Riociguat hmoov

Kev siv Riociguat

Riociguat hmoovtseem hu ua BAY 63 2521 hmoov.Cov tshuaj no yog siv los kho mob thromboembolic pulmonary arterial hypertension (CTEPH) thiab pulmonary arterial hypertension (PAH). Nws yog ib tug soluble guanylate cyclase activator tsim los ntawm lub teb chaws Yelemees's Bayer Pharmaceuticals. Nws tuaj yeem txhim kho cov neeg mob lub cev ua haujlwm siab, tsis muaj hemodynamic, thiab kev ua haujlwm ntawm lub plawv thiab ua rau lub sijhawm kho mob tsis zoo (PATENT txoj kev tshawb fawb). Tsis tas li ntawd, nws tuaj yeem kho CTEPH (CHEST Study). Thaum Lub Kaum Hli 8, 2013Chemicalbook, US FDA pom zoo riociguat rau kev kho mob Chronic Thromboembolic Pulmonary Hypertension thiab Pulmonary Arterial Hypertension. Nws ua haujlwm los ntawm dilating cov hlab ntsha hauv lub ntsws, pab txo cov ntshav siab thiab txhim kho cov ntshav khiav. Cov hlab ntsha me me hauv lub ntsws ntsws ntsws thiab mob ntsws nrog ntshav siab, uas ua rau nws nyuaj rau lub plawv dhia ntshav los ntawm lawv. Nws pab cov hlab ntsha no so thiab nthuav dav, uas ua rau lub plawv tsis zoo thiab ua rau muaj peev xwm ntawm cov neeg mob pulmonary hypertension rau kev tawm dag zog. Hauv CTEPH, cov ntshav txhaws tsim nyob rau hauv cov hlab ntsha pulmonary, ua rau muaj zog hauv cov hlab ntsha pulmonary thiab ua pa nyuaj. Nws tuaj yeem pab txhim kho cov ntshav khiav los ntawm kev nthuav dav cov hlab ntsha pulmonary thiab rhuav tshem cov ntshav txhaws. Yog tias koj xav tau, Xi'an Sonwu tuaj yeem muab riociguat. Xi'an Sonwu tos ntsoov yuav hnov ​​​​los ntawm koj.

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Riociguat Yuav Online

Xi'an Sonwu Biotech Co. Ltd. muaj kev paub dhau los hauv kev lag luam thoob ntiaj teb thiab kev lag luam kev noj qab haus huv. Insisting rau txoj kev ntseeg raws li kev ntseeg thiab zoo ua ntej yog peb lub tuam txhab txoj cai. Peb nruj me ntsis tswj cov khoom zoo, uas txhais tau tias kev xaiv pib los ntawm raw khoom. Tsis tas li ntawd, peb tswj txhua qhov kev nthuav dav thiab txo cov nqi kom siab tshaj plaws kom peb cov neeg siv khoom tuaj yeem tau txais cov khoom lag luam zoo. Raws li cov no, cov neeg siv khoom tau muab ntau cov lus pom zoo txog peb cov khoom. Yog li nrhiav Xi'an Sonwu Biotech Co. Ltd. thaum yuav riociguat.

Xi'an Sonwu ua kom cov khoom zoo thiab tuaj yeem muab cov qauv. Ntawm no yog qhov ntau.

Cov neeg siv khoom 'Cov lus pom zoo

Riociguat siv rau dab tsi

Thaum kho mob thromboembolic pulmonary hypertension (CTEPH) thiab pulmonary arterial hypertension (PAH), rivicuat muab cov txiaj ntsig hauv qab no:

1. Ua kom muaj peev xwm ua tau zoo: Nws txo cov ntshav ntws los ntawm kev nthuav dav cov hlab ntsha hauv lub ntsws. Qhov no tso cai rau kom muaj cov pa oxygen zoo dua ntawm cov ntshav thiab txhim kho kev xa oxygen mus rau lub cev cov ntaub so ntswg, thaum kawg ua rau muaj peev xwm ua kom muaj zog thiab txo qis qaug zog hauv cov neeg mob PAH thiab CTEPH.

2. Txo Pulmonary Arterial Pressure: Los ntawm dilating cov hlab ntsha pulmonary, nws txo cov siab hauv cov hlab ntsws. Txo cov hlab ntshav siab tuaj yeem pab daws cov tsos mob ntawm CTEPH thiab PAH, suav nrog kiv taub hau, mob hauv siab, thiab ua tsis taus pa.

3. Muaj peev xwm txhim kho Lub Sij Hawm Ntev: Cov kev tshawb fawb soj ntsuam tau pom tias nws tuaj yeem ua rau muaj kev txhim kho hauv kev tawm dag zog, hemodynamics (ntshav dynamics), thiab kev ua haujlwm ntawm cov neeg mob PAH thiab CTEPH mus ntev.

4. Kev Xaiv Kev Kho Mob rau CTEPH tsis tuaj yeem: Nws tau pom zoo rau kev siv tsis tau lossis tsis tu ncua / rov tshwm sim CTEPH tom qab kev phais mob.Rau cov neeg mob uas tsis tsim nyog rau kev phais mob pulmonary endarterectomy, qhov kev phais raug kho rau CTEPH, nws muaj kev xaiv kho tau zoo.

Nws ua kom muaj peev xwm ua kom lub cev muaj zog, txo qis ntshav siab, thiab txhim kho cov txiaj ntsig ntev rau cov neeg mob PAH thiab CTEPH. Txawm li cas los xij, cov neeg mob yuav tsum sib tham txog cov txiaj ntsig thiab kev pheej hmoo ntawm nws nrog lawv tus kws kho mob ua ntej pib kho.

Riociguat Mechanism Ntawm Kev Ua

Riociguat hmoovyog siv los kho mob ntsws ntsws vim mob thromboembolic (CTEPH) thiab pulmonary arterial hypertension (PAH). Nws cov txheej txheem ntawm kev ua yog tsom rau txoj hauv kev nitric oxide (NO) thiab soluble guanylate cyclase (sGC) enzyme.

Ntawm no yog ib tug tawg ntawm nws mechanism ntawm kev txiav txim:

1. TSIS MUAJ Txoj Kev: Nws sensitizes soluble guanylate cyclase (sGC) rau endogenous nitric oxide (NO). Lub cev xav tau nitric oxide raws li cov khoom siv hluav taws xob sab hauv rau ntau lub hom phiaj, suav nrog vasodilation (cov hlab ntsha so) thiab kev tawm tsam ntawm platelet aggregation (tiv thaiv cov ntshav txhaws).

2. sGC Activation: Nws ncaj qha nkoos sGC enzyme, nce cyclic guanosine monophosphate (cGMP) ntau lawm hauv vascular du leeg hlwb.

3. CGMP Teeb Qhia: Vasodilation tshwm sim los ntawm kev so ntawm cov leeg nqaij leeg hauv cov hlab ntsha coj los ntawm qib siab ntawm cGMP. Hauv cov tib neeg uas muaj PAH thiab CTEPH, qhov kev nthuav dav no ua rau muaj peev xwm ua kom lub cev muaj zog thiab txo qis pulmonary vascular resistance (PVR).

4. Dual Action: Nws muaj ob hom kev ua haujlwm. Nws tuaj yeem txhawb nqa sGC ntawm nws tus kheej ntawm NO, uas tshwj xeeb tshaj yog muaj txiaj ntsig zoo rau cov neeg mob uas tsis muaj bioavailability txo qis, xws li cov neeg muaj PAH.

Hauv cov neeg mob ntshav siab, nws pab txhim kho kev tawm dag zog lub cev thiab pulmonary hemodynamics los ntawm kev tsom mus rau NO-sGC-cGMP txoj hauv kev.

Riociguat Contraindications

Riociguat yog contraindicated nyob rau hauv tej lub sij hawm uas nws siv yuav ua rau mob. Contraindications yog cov xwm txheej tshwj xeeb lossis cov xwm txheej uas yuav tsum tsis txhob siv tshuaj. Nov yog qee qhov contraindications rau nws:

1. Nitrate Therapy: Vim muaj qhov ua tau ntawm qhov mob hnyav heev, riciguat yuav tsum tsis txhob noj nrog nitrogen lossis nitric oxide (NO) pub (xws li nitroglycerin).

2. Severe Hypotension: Nws yog contraindicated nyob rau hauv cov neeg mob uas muaj mob hnyav hypotension (systolic ntshav siab <90 mmHg) vim nws yuav ua rau tus mob hnyav dua.

3. Pulmonary Hypertension Associated with Idiopathic Interstitial Pneumonias (PH-IIP): Nws yog contraindicated nyob rau hauv cov neeg mob uas muaj PH-IIP, raws li nws yuav ua rau kom qhov cua/perfusion mismatching thiab ua rau muaj kev pheej hmoo ntawm pulmonary edema.

4. Siv nrog Phosphodiesterase-5 Inhibitors (PDE5Is) lossis Guanylate Cyclase Stimulators (GC Stimulators): Nws yuav tsum tsis txhob siv nrog PDE5Is (xws li sildenafil lossis tadalafil) lossis lwm yam guanylate cyclase stimulators (such as ). Kev siv tib lub sijhawm tuaj yeem ua rau cov teebmeem hypotensive ntawm nws.

5. Cev xeeb tub thiab pub niam mis: Tej zaum nws yuav ua rau fetus raug mob thiab yog contraindicated rau cov poj niam cev xeeb tub. Nws kuj tsis raug qhia thaum saib xyuas neeg mob vim muaj kev cuam tshuam tsis zoo rau tus menyuam.

6. Mob raum hnyav lossis mob siab: Hauv cov neeg uas muaj lub raum tsis zoo lossis lub siab tsis zoo, rivicuat yuav tsum tau ceev faj. Nws tsis pom zoo rau cov neeg mob uas muaj kev puas siab puas ntsws hnyav (Child-Pugh Class C) lossis mob raum tsis zoo (creatinine clearance < 15 mL / min).

7. Hypersensitivity: Nws yog contraindicated nyob rau hauv cov neeg mob uas muaj ib tug paub hypersensitivity rau nws los yog ib yam ntawm nws cov Cheebtsam.

Hoobkas

1. Xi'an Sonwu muaj lub Hoobkas nrog cov khoom lag luam txaus. Tsis tas li ntawd, Xi'an Sonwu muaj chav ua haujlwm huv thiab huv si nrog cov cuab yeej siv siab heev. Raws li lub tuam txhab kev coj noj coj ua, cov kws tshawb fawb txuas ntxiv tsim cov khoom tshiab kom tau raws li cov neeg siv khoom xav tau.

2. Xi'an Sonwu muaj cov cuab yeej ntsuas qib siab thiab cov neeg ua haujlwm kuaj cov kws tshaj lij, txhua yam qhia tau tias Xi'an Sonwu lub hom phiaj muab cov ntaub ntawv raug thiab ua tau zoo thiab kev pabcuam zoo.

Daim ntawv pov thawj

Ntim

Logistics Hloov tshiab

Ntxiv nrog rau kev lees paub cov khoom zoo, lwm qhov tseem ceeb tshaj plaws yog cov neeg tau txais cov khoom lag luam zoo. Yog li, Xi'an Sonwu muab txhua yam kev xa khoom raws li kev xav tau sib txawv.

FAQ

1. Yuav nug li cas?

Peb tuaj yeem hu xov tooj, email, lossis social media.

2. Koj tuaj yeem lav qhov khoom zoo li cas?

Txhua pawg yuav tsum tau sim, thiab COA tuaj yeem muab rau cov neeg siv khoom. Tsis tas li ntawd, tag nrho cov khoom dhau qhov kev xeem: HPLC, UV, GC, TLC, thiab lwm yam. Peb koom tes nrog cov neeg thib peb, zoo li SGS.

3. Koj ntim thiab khaws cia li cas?

Pob: Siv cov khoom ntim ntim khoom ntim thiab ntim cov ntawv ntim khoom ntim, lossis ntim cov khoom raws li cov neeg siv khoom xav tau.

Cia: Koj tuaj yeem khaws cia rau hauv qhov chaw qhuav thiab txias thiab ua kom tsis txhob tshav ntuj.

Yog koj xav paub txog lubriociguat hmoov, koj tuaj yeem tiv tauj Xi'an Sonwu. Nyem rau email, thiab tom qab ntawd koj tau txais cov khoom zoo BAY 63 2521 hmoov.

Email:sales@sonwu.com

Cim npe nrov: riociguat hmoov, Tuam Tshoj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, ntshiab, raw, mov, kev muag khoom