Ntau tshaj li qhov kev xav yav dhau los, 3.75 lab tus tib neeg tuag los ntawm cov kab mob fungal thoob ntiaj teb txhua xyoo
Kev kwv yees ntawm qhov tshwm sim ntawm cov kab mob fungal tam sim no yog qhov tsis tseeb, nrog rau kev tshawb fawb tsis ntev los no, luam tawm xyoo 2017, muab cov naj npawb ntawm cov kab mob fungal tuag ntawm kwv yees li 1.5 lab rau 2 lab.
Tag nrho cov neeg tuag los ntawm cov kab mob fungal thoob ntiaj teb txhua xyoo tau nce mus rau 3.75 lab, ob npaug ntawm kev kwv yees yav dhau los, raws li kev tshawb fawb tshiab.
Txoj kev tshawb no yuav raug luam tawm nyob rau hauv Lancet Infectious Diseases nyob rau hauv lub npe: Ntiaj teb no tshwm sim thiab tuag ntawm tus kab mob loj fungal nyob rau yav tom ntej.
Hauv daim ntawv, David Denning, tus kws tshaj lij ntawm cov kab mob sib kis ntawm University of Manchester, tau siv cov ntaub ntawv los ntawm ntau dua 80 lub tebchaws los suav tias muaj kwv yees li 6.55 lab tus kabmob kis kabmob kis thoob ntiaj teb txhua xyoo, ua rau 3.75 lab tus neeg tuag.
Txawm hais tias cov kab mob fungal muaj ntau yam ua rau, qhov hloov tshiab ntawm cov kab mob fungal cuam tshuam txog kev tuag tseem nyob deb tshaj cov los ntawm lwm cov kab mob, rau lub sijhawm ntau dua li cov uas tshwm sim los ntawm malaria thiab yuav luag peb npaug ntawm cov uas tshwm sim los ntawm tuberculosis.
Txoj haujlwm no yog qhov tshwm sim los ntawm kev sib koom tes ntawm ntau tshaj 300 tus kws tshawb fawb thoob ntiaj teb, uas tau tshaj tawm kev kwv yees ntawm cov kab mob fungal hauv lawv lub tebchaws thiab cov tib neeg.
Tus xibfwb David Denning ntseeg tias qhov kev kwv yees yav dhau los tsis raug vim tias muaj ntau cov kab mob fungal tuaj yeem ua rau cov kab mob uas twb muaj lawm, xws li leukemia lossis AIDS, thiab cov kab mob no feem ntau mob hnyav.
Raws li qhov kev tshawb fawb tshiab no, kwv yees li 68% (2.55 lab) ntawm cov kab mob fungal uas cuam tshuam txog kev tuag (3.75 lab) tuaj yeem cuam tshuam ncaj qha los ntawm cov kab mob fungal. Qhov seem 32% (1.2 lab tus tib neeg) muaj lwm yam kab mob hauv qab, nrog cov kab mob fungal yog ib qho ntawm cov txiaj ntsig.
Txoj kev tshawb nrhiav pom tias kwv yees li ib feem peb ntawm 3.23 lab tus neeg tuag los ntawm tus kab mob ntsws ntsws ntev (COPD) thoob ntiaj teb muaj feem cuam tshuam nrog kev kis tus kab mob fungus Aspergillus. Tsis tas li ntawd, 1.2 lab tus tib neeg tuag los ntawm tuberculosis hauv 2019, tab sis txoj kev tshawb fawb kwv yees tias ntau npaum li 340,000 ntawm cov neeg tuag (28%) tej zaum yuav yog los ntawm cov kab mob fungal.
Muaj kwv yees li ntawm 311,594 tus kab mob leukemia tuag thoob ntiaj teb xyoo 2020, ntawm 14,000 (4.5%) yog vim muaj kab mob los ntawm cov kab mob fungal Aspergillus thiab qee qhov rau lwm yam kab mob fungal. Mob ntsws thiab mob ntsws bronchial tua 1.8 lab tus tib neeg txhua xyoo, thiab txoj kev tshawb fawb kwv yees tias 49,{10}} (2.7%) ntawm cov neeg tuag no tej zaum yuav tshwm sim los ntawm cov kab mob Aspergillus.
Candida yog tus kab mob fungal loj uas tshwm sim hauv kev saib xyuas hnyav, cov neeg mob phais nyuaj, ntshav qab zib, mob qog noj ntshav thiab lub raum tsis ua haujlwm, thiab hauv cov menyuam mos ntxov ntxov. Txoj kev tshawb fawb tau kwv yees tias kwv yees li 1.57 lab tus tib neeg tsim cov kab mob Candida hauv cov hlab ntshav lossis cov kab mob Candida invasive txhua xyoo, ntawm 995, 000 (63.6%) tuag.
Tus xibfwb David Denning tau hais tias txoj haujlwm no yog thawj qhov kev tshwm sim txhua xyoo kwv yees ntawm cov kab mob fungal hauv ntiaj teb, tab sis tseem muaj ntau qhov sib txawv thiab tsis paub tseeb. Kev kwv yees yav dhau los ntawm tus naj npawb txhua xyoo ntawm cov kab mob fungal tuag yog 1.5 lab rau 2 lab, tab sis tam sim no tau pom tias tus naj npawb ntawm cov neeg yuav tuag los ntawm cov kab mob fungal yog ob npaug ntawm tus lej, kwv yees li 3.75 lab.
Nws kuj tau hais tias txoj haujlwm no yuav tsis tuaj yeem ua tsis tau yog tias tsis muaj kev sib koom tes zoo ntawm ntau dua 300 tus kws tshawb fawb los ntawm thoob plaws ntiaj teb, uas tau tshaj tawm cov ntaub ntawv ntsuam xyuas cov kab mob fungal hauv lawv lub tebchaws thiab cov tib neeg.
Micafungin sodium hmoovyog ib tug semi-synthetic lipopeptide compound uas belongs rau ib chav kawm ntawm cov tshuaj hu ua cyclosporins.lt yog tus thib ob echinocandin tshuaj mus rau hauv kev kho mob xyaum tom qab caspofungin.Ilt muaj peev xwm competltively inhibit lub synthesis ntawm 1, 3-$-Dglucan, ib tug tseem ceeb tivthaiv. Cov kab mob fungal ntawm phab ntsa ntawm tes, uas yog qhov ua rau cov kab mob sib sib zog nqus fungal. Cov kab mob fungi Aspergillus thiab Candida muaj cov kab mob dav dav ntawm cov kab mob fungal.Lawv tiv thaiv thiab kho cov kab mob loj heev los ntawm cov poov xab thiab cov fungi, xws li candida thiab fungal kab mob.
Nws muaj zog heev tiv thaiv Candida Aspergillus thiab tawm tsam azole-thiab amphotericin B-resistant hom.In immunocompromised cov tib neeg, candidiasis thiab aspergillosis tuaj yeem kho nws tus kheej lossis nrog lwm cov tshuaj tua kab mob. Lawv yog cov cuab yeej siv los tiv thaiv cov kab mob fungal hauv cov neeg txais kev cog qoob loo.Indications suav nrog cov kab mob fungal tshwm sim los ntawm Aspergillus thiab Candida, ua pa mycoses, thiab plab hnyuv mycoses. , 3-8-Dglucansynthase, thiab asan antifungal tus neeg sawv cev tsis cuam tshuam cov kab mob.Txawm hais tias nws tsis ncaj qha inhibit cov kab mob, nws txhim kho cov ciaj sia taus ntawm G.mellonella thiab inhibits biofilm tsim los ntawm thaiv 1,3-8-D-glucan synthesis hauv Candidalbicans.
Invasive Candidiasis:Micafungin zoo kho cov kab mob Candida invasive, suav nrog Candidemia (systemicCandidainfection) thiab lwm yam kab mob Candida sib sib zog nqus.
Esophageal Candidiasis:Micafungin yog qhia rau kev kho mob esophageal candidiasis, kab mob fungal uas cuam tshuam rau lub qhov txhab ntawm txoj hlab pas.lt pab txo cov tsos mob thiab txhawb kev kho.
Micafungin inhibits Candida kab mob nyob rau hauv cov tib neeg uas tau txais hematopoietic qia cell transplantation (HSCT), ib qho kev tiv thaiv.Vim lawv lub cev tsis muaj zog, HSCT cov neeg mob feem ntau yuav kis tau tus kab mob fungal; micafungin pab txo qis kev kis tus kab mob Candida hauv cov neeg no.
Prophylaxis hauv Invasive Aspergillosis: Micafungin tau kawm txog nws txoj kev siv tshuaj tiv thaiv kab mob tiv thaiv kab mob invasiveAspergillus hauv qee cov neeg mob uas muaj kev pheej hmoo siab, xws li cov neeg uas muaj neutropenia ntev.
Yog tias koj txaus siab rau cov khoom siv tshuaj tua kab mob thiab xav tau ntshiab micafungin sodium, Xi'an Sonwu yuav tsum yog koj qhov kev xaiv zoo tshaj.