Masitinib hmoov

Masitinib tshuaj

Masitinib hmoovfeem ntau hu ua Ab 1010 lossis masitinib mesylate. Nws yog platelet-derived growth factor / receptor tyrosine kinase inhibitor uas tuaj yeem kho ntau yam myeloma, qog nqaij hlav plab, thiab prostate malignancies. Masitinib muaj cov txheej txheem tshwj xeeb ntawm kev ua, nws ua lub luag haujlwm tshwj xeeb hauv oncology - nws tuaj yeem cuam tshuam rau kev ciaj sia ntawm cov neeg mob qog thiab kho cov qog nqaij hlav hauv plab los ntawm Ckit mutations. Masitinib tuaj yeem cuam tshuam qhov mob los ntawm kev ua haujlwm ntawm cov hlwb mast thiab microglia thiab zoo rau cov tsos mob cuam tshuam nrog qee yam kab mob hauv nruab nrab paj hlwb thiab degeneration ntawm cov kab mob.

Nyob rau hauv xyoo tas los no, molecular lub hom phiaj tshuaj kho tau txais kev saib xyuas nrog kev loj hlob sai ntawm cov qog nqaij hlav molecular biology. Masitinib, raws li cov tshuaj molecular lub hom phiaj kho mob, tau txais kev saib xyuas ntau dua. Ntau thiab ntau cov kev tshawb fawb tau pom tias masitinib yog thawj tyrosine kinase inhibitor raws li cov qauv ntawm imatinib, uas tuaj yeem daws cov tshuaj tiv thaiv ntawm imatinib los ntawm kev hloov cov pyrimidine nrog thiazole los ntawm lub hauv paus ntsiab lus ntawm bioelectronic isosteres kev sib deev tshuaj. Tsis tas li ntawd, txoj kev tshawb fawb kuj pom tias masitinib muaj kev kho mob ntawm COVID-19, mastocytosis, ntau yam myeloma, amyotrophic lateral sclerosis, thiab Alzheimer's disease. Xi'an Sonwu muab tsis tau tsuas yog raw cov ntaub ntawv tab sis kuj capsules. Yog tias koj xav nrhiav cov chaw tsim khoom masitinib, Xi'an Sonwu yuav yog qhov kev xaiv zoo.

Masitinib yog ib qho kev xaiv kinase inhibitor thiab yog cov tshuaj hluavtaws. Masitinib, muaj nyob rau hauv khw, synthesizes N-(2-methyl-5-nitrophenylaminothioformyl)acetamide los ntawm 2-methyl-5-nitroaniline, acetyl chloride, thiab ammonium thiocyanate thiab tom qab ntawd ua ib lub nplhaib nrog tus kheej ua 2-Bromo-1-(pyridine-3-}yl) ethanone hydrobromide nyob rau hauv alkaline tej yam kev mob, thiab undergo catalytic hydrogenation txo nrog Raney Ni kom tau txais 6-methyl-N-[ 4-(Pyridin-3-yl)thiazol-2-yl]-1,3-phenylenediamine, ua raws li cov tshuaj tiv thaiv hauv tsev 4-({{18} }methyl piperazine-1-ylmethyl) benzoic acid hydrochloride Tsim los rau hauv amide yields masitinib.

Certificate Of Analysis

Qhov twg yuav Masitinib

Xi'an Sonwu Biotech Co., Ltd. muaj ntau tshaj kaum xyoo ntawm kev tsim khoom. Nws muaj kev koom tes dav thiab ruaj khov nrog cov teb chaws thoob ntiaj teb hauv Asmeskas, Asia, Europe, thiab Oceania. Xi'an Sonwu yeej ib txwm hais rau cov khoom zoo ua ntej. Pab txhua tus neeg siv khoom zoo thiab txaus siab rau txhua tus neeg siv khoom yog Xi'an Sonwu txoj kev nrhiav. Xi'an Sonwu nruj me ntsis tswj txhua kauj ruam, los ntawm kev xaiv cov khoom siv raw mus nrhiav cov khoom zoo los ntawm txhua yam, xws li kev xaiv cov khoom siv, kev tsim khoom, kev kuaj cov qauv, thiab cov neeg ua haujlwm tshaj lij. Tsis tas li ntawd, Xi'an Sonwu siv zog ua txhua yam kom txo tau cov nqi thiab tso cai rau cov neeg siv khoom kom tau txais cov khoom lag luam nrog cov nqi siab. Raws li cov no, cov neeg siv khoom tau muab cov lus pom zoo ntawm cov khoom. Yog li yog tias koj xav tau masitinib, tsis txhob yig tiv tauj Xi'an Sonwu.

Xi'an Sonwu thaum kawg ua rau qee yam khoom zoo thiab tseem muaj cov qauv. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'Cov lus pom zoo

Kev Pabcuam OEM

Xi'an Sonwu tsis tsuas yog tuaj yeem muab cov khoom zoomasitinib hmoovtab sis kuj capsules.

Cov neeg siv khoom tuaj yeem kho cov tshuaj ntsiav uas lawv xav tau. Thiab peb tuaj yeem muab cov khoom hauv qab no.

1. Customized capsules shells (loj, xim, khoom)

2.Customized fwj (loj, xim, khoom, style)

3.Customized ntim (nqus foil ntim, thawv, nruas)

4.Customized daim ntawv lo (xim zaj duab xis, matte zaj duab xis, daim npog qhov muag)

Masitinib ua haujlwm li cas

Masitinib yog ib qho kev xaiv kinase inhibitor uas tuaj yeem cuam tshuam tyrosine kinases los ntawm inhibiting qhov kev khi ntawm ATP rau mutant tyrosine kinase receptors thiab thaiv cov phosphorylation ntawm qhov chaw ua haujlwm ntawm tyrosine kinase receptors. Inhibiting tyrosine kinase inhibits qog cell proliferation, tshwj xeeb tshaj yog rau MCTs uas tau hloov pauv hauv c-kit gene. Masitinib tuaj yeem thaiv cov haujlwm ntawm C-kit, FDGRR, Lyn, thiab FGFR3 tyrosine kinases thiab FAK cellular txoj hauv kev los ntawm inhibiting phosphorylation kev ua ntawm FAK.

Thaum cov concentration ntawm Masitinib tsawg dua los yog sib npaug rau 500nM, nws yog ATP kev sib tw inhibitor, uas tuaj yeem cuam tshuam cov PDGFR recombinant, intracellular kinase Lyn, thiab FGFR3. Piv nrog rau imatinib, nws muaj zog inhibitory nyhuv ntau dua ntawm degranulation, cytokines, thiab tsiv teb tsaws ntawm cov pob txha pob txha mast hlwb. Masitinib inhibited SCF-induced cell proliferation nyob rau hauv Ba / F3 hlwb qhia tib neeg qus-hom KIT. Hauv Ba / F3 hlwb qhia PDGFR-, Masitinib inhibits PDGF-BB-stimulated proliferation thiab PDGFR- tyrosine phosphorylation. Nws tuaj yeem cuam tshuam KIT tyrosine phosphorylation thaum nws ua rau mast cell qog cell kab thiab BMMC. Thaum nws ua rau Ba / F3 hlwb, nws tuaj yeem cuam tshuam qhov kev hloov pauv ntawm V559D thiab Δ27 nas kev hloov pauv los ntawm KIT. Masitinib inhibits cell proliferation ntawm HMC-1 155 thiab FMA3 nyob rau hauv mast cell qog cell kab. Tsis tas li ntawd, masitinib tau pom tias thaiv kev rov ua dua ntawm SARS-CoV{16}} los ntawm inhibiting lub ntsiab protease 3CLpro, uas txhais tau hais tias masitinib tuaj yeem cuam tshuam qhov kev rov ua dua ntawm COVID-19.

Masitinib rau ALS

Lub npe tag nrho ntawm ALS yog amyotrophic lateral sclerosis, tseem hu ua motor neuron disease. Nws yog kev puas tsuaj rau lub cev muaj zog neurons. Nws txo qis lub cev muaj zog neurons, uas ua rau maj mam qaug zog thiab atrophy ntawm cov nqaij ntshiv innervated los ntawm medulla, ceg, pob tw, hauv siab, thiab plab. Phem. Masitinib tau txo qis kev tuag thiab lub cev muaj zog neuron atrophy hauv ob peb nas thiab tsiaj qauv. Los ntawm inhibiting lub receptor ntawm CSF-1R, nws inhibits kev loj hlob thiab ua kom cov hlwb glial. Mounting pov thawj qhia tias "crosstalk" ntawm microglia, mast hlwb, thiab astrocytes hauv ALS cov neeg mob tuaj yeem ua rau lub cev muaj zog. Masitinib, ntawm qhov tod tes, inhibits tus naj npawb ntawm kinases tsom rau microglia thiab mast hlwb.

Hauv lwm qhov kev sim 48-lub lim tiam, 394 tus neeg laus nrog amyotrophic lateral sclerosis tau kho nrog masitinib ntawm 3 lossis 4.5 mg / hnub lossis 100 mg / hnub riluzole. Txoj kev tshawb no randomized cov neeg mob no tau txais masitinib los yog ib qho placebo kom pom tias cov tshuaj muaj txiaj ntsig thiab nyab xeeb npaum li cas hauv ob pawg. Raws li txoj cai txoj kev tshawb fawb, lawv tuaj yeem ua qhov kev soj ntsuam ib ntus ib zaug 50 feem pua ​​​​ntawm cov neeg kawm (191 tus neeg mob) mus txog 48- lub sijhawm kho mob lub lim tiam. Cov txiaj ntsig kev xeem zaum kawg tau ua raws li qhov hloov kho ntawm Amyotrophic Lateral Sclerosis Functional Rating Scale. Cov txiaj ntsig tau pom tias riluzole ncua kev xaiv ntawm lub tshuab ua pa los yog kev kho mob tracheostomy, thaum masitinib ntawm koob tshuaj 4.5 mg / kg ua rau qeeb ntawm tus kab mob. Qhov txiaj ntsig no kuj txhais tau tias masitinib tuaj yeem ua rau lub neej ntev ntawm tib neeg nyob rau hauv chav kawm ntawm ALS.

Masitinib Covid

Masitinib yog tus kab mob 3CL dav dav uas thaiv kev rov ua dua ntawm SARS-CoV-2. Hauv ib txheej ntawm kev sim vivo hauv cov nas, pab pawg tshawb fawb intranasally kis 20 K18-hACE2 cov nas hloov pauv nrog 2 × 10E4 PFU ntawm tus kabmob tshiab. Ib nrab tau kho nrog PBS raws li pab pawg tswj hwm, thiab ib nrab tau kho nrog masitinib (25 mg / kg) ob zaug hauv ib hnub, pib 12 teev tom qab kis kab mob thiab txuas ntxiv mus rau kaum hnub. Hnub thib rau ntawm qhov kev sim, masitinib tuaj yeem txo tus kabmob tshiab tus kabmob titer hauv nas lub ntsws thiab qhov ntswg kom tsawg dua 1 feem pua ​​​​ntawm qhov qub, thiab nws kuj tuaj yeem txo qhov mob ntsws. Nws tuaj yeem tswj hwm kev ua haujlwm hauv cov nas sim, kho lawv qhov mob, thiab muaj txiaj ntsig zoo tiv thaiv cov kab mob tshiab , , thiab mutant.

Txoj kev tshawb no tseem qhia tau tias masitinib muaj zog inhibitory cuam tshuam rau ntau yam kab mob coronaviruses thiab tib neeg cov kab mob uas tuaj yeem ua rau ntau yam kab mob, suav nrog tus mob khaub thuas, mob meningitis, kab mob siab, thiab polio. Ntxiv rau qhov ua tau zoo inhibiting tus kabmob tshiab thiab nws cov kabmob mutant, masitinib kuj tseem siv tau rau ntau yam kabmob coronaviruses thiab cov kab mob RNA me me. Nws tuaj yeem kho tau lwm yam kab mob sib kis thiab ua ib qho tshuaj tiv thaiv kab mob dav dav.

Hoobkas

1. Xi'an Sonwu Biotech Co., Ltd muaj lub Hoobkas nrog cov khoom muag txaus. Xi'an Songwu muaj chav ua haujlwm huv thiab muaj kev tsim khoom zoo. Raws li Xi'an Sonwu, cov kws tshawb fawb lossi tsim cov khoom zoo tshaj plaws kom tau raws li cov neeg siv khoom xav tau.

2. Xi'an Songwu Biotechnology Co., Ltd. muaj cov cuab yeej ntsuas qib siab thiab cov neeg ua haujlwm xeem, txhua tus qhia tias Xi'an Songwu tau cog lus los muab cov ntaub ntawv raug thiab ua tau zoo thiab cov kev pabcuam zoo.

Daim ntawv pov thawj

Pob

Logistics

Dhau li lav cov khoom, lwm qhov tseem ceeb tshaj plaws yog cov neeg siv khoom tuaj yeem tau txais cov khoom zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ

Thov ua tib zoo saib thaum noj masitinib. Yog muaj

Mob plab

xeev siab thiab ntuav

Raj

o ntawm sab ceg, sab caj npab, lossis tes

Tsawg hemoglobin qib

Rau kev mob plab hnyuv, Edema, thiab lwm yam tsos mob, nco ntsoov tiv tauj nrog koj tus kws kho mob sai li sai tau. Tsis tas li ntawd, thov nco ntsoov tias masitinib tuaj yeem ua rau muaj kab mob plawv.

Yog xav paub ntxivmasitinib hmoovnqe lossis muaj lwm yam lus nug txog cov khoom, tsis txhob yig tiv tauj Xi'an Sonwu.

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Cim npe nrov: Masitinib hmoov, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, raw, mov, kev muag khoom