Brigatinib hmoov

Brigatinib yog dab tsi

Brigatinib hmoovyog ib qho tshiab dual inhibitor ntawm ALK thiab EGFR, uas tuaj yeem cuam tshuam L1196M kev hloov pauv ntawm ALK thiab T790M kev hloov pauv ntawm EGFR. Nws yog cov tshuaj tshiab thib plaub rau kev kho mob ntsws thiab yog lwm qhov kev xaiv zoo rau cov neeg mob ntsws. Raws li lub zog muaj zog ALK / EGFR inhibitor, nws tuaj yeem tsis tsuas yog inhibit L1196M kev hloov pauv ntawm ALK tab sis kuj muaj cov teebmeem tshwj xeeb ntawm T790M ob txoj kev hloov pauv uas tsis yog mob ntsws me me thiab muaj kev cuam tshuam tshwj xeeb rau C797S / T790M / del19 triple mutant cells thiab T790M / del19 ob chav hloov pauv Cells kuj tseem ua haujlwm. Xi'an Sonwnu muab ntau Brigatinib; Yog tias koj xav yuav lawv, koj tuaj yeem tiv tauj Xi'an Sonwnu yam tsis muaj hesitation.

COA

Qhov twg yuav Brigatinib

Xi'an Sonwu Biotech Co. ltd, cov khoom tsim tau nruj me ntsis tswj nyob rau hauv zoo txij thaum pib ntawm cov khoom raw hmoov. Hauv kev tsim cov khoom lag luam, peb ua txhua yam kom zoo thiab pab peb cov neeg siv khoom kom tau txais cov khoom lag luam zoo. Ntau tus neeg siv khoom tau muab cov lus pom zoo rau peb cov khoom tom qab tau txais cov khoom.

Txhawm rau kom ntseeg tau cov khoom zoo, peb tuaj yeem muab cov qauv rau kev kuaj. Ntawm no yog qhov ntau.

Cov neeg siv khoom zoo lus

Dab tsi yog ALK thiab EGFR

ALK tau pom thawj zaug hauv ib qho subtype ntawm anaplastic ALCL, yog li nws tau hu ua anaplastic lymphoma kinase, ALK. Tom qab ntawd, ntau ALK gene rearrangements tau pom nyob rau hauv diffuse B-cell lymphoid kab mob thiab inflammatory myofibroblastic kab mob (IMT), feem, ua ntej ALK gene rearrangements tau pom nyob rau hauv cov mob uas tsis yog-hlwb ntawm lub ntsws. Txog tam sim no, nws tau raug pov thawj tias ALK yog tus muaj zog oncogenic tsav gene.

EGFR yog hu ua Human Epidermal Growth Factor Receptor hauv Suav. Nws yog ib qho kev loj hlob zoo receptor nyob rau saum npoo ntawm tib neeg lub hlwb. Nyob rau hauv ib txwm muaj xwm txheej, nws tuaj yeem khi rau txoj kev loj hlob los txhawb kev loj hlob ntawm tes thiab kev loj hlob. Hauv cov hlwb necrotic, cov noob encoding qhov kev loj hlob zoo receptor yog hloov pauv, qhia txog kev loj hlob txawv txav receptors, uas ua rau kev loj hlob ntawm cov hlwb necrotic. Cov kev tshawb fawb tau pom tias EGFR noob kev hloov pauv tuaj yeem kuaj pom hauv ze li 50 feem pua ​​​​ntawm cov neeg mob uas tsis yog mob ntsws me me hauv cov neeg Esxias sab hnub tuaj thiab tuaj yeem cuam tshuam txog kev ciaj sia, kev loj hlob, thiab metastasis ntawm cov hlwb necrotic. Kev kuaj pom ntawm EGFR noob kev hloov pauv tau dhau los ua ib qho yuav tsum kuaj xyuas hauv kev kuaj mob cov neeg mob uas tsis yog cov kab mob hauv lub ntsws me, thiab cov tshuaj kho mob rau cov noob hloov pauv no tau nce zuj zus los ua ib txoj hauv kev los kho cov kab mob ntsws me me.

Dab tsi yog Kev Siv NtawmBrigatinib hmoov

Nws tau nkag siab tias Brigatinib tau raug pov thawj los inhibit ALK thiab ALK fusion proteins, yog li inhibiting kev loj hlob ntawm necrotic hlwb. Hauv vitro thiab hauv vivo xeem, brigatinib tau pom cov teebmeem suab nrov. Yog li ntawd, nws kuj tau ua tiav tau txais kev pom zoo rau kev kho mob thiab cov menyuam ntsuag kev tsim nyog tau txais txiaj ntsig los ntawm US FDA.

Hais txog kev kho mob, kev tshawb fawb tau lees paub tias brigatinib tuaj yeem kov yeej qhov kev tawm tsam rau crizotinib los ntawm ALK mutants thiab muaj kev tiv thaiv rau ntau yam kinases (xws li ALK, ROS1, insulin-zoo li kev loj hlob zoo li -1 receptor, Flt-3 ) thiab kev ua ntawm qhov chaw loj hlob ntawm qhov chaw receptor (EGFR) tshem tawm thiab taw tes hloov pauv.

Dab tsi yog qhov tsim nyog hais ntxiv yog tias brigatinib cov nyhuv inhibitory ntawm ALK yog 12 npaug siab dua li ntawm crizotinib. Nws muaj kev tiv thaiv siab rau ALK mutants, yog li nws tuaj yeem kho cov kab mob kev loj hlob tom qab kev kho mob crizotinib lossis cov neeg mob tsis haum nrog ALK-zoo metastatic uas tsis yog mob ntsws me me. Los ntawm cov txiaj ntsig ntawm kev tshawb fawb ntsig txog, nws tsis yooj yim los nrhiav kev kho mob zoo heev ntawm Brigatinib.

Dab tsi yog Qhov Kev Mob Phem Ntawm Brigatinib

1. Cov tsos mob ntawm kev ua xua: khaus khaus; ua tsis taus pa; o ntawm lub ntsej muag, daim di ncauj, tus nplaig, los yog caj pas.

2. Kev mob tshwm sim hnyav:

● Teeb meem ntsws: hnoos, ua pa nyuaj, mob hauv siab, ua npaws.

● Cov teeb meem tsis pom kev: qhov muag tsis pom kev, pom ob lub qhov muag.

● Ntshav siab.

● Cov ntshav qab zib siab: nqhis dej, tso zis ntau ntxiv, tshaib plab, xeev siab, ua tsis taus pa, tsis muaj zog, tsis meej pem.

● Teeb meem plawv.

● Pancreatitis: Mob hauv plab plab.

3. Tej yam tshwm sim muaj xws li kev tshaib kev nqhis, xeev siab, ua tsis taus pa tsw, tsis muaj zog, tsis meej pem, mob nqaij, leeg tsis muaj zog, pancreatitis, xeev siab, thiab poob phaus.

Yuav Siv Brigatinib li cas

1. Kev pom zoo ntau npaum li cas rau cov neeg laus uas tsis yog mob ntsws me me: 90 mg ntawm qhov ncauj ib hnub rau thawj xya hnub; Yog tias thawj koob tshuaj raug zam nyob rau hauv thawj xya hnub, ces nce mus rau 180 mg ntawm qhov ncauj ib hnub. Yog tias qhov koob tshuaj thawj zaug tsis raug zam nyob rau thawj xya hnub, coj tus nqi kho los ntawm tus kws kho mob.

2. Kev hloov kho koob tshuaj, yog tias koob tshuaj dhau los yog 90mg, txo nws mus rau 60mg. Yog tias tsis kam ua, tso tseg cov tshuaj tas mus li yog tias koob tshuaj kawg yog 180mg, thawj qhov txo qis rau 120mg, qhov thib ob txo mus rau 90mg, qhov thib peb txo rau 60mg, thiab thib plaub kev tshem tawm mus tas li.

Thov qhia rau koj tus kws kho mob ua ntej noj nws yog tias koj noj lwm yam tshuaj thiab noj raws li tus kws kho mob cov lus pom zoo.

Yuav Ua Li Cas Saib Xyuas Ua Ntej Ua Ntej Brigatinib

1. Mob ntsws los yog ua tsis taus pa;

2. Lub plawv dhia qeeb;

3. Ntshav siab;

4. Cov teeb meem tsis pom kev;

5. Mob ntshav qab zib los yog qabzib intolerance;

6. Pancreatic teeb meem;

7. Kab mob siab;

8. kab mob raum;

9. Nws yog txwv tsis pub noj thaum cev xeeb tub lossis lactation

Brigatinib tuaj yeem cuam tshuam nrog cov tshuaj tiv thaiv kev yug menyuam ua haujlwm li cas, yog li koj yuav tsum siv cov tshuaj tiv thaiv kev yug menyuam uas tsis yog hormonal. Cov poj niam yuav tsum siv cov tshuaj tiv thaiv tsis yog tshuaj hormones thaum kho thiab plaub lub hlis tom qab koob tshuaj kawg. Cov txiv neej thiab poj niam cov neeg koom tes yuav tsum siv cov tshuaj tiv thaiv kab mob thaum kho thiab txuas ntxiv siv kev tiv thaiv kab mob rau peb lub hlis tom qab koob tshuaj dhau los. Brigatinib tuaj yeem tsim kev puas tsuaj rau tus menyuam hauv plab.

Cov poj niam cev xeeb tub yuav tsum tsis txhob pub niam mis thaum kho nrog brigatinib thiab hauv ib lub lis piam tom qab kho.

Hoobkas ib puag ncig

1. Xi'an Sonwu Biotech Co., Ltd muaj lub Hoobkas nrog txaus Tshuag. Tsis tas li ntawd, lub tuam tsev tsim khoom ntawm Xi'an Matsuya yog huv si thiab huv si. Siv cov khoom siv ntau lawm, cov kws tshawb fawb txuas ntxiv tsim cov khoom tshiab kom tau raws li cov neeg siv khoom xav tau.

2. Xi'an Sonwu Biotech Co., Ltd muaj cov cuab yeej ntsuas qib siab thiab cov neeg ua haujlwm kuaj, uas tau tsim lub hauv paus ruaj khov rau kev muab cov neeg siv khoom nrog cov ntaub ntawv raug thiab siv tau.

Daim ntawv pov thawj

Ntim

Tsis ntev los no Logistics

Tsuas yog lav cov khoom lag luam, lwm qhov tseem ceeb tshaj plaws yog cov neeg siv khoom tuaj yeem tau txais cov khoom zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li qhov xav tau sib txawv.

FAQ

Yuav ntim thiab khaws cia li casBrigatinib hmoov?

Ntim: export qib ntim nruas, lub tshuab nqus tsev ntim aluminium foil ntim, kuj tuaj yeem ntim raws li cov neeg siv khoom xav tau.

Cia: thov khaws cia rau hauv qhov chaw txias thiab qhuav kom tsis txhob muaj lub teeb ci thiab kub.

Yog tias koj xav yuav Brigatinib, thov hu rau Xi'an Sonwu.

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