Gardenia tuaj yeem muab rho tawm
Geniposide hmoovTxoj kev rho tawm feem ntau siv cov kuab tshuaj organic xws li chloroform thiab cov ethanol kom muab rho tawm hauv Soxhlet extraction lub raj mis kom tau txais tag nrho cov khoom muaj txiaj ntsig gardenia glycosides hauv gardenia, ces cais nws ntawm silica gel kem. Yuav kom tau txais geniposide muaju, elute nrog methanol thiab chloroform sib tov. Tom qab ntawd, recrystallize lub eluate hauv acetone. Feem ntau, txog 4.0g ntawm nws tuaj yeem raug cais tawm ntawm 100g ntawm gardenia txiv hmab txiv ntoo. Cov txheej txheem rho tawm feem ntau yog siv cov kuab tshuaj los rho cov tshuaj tsw qab los ntawm paj. Cov roj rho tawm tuaj yeem siv rau ntau lub hom phiaj, xws li tshuaj tsw qab, xab npum, thiab tswm ciab.
Gardenia yog ib qho iridoid glycoside uas yooj yim soluble hauv dej thiab yog cov tshuaj tseem ceeb ntawm gardenia. Nyob ntawm qhov chaw ntawm keeb kwm, nws cov ntsiab lus yog kwv yees li 3% mus rau 8%. Nws tuaj yeem hydrolyzed rau nws los ntawm beta-glucosidase. Cov kev tshawb fawb niaj hnub no qhia tau hais tias nws cuam tshuam rau cov kab mob ntawm lub plab zom mov, kab mob plawv, thiab lub paj hlwb hauv nruab nrab. Tsis tas li ntawd, nws tseem muaj cov tshuaj tiv thaiv tshwj xeeb thiab cov ntaub so ntswg puas tsuaj. Ntxiv nrog rau nws cov tshuaj, nws kuj tau siv dav hauv lwm qhov chaw, xws li cog cov qoob loo nce cov neeg sawv cev, tshuaj tua kab mob lom neeg, thiab lwm yam. Yog tias koj xav tau cov tshuaj cog qoob loo, thov hu rau Xi'an Sonwu. Xi'an Sonwu tuaj yeem muab koj cov ntshiab gardeniposide.
Yog Gardenia zoo rau daim tawv nqaij
Geniposide muaj cov txiaj ntsig zoo rau daim tawv nqaij. Vim nws cov tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob antioxidant, nws tuaj yeem siv rau hauv cov khoom tu tawv nqaij los pab txo qhov mob thiab tiv thaiv daim tawv nqaij los ntawm kev puas tsuaj oxidants, uas tuaj yeem ua rau kev laus thiab lwm yam teeb meem ntawm daim tawv nqaij. Vim nws cov tshuaj tiv thaiv kab mob thiab antioxidant zoo, nws tau dav ntxiv rau cov khoom tu tawv nqaij. Nws tuaj yeem pab cov tawv nqaij tiv thaiv dawb radical puas rau ntawm daim tawv nqaij thiab tiv thaiv cov tawv nqaij o, yog li tiv thaiv daim tawv nqaij los ntawm kev puas tsuaj los ntawm ib puag ncig sab nraud. Tsis tas li ntawd, qee lub npe tshuaj pleev ib ce kuj ntxiv rau lawv cov khoom siv ntxuav hniav dawb, uas tau hais tias muaj txiaj ntsig zoo inhibit qhov kev sib txuas ntawm melanin thiab ua rau daim tawv nqaij translucent. Hauv ntau lub tebchaws, gardenia nquag siv tshuaj ntsuab tshuaj ntsuab rau kev kho mob thiab tshuaj pleev ib ce, thiab gardeniposide yog suav tias yog ib qho ntawm nws cov khoom xyaw tseem ceeb pharmacologically active. Ntxiv nrog rau nws cov txiaj ntsig ntawm daim tawv nqaij, nws tau pom tias muaj peev xwm siv dav hauv kev tshawb fawb sib txawv xws li tshuaj, tshuaj, tshuaj pleev ib ce, thiab kev tshawb fawb txog roj ntsha.
Kev kho mob: Geniposide tau ua rau muaj kev txaus siab rau kev kho mob, thiab muaj cov lus ceeb toom tias nws yuav muaj cov tshuaj tiv thaiv neuroprotective, antioxidant, tiv thaiv kab mob, txo cov roj cholesterol, thiab lwm yam kev cuam tshuam. Cov kev tshawb fawb tau pom tias nws tuaj yeem cuam tshuam zoo rau lub paj hlwb, muaj cov teebmeem neuroprotective, thiab muaj peev xwm ua tshuaj muaj txiaj ntsig zoo hauv kev kho cov kab mob paj hlwb. Tsis tas li ntawd, nws tau pom los ntawm cov kws tshawb fawb kom muaj cov tshuaj tiv thaiv antioxidant thiab tiv thaiv kab mob. Cov khoom no muab lub hauv paus kev tshawb fawb rau nws cov peev txheej hauv kev kho cov kab mob inflammatory lossis mob ntev. Tsis tas li ntawd, qee qhov kev tshawb fawb tau pom tias nws yuav muaj cov txiaj ntsig txo cov roj cholesterol, uas ua rau nws tseem nyiam kev kho mob plawv.
Pharmacological teb: Lub luag hauj lwm ntawm nws nyob rau hauv lub pharmacological cheeb tsam tau attracted ntau xim. Cov txiaj ntsig kev sim qhia tau hais tias nws muaj cov nyhuv anticoagulant tshwj xeeb, ua rau nws muaj txiaj ntsig zoo rau kev kho mob plawv thiab cerebrovascular. Tsis tas li ntawd, nws tau pom tias muaj cov tshuaj tiv thaiv kev ntxhov siab thiab kev ntxhov siab, ua rau nws tseem muaj peev xwm pab tau rau kev kho mob paj hlwb thiab kev puas siab puas ntsws.
Biological Sciences: Hauv kev tshawb fawb txog kev tshawb fawb ntawm lub cev, nws yog qhov tseem ceeb hauv cell thiab molecular biology.
Leej twg yuav tsum tsis txhob noj Gardenia Extract
Digestive tsis xis nyob: Muaj cov ntaub ntawv qhia tias qee tus neeg yuav ntsib kev tsis zoo ntawm plab zom mov xws li xeev siab, ntuav, raws plab, lossis plab zom mov vim siv nws.
Muaj peev xwm ua xua: Cov neeg uas ua xua rau gardenia los yog geniposide cov khoom xyaw yuav muaj kev tsis haum tshuaj xws li liab, khaus, o, lossis ua pa nyuaj.
Muaj peev xwm siv tshuaj sib cuam tshuam: Nws tuaj yeem cuam tshuam nrog qee yam tshuaj, tejzaum nws cuam tshuam cov metabolism ntawm cov tshuaj no lossis ua rau muaj kev pheej hmoo ntawm lawv cov kev mob tshwm sim.
Raws li kev paub tam sim no, cov pab pawg hauv qab no yuav tsum tau siv ceev faj lossis zam.
Cov menyuam yaus: Txij li cov yam ntxwv ntawm lub cev thiab cov tshuaj metabolism hauv cov menyuam yaus txawv ntawm cov neeg laus, tsis muaj cov ntaub ntawv tshawb fawb txaus txog kev nyab xeeb ntawm kev siv cov menyuam yaus. Yog li ntawd, kev pabcuam los ntawm cov menyuam yaus kuj yuav tsum tau ua nrog ceev faj thiab raws li tus kws kho mob qhia.
Cov poj niam cev xeeb tub thiab cov poj niam cev xeeb tub: Rau cov poj niam cev xeeb tub thiab cov poj niam laus, vim tias kev nyab xeeb ntawm nws thiab nws cov kev cuam tshuam rau tus menyuam hauv plab thiab tus menyuam mos tsis tau kawm txaus, nws yog qhov zoo tshaj rau cov tib neeg nyob rau lub sijhawm no kom tsis txhob siv nws lossis nyob rau hauv kev saib xyuas ntawm tus kws kho mob siv ceev faj.
Cov neeg mob uas muaj kab mob ntev: Rau cov tib neeg uas muaj mob ntev, tshwj xeeb tshaj yog cov neeg mob siab thiab lub raum tsis ua haujlwm, siv rau hauv cov xwm txheej no kuj yuav tsum tau ua tib zoo xav thiab nyob rau hauv cov lus qhia ntawm tus kws kho mob vim tias muaj feem cuam tshuam rau cov kab mob no.
Qhov zoo tshaj plaws Gardenia coj
Qee qhov kev tshawb fawb hauv vitro tau pom tias nws muaj ntau yam kev ua ub no xws li tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv atherosclerotic, tshuaj tiv thaiv kev ntxhov siab, kev tswj hwm ntawm Alzheimer's disease (AD), antihypertensive, toxicological, thiab tsis zoo. Nws txo qis OGD-induced zus tau tej cov IL-8, IL-1 , thiab MCP-1 nyob rau hauv lub hlwb microvascular endothelial hlwb, ua rau ib tug tseem ceeb downregulation ntawm P2Y14 receptor qhia thiab inhibiting phosphorylation ntawm RAF-1, MEK1/2, thiab ERK1/2. Hauv kev tshawb nrhiav vivo tau pom tias qhov txo qis ntawm TG, insulin, thiab ntshav qabzib tau ua tiav los ntawm geniposide (200 thiab 400 mg / kg) hauv cov nas ntshav qab zib. Cov compound kuj txo cov kev qhia ntawm GP thiab G6Pase ntawm mRNA thiab immunoreactive protein ntau thiab cov enzyme kev ua. Nws (20.0, 40.0, lossis 80 mg / kg) ua rau muaj kev cuam tshuam ntau dhau ntawm kev haus cawv ntau dhau ntawm cov ntshav ALT / AST thiab qib siab LPO. Txawm hais tias nws muaj ntau daim ntawv thov kev tshawb fawb txog kev kho mob thiab kev noj qab haus huv, kev kawm ntxiv yuav tsum nkag siab txog nws txoj kev ua thiab cov txiaj ntsig yav tom ntej hauv lwm qhov.
Yog tias koj xav paub cov chaw tsim khoom geniposide, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email, thiab tom qab ntawd koj tau txais geniposide zoo.
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