Nrhiav kom boost koj cov metabolic noj qab haus huv? Tsab ntawv xov xwm no tshawb txog O-304, lub zog hluavtaws AMPK activator tau los ntawm berberine, rau nws lub luag haujlwm hauv kev ua kom autophagy, txhawb kev noj qab haus huv mitochondrial, thiab nws cov kev siv tau hauv cov kab mob metabolic, kev tiv thaiv kab mob plawv, thiab kev tshawb fawb ntev.
O-304 yog dab tsi
O-304 hmoovyog ib qho kev sim AMPK activator (tseem hu ua 14-hydroxyberberine) tam sim no tau tshawb xyuas rau nws lub peev xwm los ua raws li qhov cuam tshuam ntawm kev tawm dag zog thiab kev txwv calorie los ntawm kev ua kom lub zog metabolic enzyme AMPK. Cov kev tshawb fawb tau pom tias muaj txiaj ntsig zoo ntawm cov ntshav qabzib, tiv thaiv insulin, thiab kev ua haujlwm ntawm lub plawv hauv cov qauv tsiaj thiab kev sim tshuaj. Nws txhawb nqa cov leeg ntshav qabzib thiab siv rau lub zog, yog li txo cov ntshav qabzib. Nws kuj tseem txhim kho lub cev rhiab heev rau insulin. Tsis tas li ntawd, nws txhawb kev tawg ntawm cov roj khaws cia rau lub zog thiab txhim kho cov roj hlawv. Nws kuj tseem txhawb kev tsim cov mitochondria tshiab (lub cell "lub zog hluav taws xob"), yog li txhim kho kev siv hluav taws xob tag nrho. Nws kuj tseem ua rau autophagy, tshem tawm cov hlwb puas thiab cov khoom siv-ib qho tseem ceeb ntawm kev tshawb fawb ntev. Nws tseem ceeb induces lub cev mus rau hauv ib tug zoo metabolic xeev, zoo ib yam li lub xeev tam sim ntawd tom qab ce los yog yoo mov. Yog tias koj txaus siab rau O-304, thov hu rau Xi'an Sonwu.
Dab tsi yog Mechanism Ntawm Kev Ua Ntawm O-304
Cov txheej txheem ntawm kev ua tau pom nyob rau hauv cell thiab tsiaj qauv rau O-304 yog qhov tob thiab dav. Ua ntej, hauv vivo kev tshawb fawb tau pom tias nws txhim kho cov piam thaj homeostasis thiab - cell function. Piv txwv li, hauv kev noj zaub mov -induced rog (DIO) nas, kev tswj qhov ncauj ntawm nws txo qis ntshav qabzib ceev thiab qib insulin. HOMA-IR (homeostasis qauv kev ntsuam xyuas ntawm insulin tsis kam) tau txhim kho zoo heev, qhia txog kev txhim kho insulin rhiab heev. Cov nyhuv no tau tshaj tawm thaum ua ke nrog metformin. Tsis tas li ntawd, hauv Phase IIa kev sim tshuaj rau cov neeg mob T2D, nws tsis tsuas yog txhim kho cov piam thaj hauv tsev, tab sis kuj tseem txhim kho peripheral microcirculatory muaj nuj nqi, suav nrog daim tawv nqaij microvascular perfusion, ib qho kev sib koom ua ke ntawm qhov tshwm sim loj ntawm T2D.
Tsis tas li ntawd, nws muaj txiaj ntsig zoo rau cov hlab plawv thiab kev ua kom muaj zog ntawm cov nas muaj hnub nyoog. Cov kev tshawb fawb tau pom tias cov nas muaj hnub nyoog tau noj nws tau pom tias muaj txiaj ntsig zoo ntawm kev ua haujlwm ntawm lub plawv, xws li lub plawv tso zis, ejection fraction, thiab infarct ntim, piv rau pawg tswj. Qhov kev txhim kho no kuj tau nrog los ntawm kev txo qis insulin tsis kam thiab hyperinsulinemia, qhia txog nws lub peev xwm los txhawb kev mob plawv, kev siv lub zog, thiab tag nrho cov metabolic homeostasis. Hauv cov qauv kev laus, nws kuj pom tau tias muaj kev txhim kho tseem ceeb hauv cov leeg nqaij pob txha, raws li kev soj ntsuam los ntawm PET, nrog rau kev nce qib hauv p-ACC (ACC Ser79) thiab txo qis hauv TXNIP qhia, qhia txog lub luag haujlwm tseem ceeb hauv kev txhawb kev hloov pauv hauv metabolic thiab txhim kho cov leeg nqaij siv zog.
Hauv kev sim ntawm tes, O-304 kuj tau pom los txhawb autophagy thiab alleviate mitochondrial dysfunction. Piv txwv li, nyob rau hauv ib tug qauv ntawm oxidative kev nyuaj siab, nws ua rau kom lub tsim ntawm LC3B- zoo autophagosomes, txhawb autophagic flux, thiab rov ua kom cov lus qhia ntawm cov ntsiab lus tseem ceeb koom nrog hauv mitochondrial biogenesis (xws li PGC-1 thiab TFAM), txo ROS ntau lawm, thiab rov ua kom lub luag haujlwm ntawm kev tiv thaiv ultra mitochondrial. tswj cellular zoo tswj thiab lub zog metabolism. Zuag qhia tag nrho, nws yog lub luag haujlwm ntawm kev ua haujlwm hla qib molecular (AMPK ua kom thiab tiv thaiv dephosphorylation), qib cellular (tswj cov metabolic homeostasis, tiv thaiv mitochondria, thiab txhawb nqa autophagy), thiab hauv vivo system (kev txhim kho insulin rhiab heev, mob plawv muaj nuj nqi), kev tshawb fawb txog kev ua haujlwm, thiab kev ua haujlwm ntawm lub cev. txoj kev los ntawm Cov txheej txheem tseem ceeb rau kev txhim kho physiological tag nrho. Qhov no yog qhov tseeb yog vim li cas cov kws tshawb fawb tau ua tib zoo saib xyuas nws "kev tawm dag zog-mimicking" muaj peev xwm thiab nws cov txiaj ntsig ntawm ob lub metabolic thiab kev tiv thaiv kab mob plawv.
Dab tsi yog Daim Ntawv Thov Ntawm O-304
O-304 muaj ntau yam kev siv, suav nrog kev tshawb fawb txog kab mob metabolic, kev tawm dag zog lub cev, kev tiv thaiv kab mob plawv, tshawb nrhiav cov txheej txheem kev laus, thiab kev tshawb fawb txog kab mob tshwj xeeb. Ua ntej, hauv kev tshawb fawb txog kab mob metabolic, nws tau siv dav hauv cov qauv nas (xws li kev noj zaub mov- ntxias cov nas rog rog) ua cov cuab yeej los kawm txog qhov cuam tshuam ntawm AMPK ua rau pancreatic -kev tiv thaiv cell, kev tswj cov piam thaj metabolism, thiab insulin tsis kam. Los ntawm kev txo qis cov piam thaj hauv cov ntshav thiab cov tshuaj insulin, ua kom cov leeg nqaij pob txha nce ntxiv, thiab txhim kho HOMA-IR, O-304 muab cov khoom siv sim ua tau zoo rau kev kawm txog cov kab mob thiab cov tswv yim cuam tshuam ntawm cov kab mob metabolic thiab hom 2 mob ntshav qab zib. Hauv kev tshawb fawb txog kev mob plawv thiab kev tawm dag zog, nws tau pom cov txiaj ntsig tseem ceeb. Hauv cov qauv nas laus, nws tsis tsuas yog txhim kho lub plawv dhia ua haujlwm, tab sis kuj tseem txhim kho kev ua haujlwm ntawm lub cev thiab kev siv cov leeg nqaij, ua rau nws yog ib tus neeg sib tw zoo tshaj plaws rau kev tshawb nrhiav cov txheej txheem molecular ntawm "kev tawm dag zog-mimicking teebmeem," tshwj xeeb hauv cov chaw uas tsis muaj kev cuam tshuam kev tawm dag zog li niaj zaus. Tsis tas li ntawd, O-304 qhov kev txhim kho microcirculation ua rau nws muaj txiaj ntsig zoo rau kev kawm txog microvascular perfusion thiab cov hlab ntshav, tshwj xeeb tshaj yog rau kev tshawb xyuas cov ntshav txaus cuam tshuam nrog cov teeb meem ntshav qab zib.
Los ntawm txoj kev xav ntawm lub xov tooj ntawm tes, O-304 tau siv dav hauv kev sim tshuaj xyuas txoj hauv kev autophagy, kev ua haujlwm mitochondrial, thiab kev tswj hwm ntawm tes. Hauv kev ntxhov siab-cov qauv tsim tawm ntawm tes, nws tau pom tias yuav txhawb nqa autophagy, txo cov mitochondrial structural abnormalities thiab oxidative puas tsuaj, thiab kho cov kev qhia ntawm mitochondrial yam tseem ceeb. Qhov no qhib txoj hauv kev tshiab rau kev tshawb fawb txog kev sib txuas ntawm kev laus, kev ntxhov siab ntawm lub cev, thiab metabolic homeostasis. Tsis tas li ntawd, nws qhov siab -purity, soluble hmoov daim ntawv, stability, thiab lub qhov ncauj muaj nyob rau hauv lub qhov ncauj ua rau nws ib tug nyiam kev xaiv rau cov koom haum tshawb fawb thiab tshuaj nrhiav tau cov tshuaj, ob qho tib si rau cov yooj yim kev tshawb fawb mechanisms thiab thaum ntxov- theem tshuaj loj hlob. Hais txog kev tsim qauv, nws tuaj yeem siv rau hauv cov kev sim tswj nrog cov tshuaj AMPK ib txwm siv (xws li AICAR thiab metformin), ua rau cov kws tshawb fawb los sib piv cov txheej txheem, ua koob tshuaj - kev tshawb fawb nce ntxiv, thiab tshuaj xyuas ntau txoj hauv kev. O-304 muaj cov cuab yeej tshawb fawb nrog cov tshuaj siv tshuaj, tshuaj lom neeg ruaj khov, thiab kev siv tshuab ua kom pom tseeb, txhim kho kev ua haujlwm ntawm cov metabolism thiab kev laus ntawm kev tshawb fawb los ntawm kev tsim cov kev tshawb fawb kom ntseeg tau thiab ua tau zoo.
Rau cov lus nug txog O-304 hmoov nqi lossis khoom, thov hu rau peb ncaj qha ntawm Xi'an Sonwu.
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