Puas yog tib neeg kev loj hlob Hormone hmoov tiag tiag ua haujlwm? ? ?

Puas yog tib neeg txoj kev loj hlob hormone hmoov tiag tiag ua haujlwm? ? ?
Nyob rau hauv xyoo tas los no, cov kev tshawb fawb hauv tsev thiab txawv teb chaws tau pom tias kev loj hlob hormone tuaj yeem txhim kho cov khoom noj khoom haus ntawm cov neeg mob uas kub hnyiab hnyav thiab txhim kho lub cev tiv thaiv kab mob.
Yog li dab tsi raws nraim yog kev loj hlob hormone hmoov?
Tib neeg txoj kev loj hlob hormone hmoov, hu ua kev loj hlob hormone, yog tsim los ntawm recombinantEscherichia coli secretoryexpression technology thiab yog tag nrho raws li tib neeg pituitary loj hlob hormone nyob rau hauv cov nqe lus ntawm cov amino acid cov ntsiab lus, ib theem zuj zus, thiab protein ntau lawm. , thiab cell egeneration hauv tib neeg thiab lwm yam tsiaj. Tsis tas li ntawd, cov tshuaj hormones loj hlob tuaj yeem txhawb nqa kev tsim cov lGF-1 thiab ua kom cov concentration ntawm qabzib thiab cov rog dawb.
Nyob rau hauv lub feld ntawm pediatrics, hloov kho nrog recombinant tib neeg txoj kev loj hlob hormone tuaj yeem txhawb cov menyuam qhov siab loj hlob thiab txhim kho kev loj hlob thiab kev loj hlob ntawm ntau yam kabmob thiab cov ntaub so ntswg thoob plaws hauv lub cev. kub hnyiab, thiab tiv thaiv agingfields.ltis tam sim no tau tshawb fawb kom muaj txiaj ntsig zoo ntawm cov tsiaj txhu hauv kev ua liaj ua teb. Hauv Tebchaws Meskas, theonlyFDA-pom zoo kev loj hlob hormone siv rau hauv cov tsiaj nyeg yog ib qho kev loj hlob hormone tshwj xeeb rau cov nyuj, hu ua bovine somatotropin, txhawm rau nce cov kua mis hauv cov nyuj.
HGH yog ib qho tshuaj hormones protein secreted los ntawm eosinophils nyob rau hauv lub anterior pituitary caj pas thiab muaj ib tug high degree ntawm hom kab mob.Encoded los ntawm GH noob nyob rau ntawm chromosome 17, nws tsuas yog muaj nyob rau hauv lub cev nrog ib tug molecular hnyav ntawm 22, 000 Daltons (22Kd), accounting txog li 90% ntawm circulating GH.
(1) Indirect cell-txhawb cov nyhuv
Cov tshuaj hormones loj hlob tuaj yeem ua rau muaj kev loj hlob ntawm cov hlwb.Nws tsim cov tshuaj hormones loj hlob los ntawm kev ua haujlwm ntawm kev loj hlob hormone receptor (GHR) ntawm daim siab cell membrane, xws li los ntawm IGF-1 kev sib kho, los txhawb kev loj hlob thiab kev loj hlob ntawm cov hlwb thoob plaws hauv lub cev. .
(2) Direct metabolic kev cai
rhGH tuaj yeem txhawb kev tsim cov protein, txo cov protein decomposition, tswj cov nitrogen tshuav, nce cov rog oxidation thiab deterioration, nce gluconeogenesis, txhim kho kev siv suab thaj, thiab txhim kho cov khoom noj hloov pauv. nce plab hnyuv Absorption ntawm calcium thiab phosphorus.
(3) lmmunomodulatory nyhuv
HGH txhawb kev tsiv teb tsaws ntawm phagocytes los ntawm kev txhawb nqa kev loj hlob ntawm cov pob txha hlwb, ua rau phagocytes tsim cov superoxide anion thiab cytokines, thiab txhim kho kev ua haujlwm ntawm opsonins. Tsis tas li ntawd, nws tseem ua lub luag haujlwm tseem ceeb hauv stimulatingB hlwb los tsim cov immunoglobulins, thiab lwm yam, thiab txhim kho kev tiv thaiv kab mob.