NSI-189 Phosphate

Khoom Taw Qhia

NSI -189 phosphatelos ntawm NSI -189, ib qho kev sim neurogenic compound uas yuav muaj peev xwm kho tau MDD (Major Depressive Disorder), kev raug mob ntawm lub hlwb, mob stroke, teeb meem kev paub, kev puas siab puas ntsws, kev nyuaj siab tom qab, thiab kab mob neurodegenerative vim kev laus. Cov tshuaj tau raug tshuaj xyuas raws li lwm cov tshuaj uas tsim los rau cov neeg mob uas tsis teb rau cov tshuaj ib txwm siv. Tam sim no, NSI189 tseem tab tom sim rau lwm yam mob xws li kev txhim kho lub hlwb, mob ntshav qab zib neuropathy, mob stroke, kab mob neurodegenerative, kev nyuaj siab tom qab, thiab Angelman syndrome. Nws yog siv los kho mob hlwb raug mob.

Specification

Mechanism ntawm Action

Cov teebmeem neuropsychopharmacological ntawm NSI-189 tseem tsis tau pom tag nrho los ntawm cov kws tshawb fawb. Nov yog qee cov txheej txheem uas cov kws tshawb fawb tau tshawb nrhiav thiab pom muaj feem cuam tshuam los ntawm NSI-189.

NSI -189 yog ib qho tshiab neurogenic antidepressant. Cov tshuaj Neurogenic txhawb kev txhim kho thiab kev loj hlob ntawm cov neurons tshiab, lossis cov hlwb hlwb. Qhov no txhais tau hais tias NSI -189 tuaj yeem kho lub hlwb puas lossis ploj lawm uas ua rau tus neeg tsis tuaj yeem muaj kev zoo siab lossis lwm yam kev nyuaj siab. Raws li kev tshawb fawb, nws ntseeg tias nws tuaj yeem pab kho kev nyuaj siab thiab txo cov tsos mob ntawm kev nyuaj siab thiab kev ntxhov siab.

NSI -189 phosphatetuaj yeem txhawb nqa neurogenesis hauv hippocampus-derived neural qia cell thiab cuam tshuam rau qhov chaw ua haujlwm rau kev kawm, nco, thiab kev xav. Qhov no tshwm sim nrog rau cov txheej txheem sib txawv. Cov tshuaj yog ib qho benzylpiperazine-aminopyridine uas yuav kis tau cov ntshav-hlwb barrier.

Neurogenesis yog stimulated nyob rau hauv hippocampal slices, tshwj xeeb tshaj yog sab laug ntawm tib neeg lub hlwb. Qee zaum, xws li tom qab mob stroke, nws yuav nce Ki67 thiab MAP2. Nws kuj pab txhim kho BDNF, GDNF, thiab VEGF. Ib yam li ntawd, cov haujlwm sau tseg tau pom ntawm Skp, Cullin, F-box uas muaj cov complex.

Cov txiaj ntsig & Cov txiaj ntsig

1. Txhim kho kev nyuaj siab

Kev puas tsuaj ntawm hippocampus yog ib qho kab mob tshwm sim hauv Major Depressive Disorder (MDD). NSI-189 tuaj yeem kho MDD zoo li lwm yam kev puas siab puas ntsws los ntawm kev ua kom muaj neurogenesis (loj hlob) hauv hippocampus, ib feem ntawm lub hlwb lub luag haujlwm rau kev xav, kev kawm, thiab kev nco. Hauv kev tshawb nrhiav cov tshuaj placebo, noj 40 mg rau 80 mg ib hnub ntawm NSI 189 rau 28 hnub tau pom tias muaj kev txhim kho tseem ceeb rau cov tsos mob kev nyuaj siab hauv ntau tus neeg.

2. Txhim kho kev paub

Nws tuaj yeem txhim kho kev paub thiab tuaj yeem txhim kho Lub Sij Hawm Ntev (LTP).

Tib theem I thiab II kev sim tshuaj uas tau kawm txog kev nyuaj siab kuj pom muaj txiaj ntsig zoo rau kev paub.

Kev tshaj tawm txog kev txhim kho ntawm tus kheej hauv kev paub tau raug tshaj tawm los ntawm cov neeg nyob hauv theem kuv mus sib hais. Qhov no suav nrog tsis yog kev nco xwb tab sis kuj muaj peev xwm kawm thiab ua kom pom tseeb.

Ib yam li ntawd, nyob rau theem II sim ntawm 220 tus neeg, koob tshuaj 40 mg kuj tseem cuam tshuam nrog kev tshaj tawm tus kheej kev txhim kho hauv kev paub, suav nrog kev txhim kho kev nco, kev ua haujlwm nco, thiab kev ua haujlwm.

3. Tej zaum yuav pab nrog ischemic stroke

Raws li kev tshawb fawb ntawm cov tsiaj, NSI -189 tuaj yeem txhim kho lub cev muaj zog thiab hippocampal tsis txaus pom hauv cov pa oxygen tsis txaus (hypoxia) mob stroke.

Ib qho laj thawj rau qhov no yog los ntawm NSI -189 lub peev xwm los ua kom muaj txiaj ntsig zoo ntawm cov kab mob neurotrophic VEGF, BDNF, GDNF, thiab SCF.

Hauv kev tshawb nrhiav nas, cov kws tshawb fawb tau muab nas NSI -189 pib 6 teev tom qab mob stroke, uas tau txuas ntxiv txhua hnub rau 12 lub lis piam. NSI-189 kev kho mob txuas ntxiv pab txhim kho qhov tsis txaus ntawm cov nas no, txawm tias tom qab tso tshuaj. Muaj kev txhim kho tseem ceeb hauv lub hlwb thiab lub cev muaj zog.

Cov kev tshawb fawb ntawm tes qhia tias NSI -189 tuaj yeem thim rov qab cov txheej txheem cell tuag los ntawm kev tsis muaj oxygen, zoo ib yam li raug mob los ntawm mob stroke.

4. Pab nrog ntshav qab zib neuropathy

Mob ntshav qab zib neuropathy yog ib hom kev puas hlwb uas tuaj yeem tshwm sim hauv cov neeg mob ntshav qab zib. Muaj qee qhov pov thawj tias NSI -189 tuaj yeem tiv thaiv thiab rov tsim cov hlab ntsha puas tsuaj los ntawm kev mob ntshav qab zib. Nws tuaj yeem pab nrog mob paj hlwb thiab neuropathy hauv ntshav qab zib.

Ib txoj kev tshawb fawb hauv nas hlwb qhia tias NSI -189 tuaj yeem txhawb kev loj hlob ntawm cov paj hlwb. Cov kws tshawb fawb kuj pom tias NSI -189 tuaj yeem nres qhov kev loj hlob ntawm cov hlab ntsha puas hauv ob lub hlwb thiab hauv cov ceg.

5. Muaj peev xwm kho mob rau Angelman syndrome

Angelman syndrome yog ib hom kab mob caj ces uas feem ntau cuam tshuam rau lub paj hlwb. Cov tsos mob feem ntau muaj xws li kev txawj ntse thiab kev loj hlob tsis taus, teeb meem txav, thiab qaug dab peg. Lub paj hlwb yog qhov cuam tshuam tshaj plaws ntawm lub cev vim yog Angelman syndrome. NSI 189 tuaj yeem qhib TrkB thiab Akt txoj hauv kev thiab thim rov qab qhov kev puas tsuaj.

Hauv kev tshawb nrhiav nas, NSI -189 txhaj tshuaj thim rov qab kev paub thiab kev txav tsis zoo. Cov kws tshawb fawb qhia tias los ntawm kev ua kom TrkB thiab Akt txoj hauv kev, NSI -189 tuaj yeem sawv cev rau kev kho mob rau cov neeg mob Angelman Syndrome.

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FAQ

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2. Yuav ua li cas kom paub meej cov khoom zoo ua ntej kev txiav txim?

Txhua pawg ntawm cov khoom yuav tsum tau kuaj, yog li Xi'an Sonwu tuaj yeem muab COA rau cov neeg siv khoom. Tsis tas li ntawd, peb cov khoom tau dhau qhov kev xeem: HPLC, UV, GC, TLC thiab lwm yam, thiab Xi'an Sonwu kuj koom tes nrog peb tog, xws li SGS.

3. Yuav ntim thiab khaws cia li casNSI -189 phosphate?

Pob: Muab cov khoom ntim khoom ntim thiab lub tshuab nqus tsev ntim cov ntawv ntim, lossis peb tuaj yeem ntim cov khoom raws li cov neeg siv khoom xav tau.

Cia: Thov khaws cia rau hauv qhov chaw txias & qhuav. Khaws kom deb ntawm lub teeb thiab cua sov.

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