Clascoterone hmoov

Yog Clascoterone A Steroid
Clascoterone hmoov, tseem hu ua CB-03-01, yog ib qho tshuaj pleev ib ce thiab peripherally xaiv androgen receptor (AR) inhibitor feem ntau siv rau alopecia. Txawm li cas los xij, qhov chaw tshuaj tshiab no tseem tab tom tsim rau pob txuv. Yog lawm, CB-03-01 yog steroidal antiandrogen. CB-03-01 ua raws li androgen receptor antagonist thiab tau pom zoo rau kev kho pob txuv. Nws raug suav hais tias yog "thawj-hauv-chav kawm" cov tshuaj raws li cov txiaj ntsig ntawm US FDA qhov kev tshuaj xyuas ntawm nws 1 feem pua ​​​​ntawm kev kho pob txuv thiab tom qab kev txhim kho ntawm nws cov ntsiab lus siab rau kev kho cov txiv neej androgenetic androgenic alopecia.
CB 03 01 (1%. Thaum CB-03-01 lub tswv yim tseeb ntawm kev ua tsis paub, kev tshawb fawb hauv chav kuaj pom tias cov tshuaj sib tw nrog androgens, tshwj xeeb yog DHT, khi rau androgen receptors hauv qog sebaceous thiab cov hauv paus plaub hau. Nws inhibits lipid ntau lawm hauv kab lis kev cai oleaginous hlwb thiab txo cov pro-inflammatory cytokines cuam tshuam los ntawm androgens. Nrog rau kev siv dav ntawm CB-03-01, muaj ntau thiab ntau tus neeg muag khoom hauv khw; Yog tias koj xav tau 99 Clascoterone nyoos, Xi'an Sonwu tuaj yeem muab tau.

Clascoterone Kev Xeem Thib Peb
HNMR

HPLC

Yuav Ua Li Cas Tau Txais Clascoterone
Xi'an Sonwu Biotech Co. Ltd. muaj ntau tshaj kaum xyoo ntawm kev lag luam kev lag luam, tshwj xeeb hauv kev tsim thiab muag cov ntaub ntawv raw. Xi'an Sonwu tau tsim kev sib koom tes ruaj khov thiab txhim khu kev qha nrog cov teb chaws hauv Asmeskas, Asia, Europe, thiab Oceania. Xi'an Sonwu muab cov khoom zoo ua ntej thiab siv zog los muab txhua tus neeg siv khoom nrog cov kev pabcuam zoo kom tau raws li lawv cov kev xav tau tag nrho.
Xi'an Sonwu pib los ntawm kev ua tib zoo xaiv cov khoom siv raw. Xi'an Sonwu muab qhov tseem ceeb rau cov khoom lag luam zoo, thiab nws txoj kev cog lus rau kev ua tau zoo yog pom tseeb hauv txhua yam, suav nrog kev xaiv cov khoom siv, kev tsim khoom, kev sim qauv, thiab kev tshaj lij ntawm nws cov neeg ua haujlwm. Los ntawm kev tswj hwm txhua qhov kev nthuav dav, Xi'an Sonwu tuaj yeem txo tus nqi yam tsis muaj kev cuam tshuam zoo, ua kom cov neeg siv khoom tau txais cov khoom muaj txiaj ntsig tshwj xeeb.
Xi'an Sonwu zoo siab rau cov lus pom zoo uas nws tau txais los ntawm cov neeg siv khoom, uas tau lees paub qhov zoo ntawm cov khoom. Txhawm rau ua pov thawj ntxiv cov khoom lag luam, Xi'an Sonwu yuav muab cov qauv rau koj los kuaj.

Cov neeg siv khoom zoo lus

Clascoterone Rau Cov plaub hau poob
Hom plaub hau poob ntau tshaj plaws yog AGA. Raws li qhov tshwm sim ntawm kev sib cuam tshuam ntawm kev hloov pauv ntawm keeb kwm thiab ib puag ncig, androgen plays lub luag haujlwm tseem ceeb hauv kev tsim cov kab mob no. Tam sim no, thawj kab kev kho mob rau AGA yog tshuaj minoxidil thiab qhov ncauj finasteride. Txawm li cas los xij, ob cov tshuaj no feem ntau yuav tsum tau siv mus ntev, uas yuav ua rau muaj kev mob siab rau tshuaj thiab lwm yam kev phiv, thiab cov plaub hau poob yog ib qho yooj yim rov pib dua tom qab tso tseg cov tshuaj. Ntau qhov kev tshawb fawb tau tshawb nrhiav thiab pom tias lwm yam kev kho mob kuj muaj txiaj ntsig. Cov tshuaj pleev tshuaj tam sim no rau AGA feem ntau yog minoxidil. Cov kev kho mob tshiab muaj xws li androgen receptor inhibitors xws li pyrilamine thiab CB 03 01.

Pyrilutamide
Pyrilutamide (KX{{0}}, Freetan) yog cov tshuaj pleev xim androgen receptor inhibitor ntawm nws tus kheej tsim los ntawm kuv lub teb chaws thiab muaj peev xwm yog thawj zaug hauv ntiaj teb. Hauv Suav theem 2 kev soj ntsuam ntawm pyrilamine hauv kev kho tus txiv neej AGA, tom qab 24 lub lis piam ntawm kev kho mob, tus naj npawb ntawm cov plaub hau tsis-vellus (TAHC) nyob rau hauv lub hom phiaj ntawm 5mg (0.5 feem pua ​​concentration, ob zaug ib hnub twg) pyrilamine pawg. nce los ntawm 15.34 nti / cm2 piv nrog cov placebo pawg. Muaj qhov sib txawv ntawm tus lej (P=0.024). Tsis tas li ntawd, Suav theem 2 kev soj ntsuam ntawm cov tshuaj hauv kev kho AGA hauv cov poj niam kuj tau ntsib thawj qhov kawg 2. Ntxiv mus, qhov kev sim tau pom tias kev nyab xeeb ntawm pyrilamine yog qhov zoo.

Clascoterone
Clascoterone hmoov, tus tshiab tshuaj pleev ib ce androgen receptor inhibitor, tau pom zoo los ntawm Food and Drug Administration hauv 2020 rau kev kho pob txuv cov neeg mob 12 xyoo thiab laus dua. Qee cov kws tshawb fawb tau pom tias cov khoom tiv thaiv androgenic ntawm CB-03-01 yuav pab tau rau kev kho mob ntawm AGA. Kev tshawb nrhiav theem 2 tau pom tias nws muaj txiaj ntsig zoo dua li cyproterone acetate lossis 17-alpha estradiol hauv kev nce cov plaub hau txoj kab uas hla thiab follicle ntom. Tsis tas li ntawd, cov neeg mob uas tau txais tshuaj pleev CB-03-01 muaj plaub hau loj hlob sai dua li cov neeg tau txais tshuaj pleev minoxidil. Cov kev tshawb fawb soj ntsuam tau pom tias nws feem ntau zam tau zoo, thiab cov kev tsis zoo tshwm sim tseem ceeb yog me ntsis qhuav, erythema, thiab hirsutism ntawm qhov chaw thov.

Tsawg koob tshuaj minoxidil
Cov koob tshuaj tsawg (tsawg dua lossis sib npaug li 5mg / d) qhov ncauj minoxidil tau txais kev saib xyuas ntau dua hauv kev kho cov plaub hau. Cov kev tshawb fawb tau pom tias 0.25mg minoxidil ua ke nrog 25mg spironolactone tuaj yeem txo cov plaub hau poob thiab txhim kho cov plaub hau ceev hauv kev kho AGA hauv cov poj niam. Qhov kev sim tshuaj ntsuam xyuas yav tom ntej tau pom tias cov plaub hau kev loj hlob tau zoo dua tom qab 5 mg minoxidil tau muab rau 30 tus txiv neej AGA cov neeg mob hnub nyoog 24-59. Lwm cov kws tshawb fawb tau sib piv cov txiaj ntsig ntawm txhua hnub 1mg qhov ncauj minoxidil nrog txhua hnub 5 feem pua ​​​​cov tshuaj minoxidil thiab pom tias qhov ncauj minoxidil tau zoo sib npaug li cov tshuaj pleev. Thiab kev txhim kho cov nyhuv ntawm qhov ncauj minoxidil ntawm cov plaub hau poob tau zoo dua.
Cov lus pom zoo tshuaj rau qhov ncauj minoxidil yog raws li hauv qab no. Rau cov neeg mob AGA > 12 xyoos uas muaj kev kho mob tsis zoo lossis kev ua siab ntev lossis ua tsis tau zoo nrog cov tshuaj minoxidil, thiab cov neeg mob AGA cov hluas thiab noj qab haus huv, kev siv tshuaj tsawg minoxidil qhov ncauj hloov pauv tuaj yeem txiav txim siab; Cov poj niam yuav tsum tau txo cov koob tshuaj, qhov kev pom zoo pib koob tshuaj yog 0.25 mg / d, thiab qhov siab tshaj plaws yog 2.5 mg / d; Qhov pib koob tshuaj rau cov txiv neej yog 1.25 mg / d, thiab tag nrho cov koob tshuaj yog 5 mg / d4.

Puas Clascoterone pab pob txuv
Hauv 2018, qhov txiaj ntsig zoo tshaj plaws ntawm ob theem pivotal III qhov kev sim tshuaj ntsuam xyuas ntawm CB-03-01 (1 feem pua ​​​​cov ntsiab lus) pom tias 1440 tus neeg mob pob txuv laus dua li cuaj xyoos nrog qhov qhab nia IGA ntawm 3 los yog 4 tau cuv npe hauv Tebchaws Meskas thiab Europe. Cov ncauj lus tau txais CB0301 lossis ib qho placebo ob zaug ib hnub rau 12 lub lis piam. Tom qab ua tiav qhov kev sim siab, 604 cov ntsiab lus tau tso npe rau hauv daim ntawv qhib kev nyab xeeb mus ntev rau 12 lub hlis. Qhov kev faib ua feem ntawm txhua pab pawg kho mob nrog txo tsawg kawg yog ob feem pua ​​​​cov ntsiab lus los ntawm cov hauv paus ntsiab lus thiab qhov qhab nia IGA ntawm 0 (ntshiab) lossis 1 (yuav luag meej) ntawm lub lim tiam 12 piv rau cov hauv paus ntsiab lus; Kev hloov pauv ntawm lub hauv paus hauv cov kab mob uas tsis yog mob inflammatory (NILC) thiab inflammatory lesion count (ILC) hauv txhua pab pawg kho mob ntawm lub lim tiam 12. Raws li kev txheeb cais, tau muaj kev txhim kho tseem ceeb hauv txhua qhov chaw kho mob thawj zaug.
Tom qab lub sijhawm kho CB0301 txog li ib xyoos, tsis muaj qhov tsis txaus ntawm cov tshuaj hormones hauv tus neeg mob lub cev txawm tias tom qab nthuav tawm cov tshuaj siv tshuaj, suav nrog lub ntsej muag thiab lub cev, yog li ua kom tus neeg mob qhov chaw raug. Cov txiaj ntsig tau lees paub tias lub sijhawm ntev thiab kev pab them nqi ntawm cov tshuaj pleev ib ce ntawm cov tshuaj tsis ua rau muaj kev cuam tshuam loj heev. Zuag qhia tag nrho, kev kho mob-kev mob tshwm sim tshwm sim tshwm sim hauv 18.1 feem pua ​​​​ntawm lub sijhawm kawm, feem ntau yog nasopharyngitis (mob khaub thuas 2.6%) thiab kab mob ua pa sab sauv (1.3 feem pua).

Yog Clascoterone Side Effects
Zoo li txhua yam tshuaj, lactone tuaj yeem muaj kev phiv. Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias tsis yog txhua tus neeg siv CB-03-01 ntsib cov kev mob tshwm sim, thiab qhov tshwm sim thiab qhov hnyav ntawm cov kev mob tshwm sim txawv ntawm ib tus neeg mus rau lwm tus.
1. Cov tshuaj tiv thaiv ntawm daim ntawv thov: Cov no yuav muaj xws li liab, khaus, kub hnyiab, lossis khaus ntawm qhov chaw uas siv cov tshuaj nplaum.

2. Cov tawv nqaij qhuav los yog flaky: CB-03-01 tej zaum yuav ua rau cov tawv nqaij qhuav los yog flaky, feem ntau yog siv, zoo li lwm yam kev kho pob txuv.

3. Kev khaus qhov muag: Kev sib tsoo qhov muag yuav ua rau qhov muag khaus.

Hoobkas
1. Xi'an Sonwu Biotech Co., Ltd muaj nws lub Hoobkas los tsim, tsim thiab khaws cov khoom, yog li muaj cov khoom tsim nyog. Xi'an Sonwu muaj kev txiav txim kom zoo, huv si, thiab huv si ntau lawm. Nyob rau hauv Xi'an Sonwu, cov kws tshawb fawb tuaj yeem tsim cov khoom tshiab zoo.
2. Xi'an Sonwu muaj cov cai nruj rau cov neeg ua haujlwm faib los ntawm kev tsim khoom thiab kev sim rau kev muag khoom. Txhawm rau kom ntseeg tau tias txhua yam khoom raug thauj mus los, kev txhawb nqa cov ntaub ntawv nruj thiab kev pabcuam tom qab muag tau muab.

Daim ntawv pov thawj

Ntim

Logistics

Dhau li lav cov khoom, lwm qhov tseem ceeb tshaj plaws yog cov neeg siv khoom tuaj yeem tau txais cov khoom zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ
Nov yog ob peb lub ntsiab lus tseem ceeb uas yuav tsum nco ntsoov thaum siv CB 03 01:
Consistency: Txhawm rau kom ua tiav cov txiaj ntsig zoo tshaj plaws, siv nws tsis tu ncua raws li tau sau tseg yog qhov tseem ceeb. Ua raws li qhov pom zoo zaus thiab lub sijhawm ntawm daim ntawv thov. Cov txiaj ntsig yuav siv sij hawm ntev, yog li ua siab ntev thiab txuas ntxiv siv nws raws li qhia.
Lwm yam tshuaj thiab cov khoom lag luam: Qhia rau koj tus kws kho mob txog lwm yam tshuaj, kev kho mob, lossis cov khoom tu tawv nqaij uas koj siv, suav nrog cov tshuaj, khw muag khoom, thiab tshuaj ntsuab npaj.

Yog tias koj xav paub tus neeg muag khoom CB0301, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email ces koj tau txais high-zooClascoterone hmoov.

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