Qhov txawv ntawm Metoprolol thiab Metoprolol Succinate yog dab tsi
Metoprolol succinate hmoovthiab metoprolol yog ob qho tshuaj siv feem ntau los kho cov ntshav siab ( ntshav siab), angina pectoris ( mob hauv siab), thiab lub plawv tsis ua haujlwm. Lawv muaj nyob rau hauv ib chav kawm ntawm cov tshuaj hu ua beta-blockers, uas thaiv cov teebmeem ntawm cov tshuaj hormone epinephrine (adrenaline), yog li txo qis lub plawv dhia, ntshav siab, thiab mob plawv. Txawm hais tias sib koom cov khoom xyaw nquag, ob cov tshuaj no txawv heev, tshwj xeeb tshaj yog nyob rau hauv lawv cov formulations, pharmacokinetics, thiab cov sij hawm noj.
Metoprolol muaj nyob rau hauv tam sim-tso (IR) thiab ncua-tso tawm (ER) formulations, thaum ToprolX tsuas yog muaj raws li ib tug ncua-tso npaj. Cov formulations sib txawv no ua rau sib txawv cov sij hawm noj tshuaj thiab cov khoom pharmacokinetic. Kev tso tawm tam sim metoprolol feem ntau yuav tsum tau txhaj tshuaj txhua hnub, thaum qhov kev tso tawm txuas ntxiv yuav tsum tau noj ib zaug ib hnub. Hloov pauv, ToprolX yog tsim los rau kev noj ib hnub ib zaug. Hais txog pharmacokinetics, kev tso tawm tam sim metoprolol mus txog qib ntshav siab tshaj plaws hauv 1-2 teev tom qab noj thiab muaj lub sijhawm luv luv ntawm kev ua. ToprolX, ib qho kev ncua kev tso tawm, muaj qhov ncua sij hawm tso tawm thiab ncua sij hawm ntxiv ntawm kev ua ub no, ua rau kom muaj txiaj ntsig zoo nrog kev noj ib zaug ib hnub. Yog tias koj tseem txaus siab rau cov khoom lag luam txuas ntxiv no, thov hu rau Xi'an Sonwu. Xi'an Sonwu tuaj yeem muab koj cov lag luam wholesale metoprolol succinate.
Lub hom phiaj tseem ceeb ntawm Metoprolol Succinate yog dab tsi
ToprolX yog ib yam tshuaj uas feem ntau tau sau tseg rau kev kho mob ntawm ntau yam kab mob plawv, nrog rau kev kub siab ( ntshav siab), angina pectoris ( mob hauv siab), thiab lub plawv tsis ua haujlwm. Raws li beta-blocker, ToprolX ua lub luag haujlwm tseem ceeb hauv kev tswj cov xwm txheej no los ntawm kev cuam tshuam kev ua haujlwm ntawm lub plawv thiab cov hlab ntsha. Nws tshwj xeeb yog tsom rau lub plawv, txo nws txoj haujlwm thiab pab ua kom ntshav siab.
Lub hom phiaj tseem ceeb ntawm kev sau tshuaj ToprolX yog los tswj ntshav siab. Hais txog kev kho mob ntshav siab, cov tshuaj pab tswj cov txheej txheem tswj cov ntshav khiav thiab lub plawv ua haujlwm. Tsis tas li ntawd, ToprolX yog siv los txo qhov mob hauv siab (angina) los ntawm kev txo qis hauv lub plawv qhov xav tau oxygen. Nws kuj tseem muaj txiaj ntsig zoo hauv kev kho mob plawv tsis ua haujlwm, txo cov tsos mob, thiab txo qis hauv tsev kho mob rau cov neeg mob.
Hais txog nws cov tshuaj pharmacological, nws ua los ntawm kev thaiv cov beta-adrenergic receptors nyob rau hauv lub plawv, peripheral hlab ntsha, thiab ob lub raum. Los ntawm kev thaiv cov receptors no, nws txo cov teebmeem ntawm catecholamines, xws li adrenaline, uas koom nrog kev tswj lub plawv dhia thiab ntshav siab. Qhov no ua rau lub plawv dhia qis, txo qis contractility ntawm lub plawv cov leeg, thiab dilatation ntawm cov hlab ntsha, tag nrho cov no pab txo cov ntshav siab thiab relieving lub plawv ua hauj lwm load.
Tsis tas li ntawd, nws tau pom tias txuas ntxiv mus dhau qhov ntsuas tau tsim. Cov txiaj ntsig muaj peev xwm ntawm daim ntawv thov tawm ntawm daim ntawv no muab qhov dav ntxiv rau nws qhov kev siv tshuaj kho mob, ntxiv rau nws qhov kev ua tau zoo hauv kev tswj cov hlab plawv thiab paj hlwb.
Thaum nws los txog rau kev kho mob ntawm cov tshuaj no, nws yog ib qho tseem ceeb uas yuav tau xav txog nws lub luag haujlwm hauv kev kho ua ke. ToprolX feem ntau tau sau nrog rau lwm cov tshuaj rau kev kub siab thiab lub plawv tsis ua haujlwm, suav nrog cov tshuaj diuretics, ACE inhibitors, thiab angiotensin receptor blockers. Hauv kev sib xyaw ua ke, nws tuaj yeem ua ke nrog lwm tus neeg ua haujlwm kom tswj hwm cov kab mob plawv, hais txog ntau yam ntawm cov xwm txheej thiab txhim kho kev kho mob tag nrho.
Metoprolol Succinate Side Effects
1. qaug zog thiab kiv taub hau: Qee tus neeg yuav muaj kev qaug zog, kiv taub hau, tsis muaj zog, lossis lub taub hau, tshwj xeeb tshaj yog thaum sawv ntxov. Cov teebmeem no tuaj yeem tshwm sim los ntawm cov tshuaj uas cuam tshuam rau lub plawv dhia thiab ntshav siab.
2. Bradycardia: ToprolX tuaj yeem txo lub plawv dhia, ua rau bradycardia, qhov twg lub plawv dhia qeeb dhau.
3. Mob khaub thuas: Qee tus neeg yuav pom lawv ob txhais tes thiab ko taw txias dua li niaj zaus. Qhov no tshwm sim vim cov tshuaj muaj feem xyuam rau cov ntshav ncig.
4. Kab mob plab: xeev siab, ntuav, raws plab, thiab mob plab yog qhov tshwm sim ntawm plab hnyuv.
5. Kev pw tsaug zog tsis zoo: Qee tus neeg yuav muaj kev cuam tshuam txog kev pw tsaug zog, nrog rau kev pw tsaug zog lossis npau suav txawv txawv, vim yog noj nws.
6. Kev sib deev tsis zoo: Tej zaum nws yuav ua rau erectile kawg thiab txo libido, nrog rau lwm yam kev ua txhaum ntawm kev sib deev.
7. Hypotension: Txawm hais tias nws yog siv los kho cov ntshav siab, nyob rau qee zaus, nws kuj tuaj yeem tsim cov ntshav siab, uas tuaj yeem ua rau cov tsos mob xws li qaug zog lossis kiv taub hau.
8. Cov teeb meem ua pa: Tsis tshua muaj, nws tuaj yeem ua rau mob bronchospasm hauv cov tib neeg uas muaj kab mob ua pa xws li mob hawb pob lossis mob ntsws ntsws ntev (COPD).
9. Kev puas siab puas ntsws: Qee tus neeg yuav muaj kev hloov pauv hauv lub siab, kev nyuaj siab, lossis kev ntxhov siab thaum noj nws. Nws yog ib qho tseem ceeb los saib xyuas cov kev cuam tshuam no, tshwj xeeb tshaj yog nyob rau hauv cov tib neeg uas muaj kev puas siab puas ntsws preexisting.
10 Masking of Hypoglycemia: Qee zaum nws tuaj yeem zais cov cim qhia ntawm cov ntshav qab zib tsawg, ua rau nws nyuaj rau cov neeg mob ntshav qab zib kom txheeb xyuas thiab hnov mob rau hypoglycemia.
Dab tsi yuav tsum zam thaum noj Metoprolol
Cov khoom no yuav tsum raug zam thaum ua ke nrog cov tshuaj hauv qab no:
Barbiturates: Barbiturates (pentobarbital tau kawm) tuaj yeem nce cov metabolism ntawm metoprolol los ntawm enzyme induction.
Propafenone: Hauv 4 tus neeg mob uas twb tau siv metoprolol, plasma concentration ntawm metoprolol nce 2 mus rau 5 zaug tom qab kev tswj hwm ntawm propafenone, thiab 2 ntawm lawv tau tsim cov kev mob tshwm sim ntawm metoprolol. Qhov kev sib cuam tshuam no tau lees paub hauv 8 tus neeg ua haujlwm noj qab haus huv. Kev piav qhia ua tau rau qhov kev cuam tshuam no yog tias propafenone, zoo ib yam li quinidine, inhibits cov metabolism ntawm metoprolol los ntawm cytochrome P4502D6 txoj hauv kev. Txij li thaum propafenone kuj muaj beta-receptor-thaiv cov teebmeem, nws siv ua ke nrog metoprolol yog qhov nyuaj rau tus tswv.
Verapamil: Verapamil tuaj yeem ua rau bradycardia thiab txo cov ntshav siab thaum siv nrog beta-blockers (ua ke siv nrog atenolol, propranolol, thiab pindolol tau tshaj tawm). Verapamil thiab beta-blockers muaj cov nyhuv inhibitory ntxiv ntawm atrioventricular conduction thiab sinoatrial node muaj nuj nqi.
Kev kho tshuaj yuav tsum tau siv thaum cov khoom no siv nrog rau cov tshuaj hauv qab no:
Amiodarone
Class I cov tshuaj antiarrhythmic
Nonsteroidal anti-inflammatory / tshuaj tiv thaiv kab mob (NSAIDs)
Diphenhydramine
Yog tias koj xav paub txog ToprolX chaw tsim tshuaj paus, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email, thiab tom qab ntawd koj tau txais cov ntaub ntawv API zoo.
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