CB-03-01 hmoov

Kev piav qhia ntawm CB-03-01

CB-03-01 hmoovmuab los ntawm CB-03-01, uas yog ib qho hluavtaws steroidal antiandrogen-tshwj xeeb, ib qho androgen receptor antagonist - uas yog siv los ua cov tshuaj pleev xim rau hauv kev kho mob ntawm androgen-dependent tej yam kev mob xws li pob txuv vulgaris thiab androgenic alopecia (txiv neej-hom plaub hau poob. ).

Qhov tseeb, CB-03-01 yog lub npe kev loj hlob ntawm Clascoterone uas nws lub npe tshuaj yog 21-hydroxy-17-(1-oxopropoxy)pregna-4-ene-3 , 20-dione, qee zaum abbreviated li: 11-Deoxycortisol 17 -propionate (Cortexolone 17 -propionate).

Qhov tseeb, CB-03-01 los ntawm ob lub npe sib txawv. Lub npe Winlevi yog siv rau clascoterone cream uas tam sim no 1 feem pua ​​​​ntawm cov concentration yog feem ntau txhais tau tias kho pob txuv. Hauv kev sib piv, Breezula (7.5 feem pua ​​​​ntawm cov concentration) yog lub npe tshuaj rau cov tshuaj tiv thaiv androgenic npaj los daws qhov tshwm sim ntawm cov plaub hau poob, uas yog qhov peb tab tom tham txog niaj hnub no. Kev ua haujlwm los tiv thaiv androgenic ntawm CB-03-01 ua haujlwm hauv zos nkaus xwb hauv cov txheej txheem ntawm daim tawv nqaij.

Cov hmoov, tom qab nkag mus rau hauv lub cev, tsis muaj cov tshuaj tiv thaiv androgenic, yog li nws tsis cuam tshuam rau cov tshuaj hormones hauv lub cev. Thiab nws muaj zog ua haujlwm thiab muaj peev xwm tshaj li peb cov tshuaj tiv thaiv androgen, uas yog nws qhov tshwj xeeb. Yog li ntawd, ntau tus neeg muaj kev cia siab txog nws txoj kev cia siab, vam tias nws yuav dhau los ua cov tshuaj zoo rau cov plaub hau poob. Raws li ib qho ntawm CB-03-01 cov chaw tsim khoom thiab cov chaw muag khoom, Xi'an Sonwu muab cov khoom lag luam zoo nrog tus nqi tsim nyog. Yog tias koj txaus siab rau CB-03-01, txais tos hu rau Xi'an Sonwu.

Specification

HPLC Test

Cov ntaub ntawv keeb kwm yav dhau ntawm CB-03-01

CB-03-01 hmoovFeem ntau yog siv los kho Androgenetic alopecia (AGA), los yog feem ntau hu ua txiv neej qauv baldness, uas yog ib qho kev txiav txim plaub hau uas muaj feem cuam tshuam rau txiv neej thiab poj niam. AGA cuam tshuam rau 50 feem pua ​​​​ntawm cov txiv neej thiab 13 feem pua ​​​​ntawm cov poj niam premenopausal thiab ua rau cov poj niam postmenopausal ntau. Peb cov plaub hau ib txwm loj hlob nyob rau hauv lub voj voog ntawm 2 mus rau 6 xyoo, tab sis nrog cov neeg uas raug kev txom nyem los ntawm AGA, cov voj voog no luv luv rau 6 mus rau 8 lub hlis. Nyob rau tib lub sijhawm, cov plaub hau no ua me me thiab tau nce zuj zus thiab luv dua. AGA yog hom plaub hau ntau tshaj plaws.

Feem ntau, cov plaub hau poob hauv androgenetic alopecia tshwm sim hauv cov qauv, thawj zaug rov qab los ntawm cov tuam tsev thiab thinning ntawm lub kaus mom, nrog cov pob ntseg los yog nyias nyias thaum kawg converging.

Lub hauv paus ua rau cov txheej txheem plaub hau miniaturization yog qhov rhiab heev ntawm tawv taub hau rau androgen hu ua Dihydrotestosterone (DHT). DHT yog tsim los ntawm testosterone ntawm enzyme 5 alpha-reductase. Kev ua DHT nce ntxiv lossis rhiab heev rau DHT yog txuam nrog cov plaub hau poob. DHT khi rau androgen receptors hauv cov hauv paus plaub hau, uas thaum kawg ua rau cov plaub hau luv luv thiab pab txhawb rau cov pob txha me me.

Thaum lub Plaub Hlis 2019, lub tuam txhab tshuaj Italian-based, Cassiopea, tau tshaj tawm cov lus tshaj tawm uas ua rau cov plaub hau poob hauv zej zog. Lawv tau tshaj tawm tias lawv cov khoom lag luam tshiab, Clascoterone lossis CB-03-01, "tso tseg cov plaub hau, thiab loj hlob plaub hau tshiab." Raws li lawv, cov tshuaj yog ib qho anti-androgen, uas inhibits lub peev xwm ntawm DHT los khi nrog androgen receptors nyob rau hauv tawv taub hau. Qhov kev txiav txim no tau tshaj tawm txo cov plaub hau miniaturization, lossis thinning thiab poob.

Raws li cov tshuaj tau txav mus los ntawm theem II kev sim tshuaj, Cassiopea tau sau cov txiaj ntsig zoo txog tam sim no los ntawm kev tshaj tawm xov xwm.

Qhov tseeb thiab loj tshaj plaws kev tshuaj xyuas ntawm cov tshuaj muaj txiaj ntsig tau koom nrog 400 yam hauv lub teb chaws Yelemees thiab siv sijhawm ntev li 12 lub hlis. Cov neeg koom nrog kev sim theem II, txhua tus uas mob me mus rau nruab nrab androgenetic alopecia, siv plaub qhov sib txawv ntawm CB-03-01. Txhua pab pawg tau pom qhov nce ntawm lub hom phiaj cov plaub hau thiab cov plaub hau dav thaum lub sijhawm kawm, thiab cov kev hloov pauv zoo hauv lawv cov plaub hau kev loj hlob (HGA, daim ntawv nug rau cov neeg koom nrog kev kawm). Cov pab pawg placebo, ntawm qhov tod tes, pom kev hnyav zuj zus ntawm lawv cov plaub hau poob thaum tsis kho. Raws li kev tshawb fawb: "cov ntaub ntawv no tau lees paub tias CB-03-01 nres cov plaub hau thiab loj hlob plaub hau tshiab." Raws li kev nyab xeeb, cov chaw tsim khoom hais tias tsis muaj "kev kho mob cuam tshuam txog cov xwm txheej tsis zoo" ntawm cov neeg mob hauv kev sim tshuaj, tshaj tawm tias lawv cov tshuaj muaj kev nyab xeeb thiab tsis muaj kev phiv.

Txoj cai ua haujlwm ntawm CB-03-01

CB-03-01 lossis Clascoterone yog androgen receptor antagonist nrog cov qauv steroidal. Nws antagonizes dihydrotestosterone (DHT) los ntawm kev sib tw binding nrog cytoplasmic androgen receptors raws li nws sib koom tib fused plaub-ntiv nplhaib nraub qaum qauv. Lub ntsiab lus piav qhia yog tias nws thaiv cov androgen receptor lub luag haujlwm rau cov plaub hau poob.

Thaum siv rau ntawm daim tawv nqaij, cov formulation nkag mus rau saum npoo thiab ncav cuag cov androgen receptors nyob rau hauv cov plaub hau follicles thiab cov qog sebaceous uas nyob ib sab. Tseem tsis tau muaj pov thawj txog kev nqus ntawm clascoterone thaum siv tshuaj pleev ib ce. Nws mechanism ntawm kev txiav txim yog qhia nyob rau hauv daim duab hauv qab no:

Androgenetic alopecia tshwm sim thaum lub dihydrotestosterone (DHT) khi rau cov androgen receptors nyob rau hauv cov qog sebaceous thiab cov hauv paus plaub hau. Qhov no ua rau cov plaub hau luv luv, thiab cov hauv paus plaub hau pib me me. Cov yam ntxwv ntawm baldness tshwm sim thaum cov hauv paus plaub hau spontaneously ua me thiab nyias, thiab lawv tsis tuaj yeem tsim cov plaub hau tshiab. Qhov zoo ntawm DHT-dependent androgenetic alopecia yog tias nws tuaj yeem thim rov qab ib nrab, thiab qhov kev loj hlob tuaj yeem qeeb. Qhov no yog qhov zoo tshaj plaws los ntawm kev thaiv kev cuam tshuam ntawm DHT thiab androgenic receptor. Yog li ntawd, androgenetic alopecia yuav tsum teb zoo rau androgen receptor blockers zoo li CB-03-01. Dab tsi ua rau CB-03-01 tshwj xeeb yog tias nws cov txheej txheem ntawm kev ua haujlwm tsis cuam tshuam cov tshuaj hormones hauv lub cev. Yog li, ntxiv rau cov tshuaj pleev Finasteride, uas muaj kev nyab xeeb rau kev siv, CB-03-01 yog lwm yam riam phom hauv arsenal ntawm cov tshuaj tiv thaiv androgen uas tuaj yeem siv tau zoo tiv thaiv cov plaub hau.

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Vim Li Cas Xaiv Peb

1. Xi'an Sonwu tau koom nrog ntshuam-export rau ntau tshaj 10 xyoo nrog kev nplua nuj nyob hauv kev lag luam ntshuam thiab xa tawm.

2. Xi'an Sonwu muaj cov kws tshaj lij nrog kev faib ua haujlwm kom meej.

3. Kev pabcuam OEM muaj.

4. Cov khoom raug kuaj los ntawm cov neeg thib peb.

Yog xav yuavCB-03-01 hmoov, thov hu rau Xi'an Sonwu.

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