TIAB SA 1775

AZD1775 yog dab tsi

MK -1775yog ib tug compound uas belongs rau ib chav kawm ntawm cov tshuaj hu ua checkpoint kinase 1 (CHK1) inhibitors. CHK1 yog cov protein koom nrog hauv kev tswj hwm lub voj voog ntawm tes thiab cov lus teb DNA puas. Los ntawm inhibiting CHK1, Nws tuaj yeem cuam tshuam nrog kev kho kom zoo ntawm DNA puas, uas yuav muaj txiaj ntsig zoo hauv qee hom kev kho mob qog noj ntshav. AZD1775 feem ntau tau kawm ua ke nrog kev siv tshuaj khomob lossis kev kho hluav taws xob hauv kev sim ua ntej thiab kuaj mob. Nws ntseeg tau tias kev sib koom ua ke AZD1775 nrog cov qauv kev kho mob qog noj ntshav tuaj yeem txhim kho lawv cov txiaj ntsig los ntawm kev tiv thaiv cov qog nqaij hlav cancer los ntawm kev kho DNA puas, ua rau muaj cell tuag thiab qog nqaij hlav.

Cov ntawv thov tshwj xeeb ntawm AZD1775 hauv kev kho mob qog noj ntshav tseem raug tshawb xyuas, thiab nws yuav muaj peev xwm ua tau ntau yam mob qog noj ntshav. Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias kev siv AZD1775 lossis lwm yam tshuaj hauv kev kho mob qog noj ntshav yuav tsum tau soj ntsuam xyuas zoo los ntawm cov kws kho mob thiab feem ntau txiav txim siab raws li qhov xwm txheej. Yog tias koj muaj lus nug tshwj xeeb txog AZD1775 lossis nws muaj peev xwm siv tau hauv kev kho mob qog noj ntshav, nws raug nquahu kom sab laj nrog kws kho mob oncologist lossis kws kho mob.

COA

MK-1775 Ntxiv

Xi'an Sonwu Biotech Co. Ltd. muaj kev paub dhau los hauv kev lag luam thoob ntiaj teb thiab kev noj qab haus huv kev lag luam. Insisting rau txoj kev ntseeg raws li kev ntseeg thiab zoo ua ntej yog peb lub tuam txhab txoj cai. Peb nruj me ntsis tswj cov khoom zoo, uas txhais tau tias kev xaiv pib los ntawm raw cov ntaub ntawv. Tsis tas li ntawd, peb tuav txhua qhov kev nthuav dav thiab txo tus nqi mus rau qhov siab tshaj plaws, ces peb cov neeg siv khoom tuaj yeem tau txais cov khoom lag luam zoo. Raws li cov no, cov neeg siv khoom tau muab cov lus pom zoo rau peb cov khoom. Yog li koj tuaj yeem nrhiav Xi'an Sonwu Biotech Co. Ltd. thaum koj xav tau MK-1775 ntxiv.

Xi'an Sonwu ua kom paub tseeb ntawm cov khoom zoo, yog li cov qauv tuaj yeem muab tau. Ntawm no yog qhov ntau.

Cov neeg siv khoom zoo lus

Dab tsi yog Mechanism Ntawm Kev Ua Ntawm MK 1775

Cov txheej txheem ntawm kev txiav txim ntawm AZD1775 suav nrog nws qhov inhibition ntawm checkpoint kinase 1 (CHK1), uas yog cov protein koom nrog cov lus qhia ntawm lub voj voog ntawm tes thiab DNA ua rau cov tshuaj tiv thaiv. CHK1 ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev faib tawm ntawm tes kom txog thaum kho DNA puas.

Thaum cov hlwb raug kev puas tsuaj DNA, CHK1 ua haujlwm raws li qhov chaw kuaj xyuas kom ncua lub voj voog ntawm tes, tso cai rau lub sijhawm kho DNA. Txawm li cas los xij, cov qog nqaij hlav cancer feem ntau muaj kev hloov pauv hauv lawv cov txheej txheem kho DNA, ua rau lawv muaj sia nyob thiab txuas ntxiv faib txawm tias muaj DNA puas lawm. AZD1775 tsom rau qhov tsis zoo no.

Los ntawm inhibiting CHK1, AZD1775 tiv thaiv lub voj voog ntawm tes qeeb thiab nres cov txheej txheem kho DNA. Qhov cuam tshuam nrog kev kho DNA tuaj yeem ua rau muaj kev puas tsuaj DNA hauv cov hlwb. Thaum cov hlwb no sim sib faib nrog DNA tsis kho, lawv tuaj yeem ntsib kev tuag ntawm cov genomic instability thiab thaum kawg raug kev tuag ntawm tes.

Qhov inhibition ntawm CHK1 los ntawm AZD1775 yog xav tias yuav txhim khu kev ua tau zoo ntawm lwm yam kev kho mob qog noj ntshav DNA, xws li kws khomob lossis kev kho hluav taws xob. Los ntawm kev tiv thaiv DNA kho nyob rau hauv cov qog nqaij hlav cancer, AZD1775 tuaj yeem ua rau lawv nkag siab txog cov kev kho mob no thiab tuaj yeem txhim kho cov txiaj ntsig kev kho mob. Nws yog ib qho tseem ceeb kom nco ntsoov tias kev siv ntawmMK -1775los yog lwm yam kev kho mob yuav tsum nyob rau hauv cov kev taw qhia ntawm cov kws kho mob thiab ib tug neeg rau txhua tus neeg mob tus mob thiab tej yam kev mob.

Wee1 Inhibitor MK1775 yog dab tsi

Wee1 inhibitor MK1775 yog ib qho me me molecule inhibitor uas tsom rau cov protein kinase Wee1. Wee1 yog ib qho enzyme koom nrog hauv kev tswj hwm lub voj voog ntawm tes, tshwj xeeb yog kev tswj xyuas G2. Los ntawm inhibiting Wee1, MK1775 tiv thaiv phosphorylation thiab inactivation ntawm cyclin-dependent kinases (CDKs), ua rau ntxov ntxov nkag mus rau mitosis.

MK1775 tau kawm raws li kev kho mob qog noj ntshav uas muaj peev xwm, vim tias qhov tsis zoo ntawm lub voj voog ntawm tes yog qhov cim ntawm cov qog nqaij hlav cancer. Los ntawm thaiv qhov chaw kuaj G2, MK1775 tej zaum yuav ua rau DNA raug mob thiab cell demise nyob rau hauv malignant loj hlob hlwb, thaum sparing ib txwm hlwb rau qee yam. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias MK1775 tseem raug tshuaj xyuas hauv kev kuaj mob ua ntej thiab kuaj mob, thiab nws cov txiaj ntsig thiab kev ua tau zoo hauv kev kho mob qog noj ntshav tseem raug txiav txim siab.

Dab tsi yog Mechanism ntawm AZD1775

Lub tshuab ntawm AZD1775 (adavosertib), Wee1 inhibitor, koom nrog nws cov kev cuam tshuam nrog cov protein kinase Wee1 thiab nws cov teebmeem ntawm lub voj voog ntawm tes. Wee1 yog ib qho kinase uas ua lub luag haujlwm tseem ceeb hauv G2 qhov chaw kuaj xyuas ntawm lub voj voog ntawm tes, uas ua raws li kev tswj xyuas zoo los xyuas kom meej DNA replication ua ntej ntawm tes faib. Wee1 phosphorylates thiab inhibits cyclin-dependent kinases (CDKs), tshwj xeeb yog CDK1, uas tso cai rau lub voj voog ntawm tes thiab mitotic nkag. Los ntawm inhibiting Wee1, AZD1775 tiv thaiv phosphorylation thiab inactivation ntawm CDK1.

Qhov no inhibition ntawm Wee1 ua rau ntau yam tseem ceeb:

1. Kev nkag mus rau hauv mitosis ntxov ntxov: Feem ntau, Wee 1-induced inhibition ntawm CDK1 kev ua ub no ua rau ncua kev nkag ntawm cov hlwb mus rau hauv mitosis. Adavosertib's inhibition ntawm Wee1 tso cai rau cov hlwb nkag mus rau mitosis ntxov dua li lawv xav tau nyob rau hauv ib txwm muaj.

2. Unscheduled DNA replication: Qhov ntxov ntxov nkag mus rau hauv mitosis tsis muaj DNA replication yuav ua rau DNA puas. Qhov no tsis tau teem sijhawm DNA rov ua dua ua rau muaj kev ntxhov siab rau DNA, ua rau kev sib sau ntawm DNA raug mob thiab rov ua dua tshiab.

3. Synthetic lethality: Nyob rau hauv cov qog nqaij hlav cancer nrog rau hauv qab DNA kho qhov tsis zoo, Wee1 inhibition los ntawm AZD1775 tuaj yeem ua rau muaj kev puas tsuaj ntxiv rau DNA. Cov qog nqaij hlav cancer no tsis tuaj yeem kho DNA puas tau zoo, ua rau cytotoxicity thiab xaiv tua cov qog nqaij hlav cancer thaum sparing cov hlwb rau qee yam.

Lub hauv paus txheej txheem ntawm AZD1775 tseem tab tom kawm thiab nws cov peev xwm kho tau tag nrho, suav nrog nws kev sib xyaw nrog lwm cov tshuaj tiv thaiv kab mob, tseem tab tom tshawb nrhiav.

Dab tsi yog Cov Txheej Txheem Tsis Zoo Ntawm Adavosertib

Adavosertib, tseem hu ua AZD1775, yog ib qho me me molecule inhibitor ntawm cov protein kinase Wee1, uas koom nrog hauv kev tswj lub voj voog ntawm tes. Cov xwm txheej tsis zoo, lossis cov kev mob tshwm sim tuaj yeem tshwm sim nrog kev siv adavosertib. Qee qhov kev tshaj tawm tsis zoo cuam tshuam nrog adavosertib suav nrog:

1. Cov teebmeem hauv plab: Cov no yuav muaj xws li xeev siab, ntuav, raws plab, thiab mob plab. Nws yog ib qho tseem ceeb los tswj cov tsos mob no kom ntseeg tau tias kev noj qab haus huv ntawm cov neeg mob.

2. Hematological teebmeem: Adavosertib tuaj yeem cuam tshuam rau cov ntshav suav. Qhov no tuaj yeem suav nrog txo cov qe ntshav dawb, qe ntshav liab, lossis platelets. Kev saib xyuas cov ntshav suav feem ntau yog ua thaum kho.

3. Kev qaug zog: Qee tus neeg mob yuav muaj kev qaug zog lossis qaug zog raws li kev phiv ntawm adavosertib. Qhov no tuaj yeem cuam tshuam cov haujlwm niaj hnub thiab lub neej zoo.

4. Cov teebmeem ntawm Cutaneous: Cov teebmeem ntawm daim tawv nqaij xws li pob khaus lossis tawv nqaij qhuav tau raug tshaj tawm rau qee tus neeg mob. Cov no tuaj yeem tswj hwm nrog kev pab txhawb nqa tsim nyog.

5. Mob plawv: Tsis tshua muaj, adavosertib tuaj yeem ua rau mob plawv xws li arrhythmias lossis kev hloov hauv lub plawv. Kev saib xyuas lub plawv zoo yog qhov tseem ceeb thaum kho.

Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias qhov no tsis yog daim ntawv teev cov xwm txheej tsis zoo, thiab cov kev mob tshwm sim tshwj xeeb tuaj yeem sib txawv ntawm tib neeg. Adavosertib yuav tsum tau siv raws li kev taw qhia ntawm tus kws kho mob uas tuaj yeem saib xyuas cov xwm txheej tsis zoo thiab muab cov tswv yim tswj kom tsim nyog.

Hoobkas

Xi'an Sonwu ntau lawm Hoobkas yog zoo-tsim, huv si, thiab huv si, nrog txaus Tshuag. Raws li kev coj noj coj ua ntawm lub tuam txhab, cov kws tshawb fawb tau hais kom tsim cov khoom tshiab. Cov hauv qab no yog qhov chaw sim ntawm peb lub chaw soj nstuam, cov cuab yeej ntsuas qib siab, thiab cov kws tshaj lij kev sim, nrog tus cwj pwm nruj los muab cov ntaub ntawv tseem ceeb rau peb cov khoom thiab muab peb cov neeg siv khoom nrog kev paub zoo.

Daim ntawv pov thawj

Pob

Logistics Hloov tshiab

Ntxiv nrog rau kev lees paub cov khoom zoo, lwm qhov tseem ceeb tshaj plaws yog cov neeg tuaj yeem tau txais cov khoom lag luam zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

Vim Li Cas Xaiv Peb
 

Peb lub tuam txhab tau koom nrog ntshuam-export rau ntau tshaj 10 xyoo thiab muaj kev nplua nuj nyob hauv kev lag luam ntshuam thiab xa tawm.
Peb lub tuam txhab muaj 10- xyoo dhau los hauv kev tsim khoom, tsim khoom, thiab muag khoom.
Peb lub tuam txhab muaj cov kws tshaj lij nrog kev faib cov neeg ua haujlwm kom meej.
Peb muaj cov kws tshaj lij thiab cov cuab yeej siv los xyuas kom meej cov khoom zoo.
Cov khoom raug kuaj los ntawm cov neeg thib peb.
Peb muab kev pabcuam OEM.
Peb muab 7 * 24 kev pabcuam rau cov neeg siv khoom.

Thiab yog tias koj xav paub covMK -1775tus nqi lossis koj xav tau MK-1775 ntxiv, thov hu rau XI'an Sonwu.

Email:sales@sonwu.com

Cim npe nrov: mk 1775, Suav teb, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, raw, mov, kev muag khoom