Lub ntsiab tiv thaiv qog nqaij hlav ntawm genistein: inhibiting qhov rov ua dua thiab metastasis ntawm cov qog nqaij hlav cancer metastatic
Genisteinisoflavone ib txwm tshwm sim nyob rau hauv legumes thiab toothed nroj tsuag. Nws cov qauv zoo ib yam li cov tshuaj estrogen thiab muaj cov nyhuv estrogenic tsis muaj zog, yog li nws tseem hu ua phytoestrogens. ). Genistein tseem hu ua non-steroidal estrogen vim nws sib tw khi rau cov tshuaj estrogen receptor (ER).
Tsis tas li ntawd, genistein yog muab los ntawm cov nroj tsuag ntuj thiab muaj dav nyob rau hauv cov taum pauv, sophora pods, clover keeb kwm, thiab ntau yam zaub thiab txiv hmab txiv ntoo. Ntawm lawv, cov nroj tsuag leguminous muaj cov ntsiab lus siab thiab suav rau feem ntau isoflavones hauv tib neeg kev noj haus. 60%. Ntuj isoflavones yog ib qho sib xyaw ntawm polyphenols, feem ntau suav nrog genistein (4ˊ,5,7-trihydroxyisoflavone), daidzein, daidzein, thiab lwm yam. Genistein yog nws lub ntsiab physiological tivthaiv thiab muaj kev tiv thaiv kabmob kheesxaws.
1. Kev tshawb fawb xaus ntawm lub peev xwm ntawm genistein los inhibit qhov rov ua dua thiab metastasis ntawm ntau cov qog nqaij hlav cancer
Thaum ntxov li 1987, Akiyama li al. Genistein tau pom tias yog ib qho tshwj xeeb thiab muaj zog inhibitor ntawm tyrosine-protein kinases. Cov txiaj ntsig kev tshawb fawb pom tau tias cytisin tawm dag zog los tiv thaiv qog noj ntshav los ntawm inhibiting cov haujlwm ntawm kev loj hlob receptor "tyrosine protein kinase". Txij li thaum cov kev tshawb fawb txog kab mob kis tau pom tias genistein yog ib qho tshuaj tiv thaiv kab mob qog noj ntshav, genistein tau ua rau muaj kev tshawb fawb txog kev txaus siab ntawm cov kws tshawb fawb thoob ntiaj teb.
2. Lub hauv paus ntsiab lus ntawm genistein inhibiting qhov rov ua dua thiab metastasis ntawm cov qog nqaij hlav cancer
Ntau cov kev tshawb fawb tau pom tias genistein yog ib qho muaj zog inhibitor ntawm tyrosine protein kinase thiab topoisomerase. Nws muaj ntau yam tshuaj tiv thaiv qog noj ntshav thiab tuaj yeem cuam tshuam cov qog loj hlob thiab metastasis los ntawm ntau txoj hauv kev.
①. Kev tswj hwm ntawm oncogenes:Genistein tswj hwm oncogenes los ntawm inhibiting cov kev ua ntawm tyrosine protein kinase thiab topoisomerase II, inhibits tej cell cycles, thiab inhibits proliferation, loj hlob thiab metastasis ntawm malignant hlwb.
②. Inducing malignant cell apoptosis:Genistein tuaj yeem thaiv cell agonistic signaling, hloov cov noob qhia, ua rau cell DNA puas, yog li inducing programmed tuag ntawm malignant hlwb, uas yog, apoptosis, yog li inhibiting qog loj hlob.
Genistein hmoovinhibits tshwj xeeb tyrosine protein kinases thiab DNA topoisomerase, lub ntuj tsim tshuaj tiv thaiv kab mob. Qhov kev txiav txim ntawm ob qho enzymes tuaj yeem thaiv ntau txoj hauv kev, suav nrog kev tswj hwm cov noob tsis raug thiab tiv thaiv kev loj hlob thiab metastasis ntawm cov kab mob. Cov tshuaj ua rau DNA fragmentation thiab apoptosis thiab induces G2 / M cell voj voog ntes los ntawm inhibition ntawm topoisomerase-II. Nws muaj txiaj ntsig kev noj qab haus huv, suav nrog nws cov tshuaj tiv thaiv kab mob thiab antioxidant zoo, tau nyiam mloog. Genistein yog siv los thim rov qab tswj homocysteine thiab lwm yam tyrosine kinase inhibitors. Nws tuaj yeem txhim kho insulin tsis kam thiab tiv thaiv kev mob ntshav qab zib, inhibit kab mob ntawm tes ua haujlwm, inhibit prostate cancer thiab kev ua haujlwm antioxidant. Nws extraction muab tshiab raw cov ntaub ntawv thiab functional additives rau cov zaub mov thiab kws industries.
1.Anti-pathological cell nyhuv
Genistein hmoovCov tshuaj no muaj zog tiv thaiv kab mob ntawm cov hlwb.Los ntawm qhov kev pom tseem ceeb, differenola yog ib qho muaj zog inhibitor.Nws cov khoom siv tshuaj yog manifold, raws li hauv qab no:
①Cov pab pawg neeg tsis zoo ntawm kev loj hlob muaj zog PTK kev ua haujlwm ntawm qhov sib txawv receptor.
② Los ntawm lub voj voog loj hlob ntawm tes,Thaum cov hlwb dhau los ntawm GZto M theem, cell cycle-dependent protein kinases yuav ua, yog li tswj tau zoo thiab tswj cov tib neeg tyrosine phosphorylation kom zoo inhibit kev loj hlob ntawm cov kab mob hlwb.Nws yog dav siv hauv cov kab mob xws li mis, prostate, ntsws, leukemia, thiab lwm yam. .thiab tau ua tiav cov txiaj ntsig zoo.
2.Estrogen zoo li cov teebmeem
Los ntawm cov qauv tshuaj pom, cov qauv ntawm differenola zoo ib yam li estradiol.Tom qab tus neeg mob siv cov tshuaj, cov tshuaj tuaj yeem khi rau cov tshuaj estrogen hauv tib neeg lub cev.
3.Effect ntawm pob txha metabolism
Osteoporosis yog ib hom kab mob hauv chaw kho mob uas muaj cov txheej txheem nyuaj thiab ntau yam ua rau. Hauv kev sim hauv vitro, 10-5molLdifferenola thiab 10-9-10-10molL estradiol muaj qhov sib npaug ntawm cov pob txha metabolism.
4. Hypolipidemic nyhuv
Kev tshawb fawb pom tau tias cov khoom noj taum pauv thiab lawv cov khoom siv 'isoflavones tuaj yeem txo cov roj cholesterol thiab tiv thaiv atherosclerosis.Genistein muaj cov tshuaj tiv thaiv kab mob antioxidant thiab tuaj yeem ua kom cov LDL receptor ua haujlwm tau zoo, yog li txo cov roj cholesterol hauv tib neeg lub cev. Tib lub sijhawm, cov tshuaj tuaj yeem cuam tshuam cov synthesis. ntsig txog cov tshuaj hormones.
Yog tias koj tseem xav tau cov khoom xyaw isoflavone, thov hu rau Xian Sonwu.Xi'an Sonwu tuaj yeem pab koj nrog cov genistein ntshiab.