov noob. Nws tseem ua lub luag haujlwm hauv kev tswj hwm cov kev ruaj khov. Kev koom nrog DNA kev kho cov tshuab pabcuam pab txo cov kev sib txuam ntawm kev sib hloov thiab ua kom pom tseeb qhov kis tau tus mob caj ces.
Hauv lub zog thiab cov khoom siv metabolism, UMP - h ua ntau lub zog los ntawm kev hloov pauv mus rau hauv siab dua- lub zog derivatives. Nws yog ntu ua ntu zus los tsim UDP (uridine diphosphate) thiab utp (uridine mus triphosphate). Cov tom kawg, lub siab {{4 4}} lub zog hloov chaw thiab cov kua zaub ua ntej los ua ke los ua kom zoo nkauj rau glycogen ntau thiab cov khoom ntim hauv daim siab thiab cov leeg. Cov khoom tseem tsis ncaj pab txhawb rau kev tsim kho ntawm lub cev nqaij daim tawv, suav nrog cov khoom noj qab zib nucbranids tsim nyog rau glycosylation.
Cov hydrate no tseem muaj cov kev tswj hwm ua haujlwm nyob hauv cov hlab hlwb. Raws li kev tshawb fawb, nws yuav txhim kho kev txawj ntse, kev kawm, thiab cim xeeb los ntawm kev cuam tshuam phospholipid metabolism thiab neurotransmitter synthesis. Nws cov derivatives kuj koom nrog hauv cov kev taw qhia cellular txoj kev taug kev, pab tswj cov txheej txheem xws li kev loj hlob ntawm tes thiab sib txawv. Cov khoom lag luam dav no ua rau cov khoom lag luam tsis tsuas yog qhov tseem ceeb nyob rau hauv cov metabolism tab sis kuj mob hlwb nyob rau hauv kev tswj hwm lub zog thistostasis thiab txhawb nqa kev noj qab haus huv ntawm kev noj qab haus huv.
Li cas Ump - h tau nqus rau hauv lub cev
Qhov nqus ntawm cov khoom hauv tib neeg lub cev yog qhov muaj ntau -}} kauj ruam txheej txheem hauv kev zom zaub mov. Thaum cov hydrate no, muab tau los ntawm kev noj haus lossis RNA {2} iontharets cov nucleases thiab phosphatases zais cia thiab txoj hnyuv. Thaum lub sijhawm no, nws yog feem ntau dephosphorallated thiab hloov mus rau uridine. Qhov tshuaj tiv thaiv no, catalyzed los ntawm plab hnyuv alkaline phosphatase, yog ib qho tseem ceeb preprocessive kauj ruam ua ntej muaj kev tsim nyog dua li siv nucleosides ntau dua li them lub nucleotides.
Lub enterocyte ces siv cov zis los ntawm cov neeg thauj tau tshwj xeeb ntawm nws lub memental membrane. Kev thauj cov neeg thauj Nucleoside (Cnts) nquag thauj khoom nucleosides hauv lub nucleosides kom haum raws li concurrical kev hloov pauv. Qhov kev hloov tshwj xeeb no - Reeent Mechanism ua kom muaj peev xwm ua tau zoo thiab xaiv tau. Uridine mam nkag mus rau cov neeg muaj peev xwm nkag mus rau hauv cov pob zeb hauv av thiab nkag mus rau qhov chaw Portal Portal, qhov uas nws feem ntau xa mus rau daim siab.
Hauv daim siab, uridine undergoes tseem ceeb ua ntej {{}}} dhau metabolism. Hepatocytes yog nplua nuj nyob rau hauv Uridine Kinase, uas tau rov qab sai sai ntawm koj cov ntawv sau tseg, yog li rov kho dua. Qee qhov ntawm nws yog ncaj qha rau hauv Hepatocytes, piv txwv li, nyob rau hauv kev sib tham ntawm glycogen lossis RNA. Nyob rau tib lub sijhawm, lwm feem yog ntxiv rau UDP thiab UTP, uas koom nrog lub zog metabolism lossis kev tsim cov suab thaj. Cov tebchaw no tom qab ntawd nkag mus rau qhov system ncig thiab yuav thauj mus rau lwm cov plab hnyuv siab raum thiab cov ntaub so ntswg.
Thaum kawg, cov khoom no thiab nws cov derivatives tau faib thoob plaws lub cev los ntawm kev ncig lub cev. Ntau nucleouside thiab nucleotide thauj neeg nyob rau ntawm lub cell membrane kho tau ncaj qha rau lawv cov kev nce xov tooj. Hauv lub xov tooj ntawm tes, nws tuaj yeem ua cov pub rau RNNtorch lossis, dhau mus ntawm Kinase- Kev hloov pauv Glycelen, thiab kev taw qhia ntawm tes. Qhov kev ua tau zoo ntawm txoj kev ua haujlwm, los ntawm Upersion thiab hloov dua siab tshiab, ua kom txhua yam kev ua haujlwm hauv kev txawj ntse, thiab kev tswj hwm lub zog.
Yog tias koj xav nug txog tus nqi ntawm UMP {{h hmoov} h hmoov lossis thov kom tau txais cov khoom lag luam ntxiv, thov mus ntsib nrog xi'an sonwu ncaj qha.
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