Gts{0}} Nootropics

Lub ntsiab lus ntawm Gts-21

Gts{0}} Nootropicsyog ib qho tshiab, me me-molecule xaiv 7 nicotinic acetylcholine receptor agonist. Nws tseem nquag hu ua GTS-21 HCL lossis DMXBA vim tias nws yog ib qho 3-2, 4-dimethoxybenzylidene anabaseine hauv chemistry. GTS-21 tsis ntev los no tau tsim los ua kev kho mob zoo rau qhov mob. Hauv kev sim tshuaj tib neeg, GTS-21 tau qhia los txhim kho kev nco thiab kev paub txog kev ua haujlwm. Yog li nws belongs rau qeb ntawm nootropics thiab tam sim no tau tshawb fawb ntau rau kev kho mob Alzheimer's thiab Schizophrenia nrog rau Nicotine dependence.

Specification

Kev Tshawb Fawb Tom Qab GTS -21

GTS -21 Nootropicsyog ib qho kev hais lus alpha-7 nicotinic acetylcholine (nACh) receptor agonist. DMXBA yog ib qho ntawm cov muaj zog tshaj plaws 7 agonist. Nws kuj tseem khi rau alpha 4 beta 2 subtypes tab sis nws tsuas yog ua rau alpha 7 tiag tiag rau txhua qhov tseem ceeb.

Gts{0}} lub luag haujlwm tseem ceeb ntawm kev ua haujlwm yog ua kom 7 thiab nws ua qhov ntawd zoo heev. Cov txheej txheem no, inhibition ntawm alpha 7 nicotinic receptor, mediates tso tawm GABA (gamma-aminobutyric acid) los ntawm hippicampal interneurons. Qhov no yog lub ntsiab, tseem ceeb tshaj plaws mechanism ntawm kev txiav txim thiab nws kuj yog vim li cas vim li cas GTS -21 tau raug tshawb fawb ntau tam sim no. Yeej, qhov no tau dhau los ua lub hom phiaj tshiab rau kev kho mob kev kho mob hauv Schizophrenia.

Peb tau hais txog 7 nicotinic acetylcholine receptor (nACh) ntau zaus txog tam sim no, yog li nws yog dab tsi?

Nicotinic acetylcholine receptors (nAChRs) yog ligand-gated ion channel proteins uas kho cov teeb liab intersynaptic sai. nAChR tuaj yeem muab faib ua ob hom: hom nruab nrab thiab hom peripheral. nAChR yog tsim los ntawm cov subunits sib txawv, thiab 16 hom nAChR subunits tau txheeb xyuas txog tam sim no. Kev sib txawv ntawm cov subunits sib txawv yuav qhia cov yam ntxwv sib txawv ntawm cov tshuaj thiab lub cev, thiab 7 yog ib qho ntawm lawv. Qhov ob feem ntau faib receptor subtypes nyob rau hauv nruab nrab paj hlwb, 4 2 thiab 7, ntawm uas 7 nAChR yog ib tug tshwj xeeb subtype. Nws muaj tsib lub subunits zoo tib yam thiab muaj qhov zoo permeability rau calcium ions. , muaj peev xwm tswj tau qhov ua kom cov calcium thiab tso tawm cov neurotransmitter acetylcholine. 7 nAChR zoo sib xws rau cov kab mob ntawm Alzheimer's disease (AD), schizophrenia, o thiab lwm yam kab mob.

Cov cheeb tsam tseem ceeb ntawm 7 nAChR faib rau hauv lub paj hlwb yog: grey teeb meem, hippocampus, basal ganglia, thalamus, thiab lwm yam. Tom qab ua kom lub presynaptic membrane 7 nAChR, nws muaj peev xwm depolarize lub presynaptic membrane los ntawm kev txhim kho lub fusion ntawm vesicles thiab presynaptic membrane, exocytosis, thiab calcium influx rau excite voltage-dependent calcium channels, yog li nce los yog ua rau ib tug series ntawm neurotransmitters, xws li. glutamate, dopamine, norepinephrine, acetylcholine thiab gamma-amino acid (GABA), thiab lwm yam. Ntxiv nrog rau depolarizing lub postsynaptic daim nyias nyias mus ncaj qha excite neurons, excitation ntawm lub postsynaptic membrane 7 nAChR kuj tswj tau tso tawm GABA. Yog li ntawd, 7 nAChR muaj lub luag haujlwm ntawm kev tswj cov excitability ntawm neurons, uas tuaj yeem khaws cov neurons nyob rau hauv lub cev tsim nyog thiab tswj cov kev coj cwj pwm ntawm lub cev, tshwj xeeb tshaj yog cov txheej txheem kev txawj ntse.

Gts{0}} kuj txo qis kev tsim cov cytokine pro-inflammatory. Cov kev tshawb fawb tsis ntev los no kuj tau qhia tias GTS -21 inhibits cov dej num ntawm monocyte marcophages, endothelial hlwb nrog rau kev tso tawm ntawm pro-inflammatory cytokines. Nws ua txhua yam no los ntawm kev tswj hwm JAK2-STAT3 txoj hauv kev.

Cov teeb meem cuam tshuam nrog 7 nAChR

AD & 7 nCHR

AD stands rau Alzheimer's kab mob, uas feem ntau pib thaum laus los yog pre-senile hnub nyoog nrog dementia raws li lub ntsiab tshwm sim. Nws yog ib qho mob tsis txaus ntseeg thiab feem ntau ua rau dementia. Cov tsos mob yog maj mam ua rau lub hlwb tsis zoo (kev nco tsis zoo, kev kawm tsis zoo, kev saib xyuas tsis zoo, kev paub txog kev ua haujlwm, kev daws teeb meem tsis zoo), maj mam hloov mus rau hauv zej zog.

Nws cov yam ntxwv tseem ceeb ntawm cov kab mob yog senile plaques (SP) tsim los ntawm -amyloid (amyloid- protein, A) aggregation nyob rau hauv lub paj hlwb cortex thiab hippocampus, neurofibrillary tangles (NFT) tsim los ntawm txawv txav aggregation ntawm tau protein, thiab txo cov neurons uas twb muaj lawm nyob rau hauv lub paj hlwb. cortex thiab hippocampus.

Nrog rau qhov kev tshawb fawb tob, ntau thiab ntau cov pov thawj tau pom tias 7 nAChR tuaj yeem khi rau A 1-42 hauv lub hlwb ntawm cov neeg mob AD, ua rau muaj kev puas tsuaj lossis thaiv ntawm 7 nAChR, lossis ua rau kev tuag ntawm cholinergic neurons kho. los ntawm 7 nAChR, uas cuam tshuam rau kev paub thiab kev nco.

Schizophrenia & 7 nAChR

Schizophrenia yog ib qho mob puas hlwb, thiab nws cov kab mob tseem tsis tau nkag siab tag nrho. Tam sim no, feem ntau cov kws tshawb fawb ntseeg tias tus mob schizophrenia muaj feem cuam tshuam nrog kev ua haujlwm tsis zoo lossis tsis ua haujlwm ntawm tib neeg lub hlwb dopamine (DA), serotonin (5-HT) thiab glutamate (Glu) systems. Kev paub tsis meej yog ib qho ntawm cov tsos mob tseem ceeb ntawm tus mob schizophrenia, thiab tsawg kawg yog 85 feem pua ​​​​ntawm cov neeg mob uas muaj tus mob schizophrenia muaj qhov tsis txaus ntseeg thiab tsis txaus ntseeg. Muaj pov thawj tias 7 nAChR tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev tsim cov kab mob schizophrenia.

Ib nrab-Life & Dosage

Ib 100 feem pua ​​​​yog ib nrab-lub neej ntawm GTS -21 tseem tsis tau lees paub. Tab sis los ntawm kev tshawb fawb tam sim no, nws tuaj yeem pom tau tias ib nrab-lub neej ntawm GTS -21 yog nyob nruab nrab ntawm 2-3 teev.

Tu siab, qhov no txhais tau hais tias 1 koob ntawm GTS-21 yuav tsis kav ib hnub li 1 koob ntawm 9-Me-BC. Hauv lwm lo lus, nws txhais tau hais tias GTS -21 cov neeg siv yuav tsum faib lawv cov koob tshuaj ua peb ntu, noj thawj feem thaum sawv ntxov, qhov thib ob ntawm pluas su, thiab thib peb thaum tav su. Ua li no, cov neeg siv DMXBA tuaj yeem tswj hwm GTS-21 cuam tshuam txhua hnub.

Raws li kev tshawb fawb, 18 tus txiv neej noj qab haus huv tuaj yeem tuaj yeem siv cov placebo lossis GTS -21. Cov neeg ua haujlwm pab dawb tau noj 450mg ntawm DMXBA (GTS-21) txhua hnub. Nco ntsoov tias vim yog ib nrab-lub neej, lawv tau noj 150mg ntau npaum li peb zaug hauv ib hnub.

Qhov tseeb, qhov kev tshawb fawb pom tau tias muaj txiaj ntsig zoo heev. Qhov ntau npaum ntawm 450mg ib hnub tau zoo heev zam thiab nws tsis qhia txog kev phiv.

Yog li, txhawm rau txheeb xyuas, 450mg ib hnub yog qhov ntau npaum li cas. Ntau tus neeg siv cov koob tshuaj no thiab nws kuj yog qhov ntau npaum li cas uas tau siv hauv qee qhov kev sim tib neeg nrog cov txiaj ntsig tau zoo heev.

Ceev faj:

Thov nco ntsoov tias cov ntsiab lus saum toj no tsuas yog siv rau kev siv xwb, thov txheeb xyuas qhov xwm txheej tshwj xeeb.

Cov ntawv pov thawj

Shipping & Ntim

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