Dihydroartemisinin hmoov

Dihydroartemisinin yog dab tsi

Dihydroartemisinin hmoovyog ib qho tshuaj tiv thaiv kab mob muaj zog thiab cov metabolite ntawm artemisinin, ib yam khoom ntuj tsim los ntawm cov nroj tsuag Artemisia annua. Nws yog nyob rau hauv chav kawm ntawm cov tshuaj artemisinin, uas tau hloov kho kev kho mob malaria, tshwj xeeb tshaj yog nyob rau hauv cov cheeb tsam uas cov tshuaj tiv thaiv yog ib qho kev txhawj xeeb tseem ceeb. DHA tau dav siv los ua ib feem ntawm artemisinin-raws li kev kho mob ua ke (ACTs) los kho cov mob malaria tsis sib xws los ntawm Plasmodium falciparum, cov kab mob malaria feem ntau tuag taus.

Artemisinin, leej niam leej txiv ntawm DHA, raug cais tawm ntawm Artemisia annua cog los ntawm Suav cov kws tshawb fawb hauv xyoo 1970. Cov tshuaj suav tshuaj tau ntev tau lees paub txog cov khoom siv tshuaj ntawm Artemisia cog, thiab kev cais tawm ntawm artemisinin tau ua qhov tseem ceeb hauv kev tawm tsam malaria. Artemisinin tau pom tias muaj cov tshuaj tiv thaiv kab mob zoo tshaj plaws, tab sis nws tsis zoo solubility thiab lub neej luv luv txwv nws cov peev xwm kho mob. Qhov no ua rau muaj kev txhim kho ntawm nws cov khoom muaj zog thiab ruaj khov, DHA.

Hom kev ua ntawm DHA teeb nws sib nrug los ntawm ntau lwm yam tshuaj tiv thaiv kab mob. Thaum muab tshuaj, DHA nkag mus rau hauv cov metabolism hauv lub cev sai, feem ntau hauv daim siab, tsim nws cov active compound. DHA cov txheej txheem ntawm kev ua haujlwm feem ntau cuam tshuam txog kev tsim cov pa oxygen reactive (ROS) hauv cov qe ntshav liab uas muaj kab mob malaria parasite. Nyob rau hauv lub xub ntiag ntawm hlau, DHA's endoperoxide choj undergoes reductive activation, ua heev reactive dawb radicals, uas yog lom rau cov cab. Cov dawb radicals alkylate tseem ceeb parasite proteins, cuam tshuam cov cab kab mob ntawm cov cell membrane, thiab ua rau kev puas tsuaj rau nws cov biomolecules, ua rau kev puas tsuaj ntawm cov cab.

DHA paub txog nws qhov pib ua haujlwm sai thiab muaj peev xwm txo tau cov kab mob parasite biomass sai. Qhov no yog qhov tseem ceeb tshwj xeeb hauv kev kho mob malaria hnyav, qhov kev teb sai thiab zoo yog qhov tseem ceeb. Thaum ua ke nrog ib tus khub tshuaj, DHA pab kom ua tiav ob lub hom phiaj ntawm kev txo cov kab mob sai sai thaum tseem tiv thaiv qhov tshwm sim ntawm cov tshuaj tiv thaiv kab mob malaria. ACTs tam sim no suav tias yog thawj kab kev kho mob rau cov neeg mob tsis sib haum xeeb ntawm malaria hauv ntau thaj tsam.

Ntxiv nrog rau nws cov tshuaj tiv thaiv kab mob, DHA kuj tau txais kev saib xyuas rau nws cov kev siv tau rau lwm yam kab mob. Qee qhov kev tshawb fawb tau tshawb nrhiav nws cov txiaj ntsig tiv thaiv lwm yam kab mob parasitic, xws li schistosomiasis, nrog rau nws cov tshuaj tiv thaiv kab mob tiv thaiv kab mob xws li kab mob siab B.

Lub purity ntawm peb lub tuam txhab dihydroartemisinin ntxiv tuaj yeem ncav cuag 99 feem pua. Tsis tas li, peb cov nqi sib tw heev piv rau lwm lub tuam txhab. Yog tias koj xav paub ntau ntxiv, thov hu rau Xi'an Sonwu Biotech Co. Ltd.

Yuav Dihydroartemisinin

Xi'an Sonwu muaj kev paub dhau los hauv kev lag luam thoob ntiaj teb thiab kev noj qab haus huv kev lag luam. Reputation-raws li zoo ua ntej yog lub hauv paus ntsiab lus ntawm Xi'an Songwu Company. Xi'an Sonwu nruj me ntsis tswj cov khoom zoo, yog li xaiv cov ntaub ntawv pib nrog raw cov ntaub ntawv. Tsis tas li ntawd, peb tswj txhua qhov kev nthuav dav thiab txo cov nqi kom peb cov neeg siv khoom tau txais cov khoom lag luam zoo tshaj plaws. Raws li cov no, cov neeg siv khoom tau txais kev qhuas siab rau peb cov khoom. Yog tias koj xav tau dihydroartemisinin ntxiv, nrhiav Xi'an Sonwu Biotech Co. Ltd.

Peb ua kom paub tseeb ntawm cov khoom zoo, yog li cov qauv tuaj yeem muab tau. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'Cov lus pom zoo

Kev Pabcuam OEM

Xi'an Sonwu tsis tsuas yog tuaj yeem muab cov khoom zoo dihydroartemisinin tshuajhmoovtab sis kuj muab nws cov tshuaj ntsiav.

Yog li txhua tus neeg siv khoom tuaj yeem kho cov tshuaj ntsiav lawv xav tau. Thiab cov khoom hauv qab no tuaj yeem muab tau.

Customized capsules shells (loj, xim, khoom)

Customized fwj (loj, xim, khoom, style)

Customized ntim (nqus foil ntim, thawv, nruas)

Customized daim ntawv lo (xim zaj duab xis, matte zaj duab xis, daim npog qhov muag)

Dihydroartemisinin Ua li cas

Dihydroartemisinin (DHA) yog tau los ntawm ntau cov txheej txheem los ntawm nws cov precursor ntuj, artemisinin, uas yog muab rho tawm los ntawm Artemisia annua cog. Ntawm no yog ib qho kev tawg ntawm cov txheej txheem tsim khoom rau dihydroartemisinin:

1. Cog Extraction: Artemisia annua nplooj yog harvested, feem ntau thaum lub sij hawm flowering theem, kom tau lub siab tshaj plaws concentration ntawm artemisinin. Cov khoom cog yog ces qhuav kom tshem tawm noo noo, thiab nplooj raug cais los ntawm stems thiab lwm yam impurities.

2. Solvent Extraction: Cov nplooj qhuav artemisia yog raug rau cov kuab tshuaj extraction txheej txheem. Cov kuab tshuaj feem ntau siv yog cov kuab tshuaj tsis muaj polar xws li hexane lossis roj av ether. Cov kuab tshuaj no tau zoo rho tawm artemisinin los ntawm cov khoom cog. Artemisinin-nplua nuj extract yog tau tom qab pom los yog centrifugation kauj ruam los cais cov khoom cog residues.

3. Crystallization thiab Purification: Cov artemisinin-nplua nuj extract tau dhau los ua cov txheej txheem crystallization kom cais thiab ntxuav cov artemisinin compound. Feem ntau, cov kuab tshuaj zoo li ethyl acetate los yog diethyl ether yog siv los ua kom cov extract, ua raws li kev tswj kom txias los yog evaporation kom induce crystal formation. Cov crystals ces lim los yog centrifuged, thiab cov khoom artemisinin tau txais.

4. Kev hloov pauv mus rau Dihydroartemisinin: Thaum cov artemisinin tau txais, nws tuaj yeem hloov mus rau hauv dihydroartemisinin los ntawm kev txo cov tshuaj lom neeg. Ib txoj hauv kev yog siv sodium borohydride (NaBH4) ua tus neeg sawv cev txo qis. Cov artemisinin yog yaj nyob rau hauv cov kuab tshuaj uas tsim nyog, xws li methanol lossis ethanol, thiab tom qab ntawd NaBH4 ntxiv maj mam nyob rau hauv kev tswj xyuas. Cov tshuaj tiv thaiv feem ntau yog nqa tawm ntawm qhov kub thiab pH, nrog nplawm. Cov txheej txheem txo qis hloov cov artemisinin rau hauv dihydroartemisinin.

5. Crystallization thiab Purification ntawm DHA: Cov khoom txo qis, dihydroartemisinin, feem ntau tau los ua cov khoom sib tov sib xyaw. Cov khoom sib tov no tuaj yeem ua kom huv ntxiv los ntawm ntau txoj hauv kev xws li recrystallization lossis chromatography. Recrystallization cuam tshuam nrog cov khoom siv raw hauv cov kuab tshuaj uas tsim nyog thiab tom qab ntawd maj mam txias lossis evaporating cov kuab tshuaj los txhawb kev tsim cov ntshiab dihydroartemisinin crystals. Cov txheej txheem chromatography, xws li kem chromatography lossis kev npaj ua kua chromatography (HPLC), kuj tuaj yeem ua haujlwm rau kev ua kom huv, tshwj xeeb tshaj yog rau cov khoom loj.

6. Kev ziab thiab kev tsim tawm: Thaum cov ntshiab dihydroartemisinin tau txais, nws feem ntau qhuav kom tshem tawm cov kuab tshuaj seem thiab tau txais daim ntawv khov kho. Cov qhuav dihydroartemisinin tom qab ntawd tuaj yeem ua tiav thiab tsim ua ntau yam khoom siv tshuaj, xws li ntsiav tshuaj lossis tshuaj ntsiav, rau kev tswj hwm qhov ncauj. Nws feem ntau yog tsim ua ke nrog lwm cov tshuaj tiv thaiv kab mob malarial uas yog ib feem ntawm artemisinin-raws li kev kho mob sib xyaw ua ke (ACTs) txhawm rau txhim kho kev kho mob zoo thiab txo qis kev pheej hmoo ntawm cov tshuaj tiv thaiv.

Dab tsi yog Hom Kev Ua ntawm Dihydroartemisinin

Hom kev ua ntawm dihydroartemisinin (DHA) koom nrog ntau kauj ruam, thaum kawg ua rau kev puas tsuaj ntawm tus kab mob malaria. DHA yog ib qho tshuaj tiv thaiv kab mob muaj zog thiab yog cov metabolite ntawm artemisinin. Nws muaj ib tug tshwj xeeb mechanism ntawm kev txiav txim uas teev nws sib nrug los ntawm ntau lwm yam tshuaj antimalarial. Nov yog cov lus piav qhia ntxaws txog yuav ua li cas DHA ua haujlwm:

1. Ua kom muaj zog thiab hloov pauv: Thaum DHA tau tswj hwm qhov ncauj lossis tso ntshav, nws nkag mus rau cov metabolism sai thiab hloov mus rau hauv nws daim ntawv nquag hauv daim siab. Qhov no active metabolite yog lub luag hauj lwm rau lub antimalarial kev ua ntawm DHA.

2. Tsim cov Reactive Oxygen Hom: DHA qhov ua tau zoo ntawm cov kab mob malaria yog nyob ntawm qhov muaj tus choj endoperoxide hauv nws cov qauv molecular. Nyob rau hauv lub xub ntiag ntawm hlau, DHA tau dhau los ua tus txheej txheem hu ua reductive activation, qhov uas nws tsim cov pa oxygen ntau heev (ROS), xws li cov dawb radicals, nyob rau hauv cov kab mob kab mob cov qe ntshav liab. Cov txheej txheem tseeb ntawm cov txheej txheem ua kom no tseem tsis tau nkag siab tag nrho tab sis ntseeg tau tias muaj cov kab mob parasite cov khoom noj vacuole thiab heme degradation khoom.

3. Alkylation ntawm Biomolecules: Lub generated ROS react nrog ntau yam biomolecules, nrog rau cov proteins thiab lipids muaj nyob rau hauv cov cab. Cov tshuaj tiv thaiv no ua rau alkylation (ntxiv ib pawg alkyl) ntawm cov kab mob tseem ceeb ntawm cov kab mob parasite. Cov txheej txheem no cuam tshuam qhov kev ua haujlwm ib txwm muaj ntawm cov proteins no, uas tsim nyog rau kev muaj sia nyob ntawm cov cab.

4. Membrane Disruption: DHA kuj cuam tshuam rau cov kab mob parasite cell membrane kev ncaj ncees. Nws muaj affinity siab rau daim nyias nyias lipids thiab tuaj yeem cuam tshuam rau hauv cov kab mob lipid bilayer. Qhov kev cuam tshuam no ua rau kev hloov pauv hauv cov txheej txheem hauv daim nyias nyias, cuam tshuam nws txoj kev ncaj ncees thiab ua rau nws dhau los ua permeable. Yog li ntawd, qhov tseem ceeb ions thiab molecules tsim nyog rau cov kab mob muaj sia nyob tawm ntawm lub cell, cuam tshuam nws cov haujlwm ntawm tes.

5. Reactive Endoperoxide Moiety: DHA's endoperoxide choj ua lub luag haujlwm tseem ceeb hauv nws txoj haujlwm. Tus choj tsis ruaj khov no yog qhov muaj txiaj ntsig zoo rau kev txo cov neeg ua haujlwm, feem ntau muaj nyob hauv cov qe ntshav liab uas muaj kab mob malaria. Nyob rau hauv lub xub ntiag ntawm cov tshuaj txo qis, DHA's endoperoxide choj tau dhau los ua cov tshuaj tiv thaiv cleavage, uas tsim cov tshuaj lom dawb radicals uas ua rau cov kab mob cab cov proteins, daim nyias nyias, thiab lwm yam biomolecules.

6. Selectivity thiab Resistance: DHA hom kev ua haujlwm zoo li yog xaiv tshuaj lom rau cov kab mob malaria, vim nws qhov kev ua haujlwm thiab ROS tiam tom ntej tshwm sim feem ntau hauv cov qe ntshav liab kab mob parasite thiab tsis cuam tshuam rau tib neeg lub hlwb. Txawm li cas los xij, tau tshaj tawm cov xwm txheej ntawm kev tiv thaiv artemisinin thiab nws cov derivatives, suav nrog DHA. Cov txheej txheem tiv thaiv no tseem tab tom tshawb nrhiav tab sis xav tias yuav cuam tshuam cov hom phiaj siv tshuaj, txo cov tshuaj ua kom muaj zog, nce tshuaj efflux, lossis txhim kho DNA kho cov txheej txheem hauv cov kab mob cab.

Dab tsi yog cov teebmeem ntawm Dihydroartemisinin

Nov yog qee qhov kev mob tshwm sim cuam tshuam nrog dihydroartemisinin ntxiv:

1. Kev mob plab hnyuv: Feem ntau cov kev mob tshwm sim ntawm dihydroartemisinin muaj feem xyuam rau lub plab zom mov. Cov no tuaj yeem suav nrog xeev siab, ntuav, raws plab, mob plab, thiab tsis qab los noj mov. Cov tsos mob no feem ntau yog me me thiab txwv tus kheej, tab sis qee zaum, lawv tuaj yeem hnyav dua thiab xav tau kev kho mob.

2. Kev cuam tshuam hauv nruab nrab ntawm lub paj hlwb: Qee tus neeg yuav muaj kiv taub hau, mob taub hau, thiab ua tsis taus pa thaum noj dihydroartemisinin. Cov teebmeem no feem ntau yog ncua sijhawm thiab daws lawv tus kheej. Txawm li cas los xij, yog tias cov tsos mob tshwm sim los yog hnyav zuj zus, nws raug nquahu kom sab laj nrog kws kho mob.

3. Kev Ua xua: Txawm tias tsis tshua muaj, qee tus neeg tuaj yeem tsim kev tsis haum rau dihydroartemisinin. Cov tsos mob ntawm kev tsis haum tshuaj yuav muaj xws li pob khaus, khaus, khaus khaus, o ntawm lub ntsej muag, daim di ncauj, tus nplaig, lossis caj pas, thiab ua pa nyuaj. Txhua yam cim qhia ntawm kev tsis haum tshuaj yuav tsum tau ua tib zoo saib xyuas, thiab nrhiav kev kho mob tam sim ntawd.

4. Kev mob siab rau lub siab: Muaj tsawg zaus, dihydroartemisinin tau cuam tshuam nrog lub siab toxicity. Cov tsos mob tuaj yeem muaj los ntawm qhov siab me me ntawm daim siab enzymes mus rau lub siab mob hnyav. Cov tib neeg uas muaj lub siab uas twb muaj lawm, xws li kab mob siab lossis mob cirrhosis, tej zaum yuav muaj kev pheej hmoo siab dua. Kev saib xyuas ntawm daim siab ua haujlwm tsis tu ncua yog pom zoo thaum kho dihydroartemisinin, tshwj xeeb tshaj yog rau cov tib neeg uas muaj teeb meem hauv siab.

5. Hematological Effects: Dihydroartemisinin tuaj yeem ua rau muaj kev hloov pauv hauv cov ntshav. Qhov no tuaj yeem suav nrog kev txo qis hauv cov qe ntshav liab (anemia), qe ntshav dawb (leukopenia), thiab platelets (thrombocytopenia). Cov teebmeem no feem ntau me me thiab thim rov qab, tab sis qee zaus, lawv tuaj yeem hnyav dua thiab xav tau kev kho mob.

6. Cov teebmeem hauv plawv: Muaj qee zaus qhia txog cov teebmeem ntawm cov hlab plawv cuam tshuam nrog dihydroartemisinin, xws li palpitations, plawv dhia ceev, thiab kev hloov ntshav siab. Cov teebmeem no feem ntau yog ib ntus thiab daws yam tsis muaj kev cuam tshuam. Txawm li cas los xij, cov tib neeg uas muaj mob plawv ua ntej yuav tsum tau ceev faj thaum noj dihydroartemisinin thiab sab laj nrog kws kho mob yog tias muaj cov tsos mob tshwm sim.

Hoobkas

Xi'an Sonwu nyob hauv ib qho chaw uas muaj ib puag ncig zoo nkauj, npog thaj tsam ntawm 10,000 square meters. Lub Hoobkas muaj cov cuab yeej tsim khoom siab heev, thiab pab pawg kws tshaj lij tau tsim khoom zoo, huv si, thiab huv si, nrog cov khoom txaus txaus. Raws li kev coj noj coj ua ntawm lub tuam txhab, cov kws tshawb fawb tau hais kom tsim cov khoom tshiab. Cov hauv qab no yog qhov chaw sim ntawm peb lub chaw soj nstuam, cov cuab yeej ntsuas qib siab, thiab cov kws tshaj lij kev sim, nrog tus cwj pwm nruj los muab cov ntaub ntawv tseem ceeb rau peb cov khoom thiab muab peb cov neeg siv khoom nrog kev paub zoo.

Daim ntawv pov thawj

Ntim

Tsis ntev los no Logistics Record

Ntxiv nrog rau kev lees paub cov khoom zoo, lwm qhov tseem ceeb tshaj plaws yog cov neeg tuaj yeem tau txais cov khoom lag luam zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

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FAQ

1. Yuav nug li cas?

Koj tuaj yeem tiv tauj peb ntawm email, xov tooj, lossis social media.

2. Yuav ua li cas lav qhov zoo ntawm cov khoom?

Txhua batch yuav tsum tau kuaj kom peb tuaj yeem muab COA rau cov neeg siv khoom. Tsis tas li ntawd, peb cov khoom dhau qhov kev xeem: HPLC, UV, GC, TLC, thiab lwm yam. Thiab peb kuj koom tes nrog peb tog, xws li, SGS.

3. Yuav ntim thiab khaws cov khoom li cas?

Pob: Lub tshuab nqus tsev ntim cov ntawv ntim & ntim cov ntawv xa tawm qib nruas lossis pob raws li cov neeg siv khoom xav tau

Cia: Rau lub sijhawm luv luv, koj tuaj yeem khaws cia rau hauv qhov chaw qhuav thiab txias thiab ua kom tsis txhob tshav ntuj.

Yog tias koj txaus siab rau peb lub tuam txhabdihydroartemisinin tshuajhmoov, thov hu rau Xi'an Sonwu Biotech Co. Ltd.

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