Kev noj tshuaj puas tuaj yeem ua rau koj muaj kev tawm dag zog? Cov kws tshawb fawb tsim cov tshuaj tawm dag zog
Kev Tshaj Tawm Xov Xwm Network tau tshaj tawm rau lub Peb Hlis 26 Raws li American Fun Science lub vev xaib nyob rau lub Peb Hlis 21, tuaj yeem noj tshuaj pub rau tib neeg cov txiaj ntsig zoo ib yam li khiav ntawm lub treadmill lossis ua kev kawm tiv thaiv? Hauv kev tshawb fawb tshiab, cov kws tshawb fawb tau ua lwm kauj ruam ntawm kev tsim cov tshuaj uas tuaj yeem sim ua kom muaj txiaj ntsig ntawm kev tawm dag zog ntawm cov hlwb.
Lub hom phiaj ntawm txoj kev tshawb no, raws li tsab ntawv ceeb toom, yog los tsim ib qho tshuaj uas tig rau cov keyboards hauv tib neeg lub hlwb uas ib txwm ua haujlwm los ntawm kev tawm dag zog. Baha Jandi, tus kws tshaj lij ntawm kws kho mob chemistry thiab tshuaj loog ntawm Washington University (St. Louis) Tsev Kawm Ntawv Tshuaj, uas tau coj txoj kev tshawb no, tau muab piv txwv tias cov keyboards no pab tswj thiab rov tsim cov leeg nqaij thiab txhawb kev ua haujlwm ntawm cellular "power stations. "
Nws tau hais tias yog tias cov kev hloov pauv ntawm tes tuaj yeem tshwm sim yam tsis muaj kev tawm dag zog, nws yuav muaj txiaj ntsig zoo rau cov neeg laus, cov neeg mob cov leeg nqaij dystrophy, thiab cov neeg uas yuav poob cov leeg nqaij thaum noj cov tshuaj xws li semaglutide uas muaj cov teebmeem yuag.
Nyob rau theem dav, nws siv rau cov neeg uas tsis tuaj yeem tawm dag zog vim lawv ntsib teeb meem loj ntawm lub cev. Jandi co-founded Paragos Pharmaceuticals, ib qho kev pib ua haujlwm rau kev tsim cov tshuaj qoj ib ce.
Hauv kev sib tham video, Jandi kuj tau hais tias cov tshuaj no kuj tseem yuav pab tau rau cov neeg uas tsis tau txais kev tawm dag zog txaus vim lawv tsis khoom ntau, lossis rau "cov neeg tub nkeeg zoo li kuv."
Hauv kev tshawb fawb yav dhau los, Jandi thiab cov npoj yaig tau tshawb pom cov molecule uas tuaj yeem tig cov kev tawm dag zog no hauv cov hlwb loj hlob hauv chav kuaj thiab hauv cov tsiaj hlwb. Tsis ntev los no, lawv tau siv cov molecule no los ua ib qho chaw pib los sim tsim cov tebchaw tshiab uas tuaj yeem ua kom zoo dua cov teebmeem ntawm kev tawm dag zog ntawm cov hlwb. Lawv tau nthuav tawm cov kev tshawb pom no ntawm lub rooj sib tham caij nplooj ntoos hlav ntawm American Chemical Society thaum Lub Peb Hlis 18. Txoj kev tshawb no yog ib kauj ruam me me rau kev siv cov tshuaj no hauv cov neeg mob.
Jandi tau hais tias "Yog tias txhua yam mus zoo, peb vam tias yuav pib sim tib neeg hauv ob peb xyoos tom ntej," Jandi tau hais.
Cov kws tshawb fawb 'quest pib nrog nrhiav cov molecules uas tuaj yeem ntsaws rau hauv cov qauv ntawm cov hlwb hu ua "estrogen-related receptors."
Cov receptors no muaj nyob thoob plaws hauv lub cev, thiab lawv tseem ceeb tshwj xeeb hauv cov ntaub so ntswg uas xav tau lub zog siab, xws li cov leeg pob txha, lub plawv thiab lub hlwb.
Muaj peb hom estrogen-related receptors - alpha, beta thiab gamma. Yav dhau los, cov kws tshawb fawb tau pom txoj hauv kev los qhib beta thiab gamma receptors nrog cov khoom siv dag zog. Txawm li cas los xij, alpha, uas paub tias muaj nyob hauv lub hlwb thiab cov leeg pob txha, yog qhov nyuaj rau lub hom phiaj.
"Qee tus neeg hais tias nws yuav tsis ua haujlwm raws li lub hom phiaj tshuaj," Jandi tau hais. Tab sis ib qho tshiab molecule tsim los ntawm pab pawg, hu ua SLU-PP-332, ua kom tag nrho peb hom estrogen-related receptors, tshwj xeeb tshaj yog alpha. Cov kws tshawb fawb tau piav qhia txog qhov sib xyaw ua ke hauv ib daim ntawv dhau los, uas tau luam tawm thaum Lub Peb Hlis 2023 hauv phau ntawv Journal ACS Chemical Biology.
Hauv kev tshawb fawb hauv chav kuaj, qhov sib xyaw ua ke txhawb cov leeg pob txha metabolism. Nws txhim kho qhov kev ua siab ntev ntawm cov nas thaum khiav thiab nce cov leeg qaug zog-resistant nqaij fibers hauv cov nas.
Hauv qhov kev tshawb fawb tshiab kawg, pab pawg tau rov hais dua ntawm SLU-PP-332 thiab tsim cov molecules tshiab. Cov molecules tshiab no tuaj yeem ua kom nruj dua nrog tag nrho peb cov receptors, muaj kev ua tau zoo dua, thiab tsis ua rau muaj kev poob siab.
SLU-PP-332 hmoovyog SLU-PP-332 peptide hmoov, nws yog siv los kawm cov kab mob metabolic thiab tuaj yeem txhim kho cov leeg nqaij vim nws tuaj yeem txhim kho mitochondrial muaj nuj nqi thiab cellular respiration nyob rau hauv skeletal leeg cell kab. nws tuaj yeem simulate cov teebmeem ntawm kev tawm dag zog los txhawb cov leeg kev loj hlob txhim kho lub cev kev ua haujlwm, thiab muaj peev xwm kho cov rog thiab cov leeg nqaij atrophy los ntawm kev tsis muaj kev tawm dag zog.
Cov txiaj ntsig ntawm SLU PP 332 qia los ntawm nws lub luag haujlwm ua lub lauj kaub-agonist rau cov tshuaj estrogen receptor-related orphan receptors (ERR .ERR thiab ERR), uas tswj lub zog metabolism thiab mitochondrial muaj nuj nqi. Txawm hais tias nws tau siv feem ntau hauv kev tshawb fawb chaw, cov txiaj ntsig hauv qab no tau pom raws li nws cov txheej txheem ntawm kev ua:
1. Txhim kho Mitochondrial Function
Nws boosts mitochondrial biogenesis thiab txhim kho mitochondrial efficiency.
2.Metabolic kev txhim kho
Los ntawm activating ERR receptors, nws txhim kho fatty acid oxidation thiab qabzib metabolism, ua rau nws muaj txiaj ntsig zoo hauv kev tshawb fawb txog cov teeb meem metabolic xws li Kev rog, Hom 2 Ntshav Qab Zib, thiab Metabolic Syndrome.
3.Potential Cardioprotective Effects
SLU-PP-332 qhia txog cov txiaj ntsig zoo rau lub plawv tsis ua haujlwm thiab lwm yam mob plawv.
4.Anti-inflammatory thiab Aging Benefits
SLU-PP-332 tuaj yeem pab rov qab cov cim ntawm kev laus thiab tiv thaiv kab mob ntsig txog hnub nyoog.
SLU-PP-332 hmoovtuaj yeem txhawb kev poob phaus, txawm hais tias nws tsis ncaj qha marketed.lts lub luag hauj lwm hauv activating estrogen receptor-related orphan rceptors (ERR .ERR thiab ERR) heps los tswj fatty acid oxidation thiab qabzib metabolism.Qhov no txhim kho cov metabolism hauv tuaj yeem nce kev siv nyiaj, ib qho tseem ceeb. hauv kev tswj qhov hnyav thiab txo cov rog.
1.Fat Oxidation:Los ntawm kev txhawb kev tawg ntawm fatty acids rau lub zog, nws tuaj yeem pab txo cov khw muag khoom rog, uas tuaj yeem ua rau poob phaus.
2.Kev Txhim Kho Zog Metabolism:Nws cuam tshuam rau kev ua haujlwm mitochondrial thiab lub zog ua haujlwm tuaj yeem txhawb nqa calorie hlawv thaum lub sijhawm ua haujlwm lub cev, txhawb kev rog.
3.Regulation ntawm Glucose Metabolism:Los ntawm kev txhim kho lub cev ua cov piam thaj li cas, nws tuaj yeem pab tswj cov qib insulin, ntxiv kev pab tiv thaiv cov rog cia thiab txhawb kev tswj qhov hnyav.
Yog tias koj xav tau SLU PP 332, Xi'an Sowu tuaj yeem muab tau.Xi'an Sonwu tos ntsoov yuav hnov los ntawm koj.