Yam tshuaj twg yog Itraconazole
99 hmoov itraconazoleyog ib tug hluavtaws dav-spectrum antifungal tshuaj, ib tug triazole derivative. Nws muaj txiaj ntsig zoo tiv thaiv dermatophytes (Trichophyton, Microsporum, Epidermophyton floccosum), poov xab [Cryptococcus neoformans, Pityrosporum, Candida (xws li Candida albicans, Candida glabrata thiab Candida krusei)], Aspergillus ii, Chromatids, Cladosporium, Blastomyces dermatitis thiab ntau yam kab mob ntawm cov poov xab thiab fungal. Nws tuaj yeem hloov mus rau hauv cov metabolites tsis ua haujlwm hauv daim siab thiab tom qab ntawd tawm hauv lub cev los ntawm cov kua tsib thiab zis. Cov kev tshawb fawb hauv vitro tau pom tias nws tuaj yeem cuam tshuam cov synthesis ntawm ergosterol, ib qho ntawm cov khoom tseem ceeb ntawm cov kab mob fungal, yog li ua rau muaj kev tiv thaiv kab mob. Nws cov tshuaj tiv thaiv kab mob zoo ib yam li fluconazole, thiab nws muaj cov tshuaj tua kab mob tseem ceeb tiv thaiv ob qho tib si sib sib zog nqus thiab sab saum toj fungi. Nws daim ntawv thov dav ua rau nws yog ib qho tseem ceeb tshuaj rau kev kho ntau yam kab mob fungal, tshwj xeeb tshaj yog qee cov kab mob refractory thiab kab mob fungal. Vim nws muaj ntau yam teebmeem, nws kho cov kab mob uas twb muaj lawm thiab tiv thaiv tau cov kab mob fungal. Nws daim ntawv thov ntau yam npog ntau yam kab mob los ntawm daim tawv nqaij mus rau cov ntaub so ntswg thiab cov kab mob sib sib zog nqus, ua rau nws yog ib qho tseem ceeb hauv kev kho mob antifungal. Yog li, yog tias koj xav tau cov ntaub ntawv raw itraconazole, Xi'an sonwu tuaj yeem muab rau lawv.
Certificate Of Analysis
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Cov khoom |
Specifications |
Cov txiaj ntsig |
|
Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Yuav luag dawb hmoov |
|
Kev txheeb xyuas |
IR ua raws li tus qauv (2.2.24) |
Ua raws |
|
Qhov tshwm sim ntawm kev daws teeb meem |
Kev daws S yog qhov tseeb (2.2.1) thiab tsis muaj xim ntau dua |
Ua raws |
|
Cov khoom muaj feem xyuam |
(2.2.29) |
|
|
Cov impurities B |
Tsis ntau tshaj 0.3% |
Tsis pom |
|
Cov impurities G |
Tsis ntau tshaj 0.3% |
0.1% |
|
Impurity E |
Tsis ntau tshaj 0.2% |
Tsis pom |
|
Qhov sib npaug ntawm impurities C thiab D |
Tsis ntau tshaj 0.3% |
Tsis pom |
|
Unspecified impurities |
Tsis ntau tshaj 0.10% |
0.06% |
|
Tag nrho impurities |
Tsis ntau tshaj 0.8% |
0.3% |
|
Poob rau ziab |
Tsis ntau tshaj 0.5% |
0.1% |
|
Sulfated tshauv |
Tsis ntau tshaj 0.10% |
0.03% |
|
Assay |
99.0% rau 101.0% |
99.7% |
Yuav Itraconazole Online
Nrog ntau tshaj kaum xyoo ntawm kev paub hauv kev lag luam, Xi'an Sonwu Biotech Co. Ltd. yog tus kws tshaj lij hauv kev tsim khoom thiab xa tawm cov khoom siv raw. Xi'an Sonwu tau tsim kev sib koom tes ruaj khov thiab vam khom nrog cov teb chaws hauv Asmeskas, Asia, Europe, thiab Oceania. Ua ntej cov khoom lag luam zoo, Xi'an Sonwu ua haujlwm nyuaj los ua kom tau raws li txhua tus neeg siv khoom xav tau los ntawm kev muab cov kev pabcuam zoo tshaj plaws.
Xi'an Sonwu tseem ceeb ua ntej ua cov khoom lag luam zoo, thiab txhua yam ntawm nws txoj haujlwm ua lag luam, xws li kev xaiv cov khoom siv raw, cov txheej txheem tsim khoom, kuaj cov qauv, thiab cov neeg ua haujlwm tshaj lij, qhia txog lub tuam txhab kev cog lus rau kev ua tau zoo. Xi'an Sonwu tuaj yeem txo cov nuj nqis yam tsis muaj kev txi zoo los ntawm kev ua tib zoo saib xyuas txhua yam, lav tias cov neeg tau txais cov khoom muaj txiaj ntsig zoo kawg li.
Xi'an Sonwu txaus siab rau cov lus pom zoo uas nws tau txais los ntawm cov neeg siv khoom tsis tu ncua lees paub qhov siab ntawm cov khoom siv. Xi'an Sonwu yuav muab cov qauv rau koj los kuaj kom pom cov khoom ntseeg siab ntxiv.
|
Daim ntawv |
Tus Qauv Zauv |
MOQ |
|
Hmoov |
100g |
100g |
Cov neeg siv khoom zoo lus
Yog Itraconazole Muaj zog dua Fluconazole
Lawv yog ob qho tib si broad-spectrum antifungal tshuaj teej tug mus rau triazole antifungal tshuaj, tab sis lawv cov txheej txheem ntawm kev ua, daim ntawv thov ntau yam, tshuaj zog, thiab kev phiv yog txawv.
1. Mechanism ntawm kev ua
Nws inhibits cov synthesis ntawm ergosterol nyob rau hauv lub fungal cell membrane, cuam tshuam nrog cov qauv thiab kev ua ntawm cov fungal cell membrane, thiab thaum kawg ua rau fungal cell tuag. Nws muaj broad-spectrum inhibitory nyhuv ntawm ntau yam fungi. Fluconazole kuj siv nws cov tshuaj tua kab mob los ntawm inhibiting cov synthesis ntawm ergosterol. Txawm li cas los xij, nws lub hom phiaj tseem ceeb yog Candida thiab qee hom fungi, thiab nws cov spectrum ntawm kev ua yog nqaim.
2. Antifungal spectrum
99 hmoov itraconazoleNws muaj txiaj ntsig zoo tiv thaiv ntau yam kab mob xws li dermatophytes, Candida, Cryptococcus, Aspergillus, Histoplasma, Blastomyces, thiab pigmented fungi. Nws muaj txiaj ntsig zoo rau ntau yam kab mob, suav nrog kab mob fungal. Fluconazole muaj txiaj ntsig zoo rau Candida, Cryptococcus, thiab qee cov kab mob dermatophytes tab sis tsis tshua muaj txiaj ntsig tiv thaiv cov kab mob fungal tsawg xws li Aspergillus, Histoplasma, thiab Blastomyces. Tsis tas li ntawd, fluconazole tsis muaj txiaj ntsig tiv thaiv qee yam Candida (xws li Candida krusei) thiab muaj kev cuam tshuam tsis zoo rau lwm yam resistant Candida (xws li Candida glabrata).
3. Daim ntawv thov kev kho mob
Nws yog siv los kho dermatophytosis (xws li tinea manuum, tinea corporis, tinea cruris), onychomycosis, kab mob fungal (xws li histoplasmosis, blastomycosis, cryptococcosis), sporotrichosis thiab chromomycosis. Nws haum rau cov kab mob Candida thiab tiv taus fluconazole. Tsis tas li ntawd, nws ua raws li lub tswv yim prophylactic tiv thaiv kab mob fungal rau cov neeg uas muaj kev tiv thaiv kab mob. Kev kho mob rau cov kab mob dermatophyte, cryptococcal meningitis, thiab kab mob Candida (xws li qhov chaw mos, esophageal, thiab qhov ncauj candidiasis) feem ntau koom nrog kev siv fluconazole. Hauv cov neeg mob AIDS, fluconazole feem ntau siv los tiv thaiv kab mob cryptococcal.
4. Pharmacokinetics
Nws yog dav faib nyob rau hauv lub cev, tshwj xeeb tshaj yog nyob rau hauv lub stratum corneum, rau tes, cov hauv paus plaub hau, thiab lwm qhov chaw nrog high concentrations, yog li ntawd nws muaj ib tug tseem ceeb kev kho mob los ntawm onychomycosis thiab dermatophytosis. Fluconazole yog nqus tau zoo ntawm qhov ncauj, muaj bioavailability siab, thiab tsis cuam tshuam los ntawm cov khoom noj, feem ntau ntau dua 90%. Fluconazole muaj cov ntshav ruaj khov thiab zoo permeability, tshwj xeeb tshaj yog nyob rau hauv lub hauv nruab nrab lub paj hlwb (CNS), qhov twg nws ncav cuag zoo concentrations, yog li nws yog feem ntau siv los kho tus mob cryptococcal meningitis.
Dab tsi yog Itraconazole siv los kho
1. Cov kab mob dermatophyte
Tinea corporis
Cov kab mob fungal ntawm lub cev, feem ntau hu ua "ringworm."
Tinea pedis
Cov kab mob fungal ntawm ko taw qee zaum hu ua "tus neeg ncaws pob ko taw" lossis "tinea pedis."
Tinea cruris
Cov kab mob fungal ntawm tus ncej puab ( puab ncej puab), feem ntau hu ua "jock khaus."
Tinea capitis
Cov kab mob fungal ntawm tawv taub hau, feem ntau hauv cov menyuam yaus.
Tinea unguium / Onychomycosis
Cov ntiv tes los yog ntiv taw cov kab mob fungus ua rau cov tes tuab, tsis muaj xim, thiab ua tsis tau zoo.
2. Candidiasis
Oropharyngeal candidiasis
Candida kab mob ntawm lub qhov ncauj thiab pharynx, feem ntau hu ua "thrush."
Candidiasis esophageal
Tus kab mob Candida hnyav dua uas cuam tshuam rau txoj hlab pas.
Vulvovaginal candidiasis
Tus kab mob candidal ntawm qhov chaw mos ntawm cov poj niam feem ntau tshwm sim los ntawm khaus, hlawv, thiab tawm.
Cov kab mob mucocutaneous candidiasis
Nws yog ib yam kab mob uas tsis tshua muaj tshwm sim uas ua rau mob candidal kab mob ntawm daim tawv nqaij, rau tes, thiab mucous daim nyias nyias.
3. Kab mob fungal
Histoplasmosis
Ua los ntawm kev nqus ntawm Histoplasma capsulatum spores, nws feem ntau cuam tshuam rau lub ntsws.
Blastomycosis
Blastomyces dermatitidis feem ntau cuam tshuam rau lub ntsws tab sis tuaj yeem cuam tshuam rau lwm yam kabmob.
Aspergillosis
Ua los ntawm Aspergillus spp., nws feem ntau cuam tshuam rau lub ntsws, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob immunocompromised.
Cryptococcosis
Ua los ntawm Cryptococcus neoformans, nws feem ntau cuam tshuam rau lub ntsws thiab lub hauv nruab nrab lub paj hlwb.
4. Sporotrichosis
Cov kab mob fungal mus sij hawm ntev feem ntau cuam tshuam rau ntawm daim tawv nqaij thiab cov ntaub so ntswg thiab yog coj los ntawm Sporothrix schenckii.
5. Paracoccidioidomycosis
Txawm hais tias nws tuaj yeem kis mus rau lwm qhov hauv lub cev, kab mob fungal no feem ntau tshwm sim los ntawm Paracoccidioides thiab cuam tshuam rau lub ntsws.
6. Coccidioidomycosis
Kuj hu ua "Valley Fever," Coccidioides spp. Nws ua rau nws thiab feem ntau cuam tshuam rau lub ntsws tab sis tuaj yeem ua rau muaj mob.
7. Chromoblastomycosis
Kab mob ntawm daim tawv nqaij ntev tshwm sim los ntawm ib hom kab mob fungus uas ua rau scaly, wart-zoo li qhov txhab ntawm daim tawv nqaij.
8. Kev tiv thaiv kev kho mob rau cov neeg mob immunocompromised
Thaum kho cov neeg mob immunocompromised (xws li cov neeg tau txais kev hloov pauv hauv nruab nrog cev lossis kws khomob), nws raug siv qee zaus los tiv thaiv kab mob fungal.
9. Cov kab mob fungal
Itraconazole kuj tseem tuaj yeem kho qhov tsis haum bronchopulmonary aspergillosis (ABPA), lub cev tiv thaiv kab mob uas tshwm sim los ntawm tus kab mob ntsws fungal.
Itraconazole Nws Ua Haujlwm Li Cas
Raws li cov tshuaj tua kab mob triazole, nws inhibits kev loj hlob thiab kev tsim tawm ntawm cov kab mob los ntawm cov hom phiaj molecular thiab cov txheej txheem ntawm kev ua. Fungi tsis tuaj yeem muaj sia nyob tsis muaj lawv cov cell membranes 'cov qauv tsim nyog thiab kev ua haujlwm. Tsis zoo li tib neeg cov cell membranes, uas feem ntau muaj cov roj cholesterol, cov khoom tseem ceeb ntawm cov cell membranes yog ergosterol. Ergosterol yog qhov tseem ceeb hauv kev tswj cov txheej txheem membrane, fluidity, thiab ua haujlwm hauv cov kab mob fungal. Yog hais tias cov synthesis ntawm ergosterol cuam tshuam, kev ncaj ncees ntawm cov fungal cell membrane yuav raug puas tsuaj, nws thiaj li ua rau cell tuag. Yog li, cov tshuaj tsom mus rau ergosterol synthesis txoj hauv kev, xws li itraconazole, ua lub luag haujlwm tseem ceeb hauv kev kho cov kab mob fungal.
Nws feem ntau yog tsom rau 14- -demethylase, ib qho tseem ceeb enzyme nyob rau hauv txoj kev ua rau ergosterol ntau lawm. 14- -demethylase yog ib feem ntawm cytochrome P450 enzyme tsev neeg. Nws yog lub luag haujlwm rau catalyzing tshem tawm cov methyl pawg ntawm 14th txoj hauj lwm ntawm lanosterol los tsim cov intermediates uas tau hloov dua siab tshiab rau hauv ergosterol. Yog tias cov txheej txheem no raug txwv, lanosterol yuav tsis hloov mus rau hauv ergosterol tab sis khaws cia hauv lub cell. Lanosterol thiab nws cov intermediates uas tsis ua kom tiav qhov kev hloov dua siab tshiab nyob hauv cov cell membrane, cuam tshuam cov qauv thiab kev ua haujlwm ntawm daim nyias nyias. Qhov no inhibition tiv thaiv demethylation cov tshuaj tiv thaiv ntawm lanosterol, yog li thaiv txoj kev ergosterol synthesis. Vim tsis muaj ergosterol, cov qauv ntawm cov kab mob fungal ntawm tes ua tsis ruaj khov. Qhov kev tsis sib haum xeeb no ua rau cov cell membrane ntau dua permeable, rhuav tshem nws cov kev cuam tshuam rau sab hauv thiab sab nraud ntawm lub cell thiab thaum kawg ua rau cell tuag.
Hoobkas
1. Xi'an Sonwu Biotech Co., Ltd. muaj lub Hoobkas tsim, tsim khoom, thiab khaws cia nws cov khoom, xyuas kom muaj cov khoom muag txaus. Xi'an Sonwu cov khoom tsim tau zoo huv si, muaj kev sib raug zoo, thiab khaws cia zoo. Cov kws tshawb nrhiav tuaj yeem tsim cov khoom tshiab, cov khoom zoo nyob hauv Xi'an Sonwu.
2. Xi'an Sonwu muaj cov lus qhia nruj me ntsis txog cov neeg ua haujlwm qib, xws li kev muag khoom thiab kev sim mus rau kev tsim khoom thiab kev sim. Tag nrho cov khoom escorting yog lav los ntawm nruj cov ntaub ntawv txhawb nqa thiab kev pab cuam tom qab muag.
Daim ntawv pov thawj
Ntim
Logistics
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5. Cov neeg siv khoom tshuaj xyuas
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