Nicotinamide Riboside Chloride Hmoov

nicotinamide riboside chloride yog dab tsi?

Nicotinamide Riboside Chloride hmoovyog muab los ntawm Nicotinamide Riboside Chloride, uas yog ib qho kev xaiv ntawm Vitamin B3, feem ntau hu ua niacin. Nicotinamide Riboside Chloride kuj tseem hu ua niagen lossis luv luv li NRC. Thaum noj hauv lub cev, nws yuav hloov mus rau Nicotinamide Adenine Dinucleotide lossis NAD ntxiv. NAD ntxiv yog ib qho tseem ceeb tshaj plaws enzymes hauv tib neeg lub cev. Nws yog lub luag haujlwm rau kev txhawb nqa ntau cov txheej txheem lom neeg tseem ceeb suav nrog kev hloov pauv ntawm cov zaub mov mus rau hauv lub zog thiab txhawb kev tiv thaiv kab mob hauv txhua lub cell. Cov enzyme kuj tseem yog qhov tseem ceeb hauv kev kho DNA puas thiab tuaj yeem muaj txiaj ntsig zoo ntxiv hauv kev txhawb nqa kev laus noj qab haus huv. Lub cev tuaj yeem tsim nws tus kheej NAD ntxiv enzyme yooj yim yam tsis muaj ntxiv. Qhov kev tu siab yog tias, raws li tib neeg mus rau hnub nyoog, tus nqi ntawm NAD ntxiv los ntawm lub cev poob qis. Hauv qhov tseeb, cov neeg laus yuav muaj qis dua ntawm cov enzyme tseem ceeb no piv rau cov hluas. Qhov no yog qhov uas supplementation yuav tseem ceeb heev. Siv cov tshuaj Nicotinamide Riboside Chloride los txhim kho NAD ntxiv rau qib, tshwj xeeb tshaj yog cov neeg laus, tuaj yeem muab ntau cov txiaj ntsig zoo kawg. Xi'an Sonwu, ua cov chaw tsim khoom thiab cov chaw muag khoom ntawm nicotinamide riboside chloride, tuaj yeem muab cov khoom lag luam zoo nrog tus nqi txaus nyiam. Yog tias koj xav tau, txais tos hu rau Xi'an Sonwu.

Specification

Dab tsi yog nicotinamide riboside chloride zoo rau?

Cov txiaj ntsig ntawm NRC tuaj yeem pom hauv kev cuam tshuam nrog lub luag haujlwm NAD ntxiv rau kev ua si hauv lub cev. Qhov no yog vim tias kev ntxiv ntawm NRC yuav nce NAD ntxiv rau qib thiab dhau los no coenzyme tseem ceeb yuav xa cov txiaj ntsig hauv qab no:

1. Yooj yim hloov rau hauv NAD ntxiv

NAD yog ib lub npe lom neeg uas nws lub npe Suav yog nicotinamide adenine dinucleotide, abbreviated li coenzyme I. Nws yog coenzyme tseem ceeb tshaj plaws ntawm oxidoreductase hauv cov txheej txheem metabolic ntawm cov kab mob. Hauv cov tsiaj nyeg, muaj ob lub xeev, oxidized (NAD ntxiv) thiab txo qis (NADH), thiab koom nrog ntau txhiab tus tshuaj tiv thaiv redox. Ntawd yog, lo lus NAD yog siv los sib sau ua ke rau ob hom NAD: NAD ntxiv thiab NADH. NAD ntxiv yog ib coenzyme, los yog pab molecule, uas koom nrog ntau yam tshuaj lom neeg. Thaum nws yog qhov tseem ceeb rau kev noj qab haus huv zoo, kev tshawb fawb qhia tau tias NAD ntxiv rau qib txuas ntxiv mus rau hnub nyoog. Tsawg NAD ntxiv rau qib yog txuas rau kev laus tsis zoo thiab ntau yam kab mob txaus ntshai. Ib txoj hauv kev los nce qib NAD ntxiv yog siv NAD ntxiv rau cov neeg ua ntej - lub tsev thaiv ntawm NAD ntxiv - xws li nicotinamide riboside. Cov kev tshawb fawb tsiaj pom tias nicotinamide riboside nce ntshav NAD ntxiv rau qib nce mus txog 2.7 npaug. Dab tsi ntxiv, nws tau yooj yim siv los ntawm lub cev dua li lwm yam NAD ntxiv rau qhov ua ntej.

2. Ua kom cov enzymes uas yuav txhawb kev laus noj qab haus huv

NRC pab nce NAD ntxiv rau qib hauv lub cev. Hauv kev teb, NAD ntxiv ua rau qee cov enzymes uas tuaj yeem txhawb kev laus noj qab haus huv.

Ib pawg yog sirtuins, uas tshwm sim los txhim kho lifespan thiab tag nrho kev noj qab haus huv ntawm cov tsiaj. Cov kev tshawb fawb qhia tias sirtuins tuaj yeem kho DNA puas, txhawb kev ntxhov siab, txo qhov mob thiab muaj lwm yam txiaj ntsig uas txhawb kev laus noj qab haus huv. Lawv kuj yog lub luag haujlwm rau lub neej ntev-ntev cov txiaj ntsig ntawm kev txwv calorie.

Lwm pab pawg yog Poly (ADP-Ribose) polymerases (PARPs), uas kho DNA puas. Cov kev tshawb fawb txuas cov haujlwm PARP ntau dua kom tsawg dua DNA kev puas tsuaj thiab lub neej ntev dua.

3. Txhim kho cell tiv thaiv mechanism nyob rau hauv lub hlwb

NAD ntxiv tuaj yeem tiv thaiv lub hlwb los ntawm kev tsis sib xws, tshwj xeeb nrog kev laus. Qee qhov kev tshawb fawb qhia tau tias NAD ntxiv tuaj yeem tswj hwm kev tsim cov protein hu ua PGC-1-alpha, cov protein uas zoo li pab tiv thaiv cov hlwb tiv thaiv oxidative kev nyuaj siab thiab kev ua haujlwm tsis zoo ntawm mitochondrial.Cov protein tseem ceeb heev hauv kev tiv thaiv cov hlwb tiv thaiv oxidative kev nyuaj siab. Nws kuj tseem tuaj yeem txhim kho thiab kho cov haujlwm mitochondrial hauv hlwb hlwb, ua rau kev paub txog kev noj qab haus huv zoo dua.

Tseem muaj ntau ntau cov kev tshawb fawb tshawb fawb txuas oxidative kev nyuaj siab thiab puas mitochondrial zog nyob rau hauv lub hlwb hlwb uas muaj hnub nyoog txog lub hlwb mob xws li Alzheimer's, Parkinson's thiab lwm yam. Qhov kev txiav txim ntawm NAD ntxiv rau hauv kev txo cov txheej txheem no tuaj yeem txo qhov kev pheej hmoo ntawm Alzheimer's thiab lwm yam kab mob hauv lub hlwb degenerative. Kev ua tau zoo ntawm NAD ntxiv hauv qhov no yog qhov ua tau siab heev. Hauv qee qhov kev tshawb fawb tsiaj uas nas nrog Alzheimer's tau kho nrog Nicotinamide Riboside Chloride, qib ntawm PGC-1-alpha hauv lub hlwb tau nce los ntawm 50 thiab 70 feem pua. Thaum kawg ntawm cov kev tshawb fawb, cov nas kho nrog NR tau pom tias muaj kev txhim kho tseem ceeb hauv kev ua haujlwm nco.

4. Tej zaum yuav pab tau lub plawv

Qhov kev pheej hmoo ntawm lub plawv tsis ua haujlwm nce ntxiv nrog kev laus. Lub plawv tsis ua hauj lwm kuj yog ib qho teeb meem loj heev nyob rau hauv qhov tseeb nws yog tus thib ib ua rau tuag thoob ntiaj teb. Nws tuaj yeem ua rau cov hlab ntsha zoo li koj lub aorta ua tuab, tawv thiab tsis hloov pauv. Cov kev hloov no tuaj yeem nce ntshav siab thiab ua rau koj lub plawv ua haujlwm hnyav dua. Tag nrho lub plawv kev noj qab haus huv yog nyob ntawm ntau yam txawm tias suav nrog kev noj zaub mov kom raug thiab kev tawm dag zog. Tab sis muaj qee yam uas yuav txo tau qhov kev pheej hmoo. Kev tsim tawm ntau ntxiv ntawm NAD ntxiv yog ib qho ntawm cov no.

Cov kev tshawb fawb soj ntsuam tau ua tiav ntawm cov tsiaj pom tias muaj kev tsim cov NAD ntxiv rau kev pab cuam rov qab cov kev hloov pauv hauv cov hlab ntsha uas tshwm sim los ntawm kev laus. Hauv qee qhov kev tshawb fawb ntawm tib neeg, qib siab ntawm NAD ntxiv tau ua rau txo qis qhov tawv nqaij ntawm lub aorta. NAD ntxiv kuj tau tshaj tawm los txo qis qhov pheej hmoo ntawm systolic ntshav siab. Qhov no tsuas yog txhais tau hais tias muaj peev xwm tiag tiag ntawm kev siv Nicotinamide Riboside Chloride ua ib qho ntxiv hauv kev txo qis kev pheej hmoo ntawm kab mob plawv.

nicotinamide riboside chloride ua haujlwm li cas?

Nicotinamide Riboside Chloride hmoovyuav hloov mus rau hauv NAD ntxiv, ib zaug noj hauv lub cev. Yog li, qhov ntxiv ntawm NRC yuav nce qib ntawm NAD ntxiv . NAD ntxiv, los yog nicotinamide adenine dinucleotide, yog ib coenzyme pom nyob rau hauv tag nrho peb lub hlwb. Nws yog ib qho tseem ceeb rau cov txheej txheem metabolic ntawm cov as-ham. Raws li nws yog coenzyme ("co-" zoo li hauv kev koom tes), nws kuj khi nrog lwm cov proteins los pab muab ntau yam txiaj ntsig xws li kho DNA thiab kho cell. Yog li, NAD ntxiv ua haujlwm li cas?

Qhov tseeb yog tias NAD tsis muab cov txiaj ntsig ncaj qha rau ib feem ntawm koj lub cev. Nws tsuas yog pab koj lub hlwb ua haujlwm zoo dua. Nov yog li cas:

Raws li peb tau hais ua ntej, NAD yog "tus pab" coenzyme. Nws ua haujlwm los ntawm kev xa cov hluav taws xob los ntawm kev thauj cov hluav taws xob los ntawm ib lub molecule mus rau lwm qhov hauv cov hlwb kom ua tiav txhua yam kev cuam tshuam thiab cov txheej txheem. Yog li, koj tuaj yeem xav txog txhua NAD coenzyme ua lub tsheb thauj me me uas lub luag haujlwm rau kev noj cov khoom siv hluav taws xob los ua haujlwm hauv mitochondria (ib feem ntawm lub cell lub luag haujlwm rau cov khoom noj metabolism).

Qhov ntau shuttle tsheb npav koj muaj, ntau electrons tau xa mus rau mitochondria. Cov hluav taws xob hluav taws xob no ua rau cov tshuaj lom neeg ua rau lub cev muaj zog thiab ua kom lub cev noj qab haus huv. Txhawm rau khaws cov khoom siv hluav taws xob thiab txav mus los ntawm qhov chaw mus rau qhov chaw, NAD ua rau lwm yam kev cuam tshuam uas ua rau lub xov tooj ntawm tes buzzing nrog lub neej. Thaum tsis muaj NAD shuttle tsheb npav ntau, tsawg cov khoom noj tau ua tiav los ntawm mitochondria, thiab tsawg dua tshwm sim hauv lub cell. Yog li ntawd, cov hlwb pib laus thiab tuag.

Puas yog nicotinamide riboside chloride muaj kev nyab xeeb?

NRC bulk yog ib qho kev nyab xeeb ntxiv rau kev siv tab sis ib yam li txhua yam khoom, nws muaj ntau yam kev mob tshwm sim uas koj yuav tsum paub txog. Hauv qee qhov kev tshawb fawb tib neeg, cov kev xeem tau muab nruab nrab ntawm 1000 milligrams thiab 2000 milligrams ntawm Nicotinamide Riboside Chloride thiab tsis pom muaj kev phom sij dab tsi. Txog tam sim no, cov tuam txhab ntawm NRC pom zoo ntawm 200 mgs thiab 300 mgs ntawm cov khoom ib hnub. Txawm hais tias cov ntaub ntawv kev nyab xeeb no, nicotinamide riboside chloride tej zaum yuav muaj qee qhov kev mob tshwm sim uas yuav tsum nco ntsoov. Ua ntej, qee cov neeg tau tshaj tawm tias xeev siab tom qab siv cov khoom. Hauv lwm qhov xwm txheej, cov neeg mob xav tias nkees thiab mob taub hau vim yog nicotinamide riboside chloride. Nws kuj tsis yog ib qho uas yuav muaj teeb meem digestive nrog rau plab tsis xis nyob thiab raws plab.

Txawm li cas los xij, qhov kev mob tshwm sim loj heev txawv ntawm ib tus neeg mus rau lwm tus. Qee tus neeg tsis txawm ntsib cov teebmeem no txhua. Yog tias koj nyob rau lwm yam tshuaj, tham nrog koj tus kws kho mob ua ntej siv nws.

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